Best Large Grants for Nonprofit Organizations in Florida

The NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) support small businesses in conducting clinical trials for NIH-funded projects. This initiative encourages partnerships with investors to assist in the commercialization of innovations in neurological disorders. Applicants must submit a comprehensive Commercialization Plan detailing anticipated funding. The program aims to promote effective transitions from research to market, enhancing the development of drugs, devices, and therapies for neurological conditions.

The Comis Foundation Grant aims to provide equitable opportunities for children to thrive through education and community engagement. It supports innovative programs that enhance educational outcomes, focusing on areas such as capacity building and pilot projects. With funding ranging from $5,000 to $75,000, the foundation prioritizes nonprofit organizations that foster inclusive environments. By emphasizing trust and collaboration, Comis Foundation strives to create lasting impacts in the communities it serves.

The Michael R. Priddy Music Scholarship, offered by the Central Kentucky Community Foundation, aims to support graduating high school seniors from Hardin County Schools, specifically Elizabethtown and LaRue County High Schools. This scholarship is intended for students who have demonstrated involvement in classical orchestra or music performance, or who plan to pursue music studies, thereby fostering musical education in the community.

The AWWA Scholarship Program, administered by the American Water Works Association, offers a $5,000 scholarship to graduate-level students pursuing careers in the water industry. Recognizing the vital role of future professionals, AWWA aims to support education in water supply and wastewater management through this scholarship initiative. Founded in 1886, American Water is the largest U.S. investor-owned water utility, emphasizing the importance of investing in education for sustainable water solutions.

What We Do

At the North Carolina Community Foundation, we bring together generous people and connect them to causes and organizations they care about.

Our mission is to inspire North Carolinians to make lasting and meaningful contributions to their communities.

Our Philanthropic Network

We believe in the power of permanent philanthropy to strengthen our communities and people. By stewarding and growing donors’ gifts, our philanthropic network makes a powerful impact through robust grants and scholarships programs.

Geraldine Mayo Beveridge Scholarship Endowment

About Geraldine Mayo Beveridge

Geraldine “Gerry” Mayo Beveridge taught school in Carteret County for 40 years. She was a Home Economics teacher and thought of her students as her children; she and husband “Captain David” had none of their own. Gerry would discreetly provide classroom supplies and clothing items for students in need. She quietly contributed money toward college for capable students who couldn’t afford it.

Gerry’s concern for students continued after retirement. As a member of the Carteret County Retired School Personnel (CCRSP), Gerry convinced members of the importance of awarding a scholarship to a graduating senior in each high school – East Carteret, West Carteret, and later, Croatan. To raise money, she organized bake sales and brought plants and canned foods to sell to members. The scholarships, though small, were a great effort for members and were greatly appreciated by recipients.

Gerry left a considerable sum of money to CCRSP with the expectation that it be managed well and used for scholarships. Today, the Geraldine Mayo Beveridge Scholarship is awarded to qualifying graduating seniors who want to teach Vocational Education, now called Career and Technical Education.

Gerry’s passion for her students and her love of education continues through this scholarship. She was an amazing educator whose philanthropy will last in perpetuity.

The John's Island Foundation (JIF) offers Core Grants annually to support capital needs of nonprofit agencies in Indian River County. Eligible agencies must be tax-exempt 501(c)(3) organizations that demonstrate a commitment to serving individuals facing challenges related to food, shelter, health, and education. JIF focuses on tangible capital improvements, ensuring that funds are used to enhance community services. This initiative reflects JIF's dedication to fostering a sustainable impact for those in need within the local community.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Young Investigator

$100,000 over 3 years

• PI must hold an academic appointment at the instructor level or higher
• PI must be within 5 years of completing a training fellowship in Pediatric Hematology/Oncology or a closely related discipline that has direct clinical contact with pediatric cancer patients
• Research must be within 2-3 years to translation to a clinical trial or already associated with a clinical trial

• Evidence of Mentor's commitment to the PI's career development plan
• Translational potential

Our Mission

To advance Mayo Clinic’s commitment to be a socially responsible Enterprise by supporting and extending Mayo’s strategic mission of integrated practice, research and education through active community engagement practices.

Our Vision

To be a proactive partner, inclusive of diverse and underserved populations, and contribute to the overall health, sustainability, livability and vibrancy of the many communities we serve. Stakeholders will better understand and appreciate Mayo Clinic’s community engagement practices and our ongoing role in strengthening partnerships and creating positive social impact.

Community Contributions Program in Florida

Mayo Clinic in Florida is a not-for-profit organization with the primary mission of patient care. As a private trust for the public good, Mayo Clinic is dedicated to giving back to its local communities through its Office of Community Relations.

Mayo Clinic partners with others to ensure that:

• Our community investments align with our mission to advance patient care, research and education
• Our community is a welcoming, vibrant and healthy environment
• Our community is an environment that attracts and sustains a diverse Mayo Clinic workforce to provide the best patient care

Program Information

Mayo Clinic considers sponsorship and grant requests from registered 501(c)(3) organizations in northeast Florida for new/ongoing programs or other community outreach activities that support the stated goals. These may include:

• Health and Human Services
• Education and workforce development
• Belonging
• Youth enrichment
• Community events

Each request will be considered for alignment with any of the following health priorities:

• Access to Care
• Mental Health
• Food Environment - access to nutritious food

Access to Care

Mayo Clinic will offer one grant funding opportunity for the Community Health Needs Assessment priority area: Mental Health

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5412 - Determinants of Workforce Retention in Public-Sector Water Utilities

Grant Information

• Quantify the relative influence of compensation, pension stability, mission alignment, schedule flexibility, leadership support, career development opportunities, and other factors on employee retention in public-sector water utilities.
• Identify and analyze key impediments to retaining talent, including structural, cultural, compensation-related, and organizational barriers.
• Identify and benchmark retention best practices from sectors outside the water industry to assess transferability and develop case studies of high-retention organizations to distill replicable strategies and measurable success factors.

The Kars4Kids Small Grant Program aims to support educational initiatives globally, impacting the lives of children. This program welcomes applications from IRS-recognized nonprofit organizations focused on youth development, mentorship, and education. Grants typically range from $500 to $2,000, depending on mission alignment and available funds. Kars4Kids, a national Jewish nonprofit, is dedicated to nurturing productive community members through educational and mentoring opportunities.

The Lynde and Harry Bradley Foundation Grant supports organizations dedicated to preserving American exceptionalism through a commitment to individual liberty, free markets, and civic responsibility. It prioritizes proposals from 501(c)(3) organizations that promote informed citizenship and strong communities. With ongoing acceptance of Letters of Inquiry, the Foundation seeks to empower initiatives that align with its principles of limited government and the rule of law, fostering a rich community culture.

The NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional) program invites applications to support innovative biomedical research focused on cystic fibrosis, diabetes, and other chronic diseases. These centers foster collaboration, provide essential resources, and mentor early-stage investigators, enhancing the research landscape. Funding will support pilot programs and access to shared services, ensuring efficient use of resources while promoting a robust scientific community dedicated to advancing health outcomes.

The Charlotte CF Education Fund Grant aims to enrich the lives of school-age children in Charlotte County, Florida, by providing additional educational opportunities and workforce development. Funded by the Charlotte Community Foundation, this grant supports programs like afterschool initiatives, career development, reading programs, and feeding programs. Eligible applicants must demonstrate fiscal responsibility and primary service to Charlotte County residents, ensuring that grant funds effectively benefit the community.

Every Kindness is a Gift

Dollar Tree Gift Card Program 2026

Every Kindness is a Gift is a gift card grant program made possible through the generosity of Dollar Tree and managed by the team here at Gift Card Bank. We are a nonprofit organization that specializes in the distribution of gift cards and our mission is to improve well-being and build financial stability by supporting people through their time of need.

Through Every Kindness is a Gift, nonprofit organizations and Title I schools located in the 48 contiguous states may apply to receive a grant of Dollar Tree gift cards.

Gift cards received through these grants are meant to be distributed directly to individuals and families in need. A primary goal of the program is to give gift card recipients the dignity of choice by empowering them to shop for what they need themselves. By putting gift cards directly in the hands of our neighbors in need, we are able to increase access to essentials like food, school supplies, paper products, cleaning products, and hygiene items.

In 2026, there will be two rounds of grant distributions. In each round, we will award a number of grants between $2,500 and $10,000.

Round One is a summer distribution. Gift cards awarded in Round One will arrive in late June, while kids are on break and back-to-school is around the corner. Round Two is a holiday distribution. Gift cards awarded in Round Two will arrive in early November, as the end-of-year holidays approach.

We know that these are times of year when budgets are tight. Through these gift card grants, we hope to connect individuals and families directly to the essential resources they need during difficult months.

The 2026 Vilcek Prizes for Creative Promise in Biomedical Science will award three $50,000 prizes to exceptional young immigrant scientists in the U.S. This prestigious prize recognizes innovative research contributions in biomedical science. Eligible candidates must be under 38 years old, hold a doctoral degree, and have made significant achievements in their field. The Vilcek Foundation aims to highlight the impact of immigrant scientists on the advancement of biomedical research, fostering diversity and excellence.

About Us

Our team is working tirelessly to heal the planet and ensure that a just and livable future prevails.

With three decades of clean energy industry experience, our leadership team draws upon a long track record of environmental stewardship and meaningful throughput to confidently navigate today's unprecedented challenges.

We are teaming up with local philanthropists, nonprofit organizations, advocates and elected officials to implement effective solutions towards stopping the climate crisis.

Solar Moonshot Program Grant

The Solar Moonshot Program is helping nonprofit organizations across the United States afford the switch to clean energy.

Grants up to $25,000 are typically awarded, with grant amounts dependent on various factors, including the organization’s need for funding. 

In addition to grants given through the program, we also offer short-term, low-interest recoverable grants to help cover the project costs offset by the Investment Tax Credit.

Grants for 2026 are made possible by the BQuest Foundation and two anonymous donors, and the program is managed by Hammond Climate Solutions Foundation. Learn more about the program's status and participants below! 

About Us

The Youth Climate Justice Fund aims to support climate justice young leaders with trust-based funding, resources, and capacity strengthening, enabling them to amplify their voices and to keep their vision and influence alive.

Collectively, we have the power to ignite meaningful change and build equitable and sustainable futures. Despite the challenges posed by the current crisis, youth climate justice organizers remain determined to address current issues and explore new approaches.

Mission & Purpose

We work to strengthen existing organizing efforts and support emerging youth-led initiatives with a focus on bridging funders and organizers to enable flexible and impactful support. Through capacity strengthening and resource sharing, we empower and support young people to drive change and build a just and sustainable future.

How To Apply

The Youth Climate Justice Fund provides funding to emerging youth-led climate justice and socio-environmental groups through a participatory decision-making process.

The AWWA Scholarship Program offers the GFT Forces of Change Scholarship, providing $5,000 to undergraduate or graduate engineering students passionate about advancing the water industry. This scholarship underscores AWWA's commitment to nurturing future professionals who will tackle critical infrastructure challenges. By investing in education, AWWA aims to empower the next generation to innovate and lead in water supply solutions. This initiative highlights the importance of skilled engineers in shaping a sustainable future.

The Brower Youth Awards for Environmental Leadership honors young leaders aged 13 to 22 in North America who excel in environmental initiatives. Awardees receive a $3,000 cash prize, training, and networking opportunities to enhance their impact. This prestigious program fosters youth leadership and amplifies diverse voices within the environmental movement, encouraging innovative solutions to pressing ecological challenges. Over the past 25 years, the awards have celebrated over 100 emerging leaders dedicated to making a difference in their communities.

The Robert Silman Award, presented biennially by the James Marston Fitch Charitable Foundation, recognizes innovative proposals in the preservation, restoration, or adaptive reuse of the built environment. Open to professionals in various design fields, the award encourages originality and practical applications that advance preservation in the U.S. With a funding limit of $15,000, it seeks projects that demonstrate a clear plan for dissemination and positive community impact, especially for underrepresented groups.

The Morris Animal Foundation invites research pre-proposals for the Wildlife Health (Reptile and Amphibian) - First Award, aimed at enhancing the health and welfare of amphibians and reptiles. This initiative focuses on impactful research, particularly in chytrid disease. Eligible applicants include early career researchers with appropriate qualifications and a clear understanding of animal health challenges. Projects should demonstrate collaboration with relevant stakeholders and provide direct benefits to wildlife populations, emphasizing conservation through an animal health perspective.

The Morris Animal Foundation is offering Pilot Study Awards focused on reptile and amphibian health and welfare, particularly for chytrid research. These awards aim to fund innovative, proof-of-concept studies that demonstrate a clear understanding of animal health issues and collaboration with stakeholders. Proposals must have a direct impact on wildlife populations and adhere to strict health study policies. The maximum funding is $20,000 for a duration of 12 months, ensuring significant contributions to wildlife health advancements.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5419 - Crossing the Divide – Best Practices for Addressing Local and Privately-Owned Lateral Sewer Issues

Grant Information

To provide water resource recovery facilities (WRRFs) and collection system operators with an interactive manual of practice for implementing inflow and infiltration (I&I) and obstruction management programs with a focus on municipal and privately owned lateral sewers in complex legal, regulatory, and multi-jurisdictional environments.

The MPPEP Phase 3 program aims to enhance processing capabilities for invasive, wild-caught catfish, benefiting both processors and fishers. By increasing processing capacity and volume, the initiative seeks to create fair wages and stable job opportunities, fostering economic growth in rural areas. This grant will support innovative strategies that ensure sustainable practices and elevate incomes within the community, thus contributing to the overall development of the meat and poultry sector.

The AAAAI Distinguished Service Award recognizes outstanding contributions from members of the American Academy of Allergy, Asthma & Immunology. This prestigious award honors those who have demonstrated long-standing commitment and service to the organization, focusing on their influence in advancing the field of allergy and immunology. Eligible recipients include senior members and past presidents, particularly those nearing retirement, thereby celebrating their dedication to the specialty and the patients they serve.

The Health Foundation of South Florida Grants aim to enhance the health of South Florida communities, particularly for vulnerable populations. The foundation invites nonprofit organizations and government agencies to submit proposals that align with its mission, focusing on access to care, social needs, and thriving communities. Preference is given to projects that demonstrate clear needs and measurable outcomes, especially those serving low-income and disadvantaged communities. Funding can support innovative collaborations and systems changes to improve healthcare access and outcomes.

The AAAAI Mentorship Award honors dedicated mentors who significantly impact the careers of trainees and colleagues in the field of allergy and immunology. By supporting and guiding more than one mentee, awardees embody the core values of the American Academy of Allergy, Asthma & Immunology. This prestigious recognition highlights the importance of mentorship in fostering professional growth and advancing the specialty, benefiting both individuals and the broader medical community.