Best Large Grants for Nonprofit Organizations in California

The Community Practice Innovation Award by the Rheumatology Research Foundation aims to foster innovative ideas from the rheumatology community that enhance practice implementation and sustainability. Grants, up to $80,000 for one year, support projects in quality improvement, implementation, and pilot studies. Recipients are expected to share findings with the broader community through presentations and disseminate tools developed with the funding. This initiative emphasizes improving patient care through effective collaboration and innovative practices.

The Marshall J. Schiff, MD, Memorial Fellow Research Award, established by the Rheumatology Research Foundation, aims to support exceptional scholarship in rheumatology. This award not only honors Dr. Schiff's legacy but also recognizes fellows presenting at ACR Convergence. Recipients receive a $1,500 award plus $1,000 for travel expenses, ensuring they can attend this crucial meeting, which showcases the latest advancements in rheumatic disease research and care.

The Chairman Tommy Taylor Memorial Scholarship

The Chairman Tommy Taylor Memorial Scholarship was opened by the Texas Alliance of Energy Producers in 2014 in memory of Tom Taylor, a former chairman of the alliance. He was a prominent figure in the oil & gas industry and an esteemed leader. The one-time $2,500 scholarship is for graduating seniors and currently enrolled college students who have graduated from a Texas high school. The student's field of study must be energy or oil and gas industry-related, including petroleum, geology, and engineering. The award can be used at any college or university.

Mission & Vision

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission:

We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Our Vision:

We envision a Greater Rochester region transformed by enduring philanthropy, where every person, neighborhood, and future generation can thrive.

Dr. Marlene Caroselli Excellence-in-Communication Scholarship

Purpose of Scholarship

To recognize those high school seniors who have consistently demonstrated excellence in both the spoken and written word and plan to pursue college and a career that requires excellence in communication.

Number and Size of Awards

Number of recipients and award amounts vary; award amount may be split between two or more recipients. Award paid in one lump sum in the Fall and divided equally between the Fall and Spring semesters. Average award $5,000; not to exceed the cost of tuition.

Donor Information

A former St. John Fisher College professor who understood and greatly admired the hard work and challenges of single-parent students created this scholarship to support their higher education endeavors and to improve their employability, their lives, and the lives of their children.

The Get Schools Cooking Grant supports medium-sized U.S. school districts in transforming their meal programs from processed to scratch-cooked foods. In partnership with the Chef Ann Foundation, it offers a multi-year journey that includes workshops, assessments, and collaborative planning, with a value of nearly $250,000 per district. Eligible districts must demonstrate commitment to fresh, whole foods, leadership support, and self-operated food service.

About Us

Overview

The Alaska Community Foundation connects people who care to the causes that make a difference and matter most to them. We encourage and nurture philanthropy through building and managing permanent endowments, convening stakeholders, working with partners to strengthen Alaskan communities, and providing donors with flexible giving options that are strategic to their philanthropic objectives.

Mission

Inspiring the spirit of giving and connecting people, organizations, and causes to strengthen Alaska’s communities now and forever.

Vision

ACF envisions an Alaska where communities come together and have resources to thrive.

Holly Dick Scholarship Fund for California Students

A scholarship fund in support of post-high school education including vocational training that will provide a future career. This scholarship fund was created by Holly Dick who learned from her own life experiences how education can change lives.

Holly WaiHung Dick left mainland China with her family in 1947 for a better life in Hong Kong. Her life experiences taught her that education changes lives. After completing school in China, Holly was hired by Japan Airlines, where she met her future husband, an American, Mike Dick. Holly and Mike lived in Anchorage, where they loved to fish and enjoy friends, family, and their Alaskan life. Holly loved to help others along their path in life. She volunteered as a translator for immigrants and helped children in daycare settings.

The Maternal and Child Health (MCH) Nutrition Training Program aims to enhance the nutrition and overall health of mothers and children. This initiative focuses on interdisciplinary graduate education, equipping a skilled workforce to support Title V and other MCH programs. It seeks to expand nutrition education and career pathways while improving access to quality nutrition services. Trainees will gain practical experience through placements at health centers, ultimately benefiting families and communities.

The State Maternal Health Innovation Program (SMHI) aims to enhance maternal health across states by addressing critical gaps. It focuses on improving service quality, developing a skilled workforce, and utilizing enhanced data capabilities. Through innovative programming, the initiative strives to significantly reduce maternal mortality and severe maternal morbidity, ensuring better health outcomes for mothers and their families.

The Care Camps Grant supports children with cancer by funding medically supervised oncology camps that provide joy, hope, and healing through outdoor experiences. With the mission to foster a sense of community and shared healing, Care Camps Foundation aims to serve every child and family affected by pediatric cancer in the US and Canada. By collaborating with donors and volunteers, the foundation ensures that each contribution maximizes benefits for the families in need.

The Hadassah Foundation supports organizations enhancing the leadership roles of women and girls in the U.S. Jewish community. Grants of $80,000 are distributed over three years, focusing on program-based or unrestricted support. Eligible applicants must have specific legal statuses and align with the Foundation's gender equity mission. Proposals are accepted until June 11, 2025, through an online system, aiming to address challenges like financial security and mental health while promoting leadership advancement.

The Action, Implementation, and Mitigation (AIM) Grants, offered by COCO, support organizations in enhancing wildfire risk reduction efforts. Since 2018, COCO has assisted over 90 groups, focusing on community resilience and restoration of fire-adapted ecosystems. Eligible applicants include nonprofits and local governments, with funding ranging from $10,000 to $75,000. Projects should align with broader wildfire strategies and require a 100% cash or in-kind match, promoting inclusive and effective community mitigation approaches.

Stark Community Foundation

Since 1963, Stark Community Foundation has been helping individuals, families, businesses and nonprofits like you support the causes you care about.

In addition to personalized donor services, we manage a competitive grantmaking program and award grants to address local needs. Today, the Foundation stewards over 1,000 charitable funds totaling $485 million in assets and has granted more than $300 million to nonprofits in our community and beyond.

Scholarships

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties.

The Manzer-Keener-Wefler Scholarship Fund

The Manzer-Keener-Wefler Scholarship Fund assists applicants with a field of study in or related to photography, visual arts (including graphic design). 

This scholarship is renewable.

This grant focuses on implementing research to identify effective combinations of community-clinical linkage strategies aimed at diabetes prevention and management. It addresses the challenges faced by Federally Qualified Health Centers and safety-net clinics, emphasizing the need for coordinated approaches. The study will explore factors influencing the adoption and integration of these strategies, ultimately aiming to develop practical evidence and best practices that enhance diabetes care in primary settings.

The Bureau of Land Management's Plant Conservation and Restoration Program (PCRP) aims to enhance the native seed supply chain, crucial for restoring resilient public lands. By collaborating with various partners, PCRP seeks to improve rangeland health, restore wildlife habitats, and create job opportunities. In 2026, the focus will be on local seed collections, supporting farmers entering the native seed market, and developing innovative technologies to ensure effective restoration outcomes and ecological resilience.

Research Grant Program 

Providing research grants to support clinicians and scientists focused on primary immunodeficiency (PI).

Scope and eligibility

• The Immune Deficiency Foundation's Research Grant Program supports patient-centered research focused on improving the treatment, health, disease management, or diagnosis of people with primary immunodeficiency (PI), as well as research that contributes to the broader body of knowledge on PI.
• Awards range from $25,000-50,000. In addition, the Michael Blaese Research Grant Award is bestowed on the highest-scored application each cycle.
• One-year term.

The Lily Smith Memorial Scholarship, established by the Central Kentucky Community Foundation, supports high school graduates from Nelson County pursuing a nursing degree. Founded in 1960, the foundation is committed to enhancing community well-being through philanthropy. This scholarship exemplifies their mission by providing financial assistance to future nurses, ensuring that local talent is nurtured and prepared to meet healthcare needs. The initiative reflects a deep commitment to education and community service.

The MCTS Legacy Scholarship Program, established by the Mobile County Training School Alumni Association in collaboration with UNCF, offers ten $3,500 need-based scholarships for MCTS attendees or their descendants. This initiative aims to support educational pursuits among students connected to MCTS, enhancing access to higher education. Recipients will be notified within eight weeks after the application deadline, promoting academic success and community engagement. The program reflects UNCF's commitment to empowering minority students and fostering leadership.

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

About the Chester County Community Foundation

Our Mission

The Chester County Community Foundation connects people who care with the causes that matter, so their philanthropy makes a difference now and forever.

Valerie Lamb Smith Art Scholarship

Mission

The purpose of this fund shall to be to ensure that more Chester County students benefit from art instruction, regardless of family income or the schools they attend.

About Valerie

Valerie Lamb Smith was a dedicated teacher and artist from Newtown Square, PA. She taught oil and watercolor painting to young, aspiring artists at Wayne Art Center. Valerie’s personal work was a chronicle of her own life and observations. She centered her art around time and the lost but recent past. Her work centered around the figurative but was also decorative. Valerie was also a flower painter and at one paint had a large exhibition at Longwood Gardens.

Born in Quakertown, PA on April 26th, 1937, Valerie always had a love for the arts. She attended Solebury School in New Hope, PA and graduated in 1954. She followed her passion to Smith College in Northampton, MA where she studied Art and Art History. Valerie met her husband, Langhorne Smith, while he was a student at Yale University. They married in 1958.

After college, Valerie and Langhorne settled in Pennsylvania where Valerie taught Art at various schools on the Main Line. During this time, Valerie pursued her Masters Degree at The Pennsylvania Academy of Fine Art. Valerie was the proud mother of three children, two sons and a daughter.

Valerie passed away in 1997 after a courageous battle with cancer. Her loving husband, Langhorne Smith, complied with her request that an art fund be established in her name. This fund, supported by her family and close friends and colleagues, helps young people from Chester County explore the world of art, regardless of their families income or the resources of their schools.

HIE Help Center Scholarship for Physical, Occupational, and Speech Therapy Students

The HIE Help Center will award one annual scholarship in the amount of $1,000 to an undergraduate or graduate student who plans to pursue a career in physical, occupational, or speech therapy.

The scholarship will be awarded to a single applicant who meets the following criteria and has submitted all required application materials outlined below by the deadline.

Award

• $1,000

Who We Are

The Community Foundation of Central Illinois will make a sustainable philanthropic impact in our community through visible leadership in connecting people who care with causes that matter.

Women in Leadership of Central Illinois Scholarship Fund

The Women in Leadership of Central Illinois Scholarship Fund was established by the Women in Leadership of Central Illinois to provide scholarship support for women in the Tri-County (Peoria) area, who are pursuing secondary or post-graduate education or certification at an accredited college or university.

Women in Leadership Mission

To promote leadership among women by providing mentoring, networking, and educational opportunities.

In 2020, GradGuard founded College Life Protected, LLC as a social purpose entity that supports programs, research, professional development, and best practices in higher education that promote greater confidence in the value of higher education as a public good. 

College Life Protected invites the higher education community to apply for grants that are consistent with our mission.

Promoting Financial Literacy

College Life Protected recognizes that that financial literacy is a critical skill for student success, impacting everything from academic persistence to long-term financial well-being. That’s why we are committed to funding programs and initiatives that equip students with the knowledge and resources they need to make informed financial decisions.

By supporting programs that enhance financial education, we aim to empower students to navigate college costs, manage personal finances, and build a strong financial future.

About

Mission, Vision & Values

To enhance our community through philanthropy.

We aspire to co-create diverse, meaningful and innovative charitable giving that yields an exponential positive impact within local communities and beyond.

Coopey Boys’ Memorial Fund

About the fund

The Coopey Boys, Raymond Peter and Lauritz Martin, were born with hemophilia, a genetic disorder that impairs the body’s ability to make blood clots. Sadly, they both died at an early age. The Coopey Boys’ Memorial Fund benefits Corvallis students who suffer from a physical handicap or serious chronic health problem.

About Pfizer

Pfizer supports the global healthcare community’s independent initiatives (e.g., research, quality improvement, or education) to improve patient outcomes in areas of unmet medical need that are aligned with medical and/or scientific strategies.

About the American Headache Society

The American Headache Society strives to improve the lives of people impacted by migraine and other headache disorders. The AHS is a professional society of health care providers dedicated to the study and treatment of headache and face pain. The Society’s objective is to promote the exchange of information and ideas concerning the causes and treatments of headache and related painful disorders. Educating physicians, health professionals, and the public while encouraging scientific research are the primary functions of the Society.

Quality Improvement and/or Research Grants: Migraine and Women’s Health

Migraine is a prevalent and debilitating neurological disease that disproportionately affects women, impacting quality of life, productivity, and overall health. Recognizing the need for innovative solutions and enhanced care, Pfizer and the American Headache Society (AHS) are collaborating to offer a new grant opportunity inviting proposals for collaborative quality improvement and research projects focused on migraine and women's health. This Request for Proposals (RFP) aims to foster high-impact research and initiatives that advance scientific understanding, improve patient outcomes, and address gaps in care. Projects should also contribute to the core goal of the AHS – improving the lives of people impacted by migraine and other headache disorders.

Objectives

• To advance research in migraine and women's health through collaborative pre-clinical and clinical projects
• To promote quality improvement initiatives that enhance diagnosis, treatment, and management of migraine in women
• To encourage multidisciplinary approaches that integrate clinical expertise, patient-centered care, and innovative research methodologies
• To generate measurable and actionable outcomes that contribute to improved standards of care and inform future research directions for women with migraine

The Ralph J. Torraco Fine Arts Scholarship, offered by the UNICO Foundation, awards two $2,500 scholarships to U.S. students studying Fine Arts, including Performing, Visual, or Technical Arts. Eligible applicants must be U.S. citizens with a minimum GPA of 3.0, enrolled full-time in an accredited college, and planning to continue their studies into the 2025-2026 academic year. This scholarship aims to support and promote Italian American culture and heritage through the arts.

Exelixis Grants & Giving focuses on impactful charitable contributions, supporting non-profit organizations in community support, healthcare-related initiatives, independent patient assistance, medical education, and sponsorships. Their aim is to enhance oncology care, particularly for renal cell carcinoma and other cancer types, while ensuring proposals are submitted within specified timelines. Exelixis partners with organizations dedicated to improving patient outcomes and community health, demonstrating their commitment to making a difference beyond medicine.