Best Unrestricted Grants for Nonprofits in Minnesota

The Minnesota Teacher of the Year Award honors outstanding educators who inspire students and elevate the teaching profession. Nominations for 2026 are now open, inviting communities to recognize exceptional teachers who embody dedication and excellence. The award will be presented on May 3, 2026, at the Saint Paul RiverCentre. This prestigious recognition not only celebrates local talent but also positions the winner as Minnesota’s representative for the National Teacher of the Year.

The MN State Arts Board's Cultural Expression Grant supports initiatives that celebrate, express, or explore culture through the arts. This program promotes both traditional and contemporary art forms, allowing funds for cultural festivals, performances, and apprenticeships. Eligible applicants can choose to apply for one of several programs, including Creative Individuals and Arts Education, fostering community engagement and preserving cultural heritage. This grant aims to enhance the vibrancy of cultural expressions in Minnesota.

The MNSAB Operating Support Grant Program offers vital funding to established arts organizations in Minnesota, enabling them to maintain operations and fulfill their missions. Grants, starting at $15,000, support organizations that produce, present, or exhibit art, as well as those providing services to artists and community arts education. The program emphasizes the importance of stability and ongoing programs, ensuring that organizations can thrive without needing to justify funding through new initiatives.

LSTA Literacy Grant FFY 2026 – State Fiscal Year 2027

Grant purpose

The Minnesota Department of Education makes this funding available to libraries as defined per Minnesota Statutes 2025, section 134.001, subdivision 2 for the purpose of helping to achieve Minnesota’s LSTA Five-Year Plan (2023-2027), Goals A, B, and C, to reduce barriers to access, promote equity, showcase libraries’ contributions to community, and empower Minnesota’s library workforce. Successful grant proposals will connect proposed project activities to improving access to services and information in areas of literacy.

While LSTA funds are primarily intended to support new projects that can serve as models or pilots, applications for new phases of a project that is underway may be submitted. Libraries may also apply for funding of an ongoing project if it reaches new audiences, incorporates new methods or significantly expands the reach of the project.

The National Board Certified Teachers Scholarship, funded by the Education Minnesota Foundation, aims to support K-12 educators pursuing National Board Certification. Each year, eligible Education Minnesota members can receive scholarships up to $1,000 to cover assessment fees. This initiative particularly encourages first-time applicants while also allowing those maintaining certification to apply. Scholarships are awarded annually, and recipients must provide proof of payment for the certification process to access their funds.

The Dr. Ralph and Marian Falk Medical Research Trust – Falk Catalyst Awards support high-risk, high-reward biomedical research with up to $350,000 in funding over one to two years. These awards aim to address critical scientific challenges and enable the translation of innovative research into clinical practices. Projects focus on identifying biological markers, therapeutic targets, and developing interventions to disrupt disease processes, ultimately improving treatment outcomes for patients.

The Will Rogers Motion Picture Pioneers Assistance Fund offers crucial financial support and counseling for individuals in the theatrical exhibition and distribution sectors facing health-related challenges. This fund assists with medical expenses, housing emergencies, and essential services like vocational rehabilitation and equipment aid. Eligible applicants must have a minimum of three years in exhibition or five years in distribution. The fund aims to provide a safety net for those impacted by illness, injury, or significant life changes.

The National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program invites applications to foster innovative research in treating mental disorders and substance use issues. This initiative promotes collaboration between academia and industry, supporting diverse, multidisciplinary projects aimed at developing rational therapies and neurostimulation techniques. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline to enhance project alignment with funding goals.

The NCDDG program supports innovative research aiming to discover and develop new treatments for mental disorders, including substance use and alcohol use disorders. This initiative encourages collaborations between academic and industry partners to advance neurostimulation techniques and drug/device development. Applicants are invited to submit proposals that focus on specific projects utilizing the U01 mechanism, with a clear emphasis on rationally designed candidate agents and cutting-edge technologies. Letters of Intent are encouraged 30 days prior to the submission deadline.

RFP: Improve Access to Medication for Opioid Use Disorder (MOUD)

The Minnesota Department of Human Services, through its Behavioral Health Administration (STATE), is seeking Proposals from qualified Responders to improve access to medication for opioid use disorder (MOUD) services throughout Minnesota. 

STATE received a State Opioid Response (SOR) grant from the Substance Abuse and Mental Health Administration (SAMHSA). The purpose of the SOR grant is to address the public health crisis caused by escalating opioid and stimulant use, Opioid Use Disorder (OUD), Stimulant Use Disorder, and opioid and stimulant-related morbidity and mortality across the nation. Minnesota has been awarded SOR funds since the grant program’s inception by SAMHSA in 2018. Multiple organizations and projects have been funded to support a continuum of care including prevention programming, treatment, MOUD, naloxone distribution, and recovery support services

Regenerative Medicine Minnesota

The mission of Regenerative Medicine Minnesota (RMM) is to bring breakthrough regenerative medicine therapies to Minnesotans and patients worldwide. Achieving this vision requires not only advancing novel therapies, but also the innovations, capabilities, collaborations and pathways that enable them to ultimately reach patients. Recognizing the need for a multi-pronged innovation strategy, RMM is calling for proposals that align with this vision through the 2027 Request for Proposals (RFP). By strategically investing across these areas, RMM aims to accelerate transformative regenerative medicine therapies, strengthen Minnesota's leadership in regenerative medicine and generate lasting health and economic benefits for Minnesotans.   

Regenerative Medicine Minnesota (RMM) RFP

This RFP is designed to solicit projects that are aligned with one or more of the following objectives:

• Advance novel regenerative medicine therapies and products towards clinical application. Proposed therapies or products should have a clearly defined target use, indication or disease area.
• Develop enabling innovations and platforms that improve the ability to discover, develop, manufacture, or deliver regenerative medicine therapies across multiple applications.
• Build sustainable capabilities and infrastructure that accelerate clinical translation and commercialization in Minnesota.
• Foster collaborations across institutions and sectors that strengthen Minnesota’s regenerative medicine ecosystem.
• Expand patient access to regenerative medicine therapies to benefit patients across Minnesota, including greater Minnesota.

Particular areas of interest for funding under this RFP include, but are not limited to:

• Platform-based approaches that can be applied to many diseases, particularly rare diseases, such as gene editing/replacement strategies, therapeutic approaches, delivery methods, manufacturing models, regulatory strategies, clinical trial designs, etc.
• Device-enabled regenerative medicine innovations such as biologic/cell-device combination therapeutics, biomanufacturing devices or tools, therapeutic delivery, etc.
• Strategies to improve immune compatibility and therapeutic durability, including promoting immune tolerance or reducing immune rejection.

MN Commercial Redevelopment Grants 

Commercial Redevelopment grants assist with the full and selective demolition of commercial and industrial buildings and the clean-up of brownfields to pave the way for new development. 

Full and selective demolition of commercial or industrial buildings and clean-up of brownfields. Abatement expenses are eligible and considered a component of the demolition project.

Funding Availability

• Funded at $1,000,000 for Fiscal Year 2026 from the Taconite Environmental Protection Fund.
• The number of grants awarded is variable and dependent upon the amount awarded to successful applicants.
• A 1:1 match per project is required.
• In-kind materials and/or labor are not eligible toward the project match.
• Applications should be submitted within nine months of the project construction start date.
• Multi-organization collaboration is welcomed.

The UNICO Foundation offers the Louise Torraco Memorial Scholarship for Science, providing two scholarships worth $2,500 each to U.S. citizens pursuing degrees in physical or life sciences. Eligible candidates must maintain a minimum GPA of 3.0 and be enrolled full-time in accredited programs. This initiative reflects UNICO's commitment to supporting educational pursuits in scientific fields while fostering Italian American heritage and community service.

The David M. Dolan Scholarship, offered by the International Association for Great Lakes Research, supports master's and Ph.D. students engaged in applied environmental statistics and modeling related to the Great Lakes. The scholarship provides a $3,000 award, complimentary conference registration, and IAGLR membership. Recipients must present their research at the annual IAGLR conference. Eligibility is limited to those whose research aligns with Dr. Dolan's work, and previous awardees are not eligible.

The Legal Services Advisory Committee (LSAC) Grant provides essential funding for legal services and alternative dispute resolution programs aimed at low-income clients across Minnesota. With support from state legislature appropriations and attorney fees, LSAC ensures access to legal support, serving nearly 50,000 clients annually. The FY24-25 cycle will focus on general operating grants in various categories, including staff legal services and private attorney involvement, thereby enhancing the availability of justice for vulnerable populations.

The Guglielmo Marconi Engineering Scholarship, offered by UNICO Foundation, provides $1,250 to students of Italian descent pursuing engineering degrees in various disciplines. Eligible candidates must be U.S. citizens, enrolled full-time in accredited programs, and maintain a GPA of at least 3.0. This scholarship not only supports academic achievement but also promotes the heritage and contributions of the Italian American community, continuing UNICO's legacy of service and support.

The HDR Foundation Grant Cycle supports community organizations aligned with HDR's values, focusing on education, healthy communities, and environmental stewardship. This employee-funded initiative emphasizes the importance of employee engagement in grant proposals, requiring a clear scope of work and completion within a year. Eligible applicants include U.S.-based nonprofits, educational institutions, and tribal governments, while grants are not provided for faith-based organizations or individual support.

The Virginia McKnight Binger Heart of Community Honor, presented by The McKnight Foundation, recognizes seven unsung champions from Minnesota for their remarkable contributions to local communities. Each honoree receives a $10,000 award in acknowledgment of their impactful work, fostering compassion and connectivity. This honor celebrates the legacy of Virginia McKnight Binger, emphasizing the importance of inclusivity, creativity, and community engagement in building a better future for all Minnesotans.

The Minnesota Department of Education is offering grants for remodeling, constructing, or repurposing gender-neutral single-user restrooms. This initiative supports safe and healthy school environments, aiming for improved accessibility and student health. Grant amounts can reach up to $150,000, with a maximum of $75,000 allocated per site. At least 80% of funds must be dedicated to restroom projects, while 20% may be used for engagement and implementation activities, ensuring a comprehensive approach to student safety.

The Medical Education and Research Cost (MERC) Grant Program supports clinical medical education in Minnesota, addressing funding challenges faced by teaching facilities. Established in 1996, the program allocates $59 million in the current fiscal year through a grant formula, with minimum awards starting at $5,000. Applications must be submitted by sponsoring institutions on behalf of clinical training sites, ensuring students gain essential clinical experience in diverse healthcare settings.

The Jeffris Heartland Fund Grant, provided by the Jeffris Family Foundation, supports significant historic preservation projects across several Midwestern states, including Iowa and Wisconsin. Grants range from $5,000 to $50,000, covering 50% of costs for Historic Structure Reports, requiring a dollar-for-dollar match. Eligible applicants include 501(c)(3) organizations and government agencies, focusing on projects with historical significance, architectural merit, and strong community ties. Applications are accepted anytime, with decisions made approximately 30 days after submission.

Project Lead The Way is offering a rolling grant for schools to implement the PLTW Biomedical Science program for the 2026-2029 academic years. Eligible schools can receive up to $14,000 to cover participation fees and training costs. This grant encourages public, private, and charter schools across the U.S. to enhance their science curriculum, supporting students with engaging, hands-on learning experiences. Schools must commit to offering specific courses during the grant period to qualify for funding.

The George Family Foundation focuses on Whole-Person Health and Wellbeing, emphasizing the importance of nurturing mind, body, spirit, and community. The foundation seeks to empower individuals and promote healthcare choice by funding community-based initiatives and select medical systems. Their funding priorities include enhancing access to whole-person care for diverse populations and supporting professional training programs for practitioners, particularly those from underrepresented communities.

The High Priority HIV and Substance Use Research funding opportunity aims to support innovative research that addresses the intersection of HIV and substance use. Researchers are encouraged to submit proposals that include a detailed research plan and preliminary data, exploring new avenues for prevention, treatment, and potential cures for HIV among people who use drugs. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.

The UNICO Foundation's Ralph J. Torraco Scholarship provides two scholarships of $2,500 each to students pursuing a degree. Open to all ethnicities, applicants must be U.S. citizens, attend an accredited college full-time, and maintain a minimum GPA of 3.0. They should continue their studies in the 2026-2027 academic year and may apply if sponsored by a UNICO chapter from specific states. This initiative underscores UNICO's commitment to supporting educational opportunities for deserving students.

Minnesota Department of Agriculture 

The Minnesota Department of Agriculture (MDA) has served our state for more than 125 years. The work we do touches every Minnesota citizen every day.

Our mission is to enhance all Minnesotans’ quality of life by equitably ensuring the integrity of our food supply, the health of our environment, and the strength and resilience of our agricultural economy.

Our three general areas of responsibility include:

• Protecting our food supply;
• Protecting our natural resources; and,
• Cultivating our agricultural economy.

Cream of the Crop Awards

The Minnesota Grown Cream of the Crop Awards recognizes school districts, early care centers, and family day cares that go above and beyond to promote foods grown and raised by Minnesota farmers and producers. Whether it’s through locally sourced meals served in your cafeteria, community events to connect families and farmers, or food focused classroom lessons, we want to celebrate all the creative ways you connect your students and kids to Minnesota Grown food!

Award Categories

1) Cream of the Crop Winners

One winner from each category will be selected. Scoring will be based on applicants’ promotion and procurement of Minnesota grown and raised foods during the 2025-2026school year.

• School District of the Year
• Early Care Center of the Year
• Family Day Care of the Year

2) Outstanding in the Field Honors

Additional applicants will be honored across three levels:

• Golden Drumstick Honorees
• Silver Squash Honorees
• Bronze Berry Honorees

3) Producer Appreciation Pick

Applicants will have the opportunity to nominate a Minnesota Grown producer that has been an outstanding partner in their Farm to Kids program. Reviewers will randomly select a nominated producer to be the 2026 Producer Appreciation Pick.

The Early-Career Artist Research & Development Grant supports Minnesota-based early-career artists engaged in public art research and development. This funding aims to amplify diverse artistic voices, particularly from BIPOC, LGBTQIA+, and rural communities. Grants of $2,500 each can be used for activities like planning and community dialogues related to public art projects. Applicants must demonstrate originality and reside in Minnesota, ensuring all projects are freely accessible to the community.