Best Unrestricted Grants for Nonprofits in Puerto Rico

The Multiple Sclerosis Clinical Care Physician Fellowship: Pediatric Care, offered by the National Multiple Sclerosis Society, aims to enhance the training of physicians in providing specialized care for pediatric patients with MS. This one-year post-residency program emphasizes direct patient care and multidisciplinary collaboration. Participants will learn under the supervision of MS specialists, gaining essential skills to improve clinical practices and contribute to the MS community, ultimately leading to better outcomes for those affected by this condition.

The Health Equity and Inclusiveness Research Fellow Award by LUNGevity supports physician-scientists conducting lung cancer research aimed at addressing health disparities. Funded projects will focus on early detection and improved outcomes for lung cancer, particularly among underserved communities. Awards can reach up to $100,000 over two years, with payments contingent on project milestones. This initiative aims to foster innovative research and enhance individualized treatment approaches for lung cancer.

Pediatric Dermatology Research Alliance Inc 

PHACE syndrome is a neurocutaneous syndrome characterized by large segmental infantile hemangiomas of the face and scalp in association with congenital anomalies that may affect the posterior fossa of the brain, cerebral and cervical arteries, heart, and/or eyes. LUMBAR syndrome is the lower-body counterpart of PHACE, characterized by large segmental infantile hemangiomas of the lumbosacral, buttock or pelvic regions associated with urogenital, spinal, bony, anorectal, and/or renal abnormalities. Those affected experience a wide range of comorbidities with significant psychosocial impact. We invite proposals for clinical research that improves diagnostic approaches, enhances quality of life, and addresses key aspects of disease burden and management.

Applications may be submitted by either a single investigator or multiple investigators at multiple institutions. A total of $40,000 is available and may be awarded as one large-scale project or as multiple smaller awards, depending on the number and quality of applications received. Equal consideration will be given to projects in either of the two award formats with decisions to be based upon merit and available funds.

Focus

Research should focus on PHACE and/or LUMBAR syndromes. Priority will be given to investigators who have not previously served as the senior investigator on an R01 NIH grant or equivalent, and to studies that include multidisciplinary teams with active roles for early-career investigators. Proposals that meaningfully integrate patient perspectives are strongly encouraged.

Important Details

• Up to $40,000 will be funded to support one large-scale project for up to two years, or as multiple awards for smaller-scale projects

The Rockefeller Family Fund's Climate Grant focuses on reducing fossil fuel production to combat climate change. It supports initiatives that hold polluters accountable and fosters citizen engagement for climate action. The fund prioritizes programs that seek to limit oil and gas production, enforce climate damages in court, and promote sustainable energy solutions. By addressing the fossil fuel industry's resistance, the grant aims to create meaningful progress towards climate goals and ensure that those responsible for climate disruption contribute to adaptation efforts.

The RRF Foundation for Aging offers research grants aimed at improving the well-being of older adults and their caregivers. Established in 1950, the foundation has awarded over $239 million to support innovative projects nationwide. Grants are targeted at nonprofit organizations proposing research with immediate implications for adults aged 60 and older, with a focus on practical knowledge and dissemination to impact policy and practice.

CHEJ Small Grants Program

The Small Grants Program has officially relaunched. Applications are now open.The Center for Health, Environment & Justice’s (CHEJ) Small Grants Program is for grassroots groups working on environmental health and justice issues related to the presence of “toxics” (toxic chemicals or hazardous substances) in their immediate communities. CHEJ prioritizes community-based organizations aiming to have local, state and regional impact through their own strategies and actions.

The Woman's National Farm and Garden Association (WNF&GA) Scholarship supports graduate students pursuing careers in conservation and natural resource management. This annual scholarship aims to continue the legacy of conservationists dedicated to protecting our planet's resources. Eligible candidates must demonstrate a strong commitment to environmental stewardship through their academic and community involvement. However, WNF&GA members and their immediate families are excluded from eligibility. The scholarship is a vital resource for future leaders in conservation.

Research Grant Program 

Providing research grants to support clinicians and scientists focused on primary immunodeficiency (PI).

Scope and eligibility

• The Immune Deficiency Foundation's Research Grant Program supports patient-centered research focused on improving the treatment, health, disease management, or diagnosis of people with primary immunodeficiency (PI), as well as research that contributes to the broader body of knowledge on PI.
• Awards range from $25,000-50,000. In addition, the Michael Blaese Research Grant Award is bestowed on the highest-scored application each cycle.
• One-year term.

The American Heart Association (AHA) offers Student Scholarships in Cardiovascular Disease to encourage research among students in health-related fields. Open for applications starting January 27, 2025, these scholarships provide $2,000 for student projects focused on cardiovascular and cerebrovascular diseases. The top awardee will be named the Howard S. Silverman Scholar, receiving an additional $1,000 stipend. AHA membership is required by April 3, 2025, to apply.

The GEMSSTAR for Emergency Medicine Supplemental Funding Program provides up to $25,000 over two years to support emergency medicine physicians who have received the NIA GEMSSTAR grant. This program aims to enhance the Professional Development Plan of GEMSSTAR awardees, ensuring they receive the necessary funding for their research endeavors. Eligibility is limited to those who have completed their clinical specialty training and are based at U.S. institutions, with funding contingent upon available resources.

Agnes McCarthy Caregiver Foundation

The Agnes McCarthy Caregiver Foundation is a 501(c)(3) not-for-profit charity that provides hope and relief to caregivers who care for a loved one with mental health conditions.

Caregiver Grant

Family caregiving has become a public health issue that receives inadequate recognition in our country. While it can be rewarding to care for our loved ones, it often comes with significant physical, emotional and financial costs to the caregiver. On average, caregivers spend over 25% of their own income to support their loved one and provide 32 hours a week in unpaid care.

AMCF currently offers a $500 financial relief grant to assist family members with unexpected expenses due to their caregiving role. If you are a family caregiver to someone living with a mood or psychiatric condition like depression, anxiety, PTSD, bipolar, schizophrenia, or other mental health/co-occurring conditions, you are not alone, and we welcome you to apply for a caregiver grant today.

Additional Information

• To ensure our limited funds reach families with the greatest need, grants may require documentation confirming a diagnosed serious mental illness (SMI).  

• The $500 grant is limited to one award per household within a 12-month period.

• Applications are generally reviewed by our Board of Directors, with decisions made within 30 days of receipt.

The SHC Student Research Grant supports research utilizing herbarium resources across various taxa, including plants, fungi, lichens, and algae. Eligible projects may involve fieldwork, data collection, or meta-analysis of herbarium data, with an emphasis on enhancing herbarium collections. Three grants are awarded annually: two for $500 and one specifically for undergraduates for $250. Applicants must be student SHC members with projects likely to lead to publication.

This program aims to enhance education for healthcare professionals regarding new therapies and patient management in ulcerative colitis (UC). It focuses on multi-channel educational strategies to address the evolving landscape of UC treatment. Key areas include educating on new oral therapies, transitioning to advanced therapies, and managing isolated proctitis. Organizations such as healthcare institutions and medical education companies are eligible to apply, ensuring a comprehensive approach to improving UC care.

The TTF Advertising for the Environment Grant, established by the Temper of The Times Foundation in 1997, aims to enhance awareness of wildland conservation through marketing initiatives. This grant is exclusively available to 501(c)(3) nonprofit organizations and funds various advertising campaigns to protect native ecosystems. Priority is given to projects that demonstrate measurable impacts on conservation, rather than those focused solely on education.

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

• funding research to improve treatment options;
• providing treatment support and education for patients and their families;
• and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Patient Travel Grant Program

A mesothelioma diagnosis and treatment often require the patient and their family to incur numerous expenses as part of their treatment. Travel to treatment, alone, can cause a significant financial burden on the patient, which might even cause the patient to not seek treatment away from home, even it’s their best option. To ensure that all patients have the ability to seek specialized help and treatments, the Mesothelioma Applied Research Foundation administers its Travel Grant Program.

The Meso Foundation’s Patient Travel Grant Program, founded by Mary and Bob Cosentino, provides travel grants to patients and one caregiver traveling for an initial consult and/or for clinical trial treatments.

• The type of eligible travel must fall into at least one of these two categories:
  • One trip for one initial consultation with a mesothelioma specialist.
  • Multiple trips to participate in an interventional clinical trial (found on clinicaltrials.gov).

The John and Polly Sparks Early Career Grant, offered by the American Psychological Foundation, supports early career psychologists focused on research and intervention for serious emotional disturbances in children. This grant empowers researchers to develop scientifically-backed treatments that can be implemented broadly across the country, encouraging diverse applicants with a commitment to improving mental health outcomes for affected youth.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Grants for Educators & Theatre Programs

A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.

For EdTA Members

Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.

Production Grants

Show-specific financial assistance for educational theatre programs

Music Theatre International: Heart of Rock and Roll "The Power of Love" Grant

Heart of Rock and Roll features a book by Jonathan Abrams and music and lyrics by Huey Lewis and his pop-rock band, Huey Lewis and the News, with new orchestrations of their music by Brian Usifer.

Selected schools will host intergenerational community events or outreach programs of their own design — because just as Huey Lewis’s music has always brought people together, school theatre has the power to do the same.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Grants for Educators & Theatre Programs

A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.

For EdTA Members

Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.

Production Grants

Show-specific financial assistance for educational theatre programs

The Wilder Estate: The Long Christmas Dinner Festival Grant

In 1931, Thornton Wilder wrote The Long Christmas Dinner, a moving, funny, and ingeniously theatrical one-act play created specifically for student theater groups. In just 40 minutes, a single holiday meal becomes a 90-year journey through four generations of a family, exploring time, tradition, family, and the stories we tell about our lives.

In 2026, the Wilder Estate is launching The Long Christmas Dinner Festival, a national holiday celebration bringing schools, cultural organizations, and audiences together around this remarkable play.

The Student Research Grant in Audiology, offered by the American Speech-Language-Hearing Foundation, supports doctoral students conducting research in clinical and rehabilitative audiology. Up to three grants of $2,000 each are available for eligible students enrolled in accredited programs in the U.S. This initiative honors the legacies of Ira Ventry and Brad Friedrich, who made significant contributions to the field of audiology. Interested candidates must submit proposals for research projects to be initiated in this vital area.

Interface Health Foundation

Interface Health Foundation is a non-profit, 501c3 tax-exempt organization driven by a collective vision of positive change. In healthcare industry policy, understanding the intricate dynamics of funding and its impact on public access, quality, and cost remains paramount. IHF is dedicated to advancing analysis and research into the crossroads of healthcare industry policy, structural frameworks and affordability.

At IHF, our mission is clear: to empower and support student-led research endeavors that shed light on critical healthcare policy and structural issues affecting the public. Through our initiatives, we seek to foster a deeper understanding of the complex dynamics shaping the healthcare landscape.

Interface Health Foundation: Research Grant

Healthcare administrative grant award opportunities are highly competitive and allow candidates to stand out as they enter the job market. Through this IHF grant award, you will get the opportunity to pull together research and content on topics that aren't fully studied or publicized. Depending on the grant topic, some grantees will also have access to a preceptor who is an executive leader in the healthcare field. The preceptor will serve as a valuable resource to the grantee during the development of the research paper and beyond.

An example of a research topic is the impact of legislated acute care nurse staffing levels on the following: nursing professional job satisfaction, the patient experience, and the standard nursing quality indicators as part of nursing Magnet status accreditation.

The Mech SS Carl C. Smith Graduate Student Award, established by the Society of Toxicology, honors Carl C. Smith's commitment to advancing graduate education in toxicology. This prestigious award encourages graduate students to submit outstanding abstracts for the 2026 SOT Annual Meeting. Eligible applicants must be graduate student members of SOT and PhD candidates who have passed their comprehensive exams. The award promotes diversity and inclusiveness in the field while recognizing exceptional contributions to toxicology.

The Mech SS Sheldon D. Murphy Student and Postdoctoral Endowment Award, established by the Society of Toxicology, honors the legacy of Dr. Sheldon D. Murphy, a pioneer in toxicology. This award supports PhD candidates and postdoctoral trainees who demonstrate excellence in mechanistic toxicology. Nominees are selected based on the scientific quality of their abstracts, ensuring a focus on impactful research. This initiative fosters the next generation of toxicologists dedicated to advancing human and environmental health.

Literary Arts Project Grants

As part of its Literary Arts Initiative, South Arts is pleased to announce Literary Arts Project Grants supporting literary arts organizations and small presses that focus on contemporary literary arts.

These grants advance South Arts’ commitment to amplifying the literary traditions and artistic practices of the American South by directly supporting the development, production, and public engagement of high-quality literary projects.

Literary Arts Project Grants support projects in poetry, fiction, creative or literary nonfiction, young readers’ literature, and drama (scriptwriting). Projects must demonstrate artistic excellence, editorial rigor, and meaningful public or community impact.

Award Amount

South Arts will award up to $5,000 per project to eligible literary arts organizations and small presses.

About Alex’s Lemonade Stand Foundation

Alex's Lemonade Stand Foundation (ALSF) emerged from the front yard lemonade stand of 4- year-old Alexandra “Alex” Scott, who was fighting cancer and wanted to raise money to find cures for all children with cancer. Her spirit and determination inspired others to support her cause, and when she passed away at the age of 8, she had raised $1 million. Since then, the Foundation bearing her name has evolved into a national fundraising movement. Today, ALSF is one of the leading funders of pediatric cancer research in the U.S. and Canada, funding research projects and providing programs to families affected by childhood cancer. ALSF is one of the only childhood cancer research organizations that has been given the NCI peer-reviewed funder designation for rigorous selection of research grants. The mission of ALSF is to change the lives of children with cancer through funding impactful research, raising awareness, supporting families, and empowering everyone to help cure childhood cancer.

Bio-Therapeutic Impact Award

The Bio-Therapeutic Impact Award accelerates the development of clinical trials for promising biologic approaches to treating childhood cancer. These approaches include, but are not limited to, immunotherapy, gene therapy and small molecules. The award, intended for investigators who are initiating clinical trials, totals the maximum of $1.8 million awarded over three years.

The IEN-WMAN Mini-Grant Program provides crucial financial support to Indigenous communities and grassroots organizations impacted by mining in the U.S. and Canada. With over $200,000 distributed annually in $4,000 grants, the program aims to address mining-related environmental and health issues. Priority is given to proposals that demonstrate a direct impact on affected communities, particularly Indigenous-led initiatives, ensuring that financial assistance is directed where it is most needed.

31Heroes

On August 6, 2011, a tragedy shook the military community and Americans everywhere. In a single instance, America lost 30 military service members, many of whom were members of the Navy SEAL community—and one military K9– when a CH-47 Chinook helicopter, call sign Extortion 17, was downed in Afghanistan.

Established to honor the 31 Americans killed in action on August 6, 2011, 31Heroes serves to impact the lives of our nation’s heroes and their families, while remembering the fallen, through athletic endeavors and competitive fundraising events.

Our Mission: The mission of 31Heroes is to raise money and awareness through social and athletic events to support the families of Extortion 17 and honor their legacy by funding treatment for Veterans suffering from mental health issues.

Our Focus

Our goal is to create opportunities for the families of Extortion 17 to create healthier lifestyles and to provide financial relief in times of need. We consider it our responsibility to make a positive impact in the lives of each family. Whether through grants we provide, or through partnering with other non-profit organizations that offer programs or services that we do not, we are devoted to the families and creating a legacy the men of Extortion 17 would be proud of.

Guidelines

• Individual limits will not exceed $3750 annually
• Family Grants range from $750 to the maximum range of $1500
• Family members must submit an online application for consideration
• Applications may be submitted at any time during this funding cycle
• Priority and funding will be based on the Primary Next of Kin list

Lifestyle Grants

Lifestyle Grants are aimed at improving health and lifestyle via physical fitness, nutrition, holistic treatment, etc. Limit for this grant is $1500

Batten Disease Support, Research, and Advocacy (BDSRA) Foundation

BDSRA is dedicated to funding research for treatments and cures, providing family support services, advancing education, raising awareness, and advocating for legislative action. Founded in 1987, by parents seeking to build a network for those diagnosed with Batten disease, BDSRA is now the largest support and research organization dedicated to Batten disease in North America. BDSRA believes that to effectively unravel the mysteries of Batten disease, the worlds of medical science, research, and families must work together toward a common goal: discover treatments and cures while assuring a better quality of life for those living with the disease.

Batten Family Help Grant

The BDSRA Foundation is committed to supporting families of all CLN types in all aspects of their fight against Batten, including the financial challenges they face. BDSRA understands that families in our community caring for people with Batten disease are often faced with financial challenges that further interfere with their well-being.

We offer grants to help cover the costs associated with battling Batten disease, such as emergency travel, loss of employment, hospital bills, and other challenges our families might face.