Best Large Grants for Nonprofit Organizations in Kentucky

The Thalassemia Patient Incentive Award, sponsored by the Cooley’s Anemia Foundation, aims to support thalassemia patients in pursuing their educational and career aspirations. Awards ranging from $250 to $2,000 will be granted to students at various academic levels, with applications due in March 2026. This initiative not only encourages academic growth but also fosters a positive outlook among patients living with thalassemia, underscoring the Foundation's commitment to improving their quality of life.

The David Moses Bridges Scholarship honors the legacy of a renowned Passamaquoddy artist and activist, providing essential support for individuals dedicated to the preservation of Wabanaki culture, traditional arts, and environmental stewardship. This scholarship aims to foster connections between master artists and apprentices, promote research on David's impactful life and work, and protect culturally significant natural spaces. It empowers artists and scholars to continue the vital work of preserving indigenous knowledge and practices for future generations.

The Cancer-Related Behavioral Health Fund, established by the HealthWell Foundation, provides financial assistance to individuals diagnosed with cancer for behavioral health treatments. This fund covers costs associated with prescription drugs, counseling services, and transportation. Aiming to alleviate financial burdens, it ensures that underinsured patients can access necessary care without delay. In 2024, the foundation awarded over $1.2 billion, emphasizing its commitment to improving health outcomes for cancer patients across the United States.

The Educational Incentive Award Application by the Cooley’s Anemia Foundation aims to support children of individuals with severe thalassemia in pursuing their educational and career aspirations. With a total funding of $10,000 for the 2025-2026 school year, awards range from $500 for two-year programs to $1,000 for higher degree studies. Eligible applicants must be diagnosed with specific thalassemia types and provide necessary documentation, including a 250-word essay detailing their educational goals.

The 2026 National Urban and Community Forestry Challenge Cost Share Grant Program aims to tackle economic, health, and environmental issues in communities through innovative tree resource utilization. By transforming wood from various sources into valuable products like lumber and biochar, this initiative promotes local economies and enhances community resilience. Projects should align with community forestry plans, adhere to safety standards, and provide job creation opportunities, ultimately fostering sustainable urban forest management and utilization.

The Ethel Strickarz Memorial Scholarship aims to address community needs through educational support in special education and related fields. Funded by the Community Foundation of Elmira-Corning and the Finger Lakes, it encourages students pursuing careers in human services, nursing, psychology, speech pathology, or therapy. This scholarship reflects a commitment to holistic community development by fostering future professionals dedicated to improving lives and addressing urgent societal challenges.

Tree Research and Education Endowment Fund (TREE Fund)

TREE Fund is a 501(c)3 nonprofit whose mission is to support scientific discovery and dissemination of new knowledge and best practices in the fields of arboriculture and urban forestry.

TREE Fund’s research and education programs shape industry best practices, improve workforce safety and contribute to the long-term sustainability of our communities in the following crucial ways:

• Improving the quality of nursery grown trees and overall tree survival through the development of hardier, drought- and disease-resistant species.
• Stopping diseases and pests while reducing pesticide use with the evolution of integrated pest management programs.
• Enhancing public and workforce safety with advanced tree risk assessment techniques and greater knowledge about why and how trees fail.
• Quantifying the benefits of trees which makes it easier for governments and businesses to project their return on tree care investment.
• Revolutionizing global best practices for growing strong, healthy landscape trees.
• Connecting youth with nature to promote environmental stewardship in the next generation and inspire them to consider careers in green industries.

Lucas Tree Experts Integrated Vegetation Management Endowed Research Fund

Since 1926, John Lucas Tree Expert Co. has worked with investor-owned utilities, electric cooperatives, municipalities, railroads, and pipeline customers throughout the United States and Canada. Innovation has always been a core value, and Lucas remains committed to innovation that makes the industry safer, greener, and more efficient. The Lucas Tree Experts Integrated Vegetation Management Endowed Research Fund is a new endowment fund of Tree Research and Education Endowment (TREE) Fund created to support research in Integrated Vegetation Management in the United States and Canada.

This fund program was created in 2026 to help celebrate Lucas Tree’s 100th anniversary. Lucas Tree’s anniversary marks a century of innovation, safety, and stewardship in utility vegetation management.

Projects are expected to be completed within one to three years. No project may receive more than one award from this program.

Application Requirements can be found here.

The Park Foundation Grants: Media support public interest media that raises awareness of critical environmental and social issues. They prioritize funding for investigative journalism, media policy, public broadcasting, and documentary films to promote a better-informed citizenry. Eligible organizations must be 501(c)(3) certified, and funding is aimed at projects that ensure diverse perspectives and community engagement. The foundation is committed to fostering a robust democracy and independent media, reflecting its mission to advance a just and sustainable society.

The Dean John A. Knauss Marine Policy Fellowship offers a unique opportunity for early career professionals to engage in marine and Great Lakes science and policy within the U.S. government. This one-year, paid fellowship encourages graduate students from accredited programs to explore impactful coastal resource issues. Interested applicants should connect with their local Sea Grant program or the National Sea Grant Office for guidance, especially if they are from Massachusetts, to ensure a competitive application.

The Harris and Frances Block Foundation, established in 2001, supports small grassroots organizations focused on social and environmental justice. They prioritize equitable solutions and sustainable community development, funding initiatives related to environmental education, justice, and food security. Grants are available to non-profit, tax-exempt organizations in specific geographical areas including Vermont, North Carolina, Virginia, and New York City, excluding funding for lobbying, land acquisition, and scholarships.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Healthcare Access Initiative

The Healthcare Access Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to expand access to essential healthcare services for uninsured and medically underserved individuals. Free and charitable clinics and pharmacies play a critical role in ensuring that patients who fall outside traditional healthcare systems can receive timely, high-quality care. However, many clinics face barriers related to staffing, care coordination, technology, and patient outreach that limit their ability to meet growing community needs. Through this initiative, NAFC will provide $20,000 grants to member clinics and pharmacies to strengthen programs that increase access to primary care, specialty services, and preventive care. Funding will support innovative and practical approaches that reduce barriers to care, improve patient engagement, and expand the capacity of clinics to serve vulnerable populations.

The National Girls and Women in Sports (NAGWS) Legacy Award, established by SHAPE America, honors exemplary contributions to increasing opportunities for women in sports. This annual award recognizes current SHAPE America members who submit impactful proposals related to women's sports, with a monetary prize of $1000. The award will be presented at the National Convention & Exposition, with a special deadline of November 1st. Nominations can include various initiatives aimed at empowering women in sports.

The Mosaic Company Foundation Community Investment Grant aims to create a lasting impact in communities by supporting initiatives in three key areas: Food, Water, and Local Community. With an annual investment of approximately $12 million, the foundation addresses food security, promotes water conservation, and enhances community sustainability. Eligible applicants must be recognized charitable organizations, primarily in North America, committed to improving quality of life through innovative solutions and partnerships.

This funding opportunity aims to support urgent research evaluating policies that impact health behaviors related to obesity. It is designed for studies that can only be performed with expedited review due to the time-sensitive nature of the research. Applications must demonstrate a compelling need for immediate funding to explore new policies or programs affecting dietary habits and physical activity, with the expectation that successful proposals will receive funding within four months.

Joseph G Markoly Foundation Inc

When Joseph Markoly originally established the foundation more than thirty years ago, its focus was on Alzheimer’s and heart disease support, funded through a number of the larger national disease-related organizations. Over time the focus has shifted to helping small to mid-size organizations in our local communities which support children and seniors in a variety of effective ways. 

Markoly Foundation was established in honor of Joseph G. Markoly, an entrepreneur and philanthropist who wanted to make a positive impact in people’s lives. Joseph’s family was affected directly by both Alzheimer’s and heart disease having lost a family member to each condition. For that reason, the foundation dedicates a majority of their resources to providing grants to organizations that focus on the treatment of each of these diseases. In addition, Markoly Foundation supports a variety of programs dedicated to helping children and seniors by providing services, supplies, programs and research in areas impacting these demographics.

Joseph G. Markoly Foundation Grant Support for Elder Organizations

The Markoly Foundation takes pride in supporting local organizations that provide services for elders in our community. Seniors face a number of challenges that come with aging, especially when they don’t have loved ones who are able to assist them with their needs. We provide grants for a variety of senior-related programs from Caregiver Education and Support to Emergency Meal Delivery and Transportation Services.

We are dedicated to providing funding for local nonprofit programs that improve the quality of life for all, but particularly for the children and elders in our community.

The NALMS Achievement Awards: Secchi Disk Award recognizes outstanding contributions to lake management by its members. NALMS aims to unite citizens, scientists, and professionals to ensure the protection and management of lakes and reservoirs. This prestigious award is open to NALMS members, with nominations encouraged from any individual or entity. However, current board and committee members are ineligible. The award celebrates those who significantly advance NALMS's goals and objectives in fostering lake ecosystem awareness and management.

The AAAP Foundation: Poultry Scholarship supports students pursuing careers in poultry health and food safety in North America. Offered by the American Association of Avian Pathologists, the scholarship aims to enhance scientific knowledge and promote the well-being of poultry. Eligible candidates must be enrolled in accredited veterinary colleges or universities with relevant programs. Scholarships may reach up to $1,500, with undergraduate awards capped at $500, fostering the next generation of poultry medicine professionals.

The Tribal Colleges Extension Program Special Emphasis (TCEP-SE) aims to enhance community engagement through pilot projects at 1994 Institutions, targeting issues like agricultural productivity, food systems, and public health. This program is open to a wide range of Tribal colleges and universities, promoting workforce development and youth involvement in agriculture. By addressing local needs, TCEP-SE fosters community vitality and prepares the next generation of Tribal agriculture leaders.

Headstream Accelerator 2026

Accelerator Application Cohort VI

The Headstream Accelerator supports entrepreneurs from all backgrounds in scaling digital solutions that improve the mental well-being of teens at risk, with a focus on the education and healthcare sectors. Our four-month, virtual-first program is designed for early-stage innovators, helping them strengthen their business models, refine their value propositions, and build the foundation for sustainable growth and meaningful impact.

Benefits:

• $30,000 non-dilutive stipend 
• Partnership with youth from Headsteam’s Youth Co-Creator Club to gain insights on cultural relevance, age-appropriateness, and user experience, ensuring your solutions resonate deeply and effectively with the next generation 
• Access to a network of expert advisors, connect with a community of founders, and engage with potential investors and capital providers 
• Access to one-on-one and group coaching sessions with our partner, FounderWell

Participant Expectations:

• Attend all activities, including virtual cohort and youth co-creation sessions, advisor calls, and an in-person kickoff event from July 28–30, 2026
• Commit 2–5 hours weekly during the program, including virtual sessions, advisor network office hours, guide calls, and more
• Embed youth voices throughout your product development

The Jim Flynn Outstanding Corporation Award, presented annually by NALMS, honors the corporation that has made significant contributions to advancing lake management goals. This award emphasizes the importance of facilitating information exchange, promoting public awareness of lake ecosystems, and supporting management programs at all levels. Eligible nominations can come from any individual or entity, focusing on achievements in lake and reservoir management. Notably, current NALMS board members and awards committee members are excluded from eligibility.

The Rural Opioid Technical Assistance Centers program aims to provide essential training and technical assistance to combat opioid and stimulant misuse in rural areas. With 10 Regional Centers and a National Coordinating Office, the initiative focuses on high-quality prevention, treatment, and recovery support services for substance use disorders. This program anticipates awarding 11 new grants to enhance community health and safety in addressing polysubstance use challenges.

The Opioid Crisis Response Program Fellowship, offered by Equal Justice Works, addresses the opioid epidemic by mobilizing public interest lawyers to provide vital civil legal aid to underserved communities affected by Opioid Use Disorder. This two-year fellowship enables attorney fellows to advocate for clients' rights, reduce barriers to treatment, and enhance community education about legal impacts. Through collaboration with various stakeholders, the program aims to improve health outcomes and foster systemic change in the fight against this public health crisis.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Clinical Trial

$200,000 over 3 years

• PI must hold an academic appointment at the Assistant Professor level or higher
• Preclinical studies must be complete
• If an FDA Investigational New Drug (IND) application is necessary for the proposed clinical study, the IND application should already have passed FDA initial review and be active
• If the PI has recruited additional patient enrollment sites, local IRB approval must be obtained for each site.

• How many treatment options would this study provide for children?
• How accessible is this study for children and families to access?

Hungry for Music

The Hungry for Music story began in 1992, when Founder and Director Jeff Campbell (in photo) organized a street musician concert to benefit the homeless. Within three years, he formed a 501(c)(3) nonprofit organization, dedicated to expanding opportunities in music for children.

Since then, Hungry for Music has placed more than 27,000 instruments into the hands of aspiring musicians. Children whose trajectory has been altered by the uplifting and life-changing gift of music.

We've delivered everything from guitars and trombones to violins and xylophones to kids in 50 states and 35 countries.

We collect and redistribute more than 2,000 instruments annually and, in our 31-year journey, we've become a full-time force for good in the musical community.

Request an Instrument

Hungry for Music collects and distributes instruments including brass, woodwinds, strings, electric keyboards, drums and other percussion, as well as amps and accessories.

Who Hungry for Music Helps

• Music teachers at Title One schools who identify children who cannot participate because of lack of funding.
• Music directors at innovative after-school music programs.
• Social workers who have young clients who would benefit from music therapy.

We only accept requests from public school music teachers, administrators, after-school/summer music program directors, and social workers. 

In our history, we have supported music programs in 40 different countries through stateside sponsors (i.e. business, school, church). We do not accept requests directly from international programs.

After-School & Summer Programs

Hungry for Music supports more than three dozen after-school/summer music programs annually across the United States. To be added to our distribution, a site visit is required.

The Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use initiative aims to enhance prevention services for infectious diseases among people who use drugs (PWUD). It encompasses two components: a biennial survey to assess service gaps and capacity, and increased support for testing and treatment services. The initiative seeks to improve data utilization in service provision, ultimately increasing testing for HBV, HCV, and HIV, and ensuring more PWUD engage in treatment and care.

Tee It Up for the Troops Grant supports 501(c)3 organizations that aid military personnel and their families. Prioritizing employment, family support, housing, PTSD treatment, sports rehabilitation, and suicide prevention, the grant aims to enhance the lives of veterans. Organizations that do not engage in fundraising events are eligible for funding. This initiative seeks to create a positive impact within the military community through various support pillars.

The Quadratec Cares 'Energize The Environment' Grant Program is dedicated to supporting individuals and organizations in the U.S. focused on environmental improvement. With two grants of $3,500 awarded annually, the program encourages initiatives like trail restoration and community educational projects. This grant aims to empower passionate individuals to enhance environmental awareness and stewardship, ensuring a healthier planet for future generations.