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Best Large Grants for Nonprofit Organizations in California

Find the perfect Large Grants for Nonprofit Organizations in California on Instrumentl. 11,000+ Large Grants for Nonprofit Organizations in California in the United States.

11,000+

Available grants

$3.61B

Total funding

$5K

Median grant

11,000+ grants
$3.61B total
$5K median

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10,797 Results based on applied filters

Hasting Innovation Award for Interstitial Lung Disease

American Lung Association
Private
United States
Up to US $75,000
The Hasting Innovation Award for Interstitial Lung Disease, offered by the American Lung Association, provides $75,000 annually for up to two years to support early-career researchers. This award targets investigators with proven excellence and a track record of accomplishment, aiming to advance lung disease science. Successful candidates must have held a K or R type award within the last three to five years, fostering innovation and discovery in lung health.
Interstitial Lung Disease

Alzheimer’s Association Research Grant For All (AARGA) Program

Alzheimer's Association
Private
United States
US $70,000 - US $200,000
The Alzheimer’s Association Research Grant For All (AARGA) Program supports early-career investigators in their first seven years as independent researchers. This grant aims to fund projects that develop preliminary data and test new hypotheses in Alzheimer’s and related dementia research. Areas of interest include disease mechanisms, biomarker development, and health equity. Applications are welcome from both U.S. and international researchers, fostering innovation and collaboration in the fight against dementia.
Dementia & Alzheimer’s Disease

Classics for Kids Matching Grant Program

Classics for Kids
Private
United States
Unspecified amount
The Classics for Kids Matching Grant Program, established by the Classics for Kids Foundation, aims to enhance music education for at-risk and rural youth by providing matching grants for fine stringed instruments. Since 1998, over $2 million has been allocated to support more than 300 programs across all 50 states. Schools and non-profits demonstrating need and commitment are encouraged to apply, fostering lifelong benefits of music participation and education.
Classical Music

CART Fund Grant

CART Fund
Private
United States
Up to US $500,000
The CART Fund Grant supports innovative Alzheimer’s Disease research projects in the U.S. with funding up to $500,000 for a two-year period. It invites full-time faculty from public and private institutions to submit Letters of Intent, emphasizing novel concepts that advance biomedical knowledge. Selected finalists will be invited to apply for standard grants. The initiative aims to foster groundbreaking research initiatives lacking extensive preliminary data, ensuring a focus on projects with transformative potential.
Dementia & Alzheimer’s Disease

Opera Grants for Women Composers: Discovery Grants

OPERA America, Inc.
Private
United States
Up to US $15,000
Opera Grants for Women Composers: Discovery Grants support the creation of new operas by women composers, promoting gender parity and diversity in the field. These grants assist composers in exploring opera as an art form, funding activities like libretto readings and workshops. OPERA America is committed to enhancing the operatic repertoire with diverse perspectives, and these grants are made possible through the support of the Virginia B. Toulmin Foundation.
Opera

Asia: Responsive Grants

Henry Luce Foundation
Private
Brunei Darussalam, Cambodia +16 more
Unspecified amount
The Henry Luce Foundation's Asia: Responsive Grants program supports initiatives that enhance understanding of East and Southeast Asia. With a focus on academic research, cultural exchange, and public education, the program seeks to promote collaboration between American and Asian institutions. Grants are awarded primarily to U.S.-based non-profits, fostering innovative teaching, resource development, and policy engagement, while prioritizing projects that bridge diverse disciplines and geographic divides.
Asian Art Asian / Pacific Island Culture & Heritage

Dalsemer Interstitial Lung Disease Award

American Lung Association
Private
United States
Up to US $100,000
The Dalsemer Interstitial Lung Disease Award, funded by the American Lung Association, provides $50,000 per year for two years to support junior investigators researching interstitial lung disease. This award aims to foster independence in early-career scientists while building on the Association's 120-year legacy of improving lung health through innovative research and advocacy efforts, ultimately enhancing the lives of those affected by lung disease.
Interstitial Lung Disease

HCLTech Grant Edition II

HCL Technologies Limited
Corporate
Argentina, Brazil +8 more
Up to US $500,000
HCLTech Grant Edition II focuses on impactful climate action by investing $5 million over five years to support NGOs in the Americas. This initiative aims to enhance sustainable projects that align with the 17 Sustainable Development Goals (SDGs). With a history of significant contributions in India, HCLTech is committed to achieving net-zero emissions by 2040 and fostering innovative solutions to address pressing climate challenges. The grant encourages collaboration and aims to transform communities through effective climate action.
Climate Change Resilience & Equity

Catholic School Leadership Development Grant

Catholic Extension
Association/Society
Acadia Parish, Louisiana, Accomack County, Virginia +994 more
Unspecified amount
The Catholic School Leadership Development Grant Program aims to cultivate and retain promising leaders within the Catholic school system. In partnership with Loyola Marymount University, this initiative offers a graduate-level online Certificate in Catholic School Administration, covering 80% of tuition costs and providing funding for essential travel. The one-year program focuses on mission effectiveness, operational management, and instructional leadership, requiring participants to serve two years in their diocese post-completion, thereby enhancing local educational leadership.
Education - K through 12 Catholicism Religious / Theological Education

MBF Small Grants Program

Monarch Butterfly Fund
Private
Canada, Mexico +1 more
Up to US $3,500
The MBF Small Grants Program supports conservation projects for monarch butterflies and their habitats, primarily in Mexico. It aims to fund initiatives focusing on habitat conservation, scientific research, education, and sustainable development. Grants are primarily awarded to Mexican organizations and individuals, with a preference for those with relevant experience. Projects should enhance local livelihoods and promote environmental awareness within the Monarch Butterfly Biosphere Reserve.
Entomology

Lipsky-Whittaker LGBTQ Scholarship

Southcoast Community Foundation
Private
United States
Unspecified amount
The Lipsky-Whittaker LGBTQ Scholarship, established by the SouthCoast Community Foundation, provides financial support to graduates from New Bedford area high schools who identify as LGBTQ+. Applicants must be under 24 years old and enrolled in or accepted to an accredited college. This scholarship aims to empower students committed to addressing LGBTQ+ issues in their communities, contributing to a more inclusive society.
Academic Scholarship Programs College Success / Persistence LGBTQIA+ Services

Kids' Chance of Massachusetts Scholarship- Initial Application

Kids' Chance of Massachusetts
Association/Society
United States
Up to US $5,000
Kids' Chance of Massachusetts offers scholarships to children of workers who have been severely injured or killed in workplace accidents. This 501(c)(3) non-profit organization awards funds based on financial need, with applications accepted annually. Eligible students must be dependents aged 17-22, enrolled full-time in post-secondary education, and demonstrate financial need. Renewal applications are available for previous recipients who maintain satisfactory academic progress.
Academic Scholarship Programs Occupational Health & Safety Education - Higher Education +1 more

Arthritis Foundation: Clinical Fellowship RFP

Arthritis Foundation
Private
United States
Up to US $300,000
The Arthritis Foundation's Clinical Fellowship RFP aims to address the rheumatology workforce shortage by inviting applications from institutions with clinical training programs. It encourages innovative training approaches to prepare future rheumatologists for the evolving needs of the arthritis community. Funding includes $150,000 for a two-year adult fellowship, $225,000 for a three-year pediatric fellowship, and $300,000 for a four-year Med-Peds fellowship, all designed to enhance access to specialized care.
Arthritis

Orthopedic Physical Therapy Research Grant

Foundation for Physical Therapy Research
Private
United States
US $40,000
The Orthopaedic Physical Therapy Research Grant, funded by the Foundation for Physical Therapy Research, aims to support innovative research that optimizes movement and enhances societal health. With a commitment to addressing health disparities, the foundation will award $40,000 for one or two years to promising researchers. This initiative not only strengthens the physical therapy profession but also contributes to the growing evidence base that underscores the value of physical therapy in various healthcare settings.
Physical Therapy Musculoskeletal Diseases

Craft Artists Emergency Relief Grant

Craft Emergency Relief Fund Inc
Private
American Samoa, Guam +4 more
US $1,000
The Craft Artists Emergency Relief Grant provides $3,000 to U.S.-based individual craft artists aged 18 and older who are facing recent, unforeseen emergencies. Established by the Craft Emergency Relief Fund (CERF+) in 1985, this grant aims to empower artists during critical times, allowing them to use the funds as needed for recovery. Applications are accepted on a rolling basis, ensuring timely support for artists in distress.
Folk Art / Traditional Art Visual Arts Textile & Fiber Arts

CERF: Artist Get Ready Grant

Craft Emergency Relief Fund Inc
Private
American Samoa, Guam +4 more
Up to US $1,000
The CERF: Artist Get Ready Grant offers up to $1,000 to craft artists for safeguarding their studios and preparing for emergencies. Priority is given to underrepresented artists, including BIPOC and folk/traditional artists. Eligible activities encompass studio safety upgrades and disaster readiness. Applicants must be 18 years or older, residing in the U.S. for two years, and not have received this grant in the previous year. Funds must be used within six months, with outcomes documented for CERF+.
Folk Art / Traditional Art Visual Arts Textile & Fiber Arts

Devinci: Community Grant Program

Devinci
Corporate
Canada, United States
C $5,000
Devinci's Community Grant Program aims to support North American cycling organizations with financial assistance for development projects. Eligible applicants include cycling clubs, non-profits, and individuals leading community initiatives. Projects must occur in Canada or the U.S. within the year, with a maximum grant of $5,000 CAD. The program collaborates with key industry partners to foster growth in the cycling community, making a lasting impact through local initiatives.
Biking Trail Creation & Maintenance

LACE: Jacki Apple Award

Los Angeles Contemporary Exhibitions
Private
Los Angeles County, California
US $10,000
The LACE: Jacki Apple Award provides a $10,000 grant to one mid- or late-career artist based in Los Angeles County. This award supports innovative projects in performance, media, exhibition, or publication that engage the public outside traditional settings. Selected artists will be chosen through the Lightning Fund application process, with no additional application required. Eligible candidates must be 18 years or older and not currently enrolled in college.
Media Arts Visual Arts Conceptual Art / Performance Art

Lightning Fund Artist Grant

Los Angeles Contemporary Exhibitions
Private
Los Angeles County, California
US $6,000
The Lightning Fund Artist Grant, presented by LACE, is an annual opportunity for artists residing in Los Angeles County. This year, 10 project grants of $6,000 each will be awarded to support innovative and socially relevant art initiatives. Applicants must be 18 years or older and not enrolled in college. The grant encourages diverse artistic practices, including traditional and contemporary forms, ensuring accessibility beyond conventional art spaces.
Visual Arts Media Arts Conceptual Art / Performance Art

Emerging Curator Program

Los Angeles Contemporary Exhibitions
Private
Los Angeles County, California
US $6,000
The Emerging Curator Program seeks to elevate curatorial talent in Los Angeles by offering emerging curators a chance to collaborate with LACE. This year's focus is on proposals for moving image works presented as a cohesive program, rather than traditional exhibitions. Selected curators will receive support for project development, a $6,000 budget, and promotional assistance to engage the intended audiences effectively.
Film Conceptual Art / Performance Art

ChemClub Student Scholarship

American Chemical Society
Association/Society
United States
Unspecified amount
The ChemClub Student Scholarship, offered by the American Chemical Society and the American Association of Chemistry Teachers, supports high school seniors who are active members of a Chartered ChemClub. Eligible students must demonstrate academic excellence and express their commitment to STEM fields. This scholarship provides financial assistance directly to the recipient's chosen college, fostering future leaders in chemistry and related disciplines.
Career / College Preparation Academic Scholarship Programs STEM / STEAM Education

Student Research Fellowship Awards

Crohns And Colitis Foundation Inc
Private
United States
Up to US $2,500
The Student Research Fellowship Awards program provides financial support of up to $2,500 for students conducting research on Inflammatory Bowel Disease (IBD) for a minimum of 10 weeks. Aimed at undergraduate, medical, and graduate students, the initiative encourages research interest in IBD. Up to 16 awards are available, and research must be conducted under a qualified mentor at an accredited institution, ensuring a professional academic environment for the study of this critical health issue.
Crohn’s Disease And Colitis

Global Down Syndrome Foundation- Education Awards

Global Down Syndrome Foundation
Private
United States
US $5,000 - US $10,000
The Global Down Syndrome Foundation's Education Awards support innovative educational programs aimed at enhancing the lives of individuals with Down syndrome. This initiative encourages applications for workshops, conferences, and webinars focused on research and medical advancements. Eligible applicants must be members of the foundation or recognized 501(c)(3) organizations, ensuring impactful contributions that benefit the Down syndrome community. With no funding limits for consecutive years, this program promotes significant educational outreach and advocacy.
Down Syndrome

Rheumatoid Arthritis Research Request for Proposals

Arthritis Foundation
Private
United States
Up to US $450,000
The Arthritis Foundation is inviting proposals for research aimed at understanding and predicting the progression of rheumatoid arthritis (RA). This includes identifying risk factors and mechanisms to prevent or slow the onset of RA. The program encourages innovative studies from early and mid-career investigators affiliated with U.S. institutions, with funding options that support both pilot and large research awards. The ultimate goal is to enhance outcomes for RA patients.
Arthritis

Jack and Fay Netchin Medical Student Summer Fellowships

American Brain Tumor Association
Private
Canada, United States
US $3,000
The Jack and Fay Netchin Medical Student Summer Fellowships, offered by the American Brain Tumor Association, provide $3,000 grants to medical students eager to engage in brain tumor research under the guidance of experienced mentors. This initiative aims to inspire the next generation of neuro-oncology researchers, fostering a deeper commitment to advancing treatment and understanding of brain tumors for those affected by this challenging diagnosis.
Cancer / Oncology Neurological Diseases & Disorders

School-Based and School-Linked Initiatives to Improve Oral Health

Carequest Institute For Oral Health Inc
Private
American Samoa, Guam +4 more
Up to US $125,000
The CareQuest Institute for Oral Health® is inviting proposals for school-based and school-linked initiatives aimed at improving oral health access for high-risk children. This grant opportunity seeks to address systemic barriers to oral health through innovative programs that engage schools and communities. Ideal projects may include workforce development, community engagement strategies, policy advocacy, and the use of technology. Proposals should focus on creating equitable oral health solutions that enhance both health and academic success for children and their families.
Children’s Health & Pediatrics Dental Health Health Care Access & Delivery +1 more

JPF Principal Grant Program RFP

Jacques Pepin Foundation
Private
United States
Up to US $10,000
The Jacques Pepin Foundation (JPF) is dedicated to advancing culinary arts education by supporting community kitchens that provide culinary training to individuals facing employment barriers. Grants of up to $10,000 are available for nonprofits to enhance their culinary programs, including operating costs and facility improvements. Eligibility extends to organizations funded in prior cycles, those that applied but were not funded, and newcomers to JPF funding. This initiative aims to empower underserved communities through culinary skills.
Workforce Preparation & Job Readiness Culinary Arts

Large Grants for Nonprofit Organizations in California Highlights

Looking for large grants for nonprofit organizations in California?


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Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in California

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

400+ Large Grants for Nonprofit Organizations in California grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

200+ Large Grants for Nonprofit Organizations in California over $25K in average grant size

200+ Large Grants for Nonprofit Organizations in California over $50K in average grant size

38 Large Grants for Nonprofit Organizations in California supporting general operating expenses

300+ Large Grants for Nonprofit Organizations in California supporting programs / projects

400+ Grants on Instrumentl focused on Disaster Relief / Humanitarian Aid

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in California?

Most grants are due in the first quarter.

Q1
28.5%
Q2
25.8%
Q3
23.3%
Q4
22.4%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in California?

Grants are most commonly $100,000.

$0 $0 Min.
$100,000 $100 K Median
$2,149,932 $2.1 M Average
$150,000,000 $150 M Max.

Average Grant Size

What's the typical amount funded for California?

Grants are most commonly $145,539.

$145,539

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in California year over year?

In 2024, funders in California awarded a total of 256,564 grants.

2022 237,186

2023 236,635

2024 256,564

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in California given out in California, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in California changing over time?

Funding has increased by -1.38%.

2022 $34,364,756,699

2023 $37,770,770,141
9.91%

2024 $37,247,795,891
-1.38%

California Counties That Receive the Most Funding

How does grant funding vary by county?

Los Angeles County, San Francisco County, and San Mateo County receive the most funding.

County Total Grant Funding in 2024
Los Angeles County $10,841,756,858
San Francisco County $5,409,542,294
San Mateo County $5,358,878,304
Santa Clara County $3,811,026,208
Alameda County $3,749,322,182

Related Grants in California

Browse Other Nonprofit Operations & Capacity Grants in California

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