Best Large Grants for Nonprofit Organizations in California

The Hanna H. Gray Fellows Program, funded by the Howard Hughes Medical Institute, aims to enhance diversity in the scientific community by supporting early-career researchers. The program provides funding for postdoctoral training and early faculty years, promoting an inclusive academic culture. Fellows receive an initial salary of $80,000 and a $20,000 annual expense allowance. This initiative helps develop future leaders in biological and biomedical sciences, ensuring equitable opportunities for all backgrounds.

The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.

The FY 2027 Department of War Multidisciplinary Research Program of the University Research Initiative (MURI) aims to fund U.S. academic teams conducting innovative research to tackle complex challenges for the Department of War. Established in 1985, MURI promotes collaboration among diverse scientific disciplines, enhancing the defense workforce and addressing critical areas of interest through multidisciplinary research efforts at U.S. universities.

The NIH Common Fund is planning to issue a NOFO to continue the Bridge2AI program, which aims to develop AI-ready datasets and best practices for biomedical research. This next stage will leverage these datasets to address significant health challenges and foster multidisciplinary collaboration. The initiative will support 3-5 Centers focused on trustworthy AI in biomedical research, creating frameworks for reproducibility, transparency, and advancing the AI workforce in health sciences.

The NIH Director's New Innovator Award supports creative early-stage investigators pursuing innovative research with transformative potential for science relevant to the NIH mission. Applications are encouraged across all NIH-related fields, enhancing support for emerging talent. This award is part of the NIH Common Fund's High-Risk, High-Reward Research Program, which aims to cultivate groundbreaking research and foster the next generation of scientists.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance understanding of biological processes and disease mechanisms due to somatic mutations in human tissues. Since 2023, it has produced multi-omic datasets from various human tissues. The NIH plans to advance this initiative by establishing the National Somatic Mosaicism Commons Data Analysis & Organizational Center, which will oversee data management, develop analytical tools, and provide training to facilitate research and clinical applications.

The NASA Innovative Advanced Concepts (NIAC) Phase I program invites proposals for groundbreaking aerospace concepts, aiming to transform potential in aeronautics. This initiative supports innovative research through multiple award phases, focusing on Phase I requirements and evaluation criteria. A virtual forum will be held on October 7, 2026, to discuss the Appendix’s details and clarify submission guidelines. Additional information will be available on the NSPIRES page, ensuring participants are well-informed about the process.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Calvin H. & Elizabeth L. Topliff Scholarship

Georgia Mathews, mother to Marion Community Foundation board member, Spencer Mathews, created this endowed scholarship in 2023 in honor of her parents. The scholarship will be awarded to Marion County students who are pursuing a career in either education or engineering, with special consideration for students who will be attending Ohio Northern University, which is where Georgia’s parents met.

Betty Beatty Topliff was born in Pittsburgh but ended up in Marion after meeting Calvin at Ohio Northern and moving to his hometown of Marion. Betty (1928-2022) was a dedicated teacher for 30 years, most recently at Ridgedale High School. Calvin (1924-2009) was an Army veteran who served in Europe during WWII and was awarded the Bronze Star. Calvin retired from the marketing department of Ohio Edison Marion Division after 36 years of service.

Following retirement, Calvin and Betty were Florida snowbirds, but Betty returned to Marion after Calvin’s death to be with her beloved children, grandchildren, and great grandchildren.

The Air Force Basic Research Sciences Conference and Workshop Support program encourages proposals from U.S. institutions of higher education and nonprofit organizations for conferences and workshops that promote research and technology interchange. These events are vital for sharing recent findings and educational techniques in key scientific areas. The program specifically invites Historically Black Colleges and Universities, Minority-serving Institutions, and Tribal Colleges to participate, aiming to foster collaboration and knowledge exchange among researchers.

The Hanna H. Gray Fellows Program, supported by the Howard Hughes Medical Institute, aims to enhance diversity in the academic research community. It provides funding of $250,000 and a $20,000 annual expense allowance for early-career researchers committed to fostering an inclusive scientific culture. Eligible applicants must hold a PhD or MD, commit to at least 75% research effort, and have no more than 24 months of postdoctoral experience. This initiative empowers fellows to become leaders in science.

The BJA FY 2026 DNA Capacity Enhancement for Backlog Reduction (CEBR) Competitive Grants Program aims to enhance the capacity of state and local government crime laboratories for processing DNA samples. This program focuses on using DNA technology to improve forensic efficiency and implement Rapid DNA in booking stations. It targets jurisdictions with operational challenges, ensuring fair access to funding. Eligible agencies can apply for both competitive and formula CEBR funding.

About the Hertz Foundation

Empowering the Nation’s Most EXCEPTIONAL Innovators

The Hertz Foundation identifies and empowers the nation’s most exceptional innovators in science and technology, fueling a lifelong community dedicated to solving our most pressing problems.

Hertz Community

Awards & Recognition

We’ve established several awards to recognize and support Hertz community members who are accelerating solutions to significant real-world challenges, either through their individual careers or volunteering to strengthen the Hertz Foundation’s work. In addition to providing financial and professional support at a critical time, we also hope to generate more awareness within the Hertz community and inspire collaborations that build on the momentum.

Hertz Thesis Prize

The Hertz Thesis Prize recognizes fellows who publish exemplary doctoral theses with applications to real-world problems. Winners receive a $5,000 honorarium.

Exemplary Graduate Work

Since 1981, more than 60 fellows have been recognized with the Hertz Thesis Prize. Much of their work has led to successful patents, the formation of influential companies and contributed solutions to some of our most pressing challenges.

The NIJ FY 2026 Crime and Justice Research funding opportunity invites applications for innovative research aimed at enhancing the effectiveness of the adult criminal justice system. It comprises two main categories: one focuses on new programs and strategies to improve workforce readiness, while the other assesses the impact of the COPS De-escalation Training Program. This initiative seeks to foster safety and operational improvements within law enforcement.

The Kelley Foundation

The Kelley Foundation was established by Robert and Judy Kelley and their daughter Marla. The Kelleys are native Oklahomans and longtime residents of Southern Oklahoma.

The foundation is primarily focused on humanitarian projects in Oklahoma, with an emphasis on Southern Oklahoma. Our mission is to develop and strengthen our community, state, and nation by providing essential resources to those in need.

The Kelley Foundation Grant

The Kelley Foundation is a private, charitable foundation, incorporated under the laws of the State of Oklahoma and operated exclusively for providing support through its gifts and grants to religious, charitable, scientific, and educational institutions which are qualified under section 501(c)(3) and which are not private foundations within the meaning of section 509(a) of the Internal Revenue Service Code.

The National Science Foundation (NSF) is offering funding through the Engineering (ENG) program, focusing on foundational research in civil, mechanical, and manufacturing innovation. Key areas include advanced manufacturing systems, civil infrastructure, and intelligent dynamic systems. The NSF ENG encourages innovative and transformative proposals that may not require immediate commercial outcomes. Award sizes and durations will vary based on budget availability, aiming to support long-term research advancements.

The Foundations of Trusted Systems initiative seeks innovative research to develop secure, resilient, and affordable technologies for Command, Control, Communications, Computers, and Intelligence (C4I) and Cyber systems. This Broad Agency Announcement (BAA) aims to establish trusted foundations for hardware and software, building on previous work to enhance information processing systems. Researchers are encouraged to submit white papers for evaluation and potential funding.

The Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant supports institutions in developing clinical and translational science training programs. This program aims to enhance the research training of postdoctoral individuals holding doctoral degrees, ensuring a diverse pool of scientists equipped to tackle critical health challenges. Applications must be submitted by 5:00 PM local time of the applicant organization, and non-U.S. entities are not eligible.

The Rea Charitable Trust, established in 2009 by Mrs. Isabel McClintic Rea, prioritizes support for charitable organizations that focus on the arts. Administered by Comerica Bank & Trust, the trust provides funding through structured application periods for organizations based on their names. Eligible applicants must be 501(c)(3) organizations, limited to one application per year. The trust aims to uphold Mrs. Rea's legacy by fostering artistic endeavors within the community.

The Ruth L. Kirschstein National Research Service Award (NRSA) offers predoctoral training grants aimed at enhancing clinical and translational science. Administered by the NCATS, this program supports institutions in training aspiring researchers for a PhD or equivalent, ensuring a diverse cohort of scientists equipped to tackle pressing health challenges. The ultimate goal is to cultivate a skilled workforce capable of advancing biomedical research and addressing community health needs effectively.

The Japanese-Language Education Project Grant supports initiatives that enhance Japanese language education across various regions. Offered by the Japan Foundation, Los Angeles, this grant targets workshops, seminars, and original projects that connect language learning with Japan Studies. Eligible applicants include non-profit educational organizations in the U.S. Projects should benefit multiple programs, ensuring a broad impact on Japanese language education. The deadline for applications is two months before the project start date, which must be between April 1, 2025, and March 31, 2026.

The L’Oréal USA For Women in Science Fellowship empowers women postdoctoral scientists by providing annual grants to support their research in STEM fields. This initiative not only recognizes their contributions but also encourages them to serve as role models for future generations. With a long-standing partnership with the AAAS, the program has awarded over $5 million to 105 scientists, demonstrating a strong commitment to advancing women's roles in science and technology.

The PLTW Gateway Program Expansion, in partnership with Lockheed Martin, aims to enhance STEM education in schools across the United States. With a total grant of $10,000 for the 2026-2027 academic year, this initiative focuses on expanding existing PLTW Gateway programs, allowing schools to introduce new units and train additional teachers. Since 2007, Lockheed Martin's support has enabled over 300 programs, providing critical skills to more than 77,000 students nationwide.

The PLTW Gateway program, supported by Lockheed Martin, offers grants for schools to implement STEM and CTE-aligned curricula. Aimed at enhancing educational access for students, it provides funding of $10,000 for the 2026-2027 academic year. Eligible schools include public and charter institutions across the U.S. This initiative, part of a long-standing partnership since 2007, addresses the critical need for future engineers and scientists, benefiting over 77,000 students through innovative coursework.

The NIH Research Education Program (R25) aims to enhance research education activities, particularly for individuals from diverse backgrounds underrepresented in the biomedical and behavioral sciences. This program encourages these individuals to pursue advanced studies and careers in research through mentoring networks and educational experiences, fostering a more inclusive and diverse research workforce.

The NIH Support for Conferences and Scientific Meetings (R13) grant aims to facilitate high-quality conferences that contribute to public health and the scientific missions of NIH Institutes and Centers. Key application deadlines range from April 2024 to January 2027, providing vital opportunities for researchers to gather and share knowledge. This grant is particularly focused on enhancing the impact of scientific dialogue in critical health areas.

The NIH Independent Scientist Award (K02) aims to support the development of promising scientists, providing three to five years of salary support and protected time for focused research. This funding opportunity is specifically for basic experimental studies involving human participants, classified as clinical trials. Eligible applicants must demonstrate a need for intensive research to advance their careers, and the proposed projects should align with the interests of the participating NIH Institutes and Centers.