Best Large Grants for Nonprofit Organizations in Florida

Florida Department of Health

Led by the State Surgeon General, the mission of the Florida Department of Health is to protect, promote, and improve the health of all people in Florida through integrated state, county, and community efforts.

The Live Like Bella Pediatric Cancer Research Initiative

The Florida Department of Health’s Live Like Bella Pediatric Cancer Research Initiative supports the pursuit of identifying cures for pediatric cancer.

The Live Like Bella Pediatric Cancer Research Initiative is established in section 381.922, Florida Statutes, works to advance progress toward curing pediatric cancer through grants awarded through a peer-reviewed, competitive process, to:

• Significantly expand pediatric cancer research capacity in Florida
• Improve both research and treatment through greater pediatric enrollment in clinical trials networks
• Reduce the impact of pediatric cancer on disproportionately impacted individuals

Research Focus

Applications submitted in response to this Funding Opportunity Announcement (FOA) must be responsive to one of the following areas of focus. 

• Prevention and Treatment
• Screening
• Obesity
• Treatment-Related Morbidities
• Technology Transfer Feasibility (TTF)
• Investigational New Drug or Investigational Device Exemption

Efforts to foster collaborations among institutions, researchers, and community practitioners should be included, when possible. Preference will be given to applications that address at least one of the cancers listed in the Research Priorities section of this FOA.

Funding Information

Applicants must request funding in the preceding grant categories to pursue research in the areas of focus outlined in the Research Focus section of this FOA. Preference will be given to applications that address the priorities listed in the Research Priorities section of this FOA. Specific grant funding amounts are available for each grant category.

Grant Categories

Applications in response to this FOA must align to a grant category (depending on the grant program) to pursue an area of focus from the Research Focus section of this FOA. Applications for research infrastructure grants that are reviewed and assigned exceptional scientific merit will be considered for preferential funding. 

The grant categories are: 1) Bridge; 2) Discovery Science; 3) Emerging Therapeutics and Technologies; 4) Equipment; 5) Multicenter Clinical Trials; 6) New Investigator Research (NIR); 7) High-Risk, High-Reward Clinical Research; 8) High-Risk, High-Reward Discovery Science; 9) Non-Typical Clinical Trials/Socio-Behavioral Research; 10) Research Infrastructure

Bella Initiative Grant Categories: Multicenter Clinical Trials

Funding from this grant category for multicenter clinical trials is intended to support evaluation of the safety, efficacy, and effectiveness (Phase I, II, III, and IV) of repurposed or new and innovative drugs and other treatments for pediatric cancers. Trials may include randomized clinical trials or innovative applications of precision medicine strategies using targeted therapies. Multicenter clinical trials need to involve investigators from at least two distinct research/clinical facilities in Florida and must be implemented in two or more locations in Florida.

Maximum Duration: 48 months

Florida Department of Transportation

The Florida Department of Transportation (FDOT) is an executive agency and directly reports to Governor Ron DeSantis. FDOT’s continuing mission is to provide a safe statewide transportation system that promotes the efficient movement of people and goods, supports the state’s economic competitiveness, prioritizes Florida’s environment and natural resources, and preserves the quality of life and connectedness of the state’s communities. This mission is accomplished through a primary purpose to plan and develop (either directly or indirectly) Florida’s robust transportation system. 

Highway Safety Grant Programs

The Florida Department of Transportation (FDOT) State Safety Office awards subgrants to traffic safety partners that undertake priority area programs and activities to improve traffic safety and eliminate crashes, serious injuries, and fatalities. Subgrants may be awarded for assisting in addressing traffic safety deficiencies, expansion of an ongoing activity, or development of a new program.

Subgrants are awarded as "seed" money to assist in the development and implementation of programs in traffic safety priority areas. Many types of organizations are eligible to receive traffic safety subgrant funding including government agencies, political subdivisions of state, local, city and county government agencies, law enforcement agencies, state colleges and state universities, school districts, fire departments, public emergency service providers, and certain qualified non-profit organizations (e.g., MADD, SADD, etc.).

Each applicant must develop a concept paper that identifies a traffic safety problem in the applicant’s jurisdiction. Applicants should provide documentation in the form of crash data of the traffic safety problem targeted by the subgrant. Concept papers must detail the activities of how the traffic safety problem will be addressed using subgrant funds.

Traffic Safety Priority Areas

The following are the priority areas that are available for subgrant funding: 1) Aging Road Users; 2) Community Traffic Safety Outreach; 3) Distracted Driving; 4) Drowsy Driving; 5) Impaired Driving; 6) Interstate Speeding Enforcement; 7) Motorcycle Safety; 8) Occupant Protection and Child Passenger Safety; 9) Pedestrian and Bicycle Safety; 10) Law Enforcement Liaison Program; 11) Public Traffic Safety Professionals Training; 12) Speed/Aggressive Driving; 13) Teen Driver Safety; 14) Traffic Records; 15) Traffic Records Coordinating Committee (TRCC); 16) Work Zone Safety.

Motorcycle Safety

Includes programs to increase safety awareness and skills among motorcyclists. Concept papers can address areas such as specialized enforcement, education, training, and public information efforts. Items eligible for funding under this category may include, but are not limited to, overtime for enforcement, overtime for SMART training, overtime for subgrant reimbursement and reporting, equipment for training, and public information and education materials. Funding for equipment is contingent upon evidence of need clearly defined in the problem statement and a comprehensive plan that requires the use of the requested equipment. Enforcement subgrants should focus on enforcement efforts and concepts requesting a majority of funding for equipment are discouraged. Subgrants for equipment only are not allowable. 

The National Institutes of Health (NIH) is inviting applications for the Screening, Brief Intervention, and Referral to Treatment or Prevention (SBIRT/P) program. This funding opportunity aims to explore innovative methods for addressing alcohol, tobacco, and other drug use among adults facing health disparities. The initiative seeks research proposals that will implement and evaluate SBIRT/P strategies in collaboration with healthcare and community partners. This approach is crucial for enhancing public health and ensuring effective interventions.

The Therapeutic Giving program by Johnson & Johnson focuses on funding initiatives that enhance patient access to treatment and advance health equity, particularly in immunology. Eligible nonprofit organizations can apply for support aimed at improving health outcomes through innovative programs. The initiative prioritizes measurable impacts over fundraising activities, emphasizing the importance of addressing healthcare disparities and promoting disease awareness efforts for diseases like rheumatoid arthritis and psoriasis.

The NHLBI Career Transition Award (K22) program supports postdoctoral fellows in transitioning their research to extramural institutions. The program includes a mentored intramural phase (up to two years) followed by an extramural phase (three years), totaling five years of support. Applications have multiple deadlines, including October 12, 2024, and February 12, 2025, among others. Successful transition depends on the awardee's progress during the mentored phase, evaluated by NHLBI.

About

Being deeply connected to the community means more than providing access to excellent healthcare. It means understanding, and investing in, the health needs of our community.

Through our Community Investment Fund (CIF), Endeavor Health has awarded more than $38.5 million to 59 local partnerships dedicated to enhancing community health and wellbeing, advancing health equity and supporting local economic growth. Together, we’re committed to helping everyone in our communities be their best.

Award categories

Through the CIF, we will make meaningful and intentional investments through impact awards and capacity builder awards. These awards are intended to meaningfully advance the health of our community over time towards three bold aspirations through investments in five areas of focus.

We aspire to a future where:

• A person’s zip code does not determine how long they will live
• Hunger and homelessness in our communities are history
• The healthcare workforce is thriving and representative of the communities we serve

To help advance these aspirations, the CIF will invest in the following areas:

• Access to healthcare
• Behavioral health
• Food insecurity
• Housing insecurity
• Workforce development for careers in healthcare

Impact awards

• Designed for 5-year initiatives where organizations come together to drive measurable impact and longer-term change in the communities we serve by improving existing systems and innovation
• Emphasize strategic cross-sector and/or intra-sector partnerships between community-based organizations
• Uplift community members of greatest need
• Directly align with CIF areas of focus and meaningfully contribute to CIF goals
• Award amount: $1 million per year, up to 5 years

The CIF Capacity Builder Awards by Endeavor Health focus on enhancing community health through strategic investments. With over $38.5 million allocated to local partnerships, these awards aim to address critical areas like healthcare access, food insecurity, and workforce development. Designed for nonprofit organizations, the awards range from $100,000 to $500,000 annually for 1-2 years, fostering long-term community impact and advancing health equity in the service areas.

The Wabtec Direct Grant Program focuses on creating sustainable impacts in local communities by funding 501(c)(3) non-profit organizations. Emphasizing education and environmental stewardship, the program supports initiatives that improve literacy, academic outcomes, and workforce readiness. Grants range from $1,000 to $10,000, prioritizing organizations that engage local Wabtec employees in volunteerism. The program promotes equitable access and non-discrimination while ensuring measurable results in funded projects.

The Pinetop Assistance League (PAL) Grant provides crucial financial support to elderly blues musicians, ensuring their well-being during emergencies. This grant, part of the Pinetop Perkins Foundation's mission, offers assistance for medical expenses, home care, and essential living costs. Eligible applicants must be professional artists aged 50 or older with a household income below $35,000. By addressing these needs, PAL plays a vital role in preserving the legacy and care of blues musicians.

The Florida Department of Environmental Protection offers the Resilient Florida – Planning Grants to support local governments and organizations in resilience planning efforts. These grants aim to enhance the assessment of vulnerabilities to critical assets, ensuring that coastal communities can recover more swiftly from natural disasters. Eligible applicants include counties, municipalities, and water management districts, which can also collaborate with the Florida Flood Hub for Applied Science and Innovation to address data gaps.

About QuikTripQuikTrip believes in investing in the communities in which our employees live and work. Every year, QuikTrip donates 5% of our annual net profit to qualified 501c3 non-profit agencies, which includes our United Way campaign match, support for National Safe Place agencies, Folds of Honor scholarships and many other agencies that support at-risk youth and early childhood education.Mission: To wisely invest dollars in community efforts that will help impact (in measurable terms) individuals in our society who are dependent on the charitable support of others. We believe the most effective way to do that is to invest our contribution dollars and volunteers in strategic efforts that help those at risk reach their functional capacity as successful, independent citizens.About QuikTrip Charitable GrantsQuikTrip funds 501c3 agencies located in the cities in which we have stores and our employees live and work. Funding can include: “in-kind” products (coupons, gift cards or product donation), formal grants, fundraiser/event sponsorships and employee volunteer time.Focus Areas:

• Creating Safe Communities
  • First Responders: QuikTrip is proud to partner with law enforcement and first responders in every market we serve, making sure that they have the tools, training and support they need to keep our communities safe and to return home safely to their families after each shift.
  • Homeless Outreach & Alternatives to Police Response: To significantly reduce non-emergency calls and help people in crisis get back on their feet, QuikTrip funds dedicated homeless outreach teams across our communities. These teams engage individuals experiencing homelessness and living in encampments – connecting people to services, shelter, detox and long-term care.

• Creating Strong Communities
  • Ending Homelessness: We support emergency, transitional and permanent supportive housing, diversion and prevention programs, and more.
  • Mental Health & Substance Abuse : We know that healthy communities are safe communities, which is why we invest in detox and substance abuse treatment centers, and behavioral health centers and services to end the perpetuation of cycles of trauma and addiction.
  • At-Risk Youth: We especially prioritize services for at-risk youth – those aging out of foster care, justice-involved or without stable support systems.
• Additional Community Commitments
  • United Way: Employee donation matching in all markets.
  • Folds of Honor: Scholarships for families of fallen or wounded service members and first responders.
  • National Safe Place: QT stores serve as Safe Place locations for youth in crisis, with trained staff ready to assist.

The Josh Turner Scholarship Fund for the Arts, established by the Community Foundation of Middle Tennessee, empowers high school seniors from rural areas across ten southern states to pursue careers in music and the arts. This fund honors Josh Turner's journey in the music industry and aims to support students focusing on diverse opportunities within the music business, including performance, writing, and production, as well as various art disciplines.

The Edward T. Bedford Foundation, established in 1994, focuses on supporting charitable endeavors for children and young adults. The foundation primarily funds tax-exempt organizations that promote educational, athletic, and artistic initiatives. Grant applications are accepted on a rolling basis and are typically decided within 90 days. Nonprofit organizations exempt under IRS 501(c)(3) are eligible to apply, making it a vital resource for community-focused programs.

The Big Bets Fellowship: Economic Opportunity in the United States is a transformative 4-month program designed to empower emerging leaders to tackle economic challenges head-on. With a focus on innovative solutions for job creation, affordable housing, and equitable access to resources, the fellowship equips participants with essential skills and a supportive network. The initiative aims to drive systemic change and promote sustainable economic prosperity, addressing inequalities while fostering resilient communities across the nation.

The Professional Development and Artistic Planning Grants, offered by South Arts, support the professional growth of presenters, programmers, and curators in the Southern U.S. These grants facilitate travel to conferences, workshops, and other opportunities to enhance organizational capacity and program design. Emphasizing diversity and inclusion, South Arts encourages applications from organizations led by BIPOC, LGBTQIA+, and disabled individuals. Funding covers travel, training, and related expenses, promoting equitable access to professional development.

The Connected Healthy Lives Grant, provided by the Humana Foundation, aims to enhance health equity by removing social barriers to health. It supports community organizations in delivering essential services such as suicide prevention and nutritional literacy. The grant focuses on fostering emotional connections and lifelong wellness through collaboration across various states, ensuring that all individuals have access to healthy choices that can improve their quality of life.

The Vulcan Materials Company Foundation Grant focuses on enhancing community quality of life through education, environmental stewardship, and employee involvement. Established in 1988, the Foundation supports public charities and government units, prioritizing proposals that improve public education and promote sustainable practices. Special consideration is given to initiatives that engage Vulcan employees and integrate multiple focus areas, ensuring a positive impact in the local communities where Vulcan operates.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CRRP 

Through the competitive Collaborative Regional Research Programme (CRRP), we promote regional research that has potential to improve our understanding of global change and its implications while contributing to a sound scientific basis for policymaking in areas affected by global change. Under this pillar, APN supports collaborative research that contributes to the evolving science-policy arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction and the UN Decade of Ocean Science as well as ongoing and new global change and sustainability research programmes.

Activities of interest under the CRRP Programme

APN promotes regional collaborative research that improves understanding of the physical, biological and human dimensions of change in the Earth system and advances actionable science that informs decision-making. APN accepts proposals that engage at least 3 member/approved countries in the region, and prioritise collaboratively designed, actionable research with non-academic stakeholders. Proposals must address one or more of the following activities:

• Collaborative research on global change and sustainability that particularly addresses GAPS, ANALYSIS, SYNTHESIS and ASSESSMENT work.
• Collaborative research that develops PATHWAYS and MECHANISMS to achieve sustainable development, and develop adaptation strategies.
• Collaborative PLACE-BASED INTEGRATIVE RESEARCH, particularly from developing countries.
• Collaborative research that is CO-DESIGNED to contribute to the Paris Agreeemnt, Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, Post-2020 Global Biodiversity Framework, UN Decade of Ocean Science (2021-2030), and the accumulation of scientific knowledge at IPCC, IPBES, etc.

The Health Equity Innovation Fund, managed by the Humana Foundation, provides seed funding to organizations aimed at reducing health disparities. By focusing on innovative solutions, the Fund supports interventions that improve emotional health and nutrition for underserved populations. Launched in October 2022, it prioritizes high-risk, high-reward projects that can lead to sustainable improvements in health equity across diverse communities.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation focuses on supporting nonprofit organizations within specific states. They prioritize initiatives that enhance community welfare, especially in agriculture, education, health, and environmental sustainability. Organizations must have 501(c)(3) status to apply, and preference is given to those involving Perdue associates. Ineligible requests include those from religious, political, or individual-focused groups. This program emphasizes broad community benefits over organizational affiliations.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

The Frank L. Weyenberg Charitable Trust provides grants to organizations engaged in charitable, educational, scientific, literary, and religious activities. Established by Frank L. Weyenberg, a successful businessman from Wisconsin, the trust focuses on supporting causes primarily in Milwaukee and Palm Beach. Eligible organizations must be 501(c)(3) exempt, while grants are not available for political purposes or discriminatory practices. The trust continues Mr. Weyenberg's legacy of generosity, benefiting communities for years to come.

The James M. Cox Foundation Grant offers support to nonprofit organizations focused on conservation, early childhood education, family empowerment, and health. Organizations must be 501(c)(3) tax-exempt and located in areas where Cox Enterprises operates. Grant applications are accepted year-round, with deadlines before Trustee meetings. Preference is given to organizations with a history of local engagement. This foundation embodies the philanthropic spirit of its founder, James M. Cox, by giving back to the community.

About FDOT

The Florida Department of Transportation (FDOT) is an executive agency and directly reports to Governor Ron DeSantis. FDOT’s continuing mission is to provide a safe statewide transportation system that promotes the efficient movement of people and goods, supports the state’s economic competitiveness, prioritizes Florida’s environment and natural resources, and preserves the quality of life and connectedness of the state’s communities. This mission is accomplished through a primary purpose to plan and develop (either directly or indirectly) Florida’s robust transportation system. The unique nature of the Sunshine State and its year-round warm climate provides numerous opportunities to move people and goods through multiple modes including highways/streets, air, rail, sea, spaceports, transit, and ever-expanding deployment of bicycle & pedestrian facilities.

The department is committed to building a transportation system that not only fits the current needs of Florida’s residents and visitors but also enhances mobility throughout the state to accommodate its consistent and rapid growth. FDOT is proud to recruit and retain some of the best and brightest professionals in the transportation industry who consistently help the department inspire innovation and improve safety for all of our transportation modes.

Florida Highway Beautification Grant Program

Thank you for your interest in the FDOT Beautification Grants. Grant funds are allocated by the legislature and budgets are approved by July 1 of each year.

It is available to State of Florida local governmental entities interested in providing landscaping and irrigation along State transportation facilities.

All completed applications received by Thursday, October 1, 2026 will be checked for completeness, assembled, and distributed to a panel selected by the Grant Coordinators. A virtual public meeting to discuss all received applications will be scheduled once applications are received.

Each panelist will independently rank each applicant prior to being combined into an overall ranked list of potential awards. Grants will be awarded in the order they appear on the ranked list and in accordance with available funding. Official notice of each grant award will be made by the Department by email to the Applicant named in the grant application.

To accept a grant, an Applicant must send a letter of acceptance by email to the Grant Coordinator within 15 days from the date of receipt of the offer of the award. Funds will be released by the Department when agreements are executed, the project is constructed as per plans approved by the Department, there is written final acceptance by the Department and receipts for grant expenses are reviewed and approved by the Department.

The XENO PRIZE for Performance Arts, awarded by Franklin Furnace, supports early-career LGBTQ+-identifying performance artists creating new work in 26 states with restrictive gender-affirming laws. This annual prize, established in 2023, offers $5000 to a selected recipient from proposals submitted for the Franklin Furnace FUND for Performance Art. The deadline for submissions is April 1, 2025, encouraging innovative voices in the contemporary performance art landscape.

The James E. Huffer and Betty J. Huffer Foundation aims to support non-profit organizations that enhance community welfare through educational, artistic, and humanitarian initiatives. The foundation prioritizes multidisciplinary efforts that demonstrate a strong commitment to regional service and impactful contributions. Focus areas include arts, environmental stewardship, health sciences, and youth education. Organizations must confirm tax-exempt status and provide financial documentation to be considered for funding.

The J. Bulow Campbell Foundation, established in 1940, focuses on grantmaking in Atlanta and Georgia, prioritizing capital projects in education, youth development, human services, public spaces, and cultural institutions. With a legacy of over $800 million awarded, the Foundation reflects the values of its founder, J. Bulow Campbell, emphasizing careful stewardship and Christian principles. While open to neighboring states, grants are generally restricted to tax-exempt institutions, excluding individuals and certain funding purposes.