Best Large Grants for Nonprofit Organizations in Minnesota

The James Ledwith Memorial Scholarship Fund, established in 2011 by the Albuquerque Community Foundation, supports high school graduates from the Albuquerque Metro Area who have faced extraordinary challenges. This scholarship awards up to $2,000 to those pursuing post-secondary education while demonstrating hope, faith, and courage. Applicants must submit letters of reference and a personal essay outlining their life dreams and challenges. One to two scholarships are awarded annually, promoting resilience and personal growth in the face of adversity.

Democracy Grant Program 

Our Democracy Grant Program will consider proposals that address one or more of the following:

• Organizing across issues (e.g., economic justice, climate justice) that builds power and strengthens democratic participation and/or works to improve the material conditions of Minnesota communities
• Narrative infrastructure and storytelling that expands civic voice and dialogue toward an equitable democracy and a just Minnesota
• Infrastructure and institution building that expands our movement landscape, strengthens leaders and equips our changemaking ecosystem for lasting power-building

We understand this work of realizing and strengthening our democracy manifests across issues. We also understand that organizing leverages various strategies required to shape political agendas and social conditions for long-term change include strengthening narrative infrastructure, organizing resources, increasing democratic participation, and building new institutions.

Organizing that works to change the material conditions of communities will both fortify our civic infrastructure and strengthen the democratic participation of communities across the state. Efforts grounded in strong issue-based campaigns, the defense of democratic institutions, leadership development that brings new leaders into the fold, and an orientation of institution building all lay the groundwork for long-term change.

Funded work could include any of the following and more:

• Cross-issue organizing around topics of economic justice, public safety, environment/climate, LGBTQIA+ rights, racial justice, immigration, Indigenous governance and sovereignty, civic engagement working to improve the material conditions of Minnesota communities
• Organizing strategies that expand base-building and grow new constituencies to build a bigger “we”
• Organizing that builds narrative infrastructure and power to shape storytelling and expand civic discourse for a just Minnesota

Grant Details

Grant amounts will be $100,000 per year for a five-year grant period, for total grant amounts of $500,000 per grantee

In 2026, up to $2,000,000 is available for this grant program, and we anticipate awarding approximately 20 grants

The Jonathan Sherman Spradling Memorial Scholarship Fund, established in 2023, honors the legacy of Jonathan Sherman Spradling, a dedicated New Mexico resident committed to education and community service. This scholarship provides financial assistance to high school seniors who demonstrate a strong commitment to volunteerism. With a focus on applicants from Valencia County, NM, the fund aims to support students pursuing higher education at accredited institutions while encouraging continued involvement in community service.

The David R. Woodling Memorial Scholarship, established by The Stocker Foundation in 2007, supports students pursuing certificates or degrees in metals technology, focusing on machine tool technology and welding. Open to legal residents of New Mexico, eligible applicants include high school seniors and nontraditional students. The scholarship aims to provide financial assistance for tuition, fees, books, and required materials, ensuring that recipients can achieve their educational and career goals in this vital field.

The Pederson Nursing Scholarship, awarded by the Minnesota Ovarian Cancer Alliance, provides $1,000 to support an oncology nurse at the University of Minnesota Fairview Hospital. This scholarship aims to enhance the education of nurses caring for women with ovarian cancer, improving their ability to provide quality care. Established in memory of Janet Pederson, who succumbed to ovarian cancer in 2015, this scholarship honors her legacy and commitment to healthcare.

 Cherokee Nation Nursing and Allied Health Scholarship

The Cherokee Nation Nursing and Allied Health Scholarship is to provide financial assistance to Cherokee Nation citizens pursuing college degrees in nursing and health care fields to support their readiness to contribute to and grow within the Cherokee Nation reservation labor market. 

The James Knott Memorial Scholarship, established by the New Mexico Manufactured Housing Association, supports graduating high school seniors residing in manufactured homes. Awards of up to $1,000 are given annually to students with a minimum GPA of 3.0 who attend a nonprofit or public educational institution full-time. Applicants must provide proof of residency, a written statement of financial need, and a reference from a teacher or counselor. This scholarship aims to empower students to achieve their educational goals.

The Davis-Kozoll Scholarship, established in 2019 by the Sandia Foundation, supports students from northwest New Mexico pursuing higher education in science or human service disciplines. Scholarships range from $1,000 to $5,000 and can be renewed annually based on academic progress. Applicants must have a minimum GPA of 2.0, demonstrate community ties, and may pursue various degrees or vocational certificates. Priority is given to students from specific local communities, enhancing educational opportunities in the region.

Mission

To empower worthy nonprofits by providing critically needed, unrestricted funding that helps them fulfill their missions with confidence and sustainability.

How We Serve Nonprofits

AmFund partners with nearly 800 organizations annually—supporting causes related to health, education, the arts, human services, animal welfare, and more. We’re known for our:

• Signature silent and live auctions featuring once-in-a-lifetime travel experiences.
• National reach with personalized service at events in all 50 states.
• Comprehensive marketing toolkits, onsite staff support, and beautifully displayed materials
• No-cost platform development for virtual and hybrid fundraising
• In-house travel specialists who provide custom planning, extensions, insurance, and 24/7 emergency support.
• Ongoing educational resources, grants, and consulting support for nonprofit development.

Request Support

Our model is built on relationship, trust, and results. Every trip sold, every service provided, and every donor interaction is designed to maximize your fundraising impact—without adding burden to your team.

Shawnee Fine Arts Club Scholarship

Provides a scholarship to graduating seniors of Shawnee High School, Liberty Academy, or home-schooled residents of Shawnee, Oklahoma with a minimum cumulative GPA of 2.7. Student must be accepted into the university of their choice, majoring in music, visual arts, dance, or drama.

The Conservation Alliance Grants program is currently under evaluation, leading to a pause in the member-directed grant cycle as the organization aligns its funding with its strategic plan launching in 2025. This initiative aims to harness the collective efforts of businesses and outdoor communities to protect North America's wild places through impactful and efficient grant-making. Future funding will focus on projects that enhance habitat, support Indigenous initiatives, and address climate change.

Mary Joan Keeney Scholarship

The Mary Joan Keeney Scholarship was established in 2017 to honor the memory of Joan Keeney and her dedication to continuing education. In 1992, at the age of fifty-nine, she attended Denver Seminary in Denver, Colorado and completed a life-long dream of earning a Master’s in Counseling. Upon graduation, she volunteered as a grief and bereavement counselor at The First Presbyterian Church in Boulder, Colorado. Her life passion was helping others heal and return to love.

The purpose of this scholarship is to provide non-traditional, female students interested in nursing and mental health careers access to funds to help further their education and/or certification. In 2026, two one-time scholarship awards of $5,000 each will be offered.

The ECMC Foundation focuses on eliminating equity gaps in postsecondary education by 2040 through strategic grantmaking and investments. They support organizations aiming to remove barriers to completion, build institutional capacity, and transform the postsecondary ecosystem. Eligible entities include nonprofit organizations, government entities, and postsecondary institutions. However, funding is not available for personal scholarships, political activities, or projects outside the U.S. that do not align with the Foundation's mission of diversity and inclusion.

The DGF Bridge Grants provide essential financial support of $500 to professional dramatists facing hardships. This one-time award helps cover non-emergency daily expenses such as housing, utilities, and healthcare. Eligible applicants must be U.S.-based dramatists with limited financial resources and have not previously received a DGF Bridge Grant. By nurturing today's creators, DGF ensures the continuation of impactful storytelling in the theater community.

Homecare Assistance Grant

MS Focus understands the daily needs and challenges that must be met by both those with MS and their caregivers. In order to meet these needs in the most timely and efficient way possible, our Homecare Assistance Grant connects you to the best available local services. Should resources within your community not be available, direct support may be provided on a temporary basis.

Available Services include:

• Home Care - Personal hygiene services, light housekeeping, grocery shopping, meal preparation, and transportation to and from appointments are all services that can be provided for a limited time.
• Therapy Visits - Based upon individual need, an appointment with an occupational, physical, or speech therapist can be arranged. Through education and training, these therapists can help to foster independence, self-esteem, and better quality of life for the person living with MS.
• Respite Care - Respite allows primary caregivers the opportunity to tend to themselves, or other family business, with the assurance that their loved one is being cared for by a properly trained individual. This service is provided on a short-term basis for a scheduled period of time. 
• Coming Home - Returning home from a stay at the hospital can be a difficult time of transition. We offer a four-hour visit from an aide who will meet the patient at the hospital, provide transportation home, and then get the patient settled comfortably at home.

Scholarships

Grand Haven Area Community Foundation scholarships are awarded competitively based on criteria set by donors. These criteria could include financial need, the school the applicant is attending, academic achievement, as well as personal or career goals. The Community Foundation has a rigorous internal selection process for each scholarship decision, and each applicant is reviewed in depth, and considered thoroughly.

Our scholarship program is simple. You are able to apply once for all foundation scholarships you may be eligible for. Once your application is submitted, you will be eligible for all those for which you meet the requirement.

Allendale Community Foundation Scholarship

This scholarship was established by the Allendale Community Foundation and Allendale Charter Township as a way to support a graduate residing in Allendale Charter Township who wishes to pursue a post-secondary education.

The Clifford and Rubye Angleton Scholarship Fund, managed by the Central Kansas Community Foundation, supports graduating high school seniors and college students from Butler County, Kansas, pursuing higher education. Scholarships are based on available funds and applicants' merit. Recipients may renew their scholarships for up to three years with satisfactory academic progress. This initiative emphasizes the importance of rural philanthropy and aims to empower local students to achieve their educational goals.

Mount Sinai Community Foundation Grant

Our Mission

The Mount Sinai Community Foundation is a collective giving circle whose members come together to support initiatives that improve health, enhance well-being, or otherwise advance medical care in the Jewish and larger communities, honoring the history and legacy of the Mount Sinai Hospital.

MSCF seeks to fund innovative grant proposals from 501(c)(3) nonprofit organizations for one-time grants up to $10,000 that fulfill MSCF’s mission to improve health, enhance well-being, or otherwise advance medical care for Minnesota residents. 

Through the generosity of the Frances & Samuel Finkelstein/Janice Finkelstein Mattison Memorial Fund, one of the grantees may receive funding in the area of: cancer research and education; mental health or cancer treatment; medical ethics and quality assurance; or patient advocacy programs.

Funding Priorities

• MSCF seeks to fund innovative programs and/or essential equipment that have a meaningful, direct, and high impact on the target population.
• MSCF is especially interested in discrete projects that can be identified as MSCF funded efforts. These projects or items may be funded by MSCF funds alone or with a limited number of other funding partners.
• Applicants with unique grant requests who may be unable to secure funding elsewhere are encouraged to apply.
• Funding sought for information technology or equipment and/or software upgrades will not be considered unless they are integral to the delivery of the health or medical services provided.
• Grant requests where MSCF grant dollars are only a small component of the overall project budget are unlikely to be funded.
• Through the generosity of the Frances & Samuel Finkelstein/Janice Finkelstein Mattison Memorial Fund, one of the grants may receive funding for cancer research or education; medical ethics/patient advocacy programs; or treatment for children, seniors, disabled, or the homeless.

The Colin and Sally Rowell Memorial Scholarship Fund, managed by the Central Kansas Community Foundation, offers financial assistance to graduating seniors from Butler County, KS high schools pursuing higher education or vocational training. This scholarship aims to support students with a demonstrated interest in education or agriculture, emphasizing financial need and potential for success in college. It reflects the foundation's mission to strengthen communities through charitable giving, promoting rural philanthropy in the central Kansas region.

Native Voices Rising (NVR) offers grants to empower Native-led grassroots organizations in the U.S. With over $16 million awarded since inception, NVR focuses on enhancing lives through collective action and advocacy. Eligible organizations must be Native-led and engage community members in policy improvement efforts. NVR supports initiatives addressing environmental justice, health, and youth involvement, with a commitment to fostering leadership and social change within Native communities.

The MyGOAL Autism Grant Program provides essential financial support for families caring for individuals with Autism Spectrum Disorders. This need-based grant assists with non-reimbursable medical expenses, nutritional needs, personal care, and educational enrichment activities. With a funding amount of $1000, the program prioritizes first-time applicants and aims to enhance the well-being and development of children with ASD, addressing gaps left by other funding sources.

The Rod's Tire and Service Scholarship Fund, managed by the Central Kansas Community Foundation, offers $2,500 to assist graduating Marion County high school seniors pursuing higher education or vocational training. The foundation, established in 1994, focuses on enhancing community welfare through charitable giving and emphasizes support for students majoring in agricultural fields. This scholarship aims to empower local youth and strengthen the community by investing in their educational futures.

The Dr. Gary King Sharp Memorial Scholarship, offered by the Central Kentucky Community Foundation, aims to support students with a cumulative GPA of 2.5 or higher. Priority is given to those connected with Hospice services or in the foster care system, and to first-generation college students. This scholarship serves as a vital resource to empower students in their educational pursuits and enhance community life.

Cures Within Reach

Cures Within Reach is the philanthropic leader in drug, device and nutraceutical repurposing research, which has the potential to transform the lives of patients with unsolved diseases by delivering treatments that can be used in the near-term. Our focus: we find and fund proof-of-concept clinical trials that, once successful, de-risk and catalyze follow-on funding, building the clinical evidence required for regulatory approval or to support off-label use by patients everywhere.

Clinical Repurposing Research to Impact US Veterans/Military

This Request for Proposals (RFP) from Cures Within Reach (CWR) is seeking clinical repurposing trials from US-based research institutions using already approved treatments to address unmet and high-priority medical needs of US veterans and/or active US military, such as mental health, post-traumatic stress disorder (PTSD) and brain injuries. Our strongest preference is for proof of concept, pivotal, Phase I or Phase IIA clinical repurposing trials. Eligible trials may be conducted at accredited US-based academic, nonprofit and governmental research institutions and/or health systems involved with medical research, including Veterans Administration (VA) health systems and hospitals. 

Repurposed therapies must be approved and/or generally recognized as safe for human use by some regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and may include drugs, devices, nutraceuticals or diagnostics, as well as combination therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care to improve patient outcomes and/or quality of life.

The Hennepin County Youth Activities Grants program provides funding to enhance youth accessibility to arts, music, sports, and safety initiatives. With grants up to $25,000 available, the program supports local governments in offering free swim lessons, sports equipment, and art education. Since 2009, over $31.2 million has been awarded to foster creativity and physical activity among youth in Hennepin County, benefiting the community and enriching the lives of its young residents.

Homeless response system (Super) Grant

The County of Hennepin, State of Minnesota (“County”) is soliciting proposals for prevention and supportive housing for youth (age 16 to 24), and crisis response services for both youth and adult populations. Services are solicited on behalf of the County’s Office of Housing Stability.  

Historically, the County solicited separate proposals for different funding sources as the funding became available, which sometimes resulted in multiple proposal submissions per organization at different times. This RFP is focused service alignment via one proposal submission process, resulting in contract terms that also cycle consistently.   

This RFP has multiple funding sources, including state, federal, County property tax, County and city of Minneapolis Local Affordable Housing Aid, and the City of Minneapolis Emergency Solutions Grant. The total maximum funding assigned to this RFP is $37 million.  Proposal submissions that include other funding sources to support proposed services may be prioritized. The County anticipates awarding multiple contracts, each for a three-year duration commencing on January 1, 2027.

The total maximum funding assigned to this RFP is $37 million. A maximum of $3 million of this total will fund youth prevention, youth supportive housing, and crisis response services provided to youth and young adults age 16 to 24. The remaining will fund crisis services provided to adults aged 18 and older. (The County issued an RFP for family shelter operations during January 2026.) Proposals that include other funding sources to support proposed services may be prioritized.

The Hennepin County Youth Activities Grants - Equipment Grants program aims to enhance youth participation in sports and recreational activities by providing funding for purchasing sports equipment. Grants of up to $10,000 are available for eligible youth aged 18 and under. Since its inception in 2009, the program has awarded over $31.2 million, supported by proceeds from the Twins ballpark sales tax. The contract term for grants is expected to be from January 1, 2026, to December 31, 2026.