Best Large Grants for Nonprofit Organizations in California

The Great Lakes Bay Pride Scholarship, offered by the Saginaw Community Foundation, supports Michigan residents dedicated to promoting respect and acceptance across diverse backgrounds. This scholarship is open to high school seniors and college students pursuing undergraduate or Career and Technical Education (CTE) programs, with awards ranging from $500 to $4,000. Eligible applicants must maintain a minimum GPA of 2.5 and demonstrate commitment through volunteer work in the LGBTQ+ community.

The Holland Scholarship, established in honor of Merle Holland Leis Frenzel, aims to support aspiring music students from Saginaw County. Funded by her friends and former students, this scholarship encourages recipients to pursue their musical dreams while honoring the support of her parents, Norton and Virginia Holland. Eligible applicants must maintain a minimum 3.0 GPA, be seniors at Saginaw County public high schools, and be involved in music programs. Awards typically range from $500 to $4,000.

Improving Metastatic Prostate Cancer (mPCa) Care Through Innovative Strategies

The National Comprehensive Cancer Network® and Pfizer Global Medical Grants (Pfizer) are collaborating to offer a new grant opportunity seeking proposals for investigator-initiated research to improve mPCa care. Pfizer (hereafter, “Grantor”) is providing $1 Million in funding to support quality improvement studies to advance health care quality, the delivery of quality care, and improve health care provider performance in mPCa care. The Grantor will serve as the funding organization. Grants are available to all investigators from institutions within the United States. 

Aim

To promote the advancement of scientific knowledge, health care provider performance, and/or health care quality improvement focused on improving mPCa care.

A total of $1 Million is available to fund all projects. The intent is to fund 2-5 studies. There is a funding cap of $250,000 per study. Exceptional studies with budgets above this amount will be considered based on scientific merit and must contain a robust justification. All budgets must include line-item information and robust justification.

The National Institute of Environmental Health Sciences (NIEHS) invites applications for the Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional). This program supports interdisciplinary research centers focused on biomedical and environmental science. Eligible institutions must be accredited higher education establishments. Applications are due by 5:00 PM local time, and successful submissions will undergo a rigorous peer-review process to ensure quality and relevance in addressing hazardous substance issues.

The American Academy of Audiology offers the Investigator Research Grant to promote essential research in audiology and balance health care. With a funding limit of $20,000 for one-year projects, the grant aims to support innovative research that enhances the evaluation and management of hearing and balance disorders. Eligible applicants must hold a doctoral degree in audiology or hearing science and be affiliated with a non-profit institution in the U.S. or Canada, fostering collaboration between academia and clinical practice.

The TTF Advertising for the Environment Grant, established by the Temper of The Times Foundation in 1997, aims to enhance awareness of wildland conservation through marketing initiatives. This grant is exclusively available to 501(c)(3) nonprofit organizations and funds various advertising campaigns to protect native ecosystems. Priority is given to projects that demonstrate measurable impacts on conservation, rather than those focused solely on education.

The CAC/Robert L. Viera Community Service Scholarship, established in 1998, supports Saginaw County high school seniors pursuing higher education. This award assists students demonstrating financial need and recognizes those with special circumstances allowing part-time college enrollment. The scholarship honors Robert Viera's legacy of leadership in the minority and low-income communities, aiming to empower future leaders through education and community service. Awards typically range from $500 to $4,000, ensuring accessibility to higher education for deserving students.

The Bernice Barlow NAACP Scholarship, awarded by the Saginaw Community Foundation, supports high school seniors pursuing higher education or vocational training. Applicants must have a minimum GPA of 2.0 and be current members or children of members of the Saginaw NAACP Branch. This scholarship honors Bernice Barlow, a dedicated educator and NAACP leader, providing financial assistance to foster educational opportunities in the community. Awards typically range from $500 to $4,000, helping students achieve their career goals.

First Tech Education Grants focus on innovative solutions for children and families, primarily in education and fundamental needs. They support nonprofits in Oregon, Washington, and Northern California with grants aimed at enhancing STEM education, early childhood literacy, and financial education for underserved communities. By partnering with local organizations, First Tech aims to build capacity and provide essential resources to help these communities thrive. Organizations can apply for support through an online application process.

The Youth Access to Nature Fund, established by Justice Outside, aims to enhance access to nature for youth of color in the San Francisco Bay Area. With a focus on racial justice and environmental education, the fund supports projects that empower young leaders and promote mental well-being. Grants up to $25,000 are available for initiatives that engage communities and foster relationships with the outdoors, ensuring that marginalized voices are prioritized in environmental movements.

The FY26 Bollards Competitive Grant Program aims to enhance pedestrian safety by funding bollard installation projects. This initiative targets areas frequented by large crowds to prevent injuries and potential acts of terrorism. Eligible applicants include State Departments of Transportation and local government entities, with a 100% federal funding share for projects. This program is vital for improving public safety in urban environments.

The California Specialty Crop Multi-State Program, established by the California Department of Food and Agriculture, aims to enhance the competitiveness of specialty crops through funding collaborative projects addressing key issues like food safety and marketing. Grants range from $250,000 to $1 million, supporting initiatives that span up to three years. This program emphasizes the importance of specialty crops, including fruits, vegetables, and horticulture, in California's agricultural landscape.

The Pulmonary Hypertension Fund, supported by the Patient Advocate Foundation, offers financial assistance for patients dealing with pulmonary hypertension. This fund covers essential healthcare costs, including medication copays and health insurance premiums. Patients must meet specific eligibility criteria, such as having a confirmed diagnosis and appropriate health insurance. Since 1996, the foundation has empowered millions to navigate healthcare challenges, ensuring they receive the care they need without financial burden.

The CAFE Group 

We resource leaders, invest in their genius, and bring people together to reimagine what philanthropy can do.

Founded by Liz and Don Thompson, The CAFE Group is a national nonprofit transforming how change is resourced. 

With a focus on education equity, social capital, and philanthropic transformation, we pair catalytic funding, community-rooted leadership development, and cross-sector collaboration to strengthen the people and institutions shaping a more just future. Everything we do is grounded in relationship, because we believe the way resources move matters just as much as where they land.

The 1954 Project Luminary Award

The 1954 Project Luminary Award celebrates transformational education nonprofit leaders dedicated to serving Black students and communities through powerful investments in their organizations' ability to create lasting change.

The Luminary Experience

Each Luminary organization gets more than funding. Through The 1954 Project, leaders gain a community, a platform, and space to grow with tailored support over the course of the three year journey.​

• $1 Million, Unrestricted: Catalytic funding to expand what’s working.
• Leadership Coaching + Capacity Support: Guidance from peers and experts who are committed to helping you build a lasting, impactful organization.
• National Network: Luminaries join a powerful community of innovators, change-makers, and visionaries driving systemic progress to support students and communities across the U.S.

The 1954 Project’s Impact Areas

We focus on three interconnected areas critical to advancing equity:

• Innovation in Teaching and Learning: Create education models that center Black students through culturally affirming approaches that challenge traditional structures and transform how learning happens, ultimately serving all students. 
• Diversity in Education: Build pathways that increase and sustain Black educators and education leaders who transform where and how students learn.
• Pathways to Economic Mobility: Build pathways to wealth, ownership, and economic power for Black students, families, and communities through innovative educational programming.

Our Selection Criteria

We seek out extraordinary applicants who embody our values and vision across three categories:

Leader: We look for leaders whose influence and vision contribute to the collective well-being and advancement of the Black community. These leaders:

• Are Visionary: They demonstrate a strategic and pragmatic mindset, articulating a transformative vision for significant, positive change.
• Show Demonstrated Commitment: They embody steadfast dedication to your cause, inspiring and influencing others, and galvanizing community involvement.
• Are Adaptive: They assertively tackle challenges, turning setbacks into opportunities for innovation, while maintaining humility and thoughtfulness in problem-solving.

Organization: We look for organizations that drive significant change, anchored by a deep love for people and driven by the genius within communities of color. These organizations: 

• Have a Defined Problem: They clearly identify the issue they are addressing and explain in detail how your organization tackles root causes. 
• Take a Strategic Approach: They have clear, measurable, and achievable organizational goals with a well-defined strategy informed by thorough analysis. 
• Show Demonstrated Impact: They have a tested model that has produced positive results, incorporating continuous learning and iteration. 
• Have a Transformation Plan: They present a clear plan for using the $1M award to advance your organization's mission, vision, and long-term goals. 
• Embrace Collaboration: They use collaborate to build partnerships based on trust, love, and common goals. 

Radical Imagination: We seek leaders who challenge and redesign societal norms to build a just and equitable future. They demonstrate:

• Community-Rooted Leadership: They maintain and cultivate genuine community ties, integrating professional expertise and personal commitment to drive visionary, impactful strategies. 
• Long-Term Commitment: They are in it for the long haul, committing to sustained impact across generations and prioritizing long-lasting solutions over short-term gains. 
• Collectivism: They embody the philosophy of "I am because we are," actively engaging in collaborative networks and fostering community-reflective solutions. 

The Bicycle Advocacy Grants Program, supported by New Belgium Brewing Co, aims to foster community engagement through bicycle projects. With over $11.3 million donated since its inception in 1995, the program focuses on breaking down barriers to cycling and promoting accessibility for all. Projects targeting increased ridership and addressing systemic inequities are prioritized. This initiative reflects New Belgium's commitment to sustainability and social equity, enhancing community connections through the joy of cycling.

The Maternal, Infant, and Early Childhood Home Visiting Program (MIECHV) aims to enhance maternal and child health, promote early childhood development, and support family well-being. By providing voluntary, evidence-based home visiting services to pregnant women and families with young children, the program addresses critical needs in communities. Funded by the US HHS: Health Resources & Services Administration (HRSA), MIECHV empowers families through tailored support and resources, fostering healthier outcomes for mothers and their children.

Tree and Soil Research Fund Grant Program

The TREE Fund Board of Trustees is launching the new Tree and Soil Research Grant, made possible by a permanently restricted endowment fund supporting areas of research of interest to the landscape architecture community with special focus in the area of trees and the soils that support them. Projects are expected to be completed within one to three years, with a maximum award value of $10,000. No project may receive more than one award from this program. This grant will be offered every other year beginning in 2021.

Award amount:

• up to $10,000 (minimum $5,000) 

Destination: Home

Destination: Home is a public-private partnership ending homelessness in Silicon Valley.

Our goal is to END homelessness in our community and we’re committed to advancing solutions that will deliver true systemic change. 

Through our collective impact model, we convene and collaborate with stakeholders across our community to advance strategies that address the root causes of homelessness and help ensure that all our neighbors have a stable home. We embrace a data-driven and human approach to our work – advocating for policies, incubating new ideas and programs, and investing in strategies that reduce and prevent homelessness in our community.

Sponsorship

As part of our commitment to support other nonprofits, we accept sponsorship requests on an ongoing basis from organizations whose mission and work align with our mission to prevent and end homelessness in Silicon Valley. 

Requests will be reviewed on a rolling basis. You can generally expect to receive a response within 2-3 business days. Payments typically take an additional 10-14 business days to process. 

Destination: Home is proud to help fund impactful strategies for preventing and ending homelessness in our community. To help individuals with lived experience overcome these barriers and build toward long-term housing stability, Destination: Home developed the Supportive Employment Assistance (SEA) Fund. The fund supports community-based organizations that deliver targeted employment services, including job readiness support and workforce connections, for eligible residents across Santa Clara County. We welcome interest from mission-aligned organizations that provide employment support to people experiencing homelessness. Partners must be able to administer financial assistance, accept referrals from Destination: Home and other network partners, and participate in regular reporting and coordination activities with Destination: Home.

The Youth Regional Treatment Center Aftercare Program aims to support American Indian and Alaska Native youth in maintaining safety, sobriety, and success post-discharge from Youth Regional Treatment Centers. This initiative enhances culturally relevant, community-based aftercare by fostering care coordination, building partnerships, and addressing barriers to improve youth outcomes.

The Urban Indian Health 4-in-1 Program is designed to enhance the health and well-being of urban Native Americans through targeted initiatives in immunization, health promotion, disease prevention, mental health support, and addressing alcohol and substance abuse issues. Funded by the US Dept. of Health & Human Services, this program aims to improve access to essential health services and foster healthier communities among urban Indian populations.

The Tribal Epidemiology Centers initiative aims to support currently unserved areas through a new cohort of TEC sites. Funded by the US Dept. of Health & Human Services: Indian Health Service, this program seeks to enhance public health capacity within tribal communities, ensuring access to essential health services and resources. The initiative underscores a commitment to addressing health disparities and promoting wellness among Native populations.

The Solidarity Fund Grant, part of the Black Feminist Fund, aims to empower Black feminist movements by providing essential resources. Acknowledging the historical underfunding of these movements, the fund supports groups led by Black women, girls, and gender-expansive individuals. It focuses on solidarity efforts that foster collaboration and joint campaigns, enabling activists to drive social change. This initiative is crucial for advancing justice, self-determination, and equity within communities, ensuring that Black feminist visions are amplified and sustained.

The Bill Monroe Memorial Scholarship, managed by the Brown County Community Foundation, offers financial support to graduates of Brown County High School pursuing a full-time baccalaureate degree in music or a related field. This scholarship is open to current and previous graduates, including those participating in Bluegrass music mentoring programs. The foundation has a strong focus on education and has facilitated numerous scholarships, enhancing opportunities for local students since its establishment.

Pediatric Dermatology Research Alliance Inc 

PHACE syndrome is a neurocutaneous syndrome characterized by large segmental infantile hemangiomas of the face and scalp in association with congenital anomalies that may affect the posterior fossa of the brain, cerebral and cervical arteries, heart, and/or eyes. LUMBAR syndrome is the lower-body counterpart of PHACE, characterized by large segmental infantile hemangiomas of the lumbosacral, buttock or pelvic regions associated with urogenital, spinal, bony, anorectal, and/or renal abnormalities. Those affected experience a wide range of comorbidities with significant psychosocial impact. We invite proposals for clinical research that improves diagnostic approaches, enhances quality of life, and addresses key aspects of disease burden and management.

Applications may be submitted by either a single investigator or multiple investigators at multiple institutions. A total of $40,000 is available and may be awarded as one large-scale project or as multiple smaller awards, depending on the number and quality of applications received. Equal consideration will be given to projects in either of the two award formats with decisions to be based upon merit and available funds.

Focus

Research should focus on PHACE and/or LUMBAR syndromes. Priority will be given to investigators who have not previously served as the senior investigator on an R01 NIH grant or equivalent, and to studies that include multidisciplinary teams with active roles for early-career investigators. Proposals that meaningfully integrate patient perspectives are strongly encouraged.

Important Details

• Up to $40,000 will be funded to support one large-scale project for up to two years, or as multiple awards for smaller-scale projects

The Elevance Health Foundation's Maternal and Child Health Grant supports community-based nonprofit organizations aiming to enhance maternal and infant health outcomes. The foundation prioritizes funding programs that address disparities, improve care access, and promote health throughout the pregnancy journey. Focus areas include reducing pre-term birth rates and severe maternal morbidity. This initiative encourages scalable solutions for measurable impact across various states, ensuring comprehensive support for mothers and infants alike.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is set to renew a Notice of Funding Opportunity (NOFO) focused on advancing translational research in maternal and pediatric pharmacology. This initiative aims to enhance precision medicine by developing innovative tools and therapeutics for pregnant and lactating women, infants, and children. The goal is to improve the safety and efficacy of medications while ensuring effective patient-provider communications. Applications are not currently being solicited.