Best Unrestricted Grants for Nonprofits in Colorado

Colorado Wildlife Habitat Program

The Colorado Wildlife Habitat Program (CWHP) offers funding opportunities for landowners who wish to voluntarily protect important wildlife habitat, provide wildlife-related recreational access to the public, and, if appropriate, sell their property to Colorado Parks and Wildlife. ​​​​​​

Thanks to funding provided by the Habitat Stamp, Great Outdoors Colorado (GOCO) and some federal dollars, the Colorado Wildlife Habitat Program has made great strides in protecting critical wildlife habitat and enhancing public access. Colorado Parks and Wildlife (CPW) thanks hunters and anglers for their continued support of this vital conservation program.

The CWHP is a statewide program focused on habitat protection and public access. This voluntary, incentive-based partnership program supports CPW’s mission through acquisitions of conservation easements (CEs), public access easements (AEs) and fee title acquisitions. The CWHP is authorized by Colorado Statute and administered by CPW. Funding priorities and preferences are established by the Parks and Wildlife Commission. The 2026 CWHP budget is at least $11,000,000.  

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The John C. Ensslin Memorial Scholarship Fund (UA1) supports students dedicated to journalism, offering a $3,000 award and consideration for additional $1,500 Damon Runyon Scholarships. Eligible candidates must be enrolled in select Colorado schools for the 2025/2026 academic year, maintain a GPA of 2.0 or higher, and show commitment to journalism. This one-time scholarship is intended to assist with tuition, fees, and related educational expenses.

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

The Choose When grant by Caring for Colorado aims to reduce financial barriers to contraception, ensuring affordable access to reproductive healthcare for all Coloradans, especially young people aged 9-25 and those in rural communities. Launched in 2017, it focuses on eliminating health disparities by funding local clinics to provide long-acting reversible contraception. The initiative emphasizes support for marginalized groups, addressing systemic barriers to care and promoting equitable health outcomes across Colorado.

The Rosendin Foundation Annual Grant provides financial support to community-focused 501(c)(3) non-profit organizations across various states, aiding initiatives in emotional, occupational, and nutritional health. Grants can reach up to $50,000 and are geared towards organizations that positively impact their communities. However, the foundation does not fund discriminatory practices, political efforts, or religiously affiliated projects, ensuring that support is directed towards inclusive and impactful community services.

The Colorado AAPI Circle Fund, supported by The Denver Foundation, aims to empower Asian, Asian-American, Native Hawaiian, and Pacific Islander communities in Colorado. By increasing resources and enhancing civic engagement, the fund seeks to uplift these communities, particularly those facing significant challenges. Organizations that connect with this mission and meet eligibility requirements, including being a 501(c)(3) nonprofit, are encouraged to apply for funding to further these vital initiatives.

The Animal Assistance Foundation provides annual grants to organizations in Colorado dedicated to enhancing the welfare of companion animals. Eligible applicants must be 501(c)(3) non-profits or government entities, actively serving local animals and demonstrating a commitment to community collaboration. The foundation aims to support initiatives that align with its mission of fostering responsible animal care and welfare, thus ensuring better lives for pets across the state.

The Great Apes and Gibbons Program Grant, administered by the Arcus Foundation, supports conservation efforts for great apes and gibbons across 24 priority landscapes in Africa and Asia. The program emphasizes sustainable coexistence between humans and wildlife, having awarded over 2,000 grants to more than 500 organizations globally. Funding is not available for individuals or specific lobbying activities, ensuring resources are directed towards impactful conservation initiatives.

The Express Health Information Outreach Awards aim to enhance public health by increasing access to biomedical information for U.S. health professionals and the general public. These awards support projects that improve health information literacy among consumers and caregivers, ensuring they can effectively find and utilize health information. Focused on partnerships and outreach to underrepresented communities, the initiative seeks to promote healthy behaviors, prevent illness, and improve health outcomes through informed decision-making.

The CO Educational Stability Grant, administered by the Colorado Department of Education, aims to support educational stability for highly mobile students, including those in foster care, experiencing homelessness, or migrants. Established by House Bill 18-1306 in 2018, the program focuses on removing educational barriers, improving attendance, and increasing graduation rates for these vulnerable populations. By providing academic and social-emotional support, the grant seeks to enhance educational outcomes for students facing high mobility challenges.

The Ernest Morgan Memorial Scholarship, managed by CommunityGiving, supports central Minnesota student athletes and leaders to pursue higher education outside their home states. This scholarship aims to expand students' horizons and experiences, with a total award of $5,000 available. Open to high school seniors from specific schools, applicants are encouraged to apply online and demonstrate their leadership or athletic skills. This initiative enhances educational opportunities and fosters personal growth among local youth.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CAPaBLE Programmes

CAPaBLE, our scientific capacity development programme, aims to enhance the capacity of scientists, policymakers and practitioners to assess global change issues, and explore options to resolve issues towards achieving sustainability. Through CAPaBLE, we support activities that enhance capacity at individual, organizational and systemic levels.

Activities of interest under the CAPaBLE Programme

APN supports CAPaBLE activities that enhance existing capacities of developing countries at three levels of individual-based capacity development; group, organisation, network-based capacity development; and societies, governance, and system level capacity development. APN accepts CAPaBLE proposals that engage 1 or more member/approved countries. Proposals must address one or more of the following activities:

SCIENTIFIC CAPACITY DEVELOPMENT ACTIVITIES that promote the following approaches related to one or more of the six thematic areas of APN:

• Utilising and strengthening existing capacity, 
• Creating opportunities to use/instil capacity, 
• Developing new capacity through innovative approaches.

AWARENESS-RAISING AND DISSEMINATION activities through policy- and decision-making communities, civil society, and/or the general public.

SCIENCE-POLICY interfacing in the context of the priority topics.

CAPACITY DEVELOPMENT PARTNERSHIP ACTIVITIES that contribute to the capacity development components of the evolving global change arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, and the UN Decade of Ocean Science, and ongoing and new global change and sustainability research programmes.

Activities geared towards using SCIENCE COMMUNICATION to disseminate knowledge generated from projects, particularly to non-science audiences.

The Region 4 Professional Development Awards for 2025-2026 foster the growth of health information access and data science skills among network members. This funding supports diverse projects such as workshops, conferences, and educational activities aimed at enhancing the professional capacity of individuals affiliated with NNLM Region 4. By encouraging proposals that address the needs of underrepresented communities, the awards aim to improve health information services and access across the region.

The SWE Rocky Mountain Section College Scholarship provides financial support for women pursuing degrees in ABET accredited engineering, computing, or engineering technology programs in Colorado and Wyoming. Three scholarships, each with a minimum value of $1,000, are awarded annually. Eligible applicants must identify as women, maintain a GPA of 3.0 or higher, and be enrolled in an eligible program. This initiative honors pioneering women engineers and aims to encourage the next generation of female leaders in STEM.

The Rupert Dunklau Foundation Grant supports organizations with 501(c)(3) status, focusing on Lutheran Higher Education, Health and Human Care, and Faith Strengthening. Since its establishment in 1968, the foundation has aimed to provide financial resources to ministries within the Lutheran tradition, particularly in Nebraska and surrounding states. Eligible projects must align with the foundation's mission to promote the welfare of mankind through educational and health initiatives.

The Marvin R. and Pearl E. Patterson Family Fund Scholarship, offered by the Grand Haven Area Community Foundation, supports students aspiring to study graphic or fine arts, as well as those interested in environmental sciences. Open to high school graduates from the Tri-Cities area, this scholarship considers leadership, community involvement, and academic achievements, although financial need is not a requirement. Applicants must provide transcripts and relevant documents to qualify for this opportunity.

CommonSpirit Health offers the Community Health Improvement Grant to enhance health equity and service systems for underserved populations. Through collaborative efforts with 501(c)(3) organizations, this initiative provides financial support for essential health projects. Grant amounts range from $19,500 for small grants to $150,000 for standard grants, varying by hospital. Participating hospitals include those under Catholic Health Initiatives and Dignity Health, aimed at addressing significant community health needs.

The Sumners Foundation Grant aims to engage and educate the public about self-government through various programs, including civic education, democracy reform, and teacher training. Grants are available to qualified 501(c)(3) organizations primarily in Texas, New Mexico, and Oklahoma, supporting activities that foster civic engagement and understanding of democratic principles. The Foundation emphasizes direct involvement in the political process and does not fund political activities or provide individual grants.

The Colorado Creates Grant, offered by the Colorado Office of Economic Development and International Trade, supports nonprofit arts organizations in Colorado. This competitive grant program provides general operating support based on the applicant's cash operating revenue. Eligible organizations must have been active for at least three years, hold a cash operating budget of at least $25,000, and focus on arts activities. The grant fosters collaboration and community engagement, aiming to enhance economic growth through the creative sector.

The Enbridge Community Grant aims to enhance the quality of life in North American communities through strategic donations and sponsorships. With funding ranging from $1,000 to $10,000, the grant supports organizations focused on safety, education, environmental stewardship, and Indigenous culture. Enbridge encourages early applications, with decisions typically made within eight weeks. The grant seeks to empower local initiatives that foster community strength, vibrancy, and sustainability.

The William B. O'Rourke Foundation offers grants primarily focused on enhancing vision care and educational services in Colorado. Eligible applicants include individuals and non-profits, with funding aimed at projects that cannot be financed through other sources. The Foundation emphasizes projects that promote eye health, develop training programs, and increase public awareness of vision services. Priority is given to applications that demonstrate matching funds from other sources, ensuring collaborative efforts in advancing vision care initiatives.

The Grand Haven Offshore Challenge Scholarship, offered by the Grand Haven Area Community Foundation, supports students pursuing studies in natural resources, including fisheries and wildlife. This scholarship is available for applicants attending any public or private college or university. The fund was established to honor community contributions towards environmental preservation and is awarded based on academic merit and financial need. Apply once for all scholarships you may qualify for to streamline your application process.

The Conservation Service Corps Grants, funded by Great Outdoors Colorado, support outdoor recreation and natural resource projects by hiring youth and veterans through conservation service corps. Annually, $1.5 million is allocated for these initiatives, enabling crews to tackle various projects like trail maintenance, invasive species mitigation, and wildlife habitat improvement. This program not only enhances natural resources but also provides job training and leadership skills to over 1,700 young participants each year.

The Colorado Respite Coalition is offering a State Respite Grant aimed at enhancing access to respite care for family caregivers across Colorado. This funding supports both non-profit and for-profit organizations that provide essential respite services, ensuring that caregivers receive necessary breaks. Grants range from $10,000 to $30,000, with applications requiring a letter of intent for the 2025-2026 cycle. This initiative reinforces the Coalition's commitment to family welfare and caregiver support.

Entergy’s Open Grants Program aims to enhance community well-being through funding initiatives in arts, education, social services, and community improvement. The program prioritizes support for organizations that serve diverse populations, including children and low-income communities. Eligible entities must have 501(c)(3) status or equivalent nonprofit recognition. Applications should be submitted three months in advance, allowing ample time for review. Entergy focuses on projects that foster self-sufficiency and enrich local neighborhoods.

The Local Planning Capacity Grant Program (CO) aims to enhance the abilities of local government planning departments to tackle affordable housing challenges. By facilitating the development review, permitting, and zoning processes, the program prioritizes support for local governments implementing fast track requirements from Proposition 123. Grants up to $250,000 are available, with a 20% minimum cash match required. This initiative seeks to bolster local planning efforts, increase affordable housing units, and fulfill Prop 123 commitments.