Best Large Grants for Nonprofit Organizations in Florida

The Bank of America Client Foundation Grant Program supports nonprofit organizations in Sarasota, FL and Delaware, focusing on arts, education, historic preservation, and human services. Grants range from $5,000 to $40,000, averaging around $20,000. Eligible applicants must be 501(c)(3) public charities and generally receive one-year grants. The foundation prioritizes program-related funding, while avoiding grants to individuals and for general operating expenses.

The OpenAI A People-First AI Fund supports U.S.-based nonprofits with 501(c)(3) status, focusing on AI literacy, community innovation, and economic opportunity. It aims to enhance public understanding of AI, promote participatory design in AI applications by communities, and expand access to meaningful work through inclusive practices. Organizations at all stages of AI adoption are encouraged to apply, especially those addressing the needs of traditionally marginalized populations. This initiative emphasizes equitable distribution of AI benefits.

The David S. Miller Young Scientist Scholarship awards $1,500 to undergraduate and graduate students in geo-environmental sciences or engineering. This scholarship seeks individuals who demonstrate strong academic potential and a commitment to leveraging their scientific education for societal benefit. One winner is selected annually, and while recipients are encouraged to apply for travel grants for AGU’s Fall Meeting, they do not automatically receive them.

The Gene Haas Foundation offers Manufacturing Education Grants to empower students in technical career pathways through CNC education. These scholarships support public and private nonprofit schools, enhancing skills in CNC technology. Funds can be allocated for the Gene Haas CNC Scholarship and tooling awards for essential tools and safety gear. By fostering hands-on experience in real-world manufacturing, the foundation ensures the next generation of skilled professionals has the necessary resources to succeed.

The Guru Krupa Foundation Grant supports charitable causes in social, educational, and religious/cultural areas, rooted in Hindu values. The foundation prioritizes projects that aid the underprivileged, enhance education, and preserve cultural heritage, particularly in India and the US. Eligible organizations must be tax-exempt and demonstrate a commitment to effective accounting practices. The foundation seeks specific projects with measurable outcomes, focusing on direct funding for programs rather than administrative costs.

About Community Foundation of Henderson County

• Mission: Helping people who care make lasting contributions to causes that matter.
• Vision: Community Foundation of Henderson County is a highly visible, philanthropic leader directed by an engaged and committed board, staffed by qualified employees, empowering donors at all levels to invest in professionally managed charitable funds that address community needs.

Elizabeth DeVilling Environmental Odyssey Scholarship

This scholarship provides support to graduating seniors or graduates of any Henderson County public, private or parochial high school seeking to further their education beyond high school. Recipients of this scholarship must be accepted to an accredited degree granting college or university and be actively pursuing an undergraduate degree in the field of environmental science or a related field. Preference will be given to those who have expressed a desire to pursue work which relates to environmental preservation and/or conservation and have financial need for assistance. Extra-curricular and extra participation in activity relevant to earth sciences/environmental sciences will be given added priority.

The ASTRO-AAPM Physics Resident/Post-Doctoral Fellow Seed Grant supports early-career scientists in radiation oncology physics research. Jointly funded by AAPM and ASTRO, this grant aims to foster innovation in the field, with up to two awards of $50,000 each available. Eligible applicants include medical physics residents and post-doctoral fellows who are active members of ASTRO and AAPM. This initiative strives to enhance the next generation of researchers, ensuring a commitment to advancing radiation oncology.

SeedMoney Challenge is a global crowdfunding initiative designed to support public food garden projects. Through a competitive 30-day challenge, participants can win grants ranging from $100 to $1000 based on the funds they raise. This program, operated by the non-profit SeedMoney, aims to empower communities by providing essential resources for food gardening efforts, thereby enhancing local food security and sustainability.

James M. Doss Sr. Charitable Foundation

Mission Statement: 

The purpose of the James M. Doss Sr. Charitable Foundation is to provide funds through a direct grant or matching grant to charitable organizations, including but not limited to Catholic faith-based organizations, college athletics programs, and children’s health and human services agencies.

Grant Guideline

The Foundation provides grants to non-profit Catholic faith-based organizations, college athletics programs, and children’s health and human services agencies. If a qualifying organization experiences a special need outside the grant cycle, consideration may be given. Grants to organizations outside the identified focus areas are awarded only in Florida’s west coast area or western North Carolina.

The AWWA Scholarship Program, specifically the Neptune Technology Group Scholarship, offers a $5,000 award to undergraduate students pursuing degrees in mechanical, electrical, computer, or software engineering. This initiative, supported by the American Water Works Association, highlights the importance of investing in the future workforce of the water industry, fostering education and innovation among aspiring professionals.

The Ken W. Davis Foundation Grant provides essential funding to nonprofit organizations in the U.S. that align with the Foundation's mission of promoting basic human needs and education in line with Constitutional freedoms. With a minimum grant size of $2,500, the Foundation focuses on supporting human service organizations in Tarrant County, Texas, and the Permian Basin of West Texas and Southeast New Mexico, while also offering national support for grants related to Constitutional freedoms.

The NCF Foundation Scholarship at New College of Florida supports students through academic merit and financial need-based funding. Established by generous donors, it aims to make higher education accessible, with nearly all students receiving some form of scholarship. Eligible applicants include incoming freshmen, transfer students, and currently enrolled students with an @ncf.edu email. A yearly scholarship application and FAFSA completion are required to ensure funding opportunities.

The Sarah Bradley Tyson Memorial Fellowship, established in 1928, honors Sarah Tyson's commitment to women's agricultural education. It offers an annual scholarship to a full-time graduate student in agriculture or horticulture at an accredited U.S. institution. Eligible candidates must have relevant experience in these fields. This fellowship not only supports academic advancement but also aims to empower women pursuing careers in agriculture, reflecting Tyson's legacy of fostering education and community involvement.

The John K. Fairbank Prize in East Asian History, awarded by the American Historical Association, recognizes exceptional scholarly work in the history of East Asia, particularly focusing on books published after 1800. Eligible works must demonstrate high literary merit and can be nominated by authors or publishers. The prize aims to highlight significant contributions to the historical disciplines, with recipients announced in October 2025 and honored at the January 2026 AHA annual meeting in Chicago.

The Bee a Rae of Sunshine Foundation – MaKenzi Rae Cash Memorial Animal Compassion Scholarship, offered by the Community Foundation of Carroll County, aims to support students dedicated to animal welfare. Eligible applicants must be graduating high school seniors from Carroll County, Maryland, with a minimum GPA of 3.0 and at least 125 service hours. This scholarship reflects MaKenzi Rae Cash's love for animals and her commitment to kindness and anti-bullying advocacy.

The BJA FY 2026 Upholding the Rule of Law and Preventing Wrongful Convictions Program aims to enhance justice by strengthening the capacity of entities that review wrongful convictions. By supporting partnerships among criminal justice and victims' services, the program seeks to effectively manage post-conviction claims of innocence and prevent future errors. This initiative will help identify actual perpetrators and ensure justice for victims, contributing to public safety and the integrity of the legal system.

The National Cancer Institute (NCI) invites applications for the Toward Translation of Nanotechnology Cancer Interventions (TTNCI) program. This funding opportunity focuses on advanced pre-clinical research aimed at developing nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards will support the maturation of innovative nanomedicines using nanoparticles and nano-devices, enhancing cancer treatment efficacy. Successful projects will progress towards further NCI translational programs, such as the NExT initiative.

The BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Training and Technical Assistance (TTA) aims to enhance the capacity of grantees through dedicated training. It addresses critical operational issues related to overdose responses, targeting illicit opioids and stimulants. The program underscores the U.S. Department of Justice's commitment to public safety, law enforcement support, and the fight against substance misuse. Applications are due by November 9, 2026.

The BJA FY 2026 Prosecuting Cold Cases Using DNA program aims to enhance public safety and justice by supporting prosecutors in the investigation and prosecution of violent cold case crimes with developed DNA profiles. This funding opportunity, provided by the US DOJ's OJP Bureau of Justice Assistance, facilitates crucial investigative and forensic activities to increase successful prosecutions and provide resolution for victims and their families. Full applications are due by November 5, 2026.

National Main Street Center Inc.

Main Street America (MSA) leads an inclusive, impact-driven movement dedicated to reenergizing and strengthening older and historic downtowns and neighborhood commercial districts through place-based economic development and community preservation. We work in collaboration with thousands of local partners and grassroots leaders across the nation who share our commitment to advancing shared prosperity, creating resilient economies, and improving quality of life.

Main Street America was founded in 1980 as the National Main Street Center®, a program of the National Trust for Historic Preservation. Over the past 40 years the MSA network has helped to generate over $115.27 billion in local reinvestment, rehab 345,801 buildings, create 815,894 new jobs, and start 181,647 new businesses in over 2,000 communities. 

Great American Main Street Awards

Main Street America celebrates communities whose successes serve as a model for comprehensive, preservation-based revitalization efforts in their historic downtowns and commercial corridor districts with the Great American Main Street Awards (GAMSA).

Winners represent the diversity of communities in the Main Street America network — small towns, mid-sized communities, and urban commercial districts from every region in the country — and demonstrate the power of the Main Street Approach™. Since the inception of the Great American Main Street Awards in 1995, 118 Main Street programs have been honored.

Selection Criteria: Semifinalists and winners are selected from a nationwide pool of applicants by a jury of Main Street professionals and leaders in the fields of community and economic development and historic preservation. Criteria for winning GAMSA include: strength of the Main Street program in spurring community transformation, commitment to historic preservation, innovative programming, implementation of cross-sector partnerships, community outreach and stakeholder engagement, and ensuring their downtown districts are for everyone. 

Accolades & Ceremony: Semifinalists are promoted through Main Street America’s digital channels and receive media relations support. Winners also receive a short documentary film, a plaque, communications and media relations support, prominent placement on the Main Street America website for two years, and recognition at the 2027 Main Street Now Conference in Detroit, Michigan.

The MPS Physics Research Programs, funded by the National Science Foundation (NSF), support transformative research in various fields of physics. This includes experimental and theoretical work in atomic and molecular physics, particle physics, gravitational physics, and more. The NSF aims to promote ambitious projects without the need for immediate commercialization, focusing instead on foundational advancements that push the boundaries of our understanding of the universe.

The All of Us Research Program seeks to advance its mission by enabling access to biospecimens stored in the All of Us supported Biobank for researchers to conduct assays to evaluate associations between biomarkers and chronic diseases and add data to the All of Us resource for broad use by researchers. Biomarker analysis includes, but is not limited to, biomarker discovery; biomarker validation; novel disease stratification; and multiomics integration for disease risk, diagnosis, and prognosis, in support of advancing precision medicine. The All of Us Research Program is a historic effort to enroll 1 million participants who share data to accelerate research and medical breakthroughs, and enable individualized prevention, treatment, and care. Researchers use data from the program to learn more about how individual differences in lifestyle, environment, and genetics can influence health and disease.Grant authorities that allow the All of Us Research Program to forecast this opportunity are as follows: 42 USC 241 and 284.

Confederated Tribes of Siletz Indians

The Confederated Tribes of Siletz Indians is a sovereign nation and has three main branches of government – Judicial, Executive, and Legislative. One of our most important resources is our people.

Education

The Confederated Tribes of Siletz seeks to provide opportunities for Tribal members to reach potential, establish independence and improve quality of life through lifelong learning and education.

Arthur S. Bensell Memorial Scholarship

Arthur S. Bensell was an educator, civic leader, Tribal Council member and Tribal Chairman. He spent many years in service to his community and Tribe as Mayor of the City of Siletz and tribal leader.

Art attended Ohio State University and graduated from Heidelberg College in 1934. During his career with the Bureau of Indian Affairs, he served as a teacher, principal and reservation principal in Minnesota, Alaska and North Dakota. Upon returning to Siletz, Art became involved in tribal business affairs and served many years on the Tribe’s Education Committee and always strived for better educational opportunities for Tribal members.

A memorial scholarship fund was established through the Confederated Tribes of Siletz Indians to honor and award Tribal members in education. The $1000 scholarship is administered by the Tribal Education Committee and strengthened by various fund raising activities throughout the year.

Committee of 100 Academic Scholarship

Awards:

• One time award of $5,000.

About

Founded in 1971, the Mensa Foundation was established by members of American Mensa to extend the organization’s impact. While connected by a shared purpose, the Foundation operates independently, guided by its own Board of Trustees, strategic plan, and initiatives.

Awards

Lifetime Achievement Award

The Lifetime Achievement Award recognizes individuals whose lifelong contributions have profoundly advanced the understanding, support, and application of intelligence.

Details

This prestigious honor highlights transformative contributions that have reshaped how intelligence is studied, taught, and applied in real-world settings.

Award Components

Recipients of the Lifetime Achievement Award receive:

• Permanent recognition as a distinguished leader in the field of intelligence.
• A $2,500 monetary award in honor of their exceptional achievements.
• A commemorative trophy celebrating their lasting impact on the field.

The Bonnie Plants 3rd Grade Cabbage Grant Program inspires young students to cultivate a love for gardening by providing free oversized cabbage plants to 3rd grade classrooms across the continental U.S. Initiated in 1996, the program encourages hands-on learning about where food comes from. Each year, students compete for a $1,000 prize awarded to the best cabbage grown, fostering excitement and education about agriculture. This initiative not only promotes environmental awareness but also engages students in practical science.

The Warren Alpert Foundation supports initiatives aimed at enhancing public health through grants exceeding $25,000 for medical research, education, and basic human services. Applications are reviewed quarterly, with deadlines preceding board meetings. The foundation's mission encompasses advancing medical treatments and cures through rigorous research and health education. This commitment empowers various projects that align with their vision of improving community health and fostering innovation in medical practices.