Best Large Grants for Nonprofit Organizations in California

The DoW Bone Marrow Failure Investigator-Initiated Research Award supports innovative research aimed at advancing the understanding and treatment of bone marrow failure. This funding opportunity encourages applications for translational and clinical studies, requiring preliminary data to strengthen proposals. Unique features include the ability for a partnering Principal Investigator to contribute to the research, thereby fostering collaboration while maintaining a focus on significant advancements in patient care.

The DoW Bone Marrow Failure Idea Development Award supports innovative, high-impact research aimed at understanding and curing bone marrow failure diseases. This grant is available to both Established Investigators and Early-Career Investigators, with no preliminary data required for applications. Reviewers assess proposals based on specific criteria tailored to the investigator's career stage. The focus is on achieving interpretable results that contribute significantly to the field.

The Kathy’s Kids Scholarship, established in honor of Kathy Smith, provides educational support for young women in the Longview area facing challenges. Administered by the East Texas Communities Foundation, this scholarship aims to empower graduating seniors to pursue their educational goals. With a focus on financial need, applicants must be from participating high schools and demonstrate resilience in overcoming adversity. Scholarships of $1,500 are available and may renew annually, emphasizing the foundation's commitment to fostering educational opportunities.

Transportation Assistance Grant

The Transportation Assistance Grant program was established to help members of the MS community remain as independent as possible, and ensure all people with MS have the transportation necessary to get the best medical care.

The program provides funding for reasonable paratransit fees. In partnership with Lyft and Uber, the program can also provide funding for transportation to and from appointments for MS care, limited to neurologist visits and infusion centers, at no cost to the person with MS.

The AAS Northeast Asia Council (NEAC) Distinguished Speakers Bureau Grant invites applications from U.S. and Canadian colleges to host distinguished scholars for public lectures on Japan and Korea. This program, initiated in 2011, aims to foster engagement with early career scholars and enhance East Asian studies. Grants cover honoraria of $500 and additional funding for in-person events, promoting accessibility and academic collaboration. Institutions are encouraged to apply every three years, ensuring support for smaller programs in Asian studies.

The Ross Merrill Award for Outstanding Commitment to the Preservation and Care of Collections recognizes North American institutions demonstrating exceptional dedication to conservation. This award highlights organizations that engage in significant outreach, involve conservation professionals, and show a commitment to community education regarding the importance of preserving cultural heritage. While no monetary prize accompanies the award, it serves as a prestigious acknowledgment of exemplary conservation efforts. Nominations are encouraged from both inside and outside organizations.

The Youth Incentive Award, established by the Coleopterists Society, encourages students in grades 7-12 to explore the fascinating world of beetles. Annually, up to $1200 is awarded, with two grants of $400 and $800 for junior and senior categories, respectively. Recipients also receive a subscription to The Coleopterists Bulletin. The program aims to promote beetle studies, develop essential life skills, and provide financial support for educational projects, fostering a passion for entomology among youth.

The MNAF Linda Knauff Clinical Practice Project Grant supports Minnesota Nurses Association members in conducting research that aligns with MNA's organizational goals. It promotes best practices through literature reviews, workgroup convening, policy development, and quality improvement initiatives. Applicants must be MNA members engaged in direct patient care, complete their projects within two years, and submit periodic reports. Preference is given to first-time applicants whose projects meet quality standards.

The Brothers Helping Brothers initiative aims to provide essential equipment to small fire departments and EMS organizations in the U.S. Established in 2014, the program offers grants to eligible agencies serving communities with populations under 10,000. With a focus on tools like wireless backup cameras, the organization strives to enhance safety and operational efficiency for first responders. Through community support, they have raised significant funds to assist in this critical mission.

The Liz Myers Scholarship, offered by the Ashland County Community Foundation, aims to support graduating seniors from Ashland County High Schools pursuing a degree in Veterinary Medicine or a related field. Applicants must maintain a GPA of 3.0 or higher and be accepted into an accredited college or university. This scholarship honors Liz Myers' dedication to animal health and welfare, reflecting her belief in the profound bond between humans and animals.

The Petrone Scholarship, offered by the Ashland County Community Foundation, supports non-traditional students pursuing nursing degrees. It aims to assist those advancing from a Nurse's Aide to an LPN or RN, or from LPN to RN, especially those with experience in Hospice Care. This scholarship provides essential financial aid to help eligible students achieve their educational goals in the nursing field, fostering a commitment to quality patient care.

Accelerating the Development of Combined CGM–Pump Devices

A combined continuous glucose monitor (CGM) and insulin pump device represents an innovative approach to simplifying diabetes management by integrating two essential technologies into a single device. This approach has the potential to improve quality of life for people with type 1 diabetes (T1D) by reducing the burden associated with wearing and managing multiple devices.

Despite this promise, the development of combined CGM–pump devices presents technical and commercialization challenges. These include the need for further advances in device compatibility and lifespan, system reliability, and scalable manufacturing, while maintaining affordability and broadaccessibility. In addition, a potential insulin dilution effect may require adjustment of the CGM algorithm.

Breakthrough T1D invites applications for research and development projects that address key technical, clinical, and translational challenges related to combined CGM–pump devices, with the goal of accelerating their development and improving outcomes for people living with T1D.

In response to this announcement, applications may request up to a total of $900,000 USD for up to three years. 

GBA1 Parkinson's Disease Research Catalyst Program

The GBA1-PD Research Catalyst Program seeks to build a deeper, globally integrated understanding of GBA1-associated Parkinson’s disease by aligning efforts across geographies and maximizing the value of shared datasets and research assets. Funding will support hypothesis- driven projects with an emphasis on integrative, cross-cohort analyses and the systematic characterization and standardization of models to enable broad use by the research community.

Funding

Duration: 12 to 24 months

Award Amount: Up to $300,000. Requested support should be commensurate with work proposed.

These budgets include direct and indirect costs. For academic and for-profit institutions, no more than 15% or 10%, respectively, may go to indirect costs. 

The Methodist Hospital of Sacramento Foundation Award Scholarship, offered by the Elk Grove Regional Scholarship Foundation, supports students pursuing education in the healthcare field. This scholarship aims to empower individuals attending four-year universities, community colleges, or vocational schools, emphasizing financial need and community involvement. Since 1973, Methodist Hospital has been committed to enhancing the health of Elk Grove, making this scholarship a vital resource for future healthcare professionals in the community.

The Joseph Nurre Football Memorial Scholarship, offered by the Elk Grove Regional Scholarship Foundation, supports students from the Elk Grove Unified School District who have played football. This scholarship prioritizes full-time students with a minimum GPA of 2.5 and requires participation in school and community activities. An essay describing the importance of football is necessary. If no eligible football players apply, the scholarship may be awarded to a foster youth from the area.

The Biocodex Microbiota Foundation invites early career researchers in the microbiome field from U.S. institutions to apply for the 2024 grant. This initiative focuses on groundbreaking research into gut microbiota's role in human health and disease, particularly in areas like circadian rhythms and metabolic disorders. The grant supports operational costs, allowing for innovative projects aimed at fostering independent research careers in microbiota studies.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

The Radiation Oncology Institute (ROI) Innovation Awards, offered by the American Society for Radiation Oncology, aim to accelerate innovative ideas in radiation therapy. Currently accepting applications for the 2026 awards, the program focuses on optimizing the combination of radiation therapy and immunotherapy to enhance cancer treatment outcomes. By supporting practical research, ROI strives to transform clinical practices and improve patient care in the fight against cancer.

The Conchologists of America (COA) offers grants up to $2,500 for research on recent or fossil mollusks. This funding is available for projects that explore malacological topics, ensuring that the proposed work is self-contained and capable of addressing specific research questions. While COA encourages applications for amounts less than the maximum, funding is not typically awarded to high school students or for institutional overhead. This initiative supports a wide range of malacological disciplines.

The Southern California Regional Meeting Abstract Submission Award invites members of the Southern California Regional Chapter to submit research abstracts for presentation at the annual meeting on October 15, 2025. This competition encourages students and postdoctoral fellows to showcase their work, with awards available for the best abstracts. Selected participants may also present short oral presentations, enhancing their academic exposure and opportunities.

The Translational Transplantation Tolerance Cooperative Study Group, supported by the National Institute of Allergy and Infectious Diseases, aims to advance transplant tolerance strategies that promote long-term graft survival without lifelong immunosuppression. This initiative focuses on developing, optimizing, and evaluating methods to induce immune tolerance in allogeneic transplants through collaborative efforts across multiple centers, utilizing translationally relevant models to ensure effective outcomes.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing research on immune tolerance through its Collaborative Network. This program aims to clarify the mechanisms of immune tolerance and develop interventions for related diseases, including transplant rejection and autoimmune disorders. Key objectives include conducting clinical trials on tolerogenic strategies and refining immune assays. This initiative is supported by regulations under the Public Health Service Act, ensuring a structured approach to improving patient outcomes.

The Community Wetland Restoration Grant Program (CWRGP) offers vital funding for community-driven restoration projects in coastal wetlands and stream corridors across Southern California. This initiative aims to enhance local capacity for planning and executing wetland restoration, while actively involving communities in educational efforts. Eligible applicants include nonprofits and government agencies. By fostering collaboration and engagement, CWRGP strives to support sustainable ecological practices and promote awareness of wetland ecosystems.

The DOW Combat Readiness – Medical Research Program's FY26 Translational Research Award supports innovative research aimed at improving trauma care outcomes. This program emphasizes hypothesis-driven studies that can transition promising technologies into practical solutions for enhancing casualty survivability. Applicants must provide preliminary data and utilize validated animal models, with a focus on projects that meet a minimum technology readiness level of 4, ensuring a mature translational research effort.

The Bounty on the Boulevard Scholarship, offered by the Elk Grove Regional Scholarship Foundation, aims to support students with a passion for Agriculture, Culinary Arts, or Teaching. Eligible candidates include full-time students enrolled in a four-year university, community college, or vocational college. This scholarship celebrates the contributions of community members and encourages local youth to pursue their educational and career aspirations, fostering a brighter future for the Elk Grove community.

The Carrothers Family Trust Scholarship, offered by the Elk Grove Regional Scholarship Foundation, supports students from the Elk Grove Unified School District pursuing a Bachelor’s Degree in Business Administration or Accounting. The foundation aims to enhance educational opportunities through scholarships funded by community donations. Eligibility includes residing within EGUSD boundaries and being a full-time student with financial need. This scholarship emphasizes the importance of community involvement and diverse career aspirations.

AD Osherman Scholarship

Benefiting first-generation students in Texas.

Funding

Four (4) scholarships awarded out:

• $3,500 for students pursuing a 4-year degree
• $2,500 for students pursuing a 2-year degree

One-time award. Previous recipients may reapply as long as all eligibility requirements are met.