Best Large Grants for Nonprofit Organizations in California

The OVC FY 2026 grant aims to improve outcomes for child and youth victims of human trafficking by integrating policies at state and Tribal levels. This funding opportunity focuses on developing strategic plans to address the challenges faced by minor victims, enhance coordination among systems like child welfare and juvenile justice, and ensure effective identification and prosecution of traffickers. By fostering multidisciplinary approaches, the program seeks to provide comprehensive support and services to these vulnerable populations.

The Food and Agriculture Defense Initiative Extension Disaster Education Network (FADI-EDEN) aims to enhance the resilience of the U.S. food and agriculture sector against various threats, including biosecurity risks and natural disasters. Through the Extension Disaster Education Network, the program fosters collaboration among CES professionals, providing essential education and technical assistance to farmers and communities to effectively manage domestic disasters and strengthen all-hazards preparedness.

Agnes McCarthy Caregiver Foundation

The Agnes McCarthy Caregiver Foundation is a 501(c)(3) not-for-profit charity that provides hope and relief to caregivers who care for a loved one with mental health conditions.

Caregiver Grant

Family caregiving has become a public health issue that receives inadequate recognition in our country. While it can be rewarding to care for our loved ones, it often comes with significant physical, emotional and financial costs to the caregiver. On average, caregivers spend over 25% of their own income to support their loved one and provide 32 hours a week in unpaid care.

AMCF currently offers a $500 financial relief grant to assist family members with unexpected expenses due to their caregiving role. If you are a family caregiver to someone living with a mood or psychiatric condition like depression, anxiety, PTSD, bipolar, schizophrenia, or other mental health/co-occurring conditions, you are not alone, and we welcome you to apply for a caregiver grant today.

Additional Information

• To ensure our limited funds reach families with the greatest need, grants may require documentation confirming a diagnosed serious mental illness (SMI).  

• The $500 grant is limited to one award per household within a 12-month period.

• Applications are generally reviewed by our Board of Directors, with decisions made within 30 days of receipt.

The Burroughs Wellcome Fund's Climate Change and Human Health Seed Grants aim to foster innovative collaborations among diverse fields to address climate change's effects on health. With $1M dedicated from Fall 2023 to Summer 2026, grants range from $2,500 to $50,000. This initiative encourages partnerships between biomedical scientists, public health experts, and community organizations, promoting sustainable health systems and effective climate communication. Proposals are accepted on a rolling basis, emphasizing creative solutions to pressing health challenges.

The AACR June L. Biedler Prize for Cancer Journalism

Prize Summary

The AACR June L. Biedler Prize for Cancer Journalism was established by the AACR in 2015 to raise awareness of the critical role that the media play in educating the public about cancer and cancer research.

Funded by a major bequest to the AACR from cancer research pioneer Dr. June L. Biedler, a scientist, mentor, and former member of the AACR Board of Directors, this prize showcases outstanding examples of cancer journalism and recognizes individual professional journalists who have produced accurate, informative, and compelling stories that enhance the public’s understanding of cancer, cancer research, cancer advocacy, or cancer policy.

The prize provides an unrestricted cash award of $5,000 and a commemorative award.

Categories

Each submission may be considered for only one category, as selected by the candidate on the application form.

Applicants may submit in any of the following categories:

Prize Acceptance

Awardees will be able to accept the prize during the AACR Annual Meeting 2027 in Orlando, April 2-7, 2027.

The ADCMS Competitive Grant Program, administered by the DOT Federal Highway Administration, aims to incentivize eligible State Departments of Transportation and partners to implement innovative technology in construction projects. This initiative promotes collaboration among various entities, including local governments and private industries, with a required cost share of 20% to enhance project viability and effectiveness. The program encourages joint applications to maximize the impact of technological advancements in the construction sector.

The FY 2026 funding opportunity aims to support Indian Tribes and intertribal consortia in implementing approved Nonpoint Source management programs under the Clean Water Act Section 319. This initiative, funded by the EPA, focuses on addressing NPS pollution through best management practices as outlined in Tribal NPS Management Program Plans, ensuring the protection of water resources and promoting sustainability in Tribal lands.

The Research Grants on Improving the Use of Research Evidence program aims to enhance the application of research findings for young people aged 5-25 in the U.S. It offers major grants ranging from $100,000 to $1,000,000 over 2-4 years, focusing on impactful studies and capacity-building for researchers. The foundation encourages collaboration among scholars and practitioners to strengthen research practices and evidence use in various settings.

The Sacramento Valley Veterinary Medical Association Charitable Fund Grant supports local 501(c)(3) nonprofits, veterinarians, and veterinary students, offering awards from $500 to $1,500 for projects improving animal welfare in Sacramento and Yolo counties during 2024-2025. Funding can cover materials, supplies, equipment, and education programs, with a strong encouragement for Pacific Islander-led organizations to apply. Detailed grant requests are essential for funding consideration.

American Headache Society

The American Headache Society (AHS) is a professional society of healthcare providers dedicated to the study and treatment of headache and face pain. The Mission of the AHS is to improve the lives of people impacted by migraine and other headache disorders. AHS advocates for those impacted by headache and the headache field, to meet our core objectives. AHS provides educational courses, scientific meetings, a journal, research support, career development opportunities, Special Interest Groups, advocacy training, and a professional community. The AHS strives to meet its objectives while fostering an inclusive sense of belonging and community.

Headache & Migraine Competitive Grant Program

The Headache & Migraine Competitive Grant Program stands at the forefront of advancing headache medicine by funding groundbreaking quality improvement initiatives. This highly competitive grant program, offered through the collaboration between the American Headache Society and Pfizer, supports projects that have the potential to reshape the field by creating widely applicable tools and driving measurable improvements in patient care. 

Migraine & Women's Health

Migraine is a prevalent and debilitating neurological disease that disproportionately affects women, impacting quality of life, productivity, and overall health. Recognizing the need for innovative solutions and enhanced care, Pfizer and the American Headache Society (AHS) are collaborating to offer a new grant opportunity inviting proposals for collaborative quality improvement and research projects focused on migraine and women's health.

Shaw's Foundation Grants support nonprofit organizations that enhance community well-being, focusing on hunger, youth education, and health. Eligible organizations must be 501(c)(3) certified and serve specific regions like California and Hawaii. An employee sponsor is mandatory for applications in these areas. The grant review process typically takes about eight weeks, and the foundation prioritizes collaborations with local partners to maximize community impact.

Spencer Educational Foundation Inc

The Spencer Educational Foundation was founded by the Rims Atlanta Chapter in 1979. To this day, Spencer remains the premier organization funding the education of tomorrow's risk management and insurance leaders.

The Spencer Educational Foundation: awards merit-based scholarships and grants to university students pursuing careers in risk management, insurance, and/or actuarial science; provides grants that create experiential learning opportunities both on and off campus; funds the development of risk management and insurance curricula in colleges and universities; supports Risk Managers by creating internship opportunities within the risk management function of their companies; and operates across the United States and Canada. 

Spencer Educational Foundation: General Grants

Spencer’s goal to help build a talent pipeline of Risk Management and Insurance professionals is achieved in part by our collaboration with Risk Management and Insurance educators across the United States and Canada. Since 2010, Spencer has awarded over $4.5 million in General Grants to support over 225 student-centered experiential learning initiatives at universities and RMI non-profit orgs.

Spencer's General Grants Program supports student-centered initiatives that (1) provide experiential learning opportunities for Risk Management & Insurance students and (2) attract new talent to risk and insurance careers. 

The Annual Recurring University Training and Research grant aims to foster the next generation of engineers and scientists by funding research and development at U.S. colleges and universities. This initiative focuses on supporting early-stage research and enhancing opportunities for underrepresented communities, ensuring that students gain essential skills for successful careers in the U.S. workforce and economy. It is a vital step toward inclusive educational advancement and workforce development.

The 3VCF Community Impact Grants aim to empower local nonprofits in addressing critical community needs, particularly in mental health, health equity, and environmental sustainability. For 2024, Three Valleys Community Foundation is expanding its grantmaking focus to include diverse and innovative proposals that respond to pressing health issues. Collaborative efforts among organizations are encouraged to foster impactful solutions and promote community well-being.

JFO Music & Cultural Arts Programs

This scholarship opportunity is available year-round.

The current program requirements include the following:

• Scholarships are awarded on a financial-need basis.
• Scholarships are available only to Jewish residents of the Omaha metropolitan area.

The Chronic Care Telehealth Centers of Excellence Program, funded by the Health Resources and Services Administration, aims to enhance chronic care management through innovative telehealth technologies. This initiative will support academic medical centers in integrating comprehensive telehealth services for chronic disease prevention, management, and acute episode treatment. The centers will also contribute to research publications, establishing national benchmarks for effective telehealth integration in chronic care.

Deana’s 7th Inning Stretch Scholarship – Baseball/Softball

The applicant must be a graduating high school senior in one of the following counties: Breckinridge, Grayson, Hardin, Hart, LaRue, Marion, Meade, Nelson, and Washington Counties.

Requirements

An essay on how baseball or softball influenced your life.

We are living in a time of intensified state violence and mass criminalization. The current political climate has doubled down on surveillance, policing, incarceration, and the criminalization of protest, migration, and mutual aid. For directly impacted communities, the trauma is relentless — and those of us committed to resistance are feeling the weight of outrage fatigue.

But we know: the antidote to outrage fatigue is movement response. The expansion of state violence and mass incarceration often forces organizations to respond quickly to unanticipated events despite lacking the necessary resources or capacity.

The Strategic Opportunities Support (SOS) Fund-CJI’s rapid-response fund-is designed to support bold, strategic, and immediate actions by grassroots organizations on the front lines of resistance. The Fund awards grants up to $7,500 and enables organizations to move quickly and collaboratively in response to emerging threats and seize opportunities to advance justice, healing, and systemic transformation.

The Emily's Hope Scholarship, managed by the Sioux Falls Area Community Foundation, offers substantial financial aid to local students pursuing higher education in art. With over $500,000 awarded annually, this scholarship targets graduating high school seniors in South Dakota who plan to study visual art. Applicants need to submit an artwork sample and a reference from an art teacher. This scholarship is designed to complement other financial aid, covering tuition and course-related expenses.

About Us

We are YOUR Community Foundation! Our mission is to bring people and resources together to strengthen the quality of life, both now and in the future, for the residents of Randolph County.

The Community Foundation of Randolph County, Inc. is here to make our community the very best place to live, work, and raise a family. As a non-political private organization, we are uniquely able to provide grant money for innovative projects that have a major impact on our community.

Dr. Dianna K. Wolfe Memorial Scholarship

Dr. Dianna K. Wolfe was a lifelong resident of Winchester. After graduating from Lee Driver High School at the age of 17, she started Nurses Training at Ball Memorial Hospital School of Nursing, where she received her nursing degree. She earned her bachelor’s degree in nursing from Indiana University. She also earned her master’s degree and her doctorate degree from Ball State University. She joined the Ball State University School of Nursing faculty in 1977, teaching in the associate, baccalaureate, and graduate nursing programs for about 33 years, where she maintained her professional clinical practice as an evening supervisor. During her career she was flexible, adaptable, and willing to try new teaching strategies as technology progressed, and her students gave her high ratings throughout her tenure as being well organized and relating course materials effectively.

During that time, she raised six children. Her love of education inspired her husband, Robert, to go to school and he subsequently earned two degrees.

In creating the Dr. Dianna K. Wolfe Memorial Scholarship, her family hopes to continue her legacy by assisting students interested in obtaining education to work in the healthcare field.

The Tribal Maternal, Infant, and Early Childhood Home Visiting Program seeks applications for Development and Implementation Grants to support evidence-based home visiting programs for expectant families and young children. Funded by the U.S. Department of Health & Human Services, these grants aim to enhance maternal and child health, improve parenting practices, and foster early childhood development within tribal communities, ultimately promoting better socio-economic outcomes and reducing instances of child maltreatment.

About Us

Marshfield Area Community Foundation, Inc. is a public, 501-C-3 charity. There are 30 community foundations in Wisconsin and more than 750 in the nation. The purpose of all community foundations is to accumulate charitable dollars that impact a specific geographic region in areas such as education, the arts, economic development, recreation, environmental protection, health care, and social services. They may be relatively small, as we are (assets of $14 million), or very large, as is the Greater Milwaukee Foundation (assets over $400 million).

Most people are familiar with private foundations, established by individuals, families, or corporations. Typically, in order to establish a private foundation, one has to have considerable wealth. You could say Community Foundations are much more democratic. We are, in a sense, an umbrella foundation containing many small foundations. We call those small foundations “funds.”

Marshfield Area Community Foundation Scholarships

The mission of the Marshfield Area Community Foundation is “Connecting people who care with causes that matter to enrich the quality of life in the Marshfield area”. Education is a valuable tool and a cause that matters to all of us. Through assisting students with financial support to receive an education, not only do students and the families of those students benefit, but also our community benefits, which further allows us to achieve our mission of enriching the quality of life in the Marshfield area.

Tom Drendel Memorial Scholarship (2025)

Visit Bucks County Tourism & Hospitality Scholarship

Provides scholarships to students from Bucks County who are planning to study a major that supports the tourism/hospitality industry and attend an accredited college or university or trade school.

The Fund for Wild Nature Grant empowers small non-profit organizations in Canada and the U.S. that prioritize the preservation of native species and ecosystems. With a biocentric approach, this grant supports innovative initiatives combating environmental degradation. Organizations must be tax-exempt and can only submit one proposal annually. Grants do not exceed $3,000, ensuring funding is directed to impactful projects addressing ecological issues often overlooked. Join the Fund in investing in the future of wild nature!

The Grants for Coordination of Tribal Temporary Assistance for Needy Families (TANF) and Child Welfare Services aim to support tribal families at risk of abuse or neglect. This funding encourages innovative projects that enhance case management, supportive services, and prevention strategies. Eligible applicants include federally recognized tribal governments and organizations. ACF prioritizes sustainable systems changes, enabling lasting improvements in the coordination of TANF and child welfare programs to better serve vulnerable tribal families.

Mission & Vision

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission:

We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Our Vision:

We envision a Greater Rochester region transformed by enduring philanthropy, where every person, neighborhood, and future generation can thrive.

John W. Burandt Scholarship

Purpose of Scholarship

To provide support for tuition, fees, books, and other expenses associated with post-secondary education for dependents of firefighters residing in the city of Rochester, NY.

Number and Size of Awards

One award of $2,000; paid in the Fall and and divided equally between the Fall and Spring semesters.

Donor Information

This scholarship was established by Mrs. Lorene (Rene) Burandt in honor of her husband, John W. Burandt, a dedicated firefighter who served the Rochester community for 30 years.