Best Large Grants for Nonprofit Organizations in California

Dr. Jill Biden Scholarship - Biden Breast Health Initiative

Essay:

• Why have you chosen a career in health care or education, and why do you feel it is important to encourage others to adopt a healthy lifestyle?

Awards:

• One time award of $2,500; one award per county. 

Logix Federal Credit Union is dedicated to fostering community through sponsorships and support for local organizations. They prioritize funding for public charities and government units within Los Angeles and Ventura County. Their commitment to service extends beyond banking, focusing on the positive impact of charitable giving and volunteerism. Organizations seeking sponsorship must meet specific eligibility criteria and submit requests at least 90 days before their events, ensuring a thorough review process.

The NIA Research and Entrepreneurial Development Immersion (REDI) program aims to support early-career scientists transitioning to industry through the Entrepreneurial Small Business Transition Award. This initiative fosters entrepreneurial skills while enabling small business concerns to hire postdoctoral fellows and early-stage researchers, enhancing their research capabilities. Focused on mentoring and training, the program is designed to ensure that participants develop essential skills for successful careers in entrepreneurship and scientific development.

Committee of 100 Academic Scholarship

Awards:

• One time award of $5,000.

The J.M. Heberlig/B.J. Helterbran Scholarship Fund, established by dedicated educators, supports Pennsylvania residents pursuing degrees in Art Education or Recreation & Parks. This scholarship aims to alleviate the financial burden on students entering their second, third, or fourth year at a 4-year institution. With a focus on academic achievement, a minimum GPA of 2.8 overall and 3.0 in the major is required, alongside a demonstrated commitment to education and community service.

Steven Thayer Hopi Scholarship

This scholarship was established by the family of Steven Thayer to provide scholarship funding for young Hopi artists to develop their talents and artistic skill.

The Lowell Berry Foundation Grants aim to enhance leadership within local Christian church ministries while providing community support in California. Established in 1950 by Mr. Lowell W. Berry, the foundation focuses on assisting organizations that foster personal development and leadership. Grants are limited to programs in Contra Costa and Alameda counties, with funding not available for individual projects or capital equipment. This initiative continues to build on a legacy of community service and leadership advancement.

The NIH Science Education Partnership Award (SEPA) fosters innovative educational initiatives aimed at pre-college students, promoting their interest in STEM fields, especially in biomedical and behavioral sciences. This program supports both classroom projects and informal science education activities, such as after-school programs and library events. Emphasizing the development of quantitative and computational skills, SEPA seeks to inspire the next generation of scientists and thinkers through engaging educational experiences.

The David S. Miller Young Scientist Scholarship awards $1,500 to undergraduate and graduate students in geo-environmental sciences or engineering. This scholarship seeks individuals who demonstrate strong academic potential and a commitment to leveraging their scientific education for societal benefit. One winner is selected annually, and while recipients are encouraged to apply for travel grants for AGU’s Fall Meeting, they do not automatically receive them.

The CHEERS Open Period 2 initiative invites white papers from researchers in various technical fields, focusing on projects that align with the objectives of the Continuing Enabling, Enhancing, Restoring, and Sustaining (CHEERS) MAA. This funding opportunity, backed by the US DOD's Air Force Materiel Command, is aimed at advancing national defense capabilities through innovative research and development in areas such as ordnance, telecommunications, and medical supplies.

The Garden Club of Houston, established in 1924, promotes gardening and environmental conservation through various community initiatives. Their funding supports nonprofit organizations and government entities, focusing on projects that enhance public landscapes, educational resources, and community gardens. Grants are not awarded for operating funds or endowments, with preference given to projects within the greater Houston area. This commitment to civic improvement underscores their mission to foster a love of gardening and environmental stewardship.

The BJS FY 2026 National Incident-Based Reporting System Estimation Program aims to enhance statistical protocols for crime and arrest data collection in the U.S. This funding opportunity supports the ongoing development of the NIBRS Estimation System, focusing on improving data quality, timeliness, and estimation methodologies. By refining these processes, the program seeks to address public safety challenges and provide reliable national estimates, thereby ensuring effective law enforcement and crime prevention efforts.

The Ann Jackson Family Foundation offers grants primarily to non-profit organizations serving Santa Barbara County, focusing on Health and Human Services, The Arts, Community, and Education. With a history dating back to 1978, the Foundation encourages applicants to submit proposals via the Common Grant Application for amounts over $10,000, or a concise letter for smaller requests. Despite processing over 100 grants annually, it operates without paid staff, relying on volunteer trustees to evaluate proposals.

The Infrastructure Capacity for Biological Research Program, supported by the National Science Foundation, aims to enhance research capabilities across various biological disciplines. This program encourages proposals for developing and improving research tools and services in areas such as Cyberinfrastructure and Biological Collections. It also welcomes planning activities to foster collaboration among researchers. Projects must ensure broad accessibility and significant scientific outcomes for the wider research community.

The Lenora Jane Perdue Scholarship, offered by the North East Community Foundation, supports graduating seniors from Westfield Academy, Ripley Central School, and North East High School pursuing a degree in education. Applicants must maintain a GPA of 3.0 or higher. This scholarship aims to encourage and assist students dedicated to a career in teaching, fostering the next generation of educators in their community.

The Wilbur Awards, presented annually since 1949 by the Religion Communicators Council, celebrate excellence in communicating religious values and themes in secular media. Open to individuals and organizations, entries must have been published or broadcast in 2024. Categories include audio, audio-visual, images, and written works, allowing for both English and non-English submissions. The awards emphasize professionalism and respect in highlighting uplifting religious narratives within diverse media platforms.

The Patient-Centered Outcomes Research Institute (PCORI) Funding Announcement aims to enhance methods for conducting patient-centered comparative clinical effectiveness research. This initiative seeks to address critical methodological gaps, focusing on improving the use of artificial intelligence in clinical research, study design, data research networks, and ethical protections in patient-centered CER. With a budget of up to $750,000, successful proposals will contribute to the quality and strength of evidence generated in CER studies.

Community Foundation of the Holland/Zeeland Area

Our Mission

The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.

Scholarships

CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.

All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.

The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.

Peter and Huberdina Weller Scholarship

• Graduating senior, graduating early college student, or current college student from a high school within the greater Community Foundation service area
• Enrolling/enrolled at an accredited post-secondary school within the United States
• Financial need (must submit the page of the FAFSA Submission Summary showing the Student Aid Index amount)
• GPA of 3.0 or greater
• Intention to pursue educational opportunities and a career in horticulture or the biological sciences with an emphasis on botany
• All other qualifications being equal, tie-breaking consideration will be given to students of color
• Previous recipients of the award are encouraged to reapply.

The Patient-Centered Outcomes Research Institute (PCORI) is offering funding up to $750,000 for studies aimed at addressing critical methodological gaps in patient-centered comparative clinical effectiveness research. This initiative focuses on enhancing the quality of evidence in clinical research by prioritizing areas such as artificial intelligence, study design improvements, support for data research networks, and ethical considerations. Successful proposals will contribute to advancing research methodologies and improving patient outcomes.

The Patient-Centered Outcomes Research Institute (PCORI) is funding Cycle 3 to enhance patient-centered comparative clinical effectiveness research (CER). This initiative targets critical methodological gaps, focusing on improving the use of artificial intelligence, study design, data research networks, and ethical protections. By addressing these areas, PCORI aims to strengthen the quality of evidence in CER, thus promoting better outcomes in healthcare decision-making.

The National Cancer Institute (NCI) invites applications for the Toward Translation of Nanotechnology Cancer Interventions (TTNCI) program. This funding opportunity focuses on advanced pre-clinical research aimed at developing nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards will support the maturation of innovative nanomedicines using nanoparticles and nano-devices, enhancing cancer treatment efficacy. Successful projects will progress towards further NCI translational programs, such as the NExT initiative.

About Borealis Philanthropy

Borealis Philanthropy is a philanthropic social justice intermediary that works to resource grassroots leaders and social justice movements for transformative change. We help funders expand their reach and strengthen their impact through donor collaboratives that support a variety of issues, communities, and movements. Borealis is home to nine donor collaboratives, including the Disability Inclusion Fund and Disability x Tech.

DIF x Tech Fund

For the Disability Inclusion Fund at Borealis, part of our efforts for disability rights and justice includes the ways disability and technology are working towards shared goals in our movements. The DIF x Tech initiative, supported by the Ford Foundation’s Technology & Society Program and the MacArthur Foundation’s Technology in the Public Interest, invites proposals that are working to bring about transformational change at the intersections of disability, justice, and technology

About the Disability Inclusion Fund and DIF x Tech

The Disability Inclusion Fund (DIF) supports U.S.-based groups run by and for people with disabilities to lead transformational change. The Fund is supported by donors including the Presidents’ Council on Disability Inclusion in Philanthropy, which is comprised of foundation presidents who are committed to disability inclusion as part of improving diversity, equity, and inclusion within philanthropy.

Part of the efforts of disability rights and justice includes the ways disability and technology are working towards shared goals in our movements. This newly launched initiative is housed at the Disability Inclusion Fund (DIF) and supported by Ford Foundation’s Technology & Society Program and the MacArthur Foundation’s Technology in the Public Interest. 

DIF x Tech Fund Values

All Disability x Tech award decisions will align with the DIF guiding values. The DIF guiding values are:

• Participation: Movement funding accountable to the disability rights movement. Those impacted by injustice/exclusion should be involved in strategies to advance justice/inclusion.
• Intersectionality: Acknowledging that disabled people have multiple and intersecting social and political identities that can influence their ability to have access and inclusion including race, gender identity, class, sexual orientation.
• Radical inclusion: Deeply committed to removing barriers and ensuring access so that those most affected by intersecting identities can participate, valuing lived experience.
• Leadership of those most impacted by ableism: Emphasis is given to organizations led by people subject to systemic bias and impacted by underrepresentation, particularly disabled people of color, queer, gender nonconforming and women with disabilities.
• Cross-movement solidarity: Intentional focus on collaboration and bridge- building amongst disability justice activists and across movements.
• Sustainability: Resources and tools that support the growth of grassroots disabled-led organizations, and expand operational capacities for ongoing movement building. 

What we fund

We invite proposals that are at the nexus of technology, disability rights and justice. This opportunity may be a good fit for your organization, if you are doing work in any of these areas below:

• Disabled people sharing technical skills and knowledge with others in the community.
• Disabled people leading policy, rights, and disability justice activism work related to tech. 
• Disabled people participate in all stages of the design and development of new tech that will enrich lives of people with disabilities.
• Enabling collective and equitable access to digital infrastructure. 
• Expanding the participation, leadership, and thought partnership of overlooked and under-resourced people with disabilities in all areas of the technology sector.
• Partnerships between disability-focused engineering design labs and maker spaces within schools, centers for independent living, or local nonprofit organizations.
• Permissible Policy Work:
  • We may support nonpartisan policy education and advocacy related to disability and technology. Any lobbying must remain within applicable 501(c)(3) limits and Borealis grant restrictions.

About Us

Mission and Vision

The Mission of the Foundation is to improve the quality of life in the Coastal Bend by building community endowment and addressing social, educational, environmental, and cultural needs through the awarding of grants and scholarships.

Beck - O.J. Beck, Jr. Memorial Scholarship

Purpose:

Established in memory of O.J. (Junior) Beck, Jr., a respected general contractor and builder in the Coastal Bend with a reputation for attention to his projects and friendly relations with owners. He served his community as a member, director, vice president and president of the South Texas Chapter of the Association of General Contractors, the Business Development Commission, Chamber of Commerce, Ada Wilson Hospital, United Way, YWCA and many other organizations. He came to an untimely death on April 15, 1982.

The NABG Scholarships support full-time undergraduate and graduate students in Geoscience programs at accredited institutions, with over $300,000 in funding raised through donations and events. Candidates must exhibit academic excellence, aiming to equip them for future careers in the geosciences. This initiative, backed by the National Association of Black Geoscientists, fosters diversity and prepares the next generation of professionals in the field.

Project Lead The Way (PLTW)

Our Mission: Empower Students to Thrive in an Evolving World

Our Philosophy for Education: We believe all students – beginning at a young age – need access to real-world, applied learning experiences that empower them to gain the skills they need to thrive in college, career, and beyond.

We believe teachers play an immeasurable role in empowering students, and our programs provide teachers with the support and resources they need to devote more time to inspiring students.

PLTW Computer Science - New Program In Partnership With Lam Research

The Lam Foundation supports schools implementing or expanding a PLTW program in or near several of their U.S. communities. Schools seeking support for PLTW Gateway or PLTW Engineering will receive priority. The Lam Foundation is the philanthropic arm of Lam Research, a leading provider of equipment and services to the semiconductor industry.

Program Requirements

The purpose of this grant is to assist the grantee's implementation of the PLTW Computer Science program. Grantee must offer at least one PLTW Computer Science course in the 2027-2028 academic year and must offer one additional course in the 2028-2029 academic year (two different courses in two years). Grantee may implement any PLTW Computer Science courses of their choosing. Grantee must complete two years of grant reporting.

Project Lead The Way (PLTW)

Our Mission: Empower Students to Thrive in an Evolving World

Our Philosophy for Education: We believe all students – beginning at a young age – need access to real-world, applied learning experiences that empower them to gain the skills they need to thrive in college, career, and beyond.

We believe teachers play an immeasurable role in empowering students, and our programs provide teachers with the support and resources they need to devote more time to inspiring students.

PLTW Computer Science - Program Expansion In Partnership With Lam Research

The Lam Foundation supports schools implementing or expanding a PLTW program in or near several of their U.S. communities. Schools seeking support for PLTW Gateway or PLTW Engineering will receive priority. The Lam Foundation is the philanthropic arm of Lam Research, a leading provider of equipment and services to the semiconductor industry.

Program Requirements

The purpose of this grant is to assist the grantee's expansion of student access to the PLTW Computer Science program. Grantee must use their grant funds to expand their existing PLTW Computer Science program. Example expansion activities include but are not limited to adding an additional PLTW Computer Science course not previously offered, and/or adding additional class periods of an existing PLTW Computer Science courses previously offered, and/or training additional teachers in PLTW Computer Science courses for the 2027-2028 academic year. Grantee must complete one year of grant reporting.