Best Large Grants for Nonprofit Organizations in California

Mission

The mission of Yolo Community Foundation is to inspire and support giving and to provide philanthropic leadership in our community. Yolo Community Foundation (YCF) promotes philanthropy by serving as a public foundation through which:

• community members pursue their own charitable goals;
• local nonprofits benefit from YCF programs and events; and
• youth learn the meaning of community involvement and service. As a community foundation, we lead the campaign to create a county-wide culture of service and giving.

Wide Wide World Fund

The Wide Wide World Fund was established by Maggie Burns and Roy Bellhorn to support nonprofits in advancing their missions and to help students pursue higher education. Upon their passing in 2024, Maggie and Roy ensured that their legacy would continue by creating a fund dedicated to supporting youth in Winters, CA.

The Sacramento Region Community Foundation (the Foundation), in partnership with Yolo Community Foundation, is proud to announce the Wide Wide World Grant. The purpose of the Wide Wide World is to promote educational and cultural enrichment for students in Winters schools that will open a wider world to them.

We will consider proposals in two categories (though we may choose to fund proposals in only one category, depending on the strength of the proposals): Programmatic Applications and Capacity Building Applications.

• The committee would entertain proposals with amounts above the caps for these two categories for truly transformational initiatives.
• Organizations may submit more than one application, but we do not expect to fund more than one application per organization.

Programmatic Funding

Organizations applying for programmatic funding do not need to be based in Winters in order to apply, however the funding must directly benefit the students of Winters and is restricted to projects that support students in Winters schools.

Mission

The mission of Yolo Community Foundation is to inspire and support giving and to provide philanthropic leadership in our community. Yolo Community Foundation (YCF) promotes philanthropy by serving as a public foundation through which:

• community members pursue their own charitable goals;
• local nonprofits benefit from YCF programs and events; and
• youth learn the meaning of community involvement and service. As a community foundation, we lead the campaign to create a county-wide culture of service and giving.

Wide Wide World Fund

The Wide Wide World Fund was established by Maggie Burns and Roy Bellhorn to support nonprofits in advancing their missions and to help students pursue higher education. Upon their passing in 2024, Maggie and Roy ensured that their legacy would continue by creating a fund dedicated to supporting youth in Winters, CA.

The Sacramento Region Community Foundation (the Foundation), in partnership with Yolo Community Foundation, is proud to announce the Wide Wide World Grant. The purpose of the Wide Wide World is to promote educational and cultural enrichment for students in Winters schools that will open a wider world to them.

We will consider proposals in two categories (though we may choose to fund proposals in only one category, depending on the strength of the proposals): Programmatic Applications and Capacity Building Applications.

• The committee would entertain proposals with amounts above the caps for these two categories for truly transformational initiatives.
• Organizations may submit more than one application, but we do not expect to fund more than one application per organization.

Capacity Building Funding

Organizations applying for capacity building funding must be based in Winters and must focus specifically on educational and cultural enrichment for students in Winters schools.

The Agriculture and Food Research Initiative (AFRI) focuses on enhancing education and workforce development in food and agricultural sciences. It invites applications for various grants aimed at professional development, non-formal education for youth, community college training, and fellowships for both predoctoral and postdoctoral candidates. The program, managed by the USDA's National Institute of Food and Agriculture, emphasizes the cultivation of skills necessary for the future workforce in agriculture, with multiple deadlines for submissions.

This funding opportunity aims to address health disparities in non-communicable and chronic diseases in Latin America. The initiative encourages collaborative research that evaluates public health policies and improves health outcomes among U.S. Hispanics/Latinos. Applications are welcomed from multi-disciplinary teams, with a requirement for collaboration with Latin American institutions. Key deadlines for submission are outlined, with a focus on innovative approaches to tackling critical health issues across the region.

The Dr. Carol J. Chrisman Nursing Scholarship, offered by the Ashland County Community Foundation, supports registered nurses and nursing students from Ashland County pursuing advanced degrees at Ashland University. This scholarship honors Dr. Chrisman's legacy in nursing and community health, encouraging local nurses to further their education. Eligible applicants include full-time nursing students and those employed in public health within the area, with prior recipients allowed to reapply once.

The Principal Student Support Services Grant, offered by the School-Based Healthcare Solutions Network, aims to enhance mental health support for students in grades 6-12 at under-resourced public schools. With funding available for hiring mental health professionals and performance-based awards, this initiative addresses critical challenges like chronic absenteeism and behavioral issues. By providing targeted interventions, the grant seeks to improve academic performance and overall well-being among students facing mental health crises.

The National Institute on Aging (NIA) is launching a Notice of Funding Opportunity (NOFO) to establish a national consortium focused on improving care for older adults with multiple chronic conditions. This initiative aims to evaluate the effectiveness of integrated primary care interventions through innovative electronic health record (EHR) platforms. By fostering collaborations among researchers and clinicians, the consortium will work to enhance patient outcomes and streamline population health management, paving the way for future advancements in aging care.

The Substance Use/Substance Use Disorder Dissertation Research Award supports doctoral candidates in completing their dissertation research on substance use disorders. This initiative encourages diverse applicants and aligns with NIDA funding priorities. Key deadlines include February 16 and June 16 of 2025 and 2026 for standard applications, with specific dates for renewal and AIDS-related projects. This funding aims to enhance the research workforce in the field.

Home

The Middle Run Foundation is a family-governed foundation based in Newark, Delaware. The Board of the foundation is chaired by Sarah Ives Gore, its founder, and includes her children, grandchildren, and non-family members who bring experience and expertise to our work.

About

Purpose:

The purpose of the foundation is to fund and support non-profit programs which focus on building healthy, self-sufficient families.

Apply

The Middle Run Foundation makes grants up to $500,000 annually with individual grants ranging from $5,000 to $50,000.

The HEAL Initiative's Career Development Awards aim to empower early career researchers and clinicians in implementation science. By providing training and funding, this initiative seeks to address substance use prevention and treatment through research projects that align with the HHS Overdose Prevention Strategy. Focused on vital areas such as opioid prescribing, OUD treatment, and recovery support, the program aspires to cultivate a new generation of experts who will significantly impact addiction clinical practices and mentorship.

The HEAL initiative aims to translate addiction research into practice to combat the opioid crisis and overdose events. It focuses on identifying barriers to reducing substance use and developing scalable, evidence-based interventions. Emphasizing recovery, prevention, and the integration of mental health, the initiative encourages collaboration among experts in various fields. Although applications are not currently solicited, potential applicants are urged to prepare for future opportunities to apply innovative solutions to enhance addiction treatment and prevention efforts.

The PERF: Career Development Grants - CNS Shields Research Grant supports early-stage investigators in pediatric neurology research. Offered by the Pediatric Epilepsy Research Foundation and the Child Neurology Society, this grant provides $150,000 over two years. Eligible applicants must be within 10 years of completing their terminal degree and have not received independent funding. The grant emphasizes clinical research, fostering advancements in the treatment of pediatric neurological conditions.

Farmer First Regenerative Pilot Program

Regenerative Agriculture is a conservation management approach that emphasizes natural resources through improved soil health, water management, and natural vitality for the productivity and prosperity of American agriculture and communities.

In December 2025, NRCS launched the NRCS Regenerative Pilot Program, a farmer first, outcomes-based approach to conservation designed to return the agency to its core mission – helping people help the land. NRCS is investing $700 million to specifically support regenerative agriculture, including:

• $400 million through the Environmental Quality Incentives Program (EQIP); and
• $300 million through the Conservation Stewardship Program (CSP)

This pilot program addresses whole-farm resource concerns through support for voluntary regenerative agriculture conservation plans. It also puts American farmers first as a part of the solution to Make American Healthy Again (MAHA) by supporting access to American-grown whole foods, critical to addressing the chronic disease crisis nationwide.

For too long, divided and highly specific funding pools have unintentionally encouraged isolated, practice-by-practice conservation, rather than holistic management. By integrating bundled regenerative practices into single applications, closing program loopholes, and recognizing outcomes, NRCS will deliver lasting benefits for farmers, natural resources, and the American consumer.

Emphasizing regenerative agriculture builds upon NRCS’s 90 years of existing conservation work by restoring land health, improving long-term productivity, and ensuring American grown production for the future. 

The contract length will be a minimum of 5 years.

The COPIC Medical Foundation Grants aim to improve healthcare outcomes by funding programs that enhance patient safety and reduce medical errors. With over $10 million awarded since its inception in 1991, the foundation focuses on scalable solutions to address healthcare fragmentation. This final grant cycle emphasizes innovative approaches that can be replicated across the healthcare community. Organizations must be 501(c)(3) certified or have a fiduciary partner to qualify for funding.

The Dementia CAReS Grants aim to enhance the lives of American Indian and Alaska Native communities affected by dementia. By providing funding, training, and support, this initiative focuses on developing actionable strategies within Tribal and Urban Indian settings. Key activities include establishing a network of dementia champions and promoting local best practices. The goal is to empower communities to improve dementia care and outcomes through collaborative efforts and innovative approaches.

The AWWA Scholarship Program, specifically the Veolia Water Technologies & Solutions Vernon D. Lucy III Scholarship, offers a $5000 award to undergraduate students pursuing careers in the water sector. Established by the American Water Works Association, this scholarship honors the mentorship of Vernon D. Lucy III and aims to support the next generation of water industry professionals. Eligible candidates must demonstrate interest in water-related fields, underscoring AWWA's commitment to fostering future leaders.

The Avant Garde Award supports innovative research on HIV and substance use disorders, encouraging creative scientists to explore high-risk, high-reward approaches. While applications are not currently being accepted, this initiative by the National Institute on Drug Abuse (NIDA) aims to stimulate collaborations and impactful research. Early-stage investigators are particularly encouraged to consider this opportunity as they develop their proposals for future funding. The program uses the DP1 activity code, fostering transformative advancements in biomedical and behavioral science.

The AWWA Scholarships Program, led by the American Water Works Association, aims to support the future of the water industry by investing in students. The Mueller Water Products Continuing Education Scholarship awards $5,000 to an undergraduate student employed by a water utility, emphasizing the importance of practical experience in education. This scholarship not only aids financial needs but also encourages students to pursue careers in water supply, fostering growth in this vital sector.

The CDC's National Center for Injury Prevention and Control invites research proposals aimed at reducing suicide and interpersonal violence among youth aged 10 to 24. This funding opportunity encourages the evaluation of pre-existing primary prevention strategies that have not yet been rigorously assessed. Proposed approaches may include community programs and policies designed to enhance social connectedness, mitigate harmful online behaviors, and address technology-facilitated interpersonal violence.

The NAWCA U.S. Standard grants provide competitive matching funds to support partnerships aimed at the long-term protection, restoration, and enhancement of wetlands and associated upland habitats in the U.S. These projects benefit migratory birds and promote ecological sustainability. A 1:1 match is required. The program seeks to improve wetland ecosystems, ensuring the conservation of waterfowl and other wildlife, while fulfilling international conservation obligations.

The AHRQ is inviting proposals for research focused on improving diagnostic safety in ambulatory care settings. This funding opportunity aims to understand the incidence and contributing factors of diagnostic errors that occur across various ambulatory care services. Proposals should address the complexities of diagnostic safety to enhance patient care and outcomes.

The See, Test & Treat Grant offers vital funding for cancer screening and health education programs targeting medically underserved communities. This pathologist-led initiative aims to reduce healthcare barriers, empower preventive care, and connect patients with local resources. Eligible organizations can apply for up to $50,000 over three years, fostering sustainable health improvements. The program emphasizes same-day results for screenings and culturally appropriate education, ensuring equitable access to essential healthcare services.

The DOE Computational Science Graduate Fellowship (CSGF) supports U.S. citizens and permanent residents pursuing Ph.D. degrees in computational sciences. Established in 1991, it provides a $45,000 annual stipend, full tuition, and a $1,000 professional development allowance over a maximum of four years. The program encourages interdisciplinary research, offering fellows practical experience in DOE laboratories, enhancing their careers in high-performance computing and scientific research across various fields.

The Walking Classroom Grant Program, offered by the Alliance for a Healthier Generation, enables classroom teachers in public schools to receive donated materials for their students. This innovative program promotes physical activity while maintaining instructional time through engaging podcasts. Ideal for grades 3-8, it enhances cognitive function and retention. Schools with the greatest need, both socioeconomically and academically, are prioritized, ensuring that all students can benefit from this unique educational approach.

The Steven Scott Quinn Scholarship Fund, established by the Stark Community Foundation, aims to support Stark County, Ohio residents pursuing higher education in fields such as culinary arts, hospitality, nursing, nutrition, physical therapy, and occupational therapy. This initiative reflects the Foundation's long-standing commitment to enhancing the community through philanthropy and addressing diverse educational needs since its inception in 1963.

The National Institute on Drug Abuse (NIDA) invites applications for longitudinal cohort studies focusing on HIV and substance use. This initiative aims to foster multidisciplinary research addressing HIV-associated co-morbidities and substance use disorders. The program encourages collaboration with a NIDA-funded Coordinating Center to enhance research agendas that align with NIH-HIV priorities, ensuring impactful policy and practice outcomes in the field of HIV/AIDS and substance use.