Best Large Grants for Nonprofit Organizations in Missouri

The Joplin Regional Community Foundation Affiliate Grantmaking Program aims to enhance the quality of life in Joplin, Carl Junction, and Webb City by providing grants to 501(c)(3) organizations and IRS approved entities. Since its inception, the Foundation has distributed over $61 million, supporting various community initiatives and fostering collaboration. This program is dedicated to empowering local organizations to drive positive change and address community needs effectively.

The AMA Foundation's Physicians of Tomorrow Scholarship in Illinois offers $10,000 in tuition assistance to medical students nearing graduation. This prestigious program, established in 1950, has awarded over $61 million in scholarships, emphasizing diversity and support for underrepresented medical students. Eligible applicants must be Illinois residents, involved in organized medicine, and plan to practice in Illinois post-residency. This scholarship continues the AMA Foundation's commitment to advancing medical education and fostering a diverse healthcare workforce.

The Dr. Glenn Neil Love Medical Scholarship, established in 2014, provides annual financial assistance to individuals pursuing medical training and education. It aims to support nontraditional applicants currently employed in healthcare who demonstrate financial need and a commitment to advancing their skills. Priority is given to those seeking additional certifications or training to enhance their expertise in the medical field.

The Goldman Fund, established in 1992, focuses on reproductive health and rights, providing vital support for organizations that enhance access to abortion services. They invite proposals from public charities with a 501(c)(3) status and prioritize projects that improve training for abortion service delivery. The fund supports initiatives across multiple states, excluding projects limited to a single state, except California, and considers requests by invitation only.

The Beaufort Jasper Water & Sewer Authority Scholarship, established in 2024, offers financial support to students from Beaufort and Jasper Counties, South Carolina. This scholarship is both merit-based and need-based, aiming to assist deserving students in pursuing their post-secondary education. Funded by the Community Foundation of the Lowcountry, it reflects a commitment to fostering educational opportunities in the region.

About Disabled Veterans National FoundationThe Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability. The Disabled Veterans National Foundation (DVNF) provides critically needed support to disabled and at-risk veterans who leave the military wounded—physically or psychologically—after defending our safety and freedom.About Comfort Kits and Grab N' Go ProgramIn addition to our direct outreach, the DVNF also supports like-minded organizations that share our commitment to serving veterans. Approved organizations can apply to receive Comfort Kits for distribution to veterans in their communities. These kits are designed to meet the unique needs of veterans and offer critical support where they are needed most.

About Disabled Veterans National FoundationThe Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability. The Disabled Veterans National Foundation (DVNF) provides critically needed support to disabled and at-risk veterans who leave the military wounded—physically or psychologically—after defending our safety and freedom.

About Grants to Provide Stability (GPS) ProgramThe Disabled Veterans National Foundation’s GPS (Grants to Provide Stability) Program is a grant program for veterans who find themselves in temporary financial setback. DVNF will provide up to $1,000 (not guaranteed) to help eligible veterans pay for rent or mortgage and essential utilities such as water or electricity. Applications are open on a monthly basis. Please note that each veteran can only be approved once per fiscal year (October – September).

The RPAC Fundraising Grants, offered by the National Association of Realtors, support state and local associations in organizing fundraising events aimed at boosting RPAC contributions. These grants require a fundraising goal three times the amount requested, ensuring tangible results. The initiative emphasizes developing detailed fundraising plans that comply with state laws regarding corporate treasury funds. This program is vital for enhancing RPAC participation and advancing property ownership advocacy.

The Arnold O. Beckman Postdoctoral Fellowship offers researchers the opportunity to advance their studies in Chemical Sciences or Chemical Instrumentation. This program supports innovative research within fundamental chemistry and the development of new instrumentation. Candidates must be U.S. citizens or permanent residents, or DACA recipients, with a PhD in the chemical sciences anticipated by May 1, 2026. Mentorship from a qualified institution is required, fostering independent research capabilities in a collaborative environment.

The Hemophilia Alliance Foundation's Impact Grants aim to support organizations enhancing services for individuals with inherited bleeding disorders. Since its inception in 2009, the foundation has awarded over $6.6 million, enabling innovative projects that expand capacity and collaboration. Eligible applicants include local organizations and federally-funded treatment centers, emphasizing creativity in project proposals. Priority will be given to initiatives that address unserved populations and foster educational advancements in the community.

The Anne S. Chatham Fellowship in Medicinal Botany, funded by the Garden Club of America, aims to protect and expand knowledge of medicinal plants. It offers a $4,500 grant to support Ph.D. students and recent graduates in pursuing essential research that may otherwise be inaccessible. This initiative not only fosters botanical research but also contributes to the development of therapies that enhance patient quality of life and potentially save lives.

The Kia Pet Adoption Grant, funded by the Petfinder Foundation as part of the Accelerate the Good program, supports organizations in the US, Canada, and Mexico with free or reduced-fee adoptions for dogs and cats. Grants are awarded monthly based on the number of adoptable pets listed on Petfinder.com until funds are depleted or November 1st. Grantees are required to report adoptions and share stories of pets adopted through this initiative.

The Montana Circle K - Key Club Renewal Scholarship Program, supported by the Kiwanis Foundation of Montana, recognizes and aids Circle K members who have previously earned a scholarship and excelled academically in college. This program emphasizes the importance of leadership, community service, and continued academic achievement, providing essential financial assistance to deserving students who contribute positively to their communities.

The Teiger Foundation's Curatorial Research and Development Grant offers support for innovative curatorial practices within the contemporary visual arts sector. Designed to address gaps in funding, this grant provides up to $50,000 for curatorial research projects, including travel and collaborative investigations. It emphasizes the importance of experimentation and creativity while aligning with values of racial justice and environmental sustainability. The next Call for Proposals will open in Fall 2026, with funding opportunities available to U.S.-based curators.

The PEN America: Phyllis Naylor Grant for Children’s and Young Adult Novelists awards $5,000 annually to authors of children's or young adult fiction. This grant supports writers at critical stages in their careers, specifically for a novel-in-progress. Candidates must have published works that received positive critical reception but limited sales. Self-published works and collaborative manuscripts are ineligible, ensuring that the grant focuses on authors with established literary merit.

The Youth Empowerment Program Scholarship, offered by the Community Foundation of the Ozarks, provides a $1,000 scholarship to a graduating high school senior who has been a member of the Youth Empowerment Project for at least one year. Applicants must submit an essay, a letter of recommendation from a project sponsor, and a transcript. This initiative aims to support students pursuing higher education at accredited institutions while fostering community engagement.

Agility Grants, initiated by the National Council on Problem Gambling, aim to minimize gambling-related harm through funding nonprofit organizations for innovative prevention programs. These grants focus on addressing gaps in services and enhancing existing initiatives. Eligible applicants include U.S.-based 501(c)(3) organizations, with priority given to projects targeting at-risk populations. The program emphasizes community impact and requires evaluations to assess effectiveness, fostering collaboration and awareness within diverse communities affected by gambling.

The Faculty Travel Grant for AGU Annual Meeting supports early-to-mid career faculty from under-resourced institutions, including community colleges and minority-serving institutions. This program aims to facilitate attendance at the AGU Annual Meeting, which attracts over 22,000 geoscience professionals globally. Awardees receive a $1,700 travel stipend, access to professional development workshops, and networking opportunities, enabling them to enhance their research and teaching capabilities through collaboration and innovation.

The Ian Miskelley Be Better Scholarship, offered by the Community Foundation of the Holland/Zeeland Area, aims to support high school seniors who are active in swimming and demonstrate strong character. Eligible applicants must be graduating seniors from public, private, or home schools within the foundation's service area, have participated in a swim team during their junior and senior years, and be recommended by a swim coach. Community service related to mental health is a plus.

In 2025, the Community Foundation of Madison & Jefferson County awarded over $233,000 in scholarships to graduating seniors of the county’s public and private high schools. Nearly 50 different students earned money toward their college costs. Scholarships are available for a variety of applicants. Some are specific to schools, majors, need, or interests.

CFMJC scholarships may be used for tuition and related expenses like fees and required equipment at accredited colleges and universities. Room and board are not covered.

Terry & Wanda Wood Memorial Scholarship

Criteria evaluated:

• Work ethic and ambition, desire to pursue a trade, and financial need

Required materials: 

• Essay of up to 250 words describing the applicant’s career path plans, 
• 2 letters of recommendation from teachers and/or counselors, and 3) FAFSA SAI PDF upload

Scholarship amount:

• $7,500 | 1 scholarship

The Feed the Hungry COVID-19 Fund, launched by American Humane, addresses the urgent needs of animal shelters struggling during the pandemic. With many animals abandoned and facilities facing shortages, this fund aims to provide essential resources for food and supplies. American Humane, a leader in animal welfare for over a century, seeks to support shelters and rescue organizations fighting to maintain operations amid the crisis, ensuring the safety and care of vulnerable animals across the nation.

Lilly Endowment Inc. focuses on enriching the religious lives of Christians in the U.S. by supporting diverse congregations and theological education. It aims to foster community development, youth education, and public understanding of religion. The Endowment prioritizes initiatives that improve life quality in Indiana while considering national projects that align with its mission. Notably, it emphasizes nurturing the faith of young people and ensuring all congregations have capable leaders to meet contemporary challenges.

The J. Leeds Barroll Dissertation Prize, awarded by the Shakespeare Association of America, honors exemplary doctoral work with a significant focus on Shakespeare. This prestigious award is conferred annually during the SAA’s Annual Luncheon. To be eligible, applicants must be SAA members in good standing, and dissertations must be approved between September 1, 2024, and September 1, 2025. This prize encourages innovative research and scholarship in Shakespeare studies.

The George H. Nettleton Foundation Grant aims to enhance the quality of life for older adults in the Greater Kansas City area by funding unmet basic needs. The foundation envisions a healthy senior population and invites both new and existing programs to apply. Grants typically average under $100,000 and can extend for a maximum of two years. Agencies must be licensed 501C3 and serve specific counties in Missouri and Kansas.

The SAA First Book Award, presented by the Shakespeare Association of America (SAA), honors the legacy of Jerome Singerman and supports early career scholars. This prestigious award recognizes the best monograph with a significant Shakespeare component, published as the first book by a current SAA member between September 1, 2024, and September 1, 2025. The award will be announced during the SAA’s Annual Luncheon, celebrating contributions to Shakespeare studies.

The TYLENOL Future Care Scholarship supports students pursuing healthcare careers, continuing a 30-year tradition of helping those dedicated to caring for others. Eligible applicants must be U.S. residents, graduate students or seniors enrolling in graduate school for the 2024-25 academic year, and provide proof of enrollment in an accredited healthcare program. Scholarships cover tuition, fees, and necessary supplies, ensuring that future healthcare professionals receive the support they need.

The OREF Michael P. Kelly Sr Leadership Fellowship Program is a one-year virtual fellowship aimed at developing leadership skills in orthopedic residents. The program includes individual coaching, clinical research mentoring, educational opportunities, and an annual leadership retreat. It prioritizes candidates like orthopedic residents (PGY3-PGY5), fellows, and early-career surgeons who show a commitment to orthopedic clinical research and leadership in the orthopedic community.