Best Large Grants for Nonprofit Organizations in Florida

Community Foundation for Mason County, MI

At the Community Foundation for Mason County, we work with donors, grantees, and advisors to address key community issues. As a leader in community philanthropy, building a vibrant community with great opportunities for all, we are focused on advancing education, increasing recreation opportunities, and community and economic development.

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Miller Family Scholarship

This scholarship has been made possible by the generosity of Michael K. Miller, who established the Miller Family Scholarship Fund of the Community Foundation for Mason County. This scholarship is presented to instrumentalists graduating from Ludington High School.

The DFO Research, Education, and Conservation Grant supports projects focused on birds and their habitats, prioritizing initiatives in the Denver area and Colorado's Front Range. Established in 1994, the fund encourages research, education, and conservation efforts with grants typically under $2,000. Recent funded projects include studies on owl habitats and educational programs for young birders. The fund aims to advance knowledge and appreciation of avian species through targeted financial support.

The William Brewster Memorial Award, awarded by the American Ornithological Society, recognizes exemplary contributions to ornithological science through a significant body of work on Western Hemisphere birds published in the last decade. This prestigious award honors the legacy of William Brewster, a founding member of the American Ornithologists' Union, and includes a medal and honorarium funded by the William Brewster Memorial Fund. Nominations are open to all, fostering diversity in ornithology.

The Research Foundation of the ASCRS offers the Limited Project Grant to support innovative research in colon and rectal surgery. With funding up to $25,000 for one year, this grant aims to foster investigator-initiated, hypothesis-driven projects conducted in the U.S. or Canada. Successful applicants may secure further funding from national agencies. ASCRS membership is required for principal investigators, ensuring a dedicated approach to advancing colorectal health and surgical techniques.

The Eugene Salvati, MD, Limited Project Grant, offered by the Research Foundation of the American Society of Colon and Rectal Surgeons, supports clinical research in colorectal surgery. This grant aims to honor Dr. Salvati's legacy by funding innovative projects that improve patient care. With a maximum funding of $25,000 for one year, it emphasizes investigator-initiated research conducted within the U.S. or Canada, encouraging collaboration among ASCRS members and adherence to ethical review board protocols.

The General Surgery Resident Research Initiation Grant aims to engage General Surgery Residents in research related to colorectal diseases. With an annual funding of $20,000, this grant supports both clinical and laboratory-based research. It is geared towards residents or recent graduates of approved General Surgery programs, prioritizing those with aspirations in Colon and Rectal Surgery. This initiative fosters innovative research to enhance patient care and surgical techniques in the field.

The NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA) aims to renew support for two research consortia focusing on the biological mechanisms of excessive alcohol consumption and Alcohol Use Disorder (AUD). By utilizing advanced technologies and fostering collaboration across multiple sites, this initiative seeks to standardize neurofunctional measures and enhance reproducibility in findings. Investigators are encouraged to prepare for future applications to this NOFO, which will utilize the U24 activity code.

The Lasher-Bottorff Award, established by the American Association of Avian Pathologists, recognizes outstanding contributions to poultry health. It honors Dr. Hiram N. Lasher and Dr. C. A. Bottorff, pivotal figures in avian medicine. The award, valued at $1,000, is presented annually to a veterinarian who has made significant advancements in avian diagnostics or technical services over the past decade, promoting the health and productivity of poultry in North America.

The Rapid Response Opioid and Pain Management ECHO Funding Opportunity by the Association of State and Territorial Health Officials (ASTHO) aims to enhance clinician training in effective pain management strategies. This initiative focuses on non-opioid treatments, substance use screening, and risk reduction counseling, promoting compassionate care while addressing public health challenges and ensuring continuity for patients affected by prescription disruptions. The program seeks to improve overall health outcomes and reduce risks associated with opioid use.

The Mike & Sofia Segal Foundation Grant provides vital funding to nonprofit organizations focused on intellectual freedom, medical research for rare diseases, Jewish heritage preservation, elder care, and climate change initiatives. By supporting innovative projects that align with their mission, the foundation aims to uplift communities and foster meaningful societal contributions. Organizations must be 501c-3 compliant and demonstrate a clear plan for engagement with beneficiaries and measurable objectives to be eligible for funding.

The Higher Education Challenge Grants Program, managed by the USDA's National Institute of Food and Agriculture, aims to enhance institutional capacities in food and agricultural sciences education. This initiative focuses on improving curriculum, faculty, and student recruitment for master's and doctoral programs, particularly in veterinary medicine. By strengthening these educational frameworks, the program seeks to ensure the availability of skilled professionals in critical agricultural sectors.

The Loye and Alden Miller Research Award, presented by the American Ornithological Society, recognizes lifetime achievements in ornithological research. It honors the legacy of Loye Holmes Miller and his son Alden Holmes Miller, who significantly contributed to the field and mentored numerous students. This prestigious award aims to uphold high ethical standards in ornithology and is open to current AOS members, promoting a diverse and supportive community in bird conservation.

The Elliott Coues Award, presented by the American Ornithological Society, honors exceptional contributions to ornithological research without geographic or disciplinary restrictions. This prestigious award includes a medal and an honorarium and is named after Elliott Coues, a pioneering ornithologist. The award emphasizes the importance of diverse nominations and aims to recognize individuals who have made significant impacts in the field of ornithology, thus fostering a vibrant ornithological community.

The Aerie Real Foundation™ Community Grant aims to enhance confidence, inclusion, and sustainability among young women while supporting non-profit organizations in the US and Canada. Grants of up to $10,000 are available to programs focused on mental well-being, fostering inclusive communities, and environmental protection. Applications are accepted from certified 501c3 nonprofits, with funding allocated for projects that align with the Foundation's mission. The goal is to empower the next generation and create a positive impact in local communities.

The Trout and Salmon Foundation Grant offers matching funds up to $5,000 to support projects aimed at restoring and enhancing trout and salmon habitats in North America. Established in 1969, the foundation prioritizes partnerships with local watershed organizations focused on habitat improvement. Grants are provided for projects that physically restore streams and fisheries, with on-site labor recognized in certain cases. The foundation seeks to diversify funding across various watersheds and regions, ensuring a broad impact in conservation efforts.

This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.

Mary Kay Ash Foundation

Guided by Mary Kay Ash’s dream to enrich the lives of women everywhere, the Mary Kay Ash Foundation® raises and distributes funds to invest in breakthrough cancer research and clinical trials to find a cure for women-related cancers and ending domestic violence.

Since 1996, the Mary Kay Ash Foundation®, a 501(c)3 organization, has contributed more than $100 million to organizations aligned with its two-fold mission. In addition, the Foundation supports awareness initiatives, community outreach programs, and advocates for legislation to ensure women are healthy and safe. Through our global charitable foundations in Brazil, Canada, China and the United States, we are collectively making a deeper impact on the lives of women around the world.

Mary Kay Ash Foundation: Cancer Research Grant

The Mary Kay Ash Foundation is a non-profit public foundation, which focuses on funding research for innovative grants for translational research of cancers affecting women (ovarian, uterine, breast, endometrial or cervical cancer among others). Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately, such research would lead to improvement in diagnosis, prognosis, prevention, or treatment of the cancer. Each year the Foundation extends invitations to NCI designated cancer institutes and accredited medical schools to apply. Only one application is accepted per institution.

Grant proposals are reviewed by a Scientific Research Review Committee comprised of notable members of the American medical and scientific community. Grants are awarded up to $100,000 (combined direct and indirect costs) for a two-year period. The Foundation anticipates funding between 10 and 15 grants annually. 

The AUKUS Scholarship, part of the Graduate Education Fund, supports American and Australian graduate students in security, technology, and diplomacy fields. Applicants must be citizens or permanent residents, with an offer from an accredited institution. The scholarship provides up to $40,000 for tuition, travel, and living expenses. Applications are due in March for Australia to USA and in September for USA to Australia. This initiative strengthens ties and promotes research in critical areas.

The NIAID Career Transition Award (K22) supports postdoctoral fellows transitioning to independent research positions, fostering their development into successful biomedical scientists. Key deadlines for applications span from February 2025 to June 2027, including specific dates for standard, renewal, and AIDS-related grants. This initiative, funded by the NIH, aims to enhance the career trajectory of emerging researchers in clinical and biomedical fields, ensuring a robust pipeline of innovative scientific talent.

About Us

Overview

The Alaska Community Foundation connects people who care to the causes that make a difference and matter most to them. We encourage and nurture philanthropy through building and managing permanent endowments, convening stakeholders, working with partners to strengthen Alaskan communities, and providing donors with flexible giving options that are strategic to their philanthropic objectives. ACF also manages the Pick.Click.Give. program.

Mission

Inspiring the spirit of giving and connecting people, organizations, and causes to strengthen Alaska’s communities now and forever.

Vision

ACF envisions an Alaska where communities come together and have resources to thrive.

Stassel Education Scholarship Fund

The Stassel Fund was established in memory of Fred L. and Jean N. Stassel who came to Alaska on their honeymoon in 1949, making Anchorage their home for over 60 years until they passed away in 2017 and 2011 respectively. Here they raised 6 children, celebrated Alaska's statehood in 1959, survived the 1964 earthquake, and became active in the community and state. The Fund honors their dedication to education and service to others focusing on creating opportunities for all Alaskans, especially the vulnerable and most in need. Fred and Jean valued education, hard work, integrity, justice, respect, and care for all people. They were both educators, commercial fishers, and very active in social services through the United Methodist Church and other organizations. Fred was very influential in establishing the now-named Credit Union 1, and Jean was active with The League of Women Voters. They would be honored to know that deserving Alaskans were able to pursue their educational goals with the help of scholarships from the Stassel Education Fund.

The Unity for Humanity Grant invites innovative creators to submit impact-driven projects that utilize real-time 3D technology. This annual grant provides funding, technical support, and marketing resources to help bring visionary ideas to life. Projects must align with UN Sustainable Development Goals and demonstrate measurable impact. Eligible submissions include prototypes across various genres, fostering a more inclusive and sustainable world. Join us in empowering changemakers to make a positive global difference.

The Luce/ACLS Dissertation Fellowships in American Art support graduate students conducting research on the history of art and visual culture in the U.S., including Native American art. These fellowships aim to enhance diversity in academia by welcoming applications from PhD candidates at all degree-granting institutions in the U.S. The program offers a stipend of $38,000 plus a travel and research allowance, with a total award of $42,000 for a nine to twelve-month period between July 2025 and May 2027.

The Peacock Foundation Inc. grants support the health and well-being of South Florida's children and families through contributions to eligible 501(c)(3) public charities. The foundation prioritizes proposals that address human services, education, health, youth, elderly care, disabilities, arts for educational purposes, and environmental education. All applicants must submit a letter of inquiry detailing their mission, project description, community served, and funding request. The foundation does not fund capital campaigns, individuals, or lobbying efforts.

The CDV5 Foundation Grant supports charitable organizations, churches, and government entities that meet IRS 501(c)(3) requirements. This grant aims to nurture successful children, foster stronger families, and cultivate healthier communities. Through partnerships, the foundation provides resources to help individuals reach their full potential. Applicants may submit one request annually for operating, capital, or program support, while event sponsorships are also considered. The foundation encourages applicants to consider their budget and history with the foundation when requesting funding.

The NEA Community Advocacy & Partnership Engagement (CAPE) Grant aims to support local affiliates in mobilizing community organizations to enhance student achievement, particularly for students of color. Key priorities include fostering initiatives for racial justice in education, engaging NEA members trained in leadership, and creating union roles for community engagement. This grant encourages collaboration between educators and community leaders to build capacity and drive positive change.

The United Way of St. Johns and Putnam Counties offers a Strategic Grant Fund aimed at empowering smaller nonprofit organizations that are often overlooked for traditional funding. Established in 1957, the organization focuses on critical areas such as housing stability, financial security, food access, and education. The goal is to support grassroots initiatives that create measurable impacts for residents, ensuring everyone has the opportunity to thrive in their communities.

The FRS Community Grant Program supports rural communities served by NTCA members, offering grants up to $5,000 for various local initiatives. Priority is given to projects that promote economic development, education, health, and public service. Eligible applicants must secure a 10% match of the grant amount requested. Ineligible projects include overhead expenses, individuals, and those without secured funding. FRS aims to foster sustainable and engaged rural communities through these efforts.