Best Large Grants for Nonprofit Organizations in California

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

The Water Buffalo Club: We Benefit Children Grant supports underserved and at-risk children in Los Angeles County. For over 35 years, the club has helped small charities grow by providing funding, resources, and active member participation. The grants focus on organizations with annual budgets of $500,000 or less and are aimed at capital projects, ensuring that 100% of donations directly benefit these charities. This unique approach combines funding with volunteer efforts to maximize community impact.

The Women’s Shelters Grant, provided by the AKC Humane Fund, offers financial assistance to domestic abuse shelters that accommodate pets. This grant aims to empower shelters to break the cycle of domestic violence by allowing women to keep their beloved pets during difficult times. By supporting organizations that facilitate this, the AKC Humane Fund fosters a community where both women and animals can find safety and solace together.

The American Legion Child Welfare Foundation (CWF) offers grants to nonprofit organizations dedicated to enhancing the welfare of children across the United States. Established in 1954, CWF prioritizes projects that address the physical, mental, emotional, and spiritual needs of youth. Grants are available annually from May 1st to July 15th, supporting initiatives that demonstrate a broad geographical impact. This foundation seeks to make a meaningful difference in the lives of children facing various challenges.

About

What is the Pizza Hut Foundation?

In pursuit of happiness, the Pizza Hut Franchisee community, in partnership with Pizza Hut U.S. is proud to announce the formation of the Pizza Hut Foundation.

Our foundation is seeking to touch the lives of over 100 youth annually by partnering with youth-serving nonprofit organizations focusing on literacy education programs to enable our team members and their peers to be career and life ready.

Pizza Hut Foundation, Inc. is a nonprofit, tax-exempt charitable organization under the Section 501(c)(3) of the Internal Revenue Code. Donations are tax deductible as allowed by law.

About the Slice of Literacy Grant

The bi-annual grant opportunity awards up to $10,000 to public libraries and non-profit organizations that are actively working to improve literacy initiatives in Pizza Hut communities.

The grants are made possible by the generosity of our customers purchase of the BOOK IT! Bundle menu item!

The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.

About Us

Driving Positive Change in Noble County!

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

As a group of invested community members, we identify local current and emerging issues and stimulate resources to address those needs, helping our region prepare for the future. We then leverage gifts and bequests from generous donors like you to drive positive change through grants in such areas as arts and culture, education, health and human services, civic affairs and other charitable areas of interest.

Our Mission

To improve the quality of life in Noble County by serving as catalyst for positive change, enabling donors to carry out charitable intent, and making grants.

Donor Story - Stahl, Josh Scholarship Fund

The Joshua Stahl Scholarship Fund was established in December 1999 by Michael Yoder. Mr. Yoder started this fund as a tribute to Josh Stahl, a friend of his son, Phillip. Joshua Stahl was a student at East Noble High School who died from a tragic car accident in 1999, but his love for running and his life is still remembered with the Josh Stahl Memorial Scholarship. Phillip Yoder dedicated his track season to his fallen friend and won the 1999 State Track Meet in the 3200 meters with a time of 9:06.

Pays $500 one-time. Extra essay: How has involvement in cross country and/or track affected your decisions and goals for your future? (cfnc)

The TIP Office of the US Department of State invites applications for projects aimed at combating human trafficking, adhering to the Trafficking Victims Protection Act. This initiative prioritizes prosecuting traffickers, protecting victims, and preventing trafficking through strategies outlined in the National Security Strategy, executive orders, and the annual Trafficking in Persons Report, while aligning with America First Foreign Policy priorities.

About Us

Driving Positive Change in Noble County!

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

As a group of invested community members, we identify local current and emerging issues and stimulate resources to address those needs, helping our region prepare for the future. We then leverage gifts and bequests from generous donors like you to drive positive change through grants in such areas as arts and culture, education, health and human services, civic affairs and other charitable areas of interest.

Our Mission

To improve the quality of life in Noble County by serving as catalyst for positive change, enabling donors to carry out charitable intent, and making grants.

Donor Story – Robinson, John E. and Joan E. Scholarship Fund

Ever since John E. (Jack) and Joan E. Robinson established a scholarship fund with the community foundation in 1997 in memory of their deceased son, William, they have been building it the way some resourceful birds incorporate bits of just about anything into their nests.

The proceeds of catered dinners have gone into the fund, as have earnings from tutoring done by Joan, a retired teacher. The Robinsons have given many donations to the fund as memorials or honorariums and had others do the same, with honorariums in recognition of such things as birthdays and dedicated service to church.

In 2001 the Robinsons celebrated their 50th wedding anniversary and asked that any gifts be to the scholarship fund. Several dozen donations were received.

Jack, a retired law enforcement officer (now deceased), and Joan have also talked up the fund at every opportunity and taken advantage of matches made available by the foundation and through the Lilly Endowment, Inc.

Several scholarships are made available each year.

Robinson, John E. and Joan E. Scholarship Fund

In memory of their son, Bill Robinson.

A one time scholarship for residents of Noble County who are high school seniors (in particular students at Central Noble, Churubusco, East Noble and West Noble schools) pursuing any sort of post high school education. CFNC

The NIDA Mentor-Facilitated Training Award aims to accelerate the dissemination of substance use disorder research, particularly focusing on opioid use disorder. This award supports trainees in developing expertise through mentorship and project completion, ultimately enhancing the adoption of evidence-based practices in healthcare settings. With a budget of up to $12,000, the award fosters professional growth and encourages the implementation of SUD treatment strategies, addressing critical knowledge gaps in clinical practice.

The Edward E. Ford Foundation offers Traditional Grants to independent schools in the U.S. for projects that enhance educational opportunities. With over $118 million granted since its inception, the Foundation emphasizes the importance of matching funds, requiring a dollar-for-dollar commitment from schools. Eligible institutions must serve grades 9-12, be NAIS members, and have a qualified Head of School. Applications are considered during the June and November Agendas, supporting diverse educational initiatives.

Community Foundation of Noble County

At the Community Foundation of Noble County we are passionate about making Noble County an even better place to call home. Since 1991, area residents have been turning to the Community Foundation of Noble County to make their philanthropic giving as effective as possible, as we see it as our mission to serve as a catalyst for positive change. The Community Foundation of Noble County is a public charity 501 (c) 3 entity.

Scholarships

The Community Foundation of Noble County offers a wide range of scholarships to support local students in achieving their academic and career aspirations. 

Sneary, M.D. Max Memorial Scholarship Fund

Awards $2,500 one-time for a high school senior from Noble County to pursue a career in the medical field, with preference given to East Noble applicants.

The 21st Century Fellowship: Specialized Fellowship, offered by the Society for Ethnomusicology, aims to enhance ethnomusicological research by providing $7,500 awards to two Ph.D. students for dissertation fieldwork. Eligible applicants must achieve ABD status and conduct a minimum of six months of full-time research. Preference is given to onsite fieldwork and students from marginalized groups or those with limited funding for their research.

Rochester Area Community Foundation

Rochester Area Community Foundation, in partnership with generous philanthropists and community partners, works to improve the quality of life for people who live and work in the eight-county region through its leadership and strategic grantmaking.

Our Mission: We are cultivating a thriving Greater Rochester region — powered by philanthropy, grounded in community, and sustained across generations.

Victor and Janet Salitan BOCES 2 Scholarship

Purpose of Scholarship

To provide scholarship assistance for BOCES 2 Career and Technical Education students planning to pursue post-secondary education.

Allowed Use of Award

Awards may be used for tuition, fees, books, and other expenses associated with higher education.

Renewability

This scholarship is a one-time award and is not renewable.

Donor Information

This scholarship was established in 1979 to honor Victor Salitan. Victor served for 30 years as a school district attorney for several school districts and specifically for the Monroe 2-Orleans BOCES.

United Negro College Fund

“A mind is a terrible thing to waste.”®

For more than seven decades, this principle has remained at the heart of UNCF, enabling us to raise more than $5 billion and help more than 500,000 students and counting not just attend college, but thrive, graduate and become leaders.

We do this in three ways: By awarding more than 12,000 students scholarships, worth more than $65 million, each year. By providing financial support to 37 historically Black colleges and universities (HBCUs). And by serving as the nation’s leading advocate for the importance of minority education and community engagement.

MetLife Foundation Legacy Endowed Scholarship

The MetLife Foundation Legacy Endowed Scholarship Program was established by the MetLife Foundation to provide need-based scholarship support to college junior enrolled at US four-year HBCUs. Successful applicants must be currently pursuing a STEM, business, finance, or accounting degree, as a full-time student at a four-year HBCU.

Community Foundation of Monroe County

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Scholarship Opportunities

We award over 120 scholarships each year to Monroe County residents. Whether you’re heading to college, pursuing a technical career, or furthering your education as an adult, there’s a scholarship for you.

Charles and Virginia Whitten Scholarship

For Monroe County high school seniors pursuing skilled trades.

The Warren Alpert Foundation's Distinguished Scholars Award aims to enhance public health by funding innovative research in basic and clinical neurosciences. Nominations are invited from medical schools and research institutions in the U.S., focusing on candidates with a strong post-doctoral record. The selection process emphasizes scholarly achievements, scientific proposals, and letters of recommendation. A total of five awards will be granted to deserving scholars, fostering significant advancements in neuroscience.

Clinical Research Training Scholarship in Autoimmune Neurology

This award recognizes the vital importance of rigorous clinical and translational research and aims to inspire and support early-career investigators pursuing clinical studies in autoimmune neurology — specifically immune-mediated diseases of the nervous system other than multiple sclerosis.

The scope of this award encompasses research on autoimmune neurologic disorders, including neural antibody-associated diseases of the nervous system, autoimmune encephalitis, immune-mediated epilepsy, autoimmune movement disorders, inflammatory myelopathies, NMOSD, MOGAD, paraneoplastic neurological syndromes, neurological complications of cancer immunotherapies, and inborn errors of immunity/autoinflammatory syndromes affecting the nervous system.

This award will consist of a commitment of $65,000 per year for two years, plus a $10,000 per year stipend to support education and research-related costs for a total of $150,000. Supplementation of the award with other grants is permissible, but to be eligible to apply for this award, the other grant source(s) cannot exceed $75,000 annually.

Community Foundation of Monroe County

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Scholarship Opportunities

We award over 120 scholarships each year to Monroe County residents. Whether you’re heading to college, pursuing a technical career, or furthering your education as an adult, there’s a scholarship for you.

Graceful Memories Memorial Endowed Scholarship

For Monroe County residents pursuing a career in medicine.

ExtremeTerrain's Clean Trail Grant Program offers $250 for trail improvement projects, encouraging responsible off-roading. Eligible participants include Wrangler and 4x4 clubs, environmental organizations, and trail managers. The program aims to enhance trails through clean-ups, restorations, and expansions. Grants can be used for tools, food for volunteers, and promotional materials. Applicants must meet specific criteria, such as having a website and providing project photos. This initiative promotes stewardship of the natural landscapes we cherish.

The Cottrell Scholar Award supports early career faculty at U.S. and Canadian research universities, fostering innovative research and teaching in Chemistry, Physics, and Astronomy. This prestigious recognition emphasizes the importance of impactful research plans and educational strategies, aiming to enhance undergraduate and graduate science education. The award also encourages academic citizenship and collaboration within institutions, providing funding for three-year projects up to $120,000, thereby promoting excellence in both research and education.

The NASPGHAN Foundation offers a one-year grant to pediatric dietitians aimed at enhancing nutrition care for children with nutritional disorders. Grants ranging from $500 to $5000 will be awarded, with funding distributed in December 2025. Applicants must be Registered Dietitians, CPNP members in good standing, and have a sustained interest in pediatric nutrition. Recipients are required to provide a financial statement and present findings at the 2027 CPNP annual symposium.

The Putting Patients First Grant Program, supported by Canon Medical and managed by AHRA, aims to enhance patient care and safety in medical imaging. In 2024, five grants of up to $10,000 each will be awarded to hospitals developing training or programs in categories such as Diagnostic Imaging and Radiation Safety. Recipients are also required to publish their findings in an AHRA publication, promoting shared best practices across institutions.

The Crohn's & Colitis Foundation/NASPGHAN IBD Young Investigator Award supports early-career researchers in inflammatory bowel disease (IBD). This three-year grant offers mentorship and funding up to $60,000 annually, plus additional support for research-related expenses. Eligible applicants must hold an MD or PhD, demonstrate relevant research experience, and commit at least 65% of their time to the project. The award also facilitates access to IBD Plexus resources, enhancing research capabilities in the field.

Harvey E. Anderson Scholarship

To be awarded to students who participate in Section V sports, have been diligent in academic and athletic endeavors, and exhibit self-motivation and extraordinary effort.

Number and Size of Awards

One award of $4,000 each to both a male and a female athlete; paid as $1,000 per year for up to four consecutive years of undergraduate study. Additionally, one non-renewable award of $1,000 to both a male and a female runner-up. Award paid in the Fall and divided equally between the Fall and Spring semesters.

Allowed Use of Award

Awards may be used for tuition, fees, books, and other expenses associated with higher education.

The NASPGHAN Foundation/NASPGHAN George Ferry Young Investigator Development Award supports promising clinical, quality improvement, translational, or basic science research focused on gastrointestinal tract diseases, liver, pancreas, and nutritional disorders in children. Eligibility includes being a NASPGHAN member for at least two years, having a recent fellowship, and holding a junior faculty position. This award fosters innovative research to enhance pediatric gastroenterology and improve child health outcomes.

The Stein Innovation Award supports innovative vision research by providing funding to Department of Ophthalmology faculty and other researchers. With deadlines in January and July, the award encourages projects that advance the understanding of the visual system and related diseases. Eligible candidates must be affiliated with U.S. institutions of higher education, and prior nomination forms are required for application acceptance. This initiative aims to foster groundbreaking research in the field of ophthalmology.