Best Large Grants for Nonprofit Organizations in California

The ACTA Apprenticeship Program has been supporting California's cultural traditions for nearly 25 years by providing $5,000 contracts to mentor artists for intensive training of eligible apprentices. This program fosters the continuity of traditional arts through one-on-one mentorship, culminating in public presentations and documentation of the learning process. Eligible applicants must submit a collaborative application, demonstrating commitment and quality in their respective art forms. This initiative not only preserves cultural practices but also enhances community engagement.

The National Library of Medicine (NLM) is seeking applications for a Training Center under the Network of the National Library of Medicine (NNLM). This initiative aims to enhance professional development for librarians, community engagement, and access to health information. By fostering partnerships and disseminating NIH resources, the NNLM will broaden its impact and improve public understanding of health data and information. The NTC will develop innovative training curricula and materials to meet diverse audience needs.

The Air Force Office of Scientific Research (AFOSR) orchestrates the basic research program for the Air Force Research Laboratory, aligning with technical guidance and Air Force needs. It promotes collaboration among Air Force, universities, and industry, ensuring that research effectively transitions to support military capabilities. AFOSR's focus encompasses significant areas of research organized under two scientific departments, enhancing national defense and peacekeeping operations.

The North Lake Tahoe-Truckee Leadership Program aims to develop community leaders in the region, having graduated over 500 participants since 2004. The program, running from January to June 2026, offers full-day sessions on vital topics like economic development and environmental issues. Participants will learn from experienced local leaders and engage in hands-on activities, enhancing their leadership skills. This year's program includes insights on intergenerational leadership, fostering a robust alumni network dedicated to community impact.

The Matthew Isakowitz Commercial Space Scholarship, presented by the Commercial Space Federation and the Matthew Isakowitz Foundation Programs, is an annual scholarship aimed at college students passionate about the commercial space industry. Recipients are awarded $1,000 and gain internship consideration and networking opportunities with industry leaders. The program emphasizes the importance of space policy knowledge, encouraging students to follow Matthew Isakowitz's legacy of kindness and generosity while pursuing careers in this evolving field.

The Joseph E. and Marjorie B. Jones Foundation is a private philanthropic organization committed to enhancing life quality in the greater Washington, D.C. area. The foundation focuses on human services, healthcare, and educational initiatives, believing in the inherent dignity of all individuals. It supports projects that foster community trust and partnership while avoiding funding for basic research, scholarships, or sectarian activities. The foundation aims to inspire and uplift communities through strategic partnerships.

The Greenwall Faculty Scholars Program supports junior faculty in bioethics research, offering 50% salary support for three years and project funding of $5,000 annually. Scholars engage in community-building through semi-annual meetings, mentoring, and philosophical seminars. Priority is given to applicants from underrepresented backgrounds and those not yet considered for tenure. This program aims to drive innovative research that addresses pressing ethical issues in clinical and public health settings, fostering future bioethics advancements.

The SLEEP Travel Grant for AASM Patient Advocacy Roundtable, funded by the American Academy of Sleep Medicine Foundation, aims to enhance sleep health by supporting organizations with limited financial resources. This grant offers $2,000 for travel and registration to the SLEEP 2026 meeting, fostering connections among members of the AASM Patient Advocacy Roundtable. This initiative emphasizes the importance of advocacy in sleep medicine and encourages participation in vital discussions surrounding sleep health.

The SLEEP Travel Grant for Medical Students and Residents, offered by the American Academy of Sleep Medicine Foundation, provides $2,000 to support medical students and residents attending the SLEEP meeting. This grant fosters career development in the sleep field and is available to those currently enrolled in accredited medical or residency programs. The funding is aimed at enhancing sleep health through research and community engagement, aligning with AASM's mission.

The SLEEP Travel Grant for Sleep Technologists and Advanced Practice Providers, funded by the American Academy of Sleep Medicine Foundation, offers a $2,000 grant to support first-time attendance at the SLEEP 2026 meeting. This initiative aims to enhance engagement among non-physician members of the sleep team, such as sleep technologists and advanced practice providers, while promoting networking opportunities within the sleep community.

Since 1977, MAHF has provided grants to help fund almost 50 research and educational projects through individuals and institutions to improve the health and welfare of all animals. These grants have improved veterinary care, animal housing and medical techniques for all species for animals.

Burns and McDonnell, a 100% employee-owned firm, partners with Project Lead The Way (PLTW) to enhance access to STEM education. By expanding PLTW Computer Science programs in local schools, they aim to engage students in real-world challenges and equip them with essential skills. Eligible schools must be located in specific counties and serve a majority of students from low-income backgrounds. This initiative supports the growth of STEM education, fostering a brighter future for communities through enhanced learning opportunities.

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. Individuals and organizations are encouraged to establish a fund with us. 

St Joseph School District Foundation Wright, Gary C Scholarship

This fund was established in memory of Gary C Wright by his family to provide academic scholarships to graduating seniors of the St. Joseph School District intending to major in education with preference given to those in math and/or science.

Guidelines:

• Scholarships will be awarded on an annual basis and disbursed in August.
• Awards are non-renewable.

Amount:

• $250 - $500

The Toshiba America Foundation offers grants of up to $5,000 for innovative STEM projects aimed at grades 6-12. These grants support teachers seeking to enhance science and math education through creative project-based learning. Eligible applicants include public and nonprofit private school teachers, with a focus on fostering engaging classroom experiences. Projects must be endorsed by a school official, and funding is not available for general operations or equipment purchases.

The Planetary Science Enabling Facilities (PSEF) program by NASA invites proposals for research facilities that support the Planetary Science Division. It aims to enhance scientific collaboration and innovation by providing resources to a diverse range of institutions, including emerging and undergraduate colleges. Proposals should highlight the scientific merit and community need for these facilities, ensuring that they serve a broad user base committed to advancing planetary science.

The URM Travel Grants, established by the American Economic Association (AEA), support junior faculty from underrepresented minority groups in economics, including American Indian, Black, Hispanic, and Pacific Islander individuals. These grants cover up to $1,000 in expenses for meals, travel, lodging, and conference registration to attend the annual ASSA meetings. The initiative aims to enhance the professional development of URM junior faculty and promote diversity within the economics field.

The John Deere FIRST Tech Challenge grant supports teams engaging in STEM through robotics. It serves schools and non-profits, prioritizing those in John Deere's Inspire communities and with volunteer mentors. Grants cover registration and equipment costs, fostering innovation and inclusion among underserved students. Teams are encouraged to apply regardless of financial need, furthering John Deere's commitment to empowering youth in engineering and technology through hands-on learning experiences.

The John Deere FIRST LEGO League Challenge aims to enhance equity, diversity, and inclusion in STEM by supporting teams from underserved communities. Eligible teams must have a John Deere mentor and meet specific criteria related to student demographics. Grants will be awarded to teams that demonstrate commitment to community engagement and volunteerism. This initiative aligns with John Deere’s goal to reach one million underserved youth by 2030, fostering innovation and creativity in future generations.

The Limited Competition for High Impact Specialized Innovation Programs aims to enhance clinical and translational science by funding unique capabilities and addressing critical gaps through the Clinical and Translational Science Award (CTSA) Program. This initiative fosters collaboration across a national network of academic medical centers, facilitating the transition of scientific discoveries into impactful health interventions. Applications are peer-reviewed, ensuring funding is directed towards the most promising proposals.

The Limited Competition Research Education Program for the Clinical and Translational Science Awards Program aims to enhance the training of a workforce to meet the nation's biomedical and clinical research needs. It supports educational activities that facilitate the translation of scientific discoveries into practical health interventions. Funded by the NIH, this program invites applications from eligible organizations, and only those with meritorious proposals will be considered for funding.

The Art Bridges Cohort Program aims to enhance access to American art by fostering multi-year partnerships among museums across the U.S. This initiative creates sustainable art-sharing ecosystems that promote collaboration and community engagement. The program supports museums through funding for various phases, including research, small art shares, and large art shares, ensuring resources for travel, exhibition design, and educational opportunities. Eligibility includes a strong commitment to community engagement and existing art collections.

The Limited Competition: Institutional Mentored Research Career Development Program aims to enhance the CTSA Program by fostering the development of postdoctoral fellows and junior faculty. This initiative focuses on training individuals for independent clinical and translational science careers, ensuring they are well-prepared for research engagement. Funded by the NIH, the program supports a national network of academic centers to facilitate the transition of scientific discoveries into practical health solutions.

The Clinical and Translational Science Award (CTSA) Program aims to enhance the translation of scientific research into effective health interventions by establishing a national network of academic medical centers. This program supports integrated research and training environments for clinical and translational science, promoting the development of innovative methods and technologies. The reissuance of the CTSA Notice of Funding Opportunity invites eligible organizations to apply, with peer-reviewed applications prioritized for funding.

The NASA Earth System Science Research Program (ESSRP) has transitioned to six Earth science research spheres, including Atmosphere, which focuses on understanding atmospheric composition and structure. This program aims to enhance comprehension of phenomena affecting air quality and weather, addressing critical issues like stratospheric ozone recovery and tropospheric dynamics. Through annual ROSES funding opportunities, NASA supports research to improve modeling efforts and observations in atmospheric sciences, ultimately benefiting public health and environmental quality.

The NASA ROSES25: A.15 Biosphere program aims to enhance our understanding of terrestrial and aquatic ecosystems through innovative research. This initiative focuses on biogeochemical interactions, biodiversity, and ecosystem function, utilizing satellite data and field studies. The program encourages reproducible and transparent science, fostering collaboration and interdisciplinary approaches. Proposals will undergo rigorous peer review, ensuring high standards and integrity in research outcomes that contribute to our knowledge of global environmental changes.

The FY26 Peer Reviewed Medical Research Program's Platform Clinical Translation Award facilitates early-phase clinical trials for innovative healthcare technologies, catering to the needs of military Service Members, Veterans, and their Families. The program allows collaborations among multiple Principal Investigators and mandates an external advisory board with patient advocate involvement. Approximately $30M is allocated to fund two applications, each capped at $15M, over a maximum period of four years, with funding contingent on performance milestones.

The Chapman Prize, established by the Daniel and Barbara Chapman Trust, honors individuals and organizations making significant contributions to American society. Each year, the award focuses on a theme; in 2025, it will spotlight Economic Prosperity. Eligible applicants include U.S. citizens and nonprofits with three years of charitable work demonstrating impact in the chosen field. Approximately $100,000 will be awarded annually to support endeavors that enhance economic prosperity through various initiatives.