Best Large Grants for Nonprofit Organizations in Florida

The Santander Charitable Sponsorship Program focuses on supporting low- to moderate-income communities primarily in the Northeast and Florida. With a commitment of $100 million in charitable giving, the program addresses key community development needs, including affordable housing, job creation, financial education, and disaster relief. Eligible organizations must have IRS 501(c)(3) status or be public agencies, demonstrating capacity to meet community needs. Unsolicited applications are not accepted.

Universal Orlando offers a charitable giving program focusing on nonprofits in Florida, particularly Central Florida. Organizations must meet specific eligibility criteria, including being tax-exempt and having a year of operational history. Donations consist mainly of theme park tickets for fundraising. However, requests from individuals or political entities and those for religious or controversial activities are not considered. The program aims to support community-focused initiatives that enhance youth education and community strength.

2026-27 Innovative Service Development (ISD) Grant Opportunity

The Florida Commission for the Transportation Disadvantaged is pleased to announce the release of the Innovative Service Development (ISD) Grant Program application package for Fiscal Year 2026–2027.

This is a competitive grant program for Community Transportation Coordinators and Non-Traditional Transportation Service Providers. Anticipated total available funding is $6 million, contingent upon legislative authority and Governor’s approval.

This funding opportunity supports projects that test new transportation services that improve the cost-effectiveness, efficiency, and accessibility of transportation services for transportation disadvantaged individuals.

Introduction

The Transportation Disadvantaged Trust Fund is administered by the Florida Commission for the Transportation Disadvantaged (CTD) in accordance with Section 427.0159, Florida Statutes (F.S.). The Trust Fund provides a dedicated funding source to support the Commission’s statutory responsibilities and is appropriated annually by the Legislature for the state fiscal year (July–June).

For Fiscal Year 2026–2027, the Commission anticipates a $6 million appropriation to support the Innovative Service Development (ISD) Grant Program.

The ISD Grant Program supports projects that improve the cost-effectiveness and efficiency of transportation services. Grant funds are limited to reimbursing a portion of eligible transportation disadvantaged passenger trips. Grantees must provide services prior to submitting invoices for reimbursement, which will be issued on a per-trip and/or mileage basis.

Funded projects may include, but are not limited to:

• Expanding service availability (e.g., evenings, weekends or level of service)
• Serving currently underserved populations
• Enhancing regional or cross-county mobility
• Reducing barriers to accessing public transportation 

The Great Apes and Gibbons Program Grant, administered by the Arcus Foundation, supports conservation efforts for great apes and gibbons across 24 priority landscapes in Africa and Asia. The program emphasizes sustainable coexistence between humans and wildlife, having awarded over 2,000 grants to more than 500 organizations globally. Funding is not available for individuals or specific lobbying activities, ensuring resources are directed towards impactful conservation initiatives.

Florida Department of Health

Led by the State Surgeon General, the mission of the Florida Department of Health is to protect, promote, and improve the health of all people in Florida through integrated state, county, and community efforts.

The Live Like Bella Pediatric Cancer Research Initiative

The Florida Department of Health’s Live Like Bella Pediatric Cancer Research Initiative supports the pursuit of identifying cures for pediatric cancer.

The Live Like Bella Pediatric Cancer Research Initiative is established in section 381.922, Florida Statutes, works to advance progress toward curing pediatric cancer through grants awarded through a peer-reviewed, competitive process, to:

• Significantly expand pediatric cancer research capacity in Florida
• Improve both research and treatment through greater pediatric enrollment in clinical trials networks
• Reduce the impact of pediatric cancer on disproportionately impacted individuals

Research Focus

Applications submitted in response to this Funding Opportunity Announcement (FOA) must be responsive to one of the following areas of focus. 

• Prevention and Treatment
• Screening
• Obesity
• Treatment-Related Morbidities
• Technology Transfer Feasibility (TTF)
• Investigational New Drug or Investigational Device Exemption

Efforts to foster collaborations among institutions, researchers, and community practitioners should be included, when possible. Preference will be given to applications that address at least one of the cancers listed in the Research Priorities section of this FOA.

Funding Information

Applicants must request funding in the preceding grant categories to pursue research in the areas of focus outlined in the Research Focus section of this FOA. Preference will be given to applications that address the priorities listed in the Research Priorities section of this FOA. Specific grant funding amounts are available for each grant category.

Grant Categories

Applications in response to this FOA must align to a grant category (depending on the grant program) to pursue an area of focus from the Research Focus section of this FOA. Applications for research infrastructure grants that are reviewed and assigned exceptional scientific merit will be considered for preferential funding. 

The grant categories are: 1) Bridge; 2) Discovery Science; 3) Emerging Therapeutics and Technologies; 4) Equipment; 5) Multicenter Clinical Trials; 6) New Investigator Research (NIR); 7) High-Risk, High-Reward Clinical Research; 8) High-Risk, High-Reward Discovery Science; 9) Non-Typical Clinical Trials/Socio-Behavioral Research; 10) Research Infrastructure

Bella Initiative Grant Categories: Emerging Therapeutics and Technologies

This grant category supports research on emerging therapeutics and technologies used in the diagnosis and treatment of cancer and tobacco-related diseases. Examples include but are not limited to personalized/precision medicine therapies, immunotherapy, gene therapy, repurposing of previously used medications, use of artificial intelligence (AI) in diagnosis and treatment, and comparative effectiveness trials of emerging treatments.

Maximum Duration: 36 months

The Watson-Brown Foundation Grant supports organizations dedicated to preserving the history and culture of the South. It offers various types of grants, including for educational programming and historic preservation, with a focus on southern studies. Eligible recipients include public charities in the southeastern United States. The Foundation's Junior Board of Trustees also awards grants to preservation projects in east central Georgia, emphasizing youth engagement in cultural heritage.

The Florida Specialty Crop Block Grant Program aims to enhance the competitiveness of specialty crops, including fruits, vegetables, tree nuts, and horticulture products. This program encourages innovative projects that promote marketing, research, and accessibility of specialty crops while addressing industry challenges. Eligible applicants include non-profits, universities, and government agencies. The program prioritizes economic benefits, feasibility, and alignment with budgetary constraints, ensuring a positive impact on Florida's agricultural landscape.

The Environmental Humanities Program Grants by Florida Humanities Council aim to fund projects that explore the interplay between humans and the environment. These grants support innovative, collaborative initiatives that celebrate Florida's diverse landscapes and foster community engagement. Eligible applicants can request up to $10,000 for programs that demonstrate public impact and address local environmental issues. Priority is given to projects serving underserved communities and those located in economically distressed areas.

The Marvin R. and Pearl E. Patterson Family Fund Scholarship, offered by the Grand Haven Area Community Foundation, supports students aspiring to study graphic or fine arts, as well as those interested in environmental sciences. Open to high school graduates from the Tri-Cities area, this scholarship considers leadership, community involvement, and academic achievements, although financial need is not a requirement. Applicants must provide transcripts and relevant documents to qualify for this opportunity.

The Southern Partners Fund's Discretionary Fund Grant aims to support grassroots community organizing for social, economic, and environmental justice in the Southeastern United States. It provides financial resources and technical assistance to rural organizations and leaders focused on transformative change. Eligible applicants include self-governed rural groups engaging in advocacy and community development. The fund prioritizes education reform, immigration rights, and voter engagement, allowing up to two requests per year, with a maximum award of $3,500.

The FirstBank Charitable Foundation (FBCF) is a 501(c)(3) nonprofit established in 2008, focused on supporting charitable organizations in New Jersey, Pennsylvania, and Florida. With over a million dollars awarded, FBCF aims to enhance community well-being through partnerships in health, housing, and education. Nonprofits aligning with FBCF's mission and demonstrating significant service impact are encouraged to apply for grants, fostering a stronger fabric within their neighborhoods.

The Abelard Foundation, established in 1958, supports progressive social change projects located east of the Mississippi River. With an average grant size of $12,000, they prioritize new initiatives with budgets under $350,000. The foundation emphasizes community organizing, civil rights, and empowering marginalized groups. Eligible applicants must be associated with a nonprofit organization and demonstrate a commitment to local leadership and broader policy connections. The board meets biannually to decide on approximately 15 grants per year, focusing mainly on general support.

The Lloyd L. and Helen R. Dilworth Foundation Grant supports charitable causes primarily in Florida. Established in 1987, the foundation offers funding for various program areas, including arts, education, health, and human services. Organizations eligible for funding must be exempt under Section 501(c)(3) of the Internal Revenue Code. Applications are accepted year-round, with a deadline for annual review on September 30. This foundation continues the philanthropic legacy of its founders, Lloyd and Helen Dilworth.

The Enbridge Community Grant aims to enhance the quality of life in North American communities through strategic donations and sponsorships. With funding ranging from $1,000 to $10,000, the grant supports organizations focused on safety, education, environmental stewardship, and Indigenous culture. Enbridge encourages early applications, with decisions typically made within eight weeks. The grant seeks to empower local initiatives that foster community strength, vibrancy, and sustainability.

The Connecting Joy Grant, provided by the Joy in Childhood Foundation, aims to enhance the hospital experience for children battling illness through engaging gaming programs. This initiative supports children's hospitals and nonprofits by funding equipment, staffing, and connectivity, ensuring children can enjoy gaming at their bedside. With grants ranging from $25,000 to $150,000, the program focuses on offering joy and distraction, helping young patients cope with their hospital stays while facilitating connections with peers.

Florida Department of Agriculture and Consumer Services

The Florida Department of Agriculture and Consumer Services supports and promotes Florida agriculture, protects the environment, safeguards consumers, and ensures the safety and wholesomeness of food. Our programs and activities are so varied and extensive, they touch the life of just about every Floridian.

T. Mark Schmidt Off-Highway Vehicle Grant Program

The purpose of the T. Mark Schmidt Off-Highway Vehicle Grant Program (hereinafter referred to as the OHV Grant Program) is to provide financial assistance to Applicants as further defined below, to provide or improve off-highway vehicle recreational areas or trails for public use on Public Lands. Through the Off-Highway Vehicle Tilting Program, the state of Florida has been allocated funds for implementing this program. The primary purpose of the OHV Grant Program is to provide and/or improve off-highway riding opportunities on Public Lands by establishing and/or maintaining existing or new riding areas; provide enforcement of applicable regulations to the System and off-highway vehicle activities; provide safety, training and rider education in the operation of off-highway vehicles and if funds are available, acquire lands to be included in the System and manage and rehabilitate such lands. Grant awards are recommended by the Off-Highway Vehicle Recreation Advisory Committee annually, with final approval by the Commissioner of Agriculture, and appropriated by the Florida Legislature.

Grant Categories

There are five grant categories:

Pre-Construction – Planning, Design, and Permitting of New OHV Areas, Trails and/or Facilities, or expansion of existing OHV Areas.

Construction – Construction of New OHV Areas, Trails and/or Facilities, or expansion of existing riding areas.

Maintenance and Monitoring: A) Repair, Maintenance, Rehabilitation of Existing OHV Areas, Trails, or Facilities. B) Monitoring and Protection of Existing OHV Areas, Trails, or Facilities.

Education: A) Rider Education, Safety, and Training Program. B) Education Outreach.

Acquisition – Acquisition of lands to be included in the System.

The National Coastal Resilience Fund (NCRF) aims to protect coastal communities through nature-based solutions, enhancing habitats while addressing the growing threats of climate change. Established in 2018, the fund focuses on restoring vital ecosystems like marshes and reefs to mitigate flooding impacts. With rising sea levels and increasing storm intensity, NCRF invests in community-led projects that foster resilience, ensuring both people and wildlife can adapt to changing environmental conditions.

The Growing Tribal Economies Through Forest Market Innovations grant program, initiated by First Nations Development Institute, aims to empower Tribes and Alaska Native Villages to engage in emerging markets that enhance forest health and resilience. With funding of $200,000 to $500,000 per grant, this initiative supports projects focusing on sustainability, innovation, and traditional knowledge. Eligible applicants are encouraged to develop forest products, certifications, and practices that contribute positively to biodiversity and ecosystem management.

The Heart of the City Foundation Grant, managed by HEART OF THE CITY FOUNDATION INC, supports Christ-centered mission organizations locally and abroad. Since its inception in 1979, the foundation has aimed to address vital community needs, including human trafficking and homelessness, through generous legacy giving. It prioritizes grants that enable organizations to enhance their ministries, initiate new projects, and purchase necessary equipment, fostering a long-lasting impact in the communities they serve.

The Exhibitions Abroad Support Grant Program, initiated by the Japan Foundation in New York, offers financial aid to U.S. museums and art institutions organizing exhibitions that showcase Japanese art and culture internationally. This program supports a range of events, including biennials and triennials featuring Japanese artists. Eligible applicants are non-profit organizations from designated states, with a focus on promoting cultural exchange and understanding through art.

The Dunkin’ Prom Grant, provided by the Joy in Childhood Foundation, aims to bring joy to teenage patients unable to attend their own prom due to illness. By funding hospitals to host prom-like events, the program ensures these patients experience this significant milestone. Grants typically range from $20,000 to $50,000, supporting the creation of memorable events with themes, food, entertainment, and formal wear for the teens, making a positive impact in their lives.

The Kroger Foundation is dedicated to uplifting communities through significant charitable contributions, having donated over $1.9 billion in the past six years. Their focus on combating hunger through the Zero Hunger | Zero Waste initiative exemplifies their commitment to social impact. Annually, they provide over $300 million to nonprofit organizations aligned with their mission, promoting health, education, and disaster relief while fostering diversity and inclusion. This initiative reflects Kroger's belief that strong communities are a shared responsibility.

The Partners for Fish and Wildlife Program, managed by the U.S. Fish and Wildlife Service, assists private landowners in restoring and protecting vital habitats for fish and wildlife. Since its inception in 1987, the program has provided technical assistance and financial support to enhance conservation efforts across the United States. By collaborating with local stakeholders, the program establishes habitat goals and directs resources effectively to conserve important ecosystems, benefiting both wildlife and the American people.

About

The Costume Society of America (CSA) is a 501(c)(3) non-profit organization founded on March 23, 1973, and incorporated in the state of New York on September 12, 1973. CSA serves it members, and promotes its goals with national symposia and publications including the journal Dress and its monthly electronic newsletter CSA e-News.

The organization began forming regional groups in 1978. There are six regional groups in the United States and Canada, and one international group. Individual regions hold annual meetings, sponsor programs and publish newsletters.

Our Mission

The Costume Society of America fosters an understanding of appearance and dress practices of people across the globe through research, education, preservation, and design. Our network of members studies the past, examines the present, and anticipates the future of clothing and fashion.

Jim Liles Student Award

 The Jim Liles Student Award is intended to assist students who want to make presentations at a CSA Southeastern Region symposium. These presentations may be on any costume-related topic. The work should be well researched and may or may not be thesis, dissertation, course research project, independent study research, or senior project related. Up to TWO students whose papers are accepted will receive up to $1,000 each to cover travel and other related expenses. The Registration fee will be waived for all student presenters, regardless of whether they receive this award.

About

The Costume Society of America (CSA) is a 501(c)(3) non-profit organization founded on March 23, 1973, and incorporated in the state of New York on September 12, 1973. CSA serves it members, and promotes its goals with national symposia and publications including the journal Dress and its monthly electronic newsletter CSA e-News.

The organization began forming regional groups in 1978. There are six regional groups in the United States and Canada, and one international group. Individual regions hold annual meetings, sponsor programs and publish newsletters.

Our Mission

The Costume Society of America fosters an understanding of appearance and dress practices of people across the globe through research, education, preservation, and design. Our network of members studies the past, examines the present, and anticipates the future of clothing and fashion.

Colleen Callahan Professional Development Award

Members are invited to apply for the Professional Development Grant offered by Southeastern Region of the Costume Society of America. Awards will be made at a minimum of $250 with the total award not to exceed $1000. Your project may be on any aspect of costume, any technical skill, or any administrative expertise which will further the mission and purposes of the Costume Society of America. The grant money may be applied to research, a course, workshop fees, or travel.

The AHRF: Bernard and Lottie Drazin Memorial Grants provide up to five $1,000 awards to otolaryngology residents conducting research projects during their residency. Eligible applicants must be from selected Chicago programs or institutions represented by AHRF Board members. Proposals are evaluated on criteria such as novelty, significance, and feasibility. Grant recipients are required to submit progress reports and notify AHRF of any publications resulting from their funded research.

William G. “Bill” Bankhead, Jr. and David Coley Cancer Research Program

Expanding Florida’s Cancer Research

• Identifying ways to attract new research talent and attendant national grant-producing researchers to cancer research facilities
• Implementing a peer-reviewed, competitive process to identify and fund the best proposals to expand cancer research institutes
• Funding proposals that demonstrate the greatest opportunity to attract federal research grants and private financial support
• Encouraging the employment of bioinformatics to create a cancer informatics infrastructure that enhances information, resource exchange, and integration through researchers working in diverse disciplines, to facilitate the full spectrum cancer investigations
• Facilitating the technical coordination, business development, and support of intellectual property for advancement of cancer research
• Aiding in other multidisciplinary research-support activities to advance cancer research

Improving research and treatment through clinical trials

• Identifying ways to increase adult enrollment in cancer clinical trials
• Supporting public and private professional education programs designed to increase the awareness and knowledge about cancer clinical trials
• Providing tools to cancer patients and community-based oncologists to identify of cancer clinical trials available in Florida
• Creating opportunities for the state’s academic cancer centers to collaborate with community-based oncologists in cancer clinical trials networks
• Reduce the impact of cancer on disparate groups by identifying those cancers that disproportionately impact certain demographic groups and building collaborations designed to reduce cancer disparities