Best Large Grants for Nonprofit Organizations in California

The Society of Interventional Radiology Foundation

SIR Foundation is a scientific foundation dedicated to fostering research in interventional radiology for the purposes of advancing scientific knowledge, increasing the number of skilled investigators, and developing innovative therapies that lead to improved patient care and quality of life. The foundation is committed to fostering the development and enhancement of innovative, minimally invasive, image-guided therapies from inception to mature clinical application and to conduct educational programs in the service of its mission.

Giving Circle for the Advancement of Women (GCAW) Award

Provide career development opportunities for women in interventional radiology. GCAW is dedicated to engaging all generations of women in interventional radiology through the power of community philanthropy.

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

Ginny and Jim Thompson Scholarship

Selection based upon (in order of priority):

Financial need, academic ability, recommendations, and an essay, “Why is education important to me?”

Awards

• One $1,000 scholarship

Dr. Jill Biden Scholarship - Biden Breast Health Initiative

Essay:

• Why have you chosen a career in health care or education, and why do you feel it is important to encourage others to adopt a healthy lifestyle?

Awards:

• One time award of $2,500; one award per county. 

The Community Heart & Soul Seed Grant Program offers $10,000 in startup funding for community-driven groups in small towns to adopt the Community Heart & Soul model. Applications are accepted until 11:59 p.m. EST on the last business day of each month, with funding decisions made the following month. This initiative aims to empower residents to engage in local development and foster community connections.

The Will Glickman Award, presented by Theatre Bay Area, honors the best new play premiering in the San Francisco Bay Area each year. Established in 1984, this award celebrates excellence in playwriting, recognizing outstanding original works that enrich the local theatre community. It not only highlights the playwright's achievements but also encourages the development and production of new plays. Submissions are accepted year-round, emphasizing the commitment to fostering diverse and inclusive artistic voices.

The Sharing Language Diversity Fellowship supports Ph.D. students engaged in Indigenous language documentation and data archiving. Funded by the Endangered Language Fund, it encourages sustainable public sharing of linguistic materials, aiming for equitable access to research. With grants up to $30,000, recipients must publicly archive documentation materials within three years, ensuring compliance with community wishes and best practices. This initiative fosters a culture of Open Access in linguistics, benefiting both scholars and Indigenous communities.

The Community Action Grants - Arts and Culture program by the Silicon Valley Community Foundation aims to empower organizations focused on racial justice and community-based solutions. It supports arts organizations that nurture creativity and civic engagement in San Mateo and Santa Clara counties. This initiative recognizes the crucial role of artists and cultural workers in driving social change, thereby fostering a vibrant, equitable Silicon Valley. Eligible organizations must demonstrate a commitment to inclusivity and community leadership.

This grant aims to enhance safety and health in U.S. mining operations through research in automation, robotics, and intelligent systems. It addresses critical issues like emergency communication and self-escape reliability while supporting the development of field-ready solutions. By leveraging advanced technologies, the initiative seeks to improve miner safety and health, reduce hazardous exposures, and foster community engagement. Applicants must be U.S. academic institutions with accredited mining programs, linking project goals to documented health burdens.

Arts Impact Grants for Organizations (AIGO) support Sonoma County's cultural nonprofits, demonstrating the arts' role in enhancing community cohesion. Funded by the County of Sonoma and the National Endowment for the Arts for 2025, these grants prioritize equitable access and participation in programs impacting diverse audiences. Eligible applicants include 501(c)(3) nonprofits with a minimum three-year history of consistent arts programming. Applications emphasizing environmental sustainability are also encouraged, reflecting the urgent climate challenges faced by the region.

The Ilpo Martikainen Audio Visionary Scholarship, provided by the Audio Engineering Society Educational Foundation, supports U.S. graduate students dedicated to advancing audio technology. This scholarship honors the legacy of Dr. Martikainen, founder of Genelec, who significantly contributed to loudspeaker innovation. Eligible students must have completed an undergraduate degree and demonstrate a commitment to audio engineering. Grants typically range from $2,000 to $5,000, paid directly to the student's graduate school.

Chautauqua Region Community Foundation

Mission: In partnership with our community, we ignite positive change and create a legacy of impact.

Scholarships

The Chautauqua Region Community Foundation annually awards more than $2 million in scholarships to students pursuing higher education, job training and certification. The Foundation hosts several different scholarship opportunities throughout the year. 

Space Camp Scholarship

Open to students (grades 4-12) or adults from Chautauqua County, NY or Warren County, PA to support the cost of attending U.S. Space Camp. 

The ACS-Hach High School Chemistry Classroom Grant aims to enhance chemistry education by providing funding for innovative teaching ideas. Since its inception in 2008, over 700 teachers have benefited from grants of up to $1,800. Eligible applicants are U.S. high school chemistry educators, and the funding can be used for laboratory supplies, instructional materials, professional development, and student-led field studies, fostering a deeper understanding of chemistry.

The Creation & Development Fund, administered by the National Performance Network, supports the creation and mobility of artistic works that promote racial and cultural justice. It fosters collaboration between artists and communities through financial support, enabling artists to develop meaningful relationships and present their work. The fund emphasizes equity, access, and the importance of public engagement, ensuring that diverse voices are represented while addressing systemic injustices in the arts.

This FOA is intended for proposals related to basic and applied research in the STEM categories, and not related to the development of a specific system or hardware procurement.The proposal submission process has two stages:I. Applicants are encouraged to submit a white paper first to Grants@NPS.edu, ; andII. Applicants must submit a full proposal through Grants.gov (do not submit white papers through Grants.gov, only full proposals)Applicants are encouraged to submit a White Paper in advance of a Full Proposal to minimize the labor and other costs associated with the production of detailed full proposals that have little chance of being selected for funding. Based on an assessment of the white papers, the responsible Research Program Officer will provide informal feedback notification to the prospective awardees to encourage or discourage submission proposals. The Research Program Officer may also, on occasion, provide feedback encouraging re-work to strengthen a proposal. White Papers may be submitted at any time during the open period of this FOA. A separate White Paper is required for each research proposal.

The Capacity Accelerator for Tribal Offshore Wind Engagement, launched by the U.S. Department of Energy, aims to empower Tribal Nations in offshore wind energy decision-making. This initiative offers up to $7.1 million in cash prizes and technical assistance through three phases: Capacity Needs, Capacity Development, and Engagement. Each phase is designed to support Tribes in outlining their priorities, building capacity, and implementing impactful projects in offshore wind energy.

The Burton and Erma Lewis Structural Engineering Scholarship, established by the estate of Mr. Lewis in 2025, aims to support students pursuing degrees in structural engineering. Awarded annually, the scholarship is available to undergraduate students enrolled in ABET-accredited programs who demonstrate a commitment to the field. Recipients can use the funds for tuition and academic fees, facilitating their education and career development in civil engineering.

The NASA ROSES 2025: A.18 Geosphere program provides funding for research on solid-Earth processes across various scales. It aims to enhance understanding of the Earth's structure and dynamics, particularly in the core, mantle, and lithosphere. Key areas of focus include Earth Surface Properties, Crustal Dynamics, and Earth Interior. This initiative supports advancements in managing natural resources, assessing geohazards, and exploring the forces driving plate tectonics, ultimately contributing to improved hazard forecasting and mitigation strategies.

The Gene Haas Foundation offers Manufacturing Education Grants to empower students in technical career pathways through CNC education. These scholarships support public and private nonprofit schools, enhancing skills in CNC technology. Funds can be allocated for the Gene Haas CNC Scholarship and tooling awards for essential tools and safety gear. By fostering hands-on experience in real-world manufacturing, the foundation ensures the next generation of skilled professionals has the necessary resources to succeed.

About Community Foundation of Henderson County

• Mission: Helping people who care make lasting contributions to causes that matter.
• Vision: Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Elizabeth DeVilling Environmental Odyssey Scholarship

This scholarship provides support to graduating seniors or graduates of any Henderson County public, private or parochial high school seeking to further their education beyond high school. Recipients of this scholarship must be accepted to an accredited degree granting college or university and be actively pursuing an undergraduate degree in the field of environmental science or a related field. Preference will be given to those who have expressed a desire to pursue work which relates to environmental preservation and/or conservation and have financial need for assistance. Extra-curricular and extra participation in activity relevant to earth sciences/environmental sciences will be given added priority.

The National Institutes of Health (NIH) is continuing support for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT), which focuses on clinical trials and biomarker validation studies for neurological disorders. This initiative aims to foster innovation in neurotherapeutics by providing essential infrastructure and expertise. The program encourages the establishment of Clinical Coordinating Centers (CCC) and Data Coordinating Centers (DCC) to enhance collaborative efforts. Note that applications are not currently being solicited.

The Arnold Ventures RFP invites proposals for causal research on community safety and the criminal justice system. This initiative aims to generate evidence that informs effective policies to enhance safety and fairness in justice. Applicants should propose robust research designs capable of isolating treatment effects, focusing on real-world outcomes in the U.S. Preference is given to interventions with potential for policy adoption and led by early-career researchers or those without previous funding from Arnold Ventures.

The Orphan Kitten Club’s Mightycat Grant Program offers financial assistance to individuals and organizations dedicated to saving neonatal kittens. Funding supports essential needs such as medical care, supplies, and innovative programs aimed at improving survival rates. Eligible applicants include 501(c)(3) organizations and independent rescuers with a proven track record in kitten care. The program's mission is to enhance rescue efforts and provide vulnerable kittens the opportunity to thrive and find loving homes.

Our Mission

KidsGardening creates opportunities for kids to play, learn, and grow through gardening, engaging their natural curiosity and wonder.

We want every child to experience the unique transformation that occurs when they spend time caring for a garden, be it outside, in a classroom, or in a cup on the kitchen windowsill. Since 1982, KidsGardening has served as a premier support provider for youth garden programs nationwide.

We support educators and families with grant funding, original educational resources, inspiration, and community to get more kids learning through the garden.

Growing the Future Intergenerational Garden Grant

In celebration of Miracle-Gro’s 75th anniversary, Miracle-Gro and KidsGardening are partnering to fund 75 intergenerational youth garden grants in 2026.

Intergenerational gardens provide opportunities for older gardeners to pass along traditions, knowledge, and skills to the next generation or share the experience of developing skills if new to gardening. In turn, young people bring their curiosity, wonder, and contagious enthusiasm for learning and life, exciting everyone involved in the growing process.

The 2026 Growing the Future Intergenerational Garden Grant is designed to support gardens that intentionally bring children and older adults together through shared gardening experiences.

Funding Priorities

The selection of winners is prioritized based on demonstrated need and program impact. KidsGardening considers a variety of factors when determining needs, including:

• Socioeconomic & Sociodemographic Factors: How does the program exist within or engage a community that has been systematically denied resources, whether physical assets and money or representative leadership and community services? Organizations affected by multiple socioeconomic and sociodemographic factors are given priority.

• Program Funding and Support: Does an organization have access to consistent, substantial monetary support or prior grant funding? Or are pre-existing resources (financial or otherwise) limited? Organizations experiencing the latter are given priority.

• Impact: Will grant funding dramatically expand learning opportunities for program participants? Does the intended impact reflect the needs of the community? Organizations working with more than 50 youth will be given priority.

Award Packages

Grantees will receive:

• A $500 cash award check
• A $250 coupon to purchase essential gardening supplies from ScottsMiracleGro.com

Excellence in Medicine Awards

The AMA Foundation’s Excellence in Medicine Awards honor physicians and medical advocates who exemplify the highest values of the profession—volunteerism, community engagement, leadership, and service to underserved populations. Each recipient is recognized at a ceremony during the AMA Annual Meeting in Chicago and receives a $2,500 grant honorarium directed to a nonprofit health organization of their choice. Since 2005, more than 100 honorees have been celebrated through this program, with over $250,000 awarded to strengthen community health and advance equitable care nationwide. 

Excellence in Medicine Awards- Dr. Debasish Mridha Spirit of Medicine Award

Recognizes the work of U.S. physicians who demonstrate altruism, compassion, integrity, leadership and personal sacrifice while providing quality health care to destitute, distressed or marginalized populations in impoverished communities.

Made possible by Debasish Mridha, MD

The ACI Foundation's Tribute to the Founders Fellowship supports graduate students in construction, design, education, or materials. Awardees receive a $10,000 educational stipend, recognition in Concrete International magazine, and travel expenses to two ACI conventions. This fellowship aims to foster the next generation of concrete industry leaders through education and mentorship, while also encouraging personal development and career readiness through a structured internship program.

The AWG Mid-Career Excellence Award honors outstanding mid-career women scientists contributing significantly to geosciences. It recognizes achievements across academia, industry, and government, with nominees evaluated on their scientific impact and community service. This prestigious award encourages nominations from the AWG membership and the broader geoscience community, fostering recognition of women's vital contributions in the field. With a commitment to diversity, the award aims to inspire future generations of women in geoscience careers.

The National Center on Elder Abuse Resource Center aims to enhance the readiness of communities to combat elder abuse, neglect, and exploitation. By offering resources, training, and information, the center empowers professionals and the public to effectively prevent and respond to elder maltreatment, ensuring that older Americans can live with dignity and independence. This initiative, supported by the US HHS Administration for Community Living, emphasizes best practices and awareness to mitigate risks associated with elder fraud and scams.