Best Intellectual and Developmental Disabilities Grants in South Carolina

Organizations in South Carolina running evidence-based programs for people with intellectual and developmental disabilities can seek up to US $20,000 to build knowledge and skills in key priority areas. Focused on community supports, employment, and self-advocacy, the South Carolina Developmental Disabilities Council funds one small grant per organization each program year.

South Carolina nonprofits serving people with intellectual or physical disabilities can access funding for capital projects, new or expanding programs, general operations, and social entrepreneurship. South Carolina disability organizations can access funding through The League Club, with awards from US $5,000 - US $25,000, depending on application type and board discretion.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

Southern U.S. 501(c)(3) organizations with at least three years of activity can seek single-year support for programs such as education, family services, health care, poverty relief, and humanitarian aid, including work in South Carolina. Focused on tangible impact, Robinson Foundation invites applicants addressing community hardships; capital projects are not eligible.

Burger Family Foundatio

Our Mission

Inspired by our daughter Penelope and the powerful symbolism of the extra 21st chromosome, our foundation is dedicated to creating opportunities for individuals with Down syndrome and their families. Through direct financial assistance, therapy, community, and the healing power of ranch life, we’re building spaces that foster hope, purpose, and belonging.

Pens Pearls

Named after Penelope, Pens Pearls is the financial support arm of our foundation, providing direct assistance to families navigating the unique joys and challenges of raising a child with a disability. From therapy grants to life-changing opportunities, we’re here to lighten the load and ensure every child has the resources they need to thrive.

Through Pens Pearls, eligible families can apply for funding to help cover essential needs, services, or opportunities that make a meaningful impact in their lives. The Burger Family Foundation is a 501(c)(3) organization, and this program is one of the ways we work to create lasting change—one story at a time.

Qualifications for Pens Pearls Grant Program, are deemed by the strict bylaws of the Burger Family Foundation. Funds are paid directly to provider. 

About Colin Farrell FoundationThe Colin Farrell Foundation is committed to transforming the lives of individuals and families living with intellectual disability through education, awareness, advocacy, and innovative programs. Inspired by his two sons, he is excited and deeply humbled by the hope that the Colin Farrell Foundation can help those who the larger systems of governance have neglected.

CFF Innovation GrantsWe’re looking for bold, scalable solutions focused on one or more of these priority areas:

• Affordable co-housing models for individuals and families
• Employer-partnered day programs and inclusive job opportunities
• Tools and technologies that enhance accessibility at home and in community spaces
• Cross-sector collaborations between public, private, and nonprofit organizations

The Children and Youth with Special Health Care Needs Research Network aims to enhance the lives of children and youth with special health care needs (CYSHCN) and their families. By establishing a robust research infrastructure, the program will generate evidence-based solutions to foster well-being and community engagement. It focuses on identifying effective interventions and measures that can be integrated into essential services and supports, ultimately helping CYSHCN thrive throughout their lives.

Students with intellectual, developmental, emotional, or physical disabilities, or those who have volunteered with such students, can receive higher education support through the Patricia Schroder Memorial Scholarship; awards range from US $1,000 - US $1,400. Focused on intellectual and developmental disabilities, Community Foundation for Southwest Washington invites graduates of specific WA and TX school districts to apply.

Students with intellectual or developmental disabilities pursuing post-secondary education may be eligible for scholarships that support college success and independent living, offered nationally by the Community Foundation of Northern Illinois. Grants from Community Foundation of Northern Illinois help South Carolina intellectual and developmental disabilities students who meet Rockford Public Schools and age criteria access this academic scholarship opportunity.

Individuals ages 18–25 with an intellectual disability pursuing post-secondary education or life-skills programs and residing in Boone, Ogle, Stephenson, or Winnebago County can apply for the Ann W. Dooley Advancement Scholarship. Offered by the Community Foundation of Northern Illinois, this scholarship may benefit those developing independent living or employment skills, including South Carolina–focused disability service programs’ participants.

U.S. 501(c)(3) nonprofits improving healthcare delivery for adults with intellectual and developmental disabilities can apply for WITH Foundation’s RFP cycle, with awards of US $150,000 - US $250,000 for program or research support. South Carolina organizations working on practitioner training, care coordination, policy, advocacy, or digital health may be especially competitive.

South Carolina research institutions and healthcare organizations conducting intellectual and developmental disabilities comparative effectiveness studies can access funding through the Patient-Centered Outcomes Research Institute. This national opportunity supports high-quality, patient-centered clinical effectiveness research focused on people with IDD, emphasizing engagement of patients and decision makers and implementation of findings in real-world healthcare settings.

Caregivers of individuals with Angelman syndrome can receive up to US $5,000 to improve their family member’s quality of life, including prosthetics, wheelchairs, beds, educational assistance, or necessary clinic travel. Grants from Angelman Syndrome Foundation help South Carolina families and others nationwide supporting intellectual and developmental disabilities when no other funding is available.

Nonprofit organizations across the U.S. that provide programs and opportunities for individuals with intellectual or developmental disabilities can apply for the David and Jacquie Clark Family Fund’s grants. While preference is given to Ohio nonprofits, South Carolina organizations supporting special needs communities outside classroom instruction may be eligible for this funding.

Nonprofit organizations supporting people with intellectual and developmental disabilities may be eligible for flexible program funding, with a giving focus on the Pacific NW but grants also made elsewhere in the U.S. Focused on empowering individuals with disabilities, Jtmf Foundation also supports children, older adults, and veterans through impactful community-based services.

Nongovernmental U.S. charities serving people in need, especially children and individuals with intellectual or developmental disabilities, may seek program funding in South Carolina. Nailba Charitable Foundation provides support for small, well-run, nonsectarian organizations backed by a NAILBA member or corporate partner, emphasizing direct services such as youth programs, disability support, mental health, substance abuse, and emergency assistance.

The Patient-Centered Outcomes Research Institute (PCORI) will announce funding for patient-centered comparative clinical effectiveness research (CER) studies focusing on rare diseases. This initiative encourages collaboration and aims to fill critical research gaps affecting approximately 30 million Americans with rare diseases. Applications can request up to $12 million over five years, including coverage for patient care costs. This funding opportunity is set to open on August 12, 2025, with a focus on addressing pressing patient-centered CER questions.

First, second, or third-year U.S. or Canadian medical students interested in neurodevelopmental disabilities or child neurology can apply for the Child Neurology Foundation’s summer research scholarship, awarding US $3,500 for NDD clinical research. Projects must focus on neurodevelopmental disabilities in children or young adults and may benefit those serving individuals with intellectual and developmental disabilities in South Carolina.

Nonprofit 501(c)(3) organizations serving intellectually or developmentally disabled and otherwise disadvantaged people in South Carolina can receive project-focused support to improve quality of life. The Robert & Joan Dircks Foundation offers US $1,000 - US $15,000, favoring small organizations and innovative programs over operating budgets or capital campaigns.

South Carolina 501(c)(3) organizations addressing intellectual and developmental disabilities can apply for McGraw Foundation support for programs such as special needs education, developmental disability services, and related human services. Grants of US $2,000 - US $10,000 may fund general operations, specific projects, or, occasionally, capital needs, with some larger awards for especially promising efforts.

South Carolina organizations that build patient and stakeholder capacity to engage in patient-centered comparative clinical effectiveness research can apply for up to US $300,000, supporting projects up to two years. Focused on patient care and services, Patient Centered Outcomes Research Institute invites programs that may include work with people with intellectual and developmental disabilities and other priority populations.

South Carolina organizations working on health policy and advocacy to improve patient-centered outcomes can access funding through the Patient-Centered Outcomes Research Institute for dissemination of comparative clinical effectiveness research findings. Eligible projects may include sharing evidence with patients, clinicians, and other stakeholders nationwide. Awards are up to US $300,000 and begin with a screened letter of intent.

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

Ameriprise Community Grants focus on supporting nonprofits that enhance community vitality and meet basic needs. With over 120 years of commitment to philanthropy, Ameriprise Financial engages employees in volunteerism and grantmaking. Key giving areas include hunger relief, housing stability, and community development. Priority is given to organizations with active volunteer engagement from Ameriprise advisors and employees, creating a meaningful impact on financial independence and community resilience.

This funding opportunity from the Patient-Centered Outcomes Research Institute aims to enhance health decision-making through comparative clinical effectiveness research, focusing on critical areas such as cancer, maternal health, and mental health. The initiative encourages robust observational studies that utilize existing data to derive patient-centered insights. Applications must address specific themes approved by PCORI and demonstrate potential benefits to the U.S. healthcare system, thus ensuring relevance and stakeholder engagement in research efforts.

State Farm's Good Neighbor Citizenship Company Grants aim to enhance community safety, development, and education. Focused on long-term impact, they support initiatives in auto and home safety, disaster preparedness, affordable housing, and educational programs. Eligible recipients include nonprofits, educational institutions, and government entities. However, funding is not available for individuals, religious programs, or organizations outside the U.S. By addressing critical community needs, these grants foster safer and more resilient neighborhoods.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.