Best Large Grants for Nonprofit Organizations in California

The NIH Research Evaluation and Commercialization Hubs (REACH) program aims to facilitate the translation of biomedical discoveries into marketable products to enhance patient care. By funding five new academic entrepreneurship hubs, NIH will provide essential resources such as funding, mentorship, and expertise in product development. These hubs will address high-priority technologies and foster public-private partnerships, ultimately supporting the goals of federal research initiatives and addressing local health needs in underserved areas.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

The Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) aims to enhance asthma prevention and treatment in economically disadvantaged pediatric populations. Funded by the NIH, CAUSE supports multi-site clinical studies to identify innovative strategies and treatment targets for asthma. Utilizing systems biology, the network seeks to discover specific disease endotypes suitable for new therapeutic approaches, addressing the high burden of asthma in urban settings.

The ASES Research Grant, provided by the ASES Foundation, offers up to $20,000 for innovative shoulder and elbow research projects. It invites applications from principal investigators who are orthopaedic surgeons working in North America. The funding supports projects lasting between 12 to 24 months and aims to foster advancements in patient care through research. Applications are limited to one per principal investigator per year, promoting focused and impactful research initiatives.

Benjamin Moore & Co. Charitable Giving is dedicated to uplifting North American communities through support for educational programs, housing development, and preservation efforts. They focus on workforce development, community transformation, and sustainable practices. The initiative emphasizes philanthropy through financial and in-kind donations, alongside volunteer work from employees. Partnering with various organizations, they aim to create lasting impacts on local communities while adhering to strict eligibility criteria for support.

The Growing Convergence Research (GCR) initiative by the National Science Foundation (NSF) promotes innovative solutions to complex societal and scientific challenges through multidisciplinary collaboration. By integrating diverse expertise, GCR aims to address specific problems and foster new research paradigms. Proposals must outline a five-year plan, divided into two phases, with budgets not exceeding $1.2 million for Phase I and $2.4 million for Phase II. Successful projects are expected to lead to transformative advances in science and technology.

The FY26 Kidney Cancer Research Program's Idea Development Award supports innovative research that enhances understanding of kidney cancer, aimed at improving patient outcomes. Proposals should feature a strong hypothesis and a detailed research plan, with team members experienced in kidney cancer research. A unique aspect is the Partnering Principal Investigator option, fostering collaboration between two investigators, ensuring comprehensive project development while allowing for distinct submissions. This award emphasizes impactful partnerships to drive advancements in the field.

The DoW Kidney Cancer Early-Career Scholar Award is a unique initiative by the Academy of Kidney Cancer Investigators, established in FY19. It aims to foster innovative kidney cancer research through a mentoring program that pairs early-career scholars with experienced mentors. This program not only enhances research capabilities but also builds a robust network of kidney cancer researchers. By supporting promising scholars, the initiative aspires to advance the field and improve treatment outcomes for kidney cancer patients.

The George Family Foundation's Youth Development Grant aims to empower youth from under-resourced communities by supporting initiatives that foster personal growth, educational enrichment, and workplace learning. By encouraging diverse interactions and community service, the foundation seeks to provide young people with the tools to thrive and positively impact their communities. Although unsolicited proposals are not accepted, Letters of Inquiry are welcomed during specific review periods.

The GEMSSTAR for Emergency Medicine Supplemental Funding Program provides up to $25,000 over two years to support emergency medicine physicians who have received the NIA GEMSSTAR grant. This program aims to enhance the Professional Development Plan of GEMSSTAR awardees, ensuring they receive the necessary funding for their research endeavors. Eligibility is limited to those who have completed their clinical specialty training and are based at U.S. institutions, with funding contingent upon available resources.

About Lions Club International FoundationLions Clubs International Foundation (LCIF) provides grants that empower the service of our members. Since its inception in 1968, LCIF has awarded more than US$1.3 billion in grant funding.  Mission :Our mission is to empower Lions clubs, volunteers and partners to improve health and wellbeing, strengthen communities, and support those in need through humanitarian service and grants that impact lives globally, and encourage peace and international understanding. And we fulfill it every day, everywhere we serve.Lions Club International Hunger Grant ProgramHunger Grants focus on strengthening infrastructure and providing essential equipment for Lions’ hunger-relief efforts. These grants empower Lions to support vital initiatives such as school feeding programs, food banks and feeding centers, ensuring that those in need receive the nourishment they require. These grants support infrastructure and equipment acquisition for Lions’ projects focused on alleviating hunger.Grant Examples: 

• Construction or expansion of food banks, feeding centers and food storage facilities.
• Purchase of refrigerators and freezers to store perishable food items.
• Vehicles to transport, collect and deliver food.

This funding opportunity aims to enhance health outcomes by addressing healthcare disparities related to non-communicable and chronic diseases in Latin America and among U.S. Hispanic populations. It encourages innovative, interdisciplinary research teams to develop and implement clinical and community-based interventions. Key partnerships with institutions in Latin America are essential for collaboration. Deadlines for applications range from February 2024 to June 2026, with specific dates for standard, renewal, and AIDS-related grant submissions.

This funding opportunity aims to address health and healthcare disparities in non-communicable and chronic diseases across Latin America. It encourages innovative, multi-disciplinary research focused on clinical epidemiology and public health policy evaluation. Collaborations should include key partners from Latin American institutions, fostering meaningful partnerships to tackle significant health challenges faced by U.S. Hispanics/Latinos. The initiative highlights multiple application deadlines for standard and AIDS-related grants, promoting timely submissions for impactful research.

Rico Memorial Scholarship

Provides a scholarship to graduating seniors in Lincoln County with a GPA between 2.5 and 2.99 and must participate in sports (preference will be given to football and or track/field)

The Parker B. Francis Fellowship for Pulmonary Research offers three years of funding, totaling $225,000, for clinical and basic scientists transitioning to independent research careers in pulmonary and critical care medicine. Eligible candidates include those with relevant doctoral degrees, U.S. or Canadian citizenship, and a track record of research experience. The fellowship encourages diverse research topics, including bioethics in pulmonary medicine, while requiring mentorship and adherence to strict eligibility criteria.

Scott Cornelius Memorial Scholarship (Piedmont)

To honor the memory of Scott Cornelius by supporting students pursuing careers in sales, marketing, insurance or related business fields who demonstrate leadership and integrity.

The Burroughs Wellcome Fund's Next Gen Pregnancy Initiative Grants aim to enhance research on pregnancy outcomes, addressing issues such as preterm birth and maternal health. With an emphasis on fostering diverse scientific collaboration, the initiative supports innovative proposals from researchers across various disciplines. Each grant offers up to $500,000 over four years, encouraging groundbreaking studies that explore the biological and environmental factors affecting pregnancy. This initiative seeks to improve health outcomes through informed research and interdisciplinary partnerships.

The George C. Cotzias, MD, Memorial Fellowship, established by the American Parkinson Disease Association, supports young neurologists in their research and treatment of Parkinson's disease and related disorders. Funded at $125,000 annually for three years, this fellowship encourages recent graduates to develop their careers in neurology, ensuring they have the mentorship and resources necessary for success. The fellowship aims to honor Dr. Cotzias' legacy and inspire the next generation of leaders in neurology.

About

What is the Pizza Hut Foundation?

In pursuit of happiness, the Pizza Hut Franchisee community, in partnership with Pizza Hut U.S. is proud to announce the formation of the Pizza Hut Foundation.

Our foundation is seeking to touch the lives of over 100 youth annually by partnering with youth-serving nonprofit organizations focusing on literacy education programs to enable our team members and their peers to be career and life ready.

Pizza Hut Foundation, Inc. is a nonprofit, tax-exempt charitable organization under the Section 501(c)(3) of the Internal Revenue Code. Donations are tax deductible as allowed by law.

Financial Assistance & Scholarships for Education

Education is key to success in life. However, each year two million students drop out of college due to financial hardship and a lack of financial assistance. In the United States there are more than 900,000 college-bound students who qualify for federal financial assistance each year. Yet almost 90% of these students don’t receive adequate guidance or support, leaving hundreds of thousands of students’ needs unmet.

The Pizza Hut Foundation is proud to partner with Kaleidoscope as our scholarship platform provider, pairing education dreams with funding.

Mentorship Program

While the Scholarship program financially supports the awarded students enrolled in higher education, it doesn’t stop there. The Pizza Hut Foundation offers a mentorship opportunity, through leaders from within the Pizza Hut organization and Vendor partners, to engage Scholarship recipients in a meaningful way throughout their educational journey.

The Pizza Hut Foundation will support engagements with the students via monthly connections to ensure a positive experience for both the mentors and the mentees.

The SHC Student Research Grant supports research utilizing herbarium resources across various taxa, including plants, fungi, lichens, and algae. Eligible projects may involve fieldwork, data collection, or meta-analysis of herbarium data, with an emphasis on enhancing herbarium collections. Three grants are awarded annually: two for $500 and one specifically for undergraduates for $250. Applicants must be student SHC members with projects likely to lead to publication.

Confederated Tribes of Siletz Indians

We the Confederated Tribes of Siletz Indians are the most diverse confederation of Tribes and Bands on a single reservation in the United States. Our ancestors spoke 10 completely different languages, each of which had multiple dialects. Our ancestors brought with them deep connections to more than 20 million acres of ancestral territory combined, including all of Western Oregon from the summit of the Cascade mountains to the Pacific and extending into what’s now SW Washington State and northern California. Our ancestors signed many treaties with the United States. We were promised the 1.1 million acres Siletz Reservation as our permanent home, but following massive reservation reductions Congress passed the Western Oregon Termination Act in 1954 (took effect in 1956), and our federally recognized status as a tribe was also taken. In 1977 our lobbying of Congress to repeal our Termination was successful, and we became the second formerly Terminated Tribe to regain federal recognition as a Tribe.

Education

The Confederated Tribes of Siletz seeks to provide opportunities for Tribal members to reach potential, establish independence and improve quality of life through lifelong learning and education.

NWIHA – Youth Scholarship Program

Scholarship applications will be reviewed to meet the following minimum eligibility before any further review of the application will be done.

• Applicant must either have an application pending or a letter of acceptance from a higher education institution such as a four (4) year college or a two (2) year community college prior to the funds being sent to the higher educational institution.
• Applicant must be less than twenty four (24) years old on the deadline submission date.
• Applicant must be an enrolled member from one of the NWIHA member Tribes.
• Payments are made directly to the school, organization, etc. and not to the Applicant or their families.
• All of these items must be postmarked on or before March 31st of each year, or the Application will be automatically rejected.
• Faxed applications will NOT be accepted.
• All Applications become the property of NWIHA. NWIHA reserves the right to publish essays.

Whitley County Builders’ Association Scholarship

This scholarship is available to a graduating senior who attends Columbia City High School, Churubusco High School, or Whitko High School and is planning to pursue a technical, associate or baccalaureate degree in the building trades field (such as Construction Engineer, Architecture, Building trades, etc.)

The Catalyst Award, offered by the American Lung Association, supports innovative research on lung disease and biology. This mentored grant provides $50,000 annually for up to two years, prioritizing novel projects with collaborative training plans. The American Lung Association aims to improve lung health and prevent diseases through research, education, and advocacy, focusing on defeating lung cancer and fostering a tobacco-free future.

About the Bertin Family Foundation

Founders: Kim and Jennifer BertinAfter a successful career innovating orthopedic surgical techniques, devices, and implants, Kim and his wife Jennifer feel a deep sense of stewardship to dedicate their resources to helping others. They engage all three generations of the Bertin family in hands-on service and grantmaking decisions, fostering a shared commitment to giving back. Through the foundation’s work, the Bertin family seeks to strengthen communities, support meaningful causes, and inspire future generations to lead with compassion and purpose. 

NOW Grants

A limited number of grants are available for one time projects or programs that emerge outside of the standard review period. These grants are for $5000 or less.

The Innovation Award by the American Lung Association offers $75,000 annually for up to two years, aimed at supporting promising investigators in lung disease research. With a legacy of over 120 years, the Association seeks to fund innovative projects that can significantly impact lung health. Eligible candidates must demonstrate prior excellence in their careers and have held a K or R type award within the last three to five years. This initiative fosters groundbreaking advancements in lung disease science.