Best Large Grants for Nonprofit Organizations in Missouri

The CDBG: Economic Development Grant for Industrial Infrastructure aims to revitalize local economies by funding public infrastructure projects that support private job creation. Eligible projects include improvements to streets, water, and sewer lines, ensuring public ownership of facilities. This program prioritizes businesses offering above-average wages and medical benefits while also requiring that at least 51% of new jobs created are for low to moderate income individuals. Applications are accepted year-round.

The Menorah Heritage Foundation's Unrestricted Operating Support Cycle aims to provide vital operating support to organizations in the Greater Kansas City area. This funding is directed towards essential services such as emergency assistance, shelter, and health care, allowing grantees to allocate resources towards administrative needs and employee benefits. Eligible organizations must maintain 501(c)(3) status and demonstrate a commitment to the community's changing needs, ensuring impactful support for those in need.

The CDBG: Economic Development Grant for Downtown Revitalization supports eligible Missouri communities in revitalizing their downtown areas through facade improvements and infrastructure investments. This open, year-round grant program aims to eliminate slum and blight conditions and enhance economic opportunities by funding projects that create jobs and restore community vitality. Applications are accepted continuously until funding is exhausted, making it a vital resource for local development efforts.

The Hall Family Foundation Grant focuses on enhancing the quality of life in Kansas City by funding initiatives that elevate community spirit, promote equity, and create strong educational foundations. Prioritizing economic opportunities for marginalized communities, the foundation supports projects that foster inclusivity and holistic approaches to poverty reduction. With a commitment to innovative and collaborative efforts, the foundation aims to ensure that all community members can realize their potential and thrive.

The Dale Jr. Foundation, founded by NASCAR driver Dale Earnhardt Jr., has raised over $8 million since 2007 to support various charities focusing on youth and underprivileged communities. The foundation emphasizes empowerment, education, wellness, hunger relief, and hope, aiming to provide resources that enhance confidence and opportunities for children facing hardships. Through fundraising efforts and partnerships with organizations like Make-A-Wish, the foundation strives to positively impact lives and foster a sense of normalcy among children in need.

Project Lead The Way is offering a rolling grant opportunity for schools to implement the PLTW Engineering program for the 2025-2026 academic year and beyond. Eligible institutions include public, private, and charter schools located in the US. Grant recipients will receive funding to cover participation fees and training costs. Total funding amounts to $16,000, distributed over three years. Schools are encouraged to create pathways for students in engineering through this initiative.

The Missouri Humanities Council offers Mini Grants aimed at supporting humanities-based projects and programs. Eligible applicants include non-profit organizations and civic entities based in Missouri. The grants encourage engagement with humanities scholars, fostering community life through open exchanges of ideas. Funding may cover various expenses such as speaker fees, supplies, and promotional costs, aiming to expand understanding and participation in cultural activities. Special consideration is given to underserved communities and first-time applicants.

Cascades Donations and Sponsorships focuses on building sustainable partnerships in education, entrepreneurship, and amateur sports. They support community organizations, promote healthy lifestyles, and recognize student engagement through grants. Cascades prioritizes projects in its operational regions and encourages initiatives that address climate change and foster inclusivity. Their funding approach is rooted in creating lasting positive impacts and supporting the next generation of leaders while adhering to their values and philosophy.

The Missouri Humanities Council (MHC) offers Major Grants to support humanities-based projects and programs in Missouri. Founded in 1971, MHC aims to connect communities with humanities scholars, fostering a deeper understanding of cultural and civic life. Grants are available to non-profit and civic organizations, with applications reviewed bi-annually. Funding can cover various costs, but must not exceed 100% of project expenses. Accessibility and community engagement are key focus areas.

West Pharmaceutical Services, Inc. offers the WPS Community Support Grants & Sponsorships, emphasizing a culture of giving and community involvement. The program supports 501(c)3 organizations that address healthcare challenges and focus on children, disabled individuals, and STEM education. Through financial support and volunteerism, West aims to foster healthier communities where its employees live and work, reinforcing its commitment to philanthropy and social responsibility.

The Career Development Bridge Funding Award: K Supplement, offered by the Rheumatology Research Foundation, supports junior investigators transitioning to independent research. Awarded up to $50,000 annually for a maximum of two years, it supplements NIH K series or VA CDA awards. Eligible applicants must hold a doctoral degree and be in the second, third, or fourth year of their existing award. This funding is crucial for developing new projects that contribute to the field of rheumatology.

The Bernie Bahr Forestry and Natural Resources Scholarship, managed by the Community Foundation of the Ozarks, awards a $1,000 grant to undergraduate students pursuing a Bachelor’s degree in Forestry or related fields. Eligible applicants must have completed at least two years of college and maintain a minimum GPA of 2.5. Preference is given to graduates from specific high schools in Missouri. This scholarship aims to support students dedicated to environmental and natural resource management.

The Gloria Barron Wilderness Society Scholarship encourages graduate students to contribute to wilderness protection, honoring Gloria Barron's legacy. The Wilderness Society prioritizes projects addressing climate change and equitable access to public lands. Applicants must be enrolled in a U.S. graduate program, possess strong academic qualifications, and focus on long-term wilderness conservation. Research proposals on biodiversity, climate adaptation, and social-ecological contexts are particularly welcome, aiming for inclusive and impactful conservation efforts.

The Stenzel Scholarship, established in 2023, awards $2,500 annually to individuals with cystic fibrosis enrolled in higher education programs in health or environmental sciences. This scholarship honors Isa and Ana Stenzel, who dedicated their lives to supporting others with CF. Applicants must provide proof of enrollment and can receive funding based on their enrollment status. This initiative aims to empower those affected by cystic fibrosis to pursue meaningful educational opportunities.

What is Emergency Assistance Fund

Emergency Financial Assistance is available to eligible performing arts and entertainment professionals:

• In times of unexpected critical need.
• To assist towards basic living expenses, such as health care, housing and utilities to prevent eviction or shut-offs.

Hunter Brown Emergency Assistance Fund

The Hunter Brown Emergency Assistance Fund offers emergency financial assistance to current or former employees of Oregon Shakespeare Festival.

The Puffin Foundation's Environmental Artistic Activism Grant Program supports artists addressing environmental issues through diverse artistic genres such as film, music, and theater. Grants, typically around $1,750, fund projects that prioritize sustainability and innovative solutions to the climate crisis. Eligible applicants include U.S. citizens, permanent residents, and current DACA recipients. The foundation emphasizes projects that avoid contributing to environmental harm while fostering artistic expression and community engagement.

The Russell Sage Foundation's Core Research Grants support innovative research in Behavioral Science and Decision Making. This program emphasizes interdisciplinary approaches, inviting insights from economics, psychology, sociology, and law to enhance our understanding of decision-making processes across various societal contexts. Applications are open to scholars with a doctorate, focusing on critical issues such as policing, housing, and immigration, while encouraging a blend of theoretical and empirical research to inform public policy.

The Voelcker Fund Grant supports 501(c)(3) non-profit organizations conducting medical research, focusing on diseases like cancer and heart disease. It provides restricted grants, emphasizing research that seeks cures in the Greater Bexar County area, particularly for conditions affecting the retina. The fund prioritizes organizations in San Antonio and offers various funding structures, including seed and matching grants, while ensuring compliance with non-discrimination policies.

About the ASHFoundation

ASHFoundation supports innovators and sparks innovation in communication sciences. We give early support to promising students, researchers, and clinicians exploring bold ideas to transform the field and improve people's lives.

Artificial Intelligence in Communication Sciences and Disorders Research Grant

About

The American Speech-Language-Hearing Foundation (ASHFoundation) invites investigators to submit proposals for up to four research grants ranging from $25,000 to $50,000. The Artificial Intelligence in Communication Sciences and Disorders Research Grant (AI in CSD Research Grant) supports interdisciplinary studies that advance the ethical, clinically and scientifically grounded application and integration of artificial intelligence (AI) into communication sciences and disorders (CSD) practice and service delivery. Funding may be applied to one- or two-year studies.

Specific Objectives of the Funding Opportunity

As part of this initiative, the ASHFoundation invites proposals that implement AI technologies to transform clinical practice, education, and research in CSD. Proposals that are submitted under this funding opportunity must meet the following:

• Include interdisciplinary research teams that integrate clinicians and AI researchers,
• Address clinically relevant questions or have a clear translational potential, and
• Cover one or more of the following priority areas: AI-driven assessment and diagnosis; personalized and adaptive interventions; equitable access to care; data infrastructure for predictive analytics; technology innovation; prevention for public health; and ethical standards for AI integration.

The Residential Treatment for Pregnant and Postpartum Women program aims to deliver essential services to women facing substance use disorders. By offering comprehensive residential treatment options, the program supports both recovery and the well-being of mothers and their children. Funded by the Substance Abuse and Mental Health Services Administration, this initiative addresses the unique challenges of pregnant and postpartum women, ensuring they receive the care necessary for a successful recovery journey.

Bob's Discount Furniture Charitable Foundation supports non-profit organizations with resources rather than individual sponsorships. They require requests to be submitted on the letterhead of a qualified 501(c)(3) organization. This ensures that assistance reaches those in need through established channels. Interested parties should provide specific details regarding their requests to facilitate the application process. With a commitment to fairness, Bob's Cares aims to effectively support community initiatives across the country.

The Public Health Laboratory Fellowship Program, supported by the Association of Public Health Laboratories, develops future public health scientists through experiential learning in laboratory science. Participants receive training aligned with core competencies and work on impactful projects in various focus areas such as bioinformatics, food safety, and infectious disease. With flexible terms and potential for extension, this fellowship ensures a robust foundation for a career in public health laboratory science.

The Andrea-Mennen Family Foundation Grant aims to enhance the quality of life for children and young adults facing mental and physical challenges. By supporting registered charitable organizations that align with its mission, the foundation seeks to ensure that 100% of grant funds directly benefit those in need within the US. Emphasizing immediate results and proven success, the foundation is dedicated to making a positive impact in the lives of future generations.

The John A. Hartford Foundation offers scholarships for the Age-Friendly Health Systems Cohort as part of the AHA Next Generation Leaders Fellowship. This initiative targets healthcare leaders aiming to implement the 4Ms Framework, enhancing care for older adults. Selected fellows will receive a program fee scholarship of $13,995, enabling them to focus on transformation efforts in health systems. This fellowship seeks diverse leaders to address critical healthcare challenges and improve quality, safety, and affordability.

The ACFM General Support Program provides funding ranging from $2,000 to $20,000 for organizations committed to contemporary American concert music and jazz. It supports performing ensembles, presenters, and music service organizations that enhance public appreciation of these genres. Eligible applicants must have a minimum of two years of programming history and a professional operational level. Activities must occur within the specified support year of September 1, 2026, to August 31, 2027.

Community Action Fund

A grant for Indigenous frontline organizations, groups, and individuals for direct action initiatives.

The Community Action Fund (CAF) grants support non-violent direct actions and organizing efforts that are often urgent and time sensitive. CAF prioritizes frontline, grassroots and community-based efforts that defend Indigenous peoples rights, communities and Nations.

Community Action Fund Intent

This grant supports Indigenous frontline, grassroots, community-based groups and organizations, Tribes, communities and villages, and individuals leading non-violent direct action or movement-building work in their effort to DEFEND Indigenous People’s rights, and protect their land, air, water, and natural resources.

The Motorola Solutions Foundation Grant supports organizations that enhance safety and community well-being, focusing on underrepresented populations. With over $100 million in donations, the foundation prioritizes technology and engineering education, first responder programming, and blended initiatives. Eligible applicants must be registered 501(c)(3) organizations or school districts in the U.S. The foundation seeks partnerships that demonstrate strong financial health and data-driven evaluation methods, aiming to create safer cities and thriving communities.