Best Large Grants for Nonprofit Organizations in California

The Michael J. Campbell Memorial Scholarship supports high school seniors in vocational programs and college freshmen pursuing degrees in construction-related fields. Established by The Community Foundation for the Greater Capital Region, this scholarship aims to empower students from Albany, Columbia, Greene, Rensselaer, Saratoga, Schenectady, Schoharie, Warren, and Washington Counties in New York. The program reflects the foundation's commitment to enhancing community quality of life through education and opportunity.

Alliance for Cancer Gene Therapy

Unlike surgery, chemotherapy and radiation, cell and gene therapies harness the power of your immune system to destroy cancer cells without harming healthy tissue. We fund the research that will make this vision a reality.

Collaborating with partners and funding research fellows, we are transforming cancer treatments today while bringing the world closer to a cure for all cancers tomorrow.

ACGT Investigator Award in Cell and Gene Therapy for SOLID TUMOR CANCERS 

Purpose

Alliance for Cancer Gene Therapy, Inc. (ACGT) funds breakthrough research that is transforming cancer treatment through cell and gene therapy. This ACGT grant award is for those conducting translational cell and gene therapy research specifically in solid tumor cancers.

Research Objectives

Cell and gene therapy for solid tumors poses major challenges driven by antigen heterogeneity, physical exclusion, immunosuppressive microenvironments, genomic instability, and safety limitations. This RFA seeks innovative, translational cell and gene therapy strategies that directly address these barriers.

Proposed approaches should demonstrate the capacity to: (1) overcome antigen escape through multi-targeted designs that broaden patient populations and account for heterogeneity and resistance due to antigen loss; (2) enhance trafficking, infiltration, and persistence within solid tumor sites; (3) resist or reprogram the immunosuppressive tumor microenvironment; and (4) incorporate built-in safety and controllability mechanisms suitable for clinical translation. Successful proposals will integrate these elements to enable durable, precise, and scalable therapeutic impact in solid tumors.

Building on the priorities outlined above, this RFP encourages proposals spanning a broad range of cell and gene therapy (CGT) platforms and rational combinations, including but not limited to:

• Engineered T Cell Approaches
• Innate and Alternative Immune Cell Platforms
• Gene Editing & Synthetic Biology Strategies
• Microenvironment-Modulating Strategies
• Combinatorial Approaches

Proposals that integrate multiple strategies to overcome trafficking, suppression, antigen escape, and safety barriers in a coordinated manner are strongly encouraged. Preference will be given to approaches with clear mechanistic rationale and a credible path toward clinical translation in solid tumors.

The Wireless Family Fund, supported by Music Movement, provides financial aid to families in the Wireless and Tech Industries, focusing on living expenses, medical bills, and educational support. Grants typically range from $1,500 to $2,500 and are available to families within the United States. Music Movement enriches the lives of individuals with Autism and other developmental differences through music-centric programs that enhance communication, social skills, and emotional expression.

The Junior Gardener Program Grants, offered by the San Clemente Garden Club, support K-12 school gardens to foster healthy lifestyles and environmental stewardship among students. Grants of up to $500 are available for new or existing programs that emphasize food growth, conservation education, and student involvement in garden maintenance. Priority is given to initiatives that promote life skills, habitat development, and scientific exploration, encouraging students to engage with their natural surroundings.

The San Clemente History, Arts & Culture Fund Grant supports local charities focused on producing and participating in arts and culture activities, including performing arts and arts education. Managed by the Orange County Community Foundation, this grant is part of a permanent endowment established by an anonymous donor to enhance cultural offerings in San Clemente. Applicants are encouraged to contact the Foundation for complete guidelines and eligibility requirements.

A better world, built with better teamwork

We bring Atlassian's funding, tools and teamwork expertise to help nonprofits drive greater impact.

Our mission

Atlassian's mission is to unleash the potential of every team. The Atlassian Foundation extends that mission to teams solving the world's hardest problems.

Atlassian Foundation – Open Call for Proposals

The Atlassian Foundation is deploying US$8 million over the next two years to help disadvantaged learners thrive in the AI era. If you're driving collective action in this space, we want to hear from you.

Reshaping education for the AI era will take teamwork

The Atlassian Foundation focuses on education because it's the most empowering force in the world – it's the key to breaking cycles of poverty and disadvantage.

But that key is slipping out of reach for far too many. UNESCO estimates that more than 250 million children are out of school. And for those in the classroom, learning isn't guaranteed: 57% of children worldwide (nearly one billion) lack the basic skills they need for the era they're growing up in. AI can expand access and accelerate learning. It can also widen inequality where it lands unevenly.

No single organisation can tackle a challenge this complex. That's why the Atlassian Foundation is backing collective action: coordinated efforts by multiple players to solve shared problems at scale. Atlassian's mission is to unleash the potential of every team, so we're uniquely positioned to power these efforts. We've spent 20+ years learning what makes teams work well together, and we're offering that expertise – plus our funding, tools and hands-on support – to help collective action initiatives drive greater impact.

We believe a better world is built with better teamwork, and collective action is teamwork at its most ambitious. Together, we want to shape a future where emerging technology closes gaps for learners the current system leaves behind, rather than widening them.

About this open call

In this open call, we're seeking partnerships with collective action initiatives that are working to improve education for disadvantaged learners in the AI era.

What our partners will receive

Each partnership will include:

The John Krakauer Charitable Trust, established in 2012, focuses on supporting 501(c)(3) nonprofits that create measurable impacts in education, health, and human services, particularly in Southern Nevada and San Diego. The foundation prioritizes mission-driven organizations that demonstrate innovation, collaboration, and a commitment to their cause. Grants, averaging $10,000 for first-time recipients, aim to enhance capacity building and provide scholarships, especially for programs aiding single mothers and non-English speaking immigrants.

The Adreani Family Scholarship, established by the Elk Grove Regional Scholarship Foundation, honors Arnold J. Adreani, a dedicated educator and principal. This scholarship supports students from various Elk Grove high schools pursuing education-related fields at community colleges or four-year universities. It reflects a commitment to fostering educational opportunities and community involvement, ensuring that students have the resources needed to succeed in their academic and career aspirations.

The Kuo Family Scholarship, established by the Kuo Family Fund, honors their legacy and supports community impact through grants. It is open to high school seniors and college students in the Bay Area with a GPA of 3.25 or higher and financial need, as determined by FAFSA. This scholarship aims to assist students pursuing full-time education at accredited four-year institutions, fostering educational and cultural growth within the community.

The San Marcos Community Foundation offers Mini Grants of up to $1,500 to support nonprofit organizations that benefit San Marcos residents. Eligible projects must be tax-exempt under 501(c)(3) and directly serve the community. Grant requests should adhere to reporting deadlines set by the Board, while funds cannot support religious, fraternal, or political purposes. The Foundation prioritizes applications with matching funds at its discretion, fostering diverse projects in arts, health, education, and more.

The ENF Community Investments Program - Beacon Grants offers a unique opportunity for Elks Lodges to initiate and lead charitable projects in their local communities. This program encourages Lodges to develop sustainable initiatives, allowing them to address community needs effectively. By fostering collaboration and providing resources, the Beacon Grants enhance the quality of life for residents, including veterans and families. In 2025-26, all Lodges will have the chance to participate, promoting a culture of giving back.

Community Foundation for Mason County, MI

At the Community Foundation for Mason County, we work with donors, grantees, and advisors to address key community issues. As a leader in community philanthropy, building a vibrant community with great opportunities for all, we are focused on advancing education, increasing recreation opportunities, and community and economic development.

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Lee Shipman Engineering Scholarship

This scholarship has been made possible by the generosity of Lee Shipman who established the Lee Shipman Engineering Scholarship Fund of the Community Foundation for Mason County.

Lee Shipman has always had a love for all things electrical as far back as grade school when he added an additional phone in his family home so calls could be answered from more than one location! This eventually led him to get his degree in electrical engineering and a career at Dow Chemical in Ludington. He continued following his passion after retiring from Dow by working with a local Ludington business helping with the selection and modifications of equipment. Through this work, he recognized the real challenges that downtown merchants face. Lee is thankful for the people who have made a difference in his life, from his Latin teacher to coworkers to close friends and, because of this, he wants to give back to others. He established this Scholarship Fund for students pursuing electrical engineering.

Booz Allen Foundation

Empowering the next generation through advanced technology

Our mission is to leverage the power of advanced technology to improve generational resilience and inspire the future workforce.

At the Booz Allen Foundation, we’re dedicated to empowering human potential and driving wider social impact in a spirit of passionate service. Driven by a purpose to be a force for positive change, we help imagine, invent, and deliver new ways to better serve the public and the world. The Foundation was established in 2017 as a separate legal entity. It holds tax-exempt status under section 501(c)(3) of the Internal Revenue Service (IRS) tax code and is focused on empowering social change by uniting nonprofit, industry, and government partners.

Our Program Areas

Our philanthropic investments today focus on championing advanced technology readiness and literacy while maintaining a steadfast commitment to the safety and wellness of students. This commitment is ever-present in our drive for innovation

We focus on empowering military-connected youth with advanced technology skills to thrive in a digital future.

We’re focusing resources and efforts in specific neighborhoods in Washington, DC, and San Diego to amplify impact.

We’re proud to support amazing nonprofits that are committed to advancing technology readiness in their communities.

The Sophia Scherman Woman in Politics Scholarship, offered by the Elk Grove Regional Scholarship Foundation, supports female seniors with aspirations in Political Science or Government. Eligible applicants must be enrolled in full-time or part-time studies at a 4-year university or community college. Preference is given to students demonstrating financial need and those with leadership experience in school or club activities. This scholarship aims to empower young women pursuing careers in politics.

The PVF Mathematics Resource Grants provide funding of up to $500 for educational materials aimed at enhancing mathematics instruction. Targeting teachers of low-income families and public school educators in San Mateo and Santa Clara Counties, these grants support resources that bridge curriculum across grade levels. Applications are open for the 2026-2027 school year, encouraging innovative approaches to teaching mathematics and improving student learning experiences.

The Tech Journalism Fund, established by Omidyar Network, aims to support U.S.-based journalists with project funding ranging from $5,000 to $25,000. It prioritizes reporting that explores the intersection of technology and society, particularly in areas like AI regulation, investigative journalism in tech, and the impact of AI on families. This initiative seeks to empower journalists tackling critical issues in today's digital landscape.

The Fiscal Year 2027 AmeriCorps Seniors RSVP Competition invites communities to apply for funding aimed at engaging adults aged 55 and older in addressing pressing local needs. Through national service and volunteerism, AmeriCorps strengthens communities and fosters civic engagement. This open competition spans all states and territories, encouraging organizations to harness the skills and expertise of older adults to enhance community well-being and promote a culture of service.

The Sustainable Slopes Grant Program, initiated by the National Ski Areas Association in 2009, supports NSAA member ski areas in their sustainability efforts. With over $890,000 awarded, the program facilitates projects that enhance energy efficiency, protect natural habitats, and promote recycling. This year, applicants can apply for Cash Grants, the Herman K. Dupré Sustainable Snowmaking Grant, or the new Recycling Grant, all aimed at reducing environmental footprints and achieving sustainability goals.

The AECOM Academic Scholarship, offered by the American Water Works Association (AWWA), supports graduate students pursuing engineering degrees focused on innovative solutions for improving urban drinking water. This $5,000 scholarship aims to invest in the future of the water industry by aiding talented students dedicated to enhancing water supply systems. AWWA emphasizes the importance of education in fostering the next generation of water professionals.

Greater Kansas City Community Foundation 

The Greater Kansas City Community Foundation is a nationally respected leader in charitable giving, dedicated to improving quality of life in Greater Kansas City by increasing philanthropy, educating and connecting donors to community needs, and leading on critical local issues. Founded in 1978 with a simple belief that charitable giving should be accessible to all, the Foundation has grown into one of the largest and most innovative public charities in the country, offering donor advised funds and other giving vehicles that make philanthropy convenient, efficient, and impactful. Today, it manages more than $7 billion in assets, administers over 7,000 charitable funds, and has distributed more than $8 billion in grants, consistently ranking among the top community foundations nationwide.

Kelly Williams Memorial Scholarship Fund

Kelly Williams Memorial Scholarship Fund provides scholarship support to children, nieces, nephews, and grandchildren of current Altec Industries employees who are pursuing an engineering degree at an accredited two year or four year college or university. Eligible applicants must be enrolled or planning to enroll as full time students in an engineering program and meet academic requirements, including a minimum 3.5 high school GPA and qualifying ACT or SAT scores for U.S. students, or an 80 percent honours average for Canadian students. The scholarship supports both U.S. and Canadian applicants who meet eligibility criteria and are preparing for careers in engineering.

The Pittsburgh Foundation

Established in 1945, The Pittsburgh Foundation is one of the nation’s oldest community foundations and as of 2022 is the 18th largest of more than 750 similar foundations across the United States.

As a community foundation, its resources comprise endowment funds established by individuals, businesses and organizations with a passion for charitable giving and fulfilling the Foundation’s mission of improving quality of life for all in the region. The Foundation currently manages about 2,500 individual donor funds and, together with its supporting organizations and its affiliate, The Community Foundation of Westmoreland County, has assets of $1.386 billion (2022). Grantmaking benefits a broad spectrum of basic needs and development opportunities within Pittsburgh and beyond.

Scholarships

The Pittsburgh Foundation and The Community Foundation of Westmoreland County provide scholarship opportunities for local students to pursue their educational goals. Scholarships are available for graduating high school seniors, undergraduates, graduate, medical and professional school students who are attending community colleges, four-year universities and career/technical schools.

David R. Miller and Sara G. Miller Scholarship Fund

The David R. Miller and Sara G. Miller Scholarship Fund was created at The Pittsburgh Foundation to provide scholarships for first year college students from Western Pennsylvania pursuing courses of study in engineering or manufacturing, or related trades.

Award Type: Single-Year Award

The Culture Works Leonard P. Roberts Memorial Scholarship honors Mr. Roberts' dedication to business and the arts. This scholarship is available for graduating high school seniors and current college students in the Dayton Region who actively participate in the arts. Eligible applicants must reside in specific counties and maintain a minimum GPA of 2.0. Preference is given to students majoring in the arts, business, or engineering, but all fields of study are welcome to apply.

Museums Empowered (2027) is a professional development initiative by the Institute of Museum and Library Services aimed at enhancing museum staff capabilities. It focuses on three vital areas: digital technology, evaluation, and organizational management. By supporting training and learning opportunities, the program seeks to empower museum professionals to effectively utilize digital tools, improve evaluation methods, and strengthen organizational resilience, ultimately fostering growth within museums of all types.

The BRAIN Initiative, led by the NIH, aims to advance neurotechnologies at institutions with limited NIH funding. This funding opportunity encourages collaboration and knowledge transfer to integrate innovative neurotechnologies into research and training programs. While applications are currently not being solicited, potential applicants should start developing partnerships and projects in preparation for future submissions. This initiative will enhance the dissemination of BRAIN technologies and support novel research practices.

NetJets Scholarship

NetJets is the leader in private aviation. We believe that service is everyone’s job and our company mission is “To enhance the life of each owner, one exceptional travel experience at a time.” The NetJets Scholarship was designed to reinforce a love of business aviation and hospitality, reward academic merit and exemplary character, as well as inspire students to consider an exciting and rewarding career with NetJets.

Award Amount:

• Three Scholarships for $25,000 each

The Freeman Hrabowski Scholars Program, funded by the Howard Hughes Medical Institute, supports exceptional scientists for a five-year term, with potential for renewal. Scholars receive up to $8.6 million over ten years, including salaries, benefits, and a substantial research budget. They dedicate at least 80% of their time to research and foster an inclusive lab environment, mentoring future scientists. This program emphasizes scientific excellence while integrating diversity, equity, and inclusion into research practices.

The National Leadership Grants for Libraries (NLG-L) program, funded by the Institute of Museum and Library Services, aims to enhance library services across the nation. By supporting projects that promote adult reading, health and financial literacy, and effective use of new technologies, this initiative fosters community prosperity and builds partnerships among libraries, archives, and museums. The grants ensure that libraries can respond effectively to public needs and enhance their contributions to education and information access.