Best Large Grants for Nonprofit Organizations in California

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Mucopolysaccharidosis Type III (MPS III) Fund

Help with healthcare costs for mucopolysaccharidosis type III

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses. 

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

The ISF New Student Scholarship supports orphaned or former foster care students in their pursuit of higher education. By providing financial assistance and mentoring, ISF empowers these students to overcome obstacles and thrive academically. Recipients are selected based on their moral character, commitment to personal growth, and readiness to engage in leadership training. This initiative aims to transform lives and foster the next generation of leaders.

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Arthur R. Hill Memorial Scholarship

This scholarship is for a college-bound student from a single-parent home. The applicant must

• have a minimum 3.0 GPA,
• have a community service background,
• demonstrate financial need,
• provide two character references, and
• demonstrate work ethic and ambition.

About the Chester County Community Foundation

Our Mission

The Chester County Community Foundation connects people who care with the causes that matter, so their philanthropy makes a difference now and forever.

Patricia Alleva DeHaven Scholarship Fund

Mission Statement

The Patricia Alleva DeHaven Scholarship Fund was established by the late William Thomas “Bill” DeHaven to honor his late wife after her long fight with cancer. Patricia was deeply loved by those around her as a loving wife, mother, second-mother to many of her children’s friends and husband’s coworkers, grandmother, and friend. Patricia was a biochemist for Merk & Co. while tremendously cooking and feeding anyone who came into her home. She worked as a volunteer for crime victims, raised money for veterans, and devoted much time to her church, St. Monica in Berwyn. The Patricia Alleva DeHaven Scholarship Award is presented annually in honor and memory of Patricia Alleva DeHaven who believed deeply in the value of Catholic education.

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Hepatitis C (HepC) Health Equity Fund

Help with healthcare costs for hepatitis C (health equity)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code. 

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

About the Emporia Community Foundation

Our Mission

To connect caring people with causes that build stronger communities within the Emporia area which includes Chase, Coffey, Greenwood, Lyon, Morris, Osage and Wabaunsee counties.

Reese Naylor Joy Fund

The purpose of the Reese Naylor Joy Fund is to provide funds to qualified individuals with a chronic or terminal illness to cover expenses of an event or experience that will bring joy and happiness to the child and their family. Grant requests will be considered for children up to the age of 21.

About the Chester County Community Foundation

Our Mission

The Chester County Community Foundation connects people who care with the causes that matter, so their philanthropy makes a difference now and forever.

Charles W. and Michelle Dickinson Scholarship Fund

The purpose of the Charles W. & Michelle Dickinson Scholarship Fund is to support charitable causes, with a particular emphasis on Christian-based organizations and initiatives that serve individuals, families, and communities in need.

In addition, the Fund is committed to investing in the next generation of skilled trades professionals by awarding scholarships to students pursuing careers in vocational and technical fields, including:

• Diesel Mechanics
• Automotive Mechanics
• Welding
• Auto Body Repair
• Collision Repair

Through charitable giving and educational support, the Fund seeks to create opportunities, encourage self-sufficiency, and make a lasting impact in the lives of individuals while honoring the values of faith, hard work, service, and community,

Charles W. Dickinson is the founder of D&D Collision Services, C M D Services Inc & Pottstown Area Rapid Transit.

The Woman of Wonder Scholarship supports women residents of Washington State pursuing higher education, whether full-time or part-time. Applicants must demonstrate financial need through FAFSA and share a personal essay about a pivotal life moment. This scholarship aims to empower single mothers and women facing challenges in their educational journey. Awards can be used for undergraduate, advanced degrees, continuing education, or certificates, ensuring accessibility for all women seeking academic advancement.

Community Foundation of Henderson County

Community Foundation of Henderson County was incorporated in 1982 by a group of fourteen dedicated and compassionate local leaders with the immediate need to manage two funds - the William C. Armstrong Scholarship Fund and the Charlie Renfrow Scholarship Fund, in addition to providing a permanent vehicle for citizens to give back to their community.

Our Mission is to help people who care make lasting contributions to causes that matter. The Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

American Legion, Post 77, Hubert M. Smith Scholarship

The applicant must be the son, daughter, grandson, granddaughter or stepchild of a current member in good standing for 12 months prior to the scholarship deadline, or of a deceased member in good standing at the time of his death, of Hubert M. Smith, Post 77, American Legion. The applicant must be age 23 or less at the time of the application and be a graduating senior or graduate of a public, parochial or private school who intends to enroll in a two-year or four-year degree granting program.

The Community Health Aide Program (CHAP) aims to assist Tribes and Tribal Organizations in planning and implementing health services tailored to their unique needs. This initiative by the Indian Health Service promotes flexibility for Tribes across the contiguous 48 states to create effective health programs. By identifying key feasibility factors, the program seeks to enhance community health outcomes and support the establishment of sustainable healthcare solutions.

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Hepatitis C (HepC) Fund

Help with healthcare costs for hepatitis C

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

The George C. Decas Scholarship, managed by the SouthCoast Community Foundation, offers financial support to graduating high school seniors from Wareham, Massachusetts. Established to assist local students, the scholarship awards recipients over four years contingent upon their academic progress. This initiative aims to enhance educational opportunities and foster community development, reflecting the Foundation's commitment to philanthropy and regional improvement since 1995.

The George Earl and Katherine Hartley Church Scholarship, managed by the SouthCoast Community Foundation, offers annual scholarships to graduating seniors from Acushnet, Rochester, Marion, and Mattapoisett, MA, as well as students from Greater New Bedford Regional Vocational Technical High School. This scholarship is aimed at those pursuing nursing degrees (LPN, RN, or BSN) at accredited two- or four-year colleges. It aims to support local students in achieving their educational goals.

The Georgia and Constantine Decas Family Scholarship, established by the SouthCoast Community Foundation, aims to support graduating high school seniors from Wareham, Massachusetts. This scholarship is awarded annually and provides funding for up to four years of education, contingent on the recipient's academic progress. With a commitment to enhancing community well-being, this scholarship reflects the Foundation's dedication to philanthropy and the support of local students in achieving their educational goals.

The Somerset Scholarship, managed by the SouthCoast Community Foundation, provides essential tuition assistance for Somerset resident students pursuing higher education at two- or four-year institutions. This initiative aims to support students who may not qualify for traditional scholarships, ensuring that financial barriers do not hinder their academic aspirations. With a strong commitment to community improvement, the foundation has distributed over $50 million to various local organizations since its inception in 1995.

The Community Health Aide Program: Tribal Assessment and Planning aims to assist Tribes and Tribal Organizations in assessing the feasibility of implementing a Community Health Aide Program tailored to their unique community needs. This initiative, supported by the Indian Health Service, emphasizes regional flexibility and empowers Tribes to identify critical factors for successful program design, ensuring effective health solutions are delivered where they are most needed.

The Samuel and Solomon Rusitzky Entrepreneurial Education Scholarship Fund, established by the SouthCoast Community Foundation, offers annual college scholarships to adult workers in the New Bedford area. These scholarships aim to assist individuals seeking to enhance their professional qualifications through higher education at accredited institutions. Since its inception, the Foundation has mobilized significant philanthropic resources to support community needs and improve the quality of life in the region.

The National Defense Science and Engineering Graduate (NDSEG) Fellowship offers U.S. citizens and nationals the opportunity to pursue doctoral degrees in science and engineering fields critical to the Department of Defense. Awardees receive full tuition coverage, a monthly stipend of $3,600, and health insurance support. With over 4,400 fellowships awarded since its inception, the program aims to foster the next generation of scientists and engineers, encouraging diverse applicants to align their research with DoD priorities.

The HEAL Initiative aims to develop non-addictive therapeutics for pain management through small molecules and biologics. This funding opportunity supports preclinical optimization, facilitating the transition of promising candidates to clinical trials. Important proposal deadlines span from January 2024 to January 2027, with optional Letters of Intent encouraged 30 days prior. The program emphasizes collaboration with NIH staff to ensure thorough project planning and monitoring, aiming to revolutionize pain treatment while ensuring safety and efficacy.

The Frank D. Sylvia Trust Scholarship, established by the SouthCoast Community Foundation, honors Frank D. Sylvia's late son. This scholarship provides financial assistance to deserving high school seniors from Dighton or Somerset. Since its inception, the foundation has mobilized philanthropy, distributing over $50 million to meet community needs. The scholarship aims to support students with financial need, fostering educational opportunities and enhancing the quality of life in the region.

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Hemophilia Health Equity Fund

Help with healthcare costs for hemophilia (health equity fund)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code. 

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

Overview

GEAR is a small grant offered by East Coast Zoological Foundation (ECZF). This grant is intended to be a catalyst for growth and development of conservation-based organizations by supporting operational costs essential for in-situ fieldwork. GEAR addresses the financial challenges organizations face when their needs fall outside large-scale project-based funding.

We aim to respond to applicants within 4 weeks of receiving the application. Funding requests up to $1,000 are anticipated, though larger requests may be considered or partially funded. Recipients must use the funds within 12 months and submit a brief report by the end of that period.

Proposals should fall within one of the three categories defined below:

• Field equipment: supplies required to monitor, survey, and assess species and habitats including, but not limited to, technology, software, tools, clothing, PPE and transport.
• Outreach: supplies needed for public engagement through schools, awareness campaigns, and activities including, but not limited to, pamphlets, books, stickers, digital content creation and signage.
• Professional development: training needed for organizational growth and greater capacity. Opportunities may include, but are not limited to, symposiums, workshops, conferences and training. Additional associated costs such as travel and housing can be included and will be assessed on a case-by-case basis.

The TFEC Student Emergency Assistance Fund provides crucial financial support for students facing unexpected hardships that threaten their continuation in post-secondary education. Grants of up to $500 per application are available, with a total funding limit of $1,500 for re-applications. This initiative is part of The Foundation for Enhancing Communities' mission to bolster local educational opportunities and foster community resilience, ensuring that students can overcome financial barriers and achieve their academic goals.

The U.S. Embassy in Tokyo is launching a competition to promote study abroad programs for Japanese students seeking graduate education in the United States. This initiative invites proposals from American and Japanese non-profit organizations to create innovative programs aimed at increasing enrollment of Japanese students in U.S. graduate schools across various fields, enhancing cross-cultural exchange and educational opportunities.

The York Rotary Foundation, supported by The Foundation for Enhancing Communities, offers scholarships to assist York County students in pursuing higher education. These scholarships reward academic excellence and community involvement, with a focus on graduating seniors and adult learners. There are 11 specific scholarships available, each with unique criteria. This initiative aims to enhance educational opportunities and foster community growth.

Coming Together Diversity Scholarship Fund

Established by Coming Together, an organization created in 1993 to promote racial harmony and cultural awareness in our community, to provide scholarships for students in Akron Public Schools.

Amount:

• $1,200

Number of awards:

• 1

Renewal:

• No

The Bill Cox Memorial Scholarship offers a $1,750 award to graduating seniors from Spokane High School, aimed at supporting their educational aspirations. Applicants must maintain a GPA of 2.5 or higher, demonstrate financial need through FAFSA-SAI, and submit a transcript along with an essay detailing community service and school activities. A letter of recommendation is also required. The scholarship application period will reopen on January 1, 2026 for the 2026–27 academic year.