Best Community Health Grants in North Carolina

The Amcor Community Support Grants Program, administered by the Amcor Cares Foundation, provides funding for projects that benefit local communities. Grants are available to 501(c)(3) organizations and accredited educational institutions that serve Amcor Flexibles North America facility communities. Focus areas include fighting hunger, supporting disaster relief, expanding STEM education, and enhancing health and wellness. Applications are reviewed quarterly, and grant amounts typically exceed $1,000.

The Cannon Foundation Grants support capital and equipment projects in North Carolina, focusing on healthcare, higher education, human services, and community initiatives. Established in 1943, the foundation prioritizes established organizations and encourages collaboration with other funding sources. Grants are not available for operational expenses or start-up funding, and applicants must demonstrate a clear funding plan for ongoing operations. This foundation seeks to empower communities while avoiding dependency on funding.

The First Horizon Foundation, established by First Horizon National Corp., supports communities in Florida, North Carolina, and South Carolina. Since 1993, it has donated over $90 million to enhance lives through grants focused on arts, education, environment, financial literacy, and health services. Eligible nonprofits in various cities can apply, while individuals and certain organizations, such as K-12 schools and political groups, are excluded from funding. This foundation is dedicated to making a positive impact in the regions it serves.

The Frankenmuth Insurance Foundation Charitable Grant supports qualified charities focused on community betterment and basic human needs. Founded in 2016, it aims to enhance lives through initiatives such as affordable housing, health programs, and the arts. Organizations eligible for funding must be tax-exempt and serve areas where Frankenmuth Insurance operates. Notably, the foundation excludes support for individuals, political groups, and projects typically financed by governments, ensuring its resources benefit the wider community.

The Amgen Foundation Inc focuses on non-healthcare donations and sponsorships that target humanitarian, social, educational, and community programs. They offer support to organizations outside the U.S. healthcare community, particularly those recognized as tax-exempt public charities. Eligible organizations must serve specific Amgen communities throughout the U.S. This initiative aims to enhance health outcomes and address critical societal needs, thereby reducing the burden of disease and improving lives.

The Rosendin Foundation Emergency Grant provides financial support for unplanned expenses due to unforeseen circumstances such as natural disasters. Grants up to $5,000 are available for community-focused non-profit organizations in states where Rosendin and MPS operate. The foundation prioritizes emotional, occupational, and nutritional health initiatives, aiming to positively impact communities and empower individuals through financial support and volunteer efforts.

The Civic Experiment Grant by the Trust for Civic Life supports innovative, community-driven projects aimed at enhancing civic engagement. It focuses on rural areas, empowering local leaders to tackle challenges collaboratively. Grants up to $25,000 are available for organizations that are non-partisan and primarily serve rural communities, emphasizing inclusivity and sustainable impact. The next nomination period begins in early 2026, following a closed cycle for 2025. This initiative fosters long-term civic infrastructure and community resilience.

The GSK IMPACT Awards in North Carolina honor outstanding nonprofit organizations making a significant impact on community health. This annual program, in partnership with the Triangle Community Foundation, recognizes up to ten organizations for their exemplary contributions to health and wellness. Applicants must demonstrate a commitment to improving community health through innovative and effective programs. Eligible organizations must operate in the Triangle area and meet specific criteria regarding revenue and community impact.

The Impact Fund provides recoverable grants to legal services nonprofits and small law firms working on social, environmental, and economic justice issues. With over $10 million awarded since 1992, the fund supports impactful litigation addressing systemic injustices. Grants range from $10,000 to $50,000 and prioritize cases directly involving affected communities. Recipients must repay the grant amount with interest if they recover fees or costs, ensuring sustainability for future funding.

The Heritage Home Group Charitable Trust, established in 1960, focuses on enhancing community resilience in North Carolina through strategic funding in areas such as financial mobility, housing access, and small business growth. With a commitment to arts, education, health, and human services, the Trust supports organizations that are tax-exempt and demonstrate fiscal stability. Funding is not available for individuals or political activities, ensuring resources are allocated to meaningful community needs.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation focuses on supporting nonprofit organizations within specific states. They prioritize initiatives that enhance community welfare, especially in agriculture, education, health, and environmental sustainability. Organizations must have 501(c)(3) status to apply, and preference is given to those involving Perdue associates. Ineligible requests include those from religious, political, or individual-focused groups. This program emphasizes broad community benefits over organizational affiliations.

The Environmental Initiative Grant Program by the Laura Jane Musser Fund aims to support public and nonprofit entities in enhancing the ecological integrity of open spaces. It promotes community involvement in planning and implementing projects that improve quality of life and public health while protecting ecosystems. Grants range from $8,000 for planning to $35,000 for implementation, targeting projects in specific states, fostering sustainability, and ensuring active local participation.

The Women's Impact Fund Grant aims to provide significant financial support to nonprofits in Mecklenburg County, NC, focusing on five key areas: Arts & Culture, Education, Environment, Health, and Human Services. The grant emphasizes trust-based philanthropy, promoting equity and accessibility while addressing community disparities. Grants range from $10,000 to $100,000, with applications evaluated based on member votes and overall grant pool size. This year, the fund is offering unrestricted operating support to enhance organizational resilience.

The Environment Pillar Award by Honda supports nonprofit organizations and schools in the U.S. focused on sustainability. Grants aim to reduce environmental impact through programs in decarbonization, clean energy, and efficient resource use. Eligible projects must align with Honda's mission and primarily benefit communities where Honda associates live and work. Organizations can apply for up to two grants, provided they meet specific eligibility criteria, including tax-exempt status under the IRS.

The Dominion Energy Charitable Foundation supports tax-exempt organizations under IRS Section 501(c)(3) in four key areas: human needs, environmental stewardship, education, and community vitality. Grants typically range from $1,000 to $15,000, with two application cycles each year. Notably, funding is unavailable for organizations without 501(c)(3) status or those located outside Dominion's service areas. This foundation aims to enhance community welfare through targeted support for impactful programs.

The Camber Foundation Grant supports community-driven initiatives in Eastern North Carolina, focusing on health, education, and economic development. It encourages nonprofits to apply for funding to enhance services without discrimination. Priorities include access to healthcare, mental health programs, and youth development. Eligible organizations must be 501(c)(3) entities based in the region, ensuring that all residents can thrive. The foundation aims to uplift communities through collaborative efforts and innovative solutions.

The Game Changer Grants, offered by the Carolina Hurricanes Foundation, aim to empower nonprofit organizations to create positive grassroots impacts in the community. With funding levels of $5,000, $10,000, or $15,000, these grants support initiatives focused on health and education for underserved populations in North Carolina. Organizations must demonstrate their commitment by meeting specific eligibility criteria, including tax-exempt status and a minimum of three years of operation. Reapplications are encouraged for declined proposals.

The North Carolina Appalachian Regional Commission Funds support economic development across 13 states, focusing on infrastructure, workforce, and community resilience. Administered by the North Carolina Department of Commerce, the program prioritizes projects that enhance local economies, particularly in areas affected by Hurricane Helene. Funding caps are set at $700,000 for construction and $300,000 for non-construction projects, with special considerations for distressed counties and workforce development initiatives.

The Underdown Family Foundation, established in 1993, supports nonprofit organizations that enhance the Hickory, NC community. The foundation prioritizes education, health, human services, and faith-based initiatives. It seeks to empower local organizations while also contributing to research on significant diseases. By focusing on community needs, the foundation aims to make a lasting impact both regionally and nationally, promoting well-being and societal benefit.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

Enterprise Community Partners

Enterprise Community Partners is a national nonprofit that exists to make a good home possible for the millions of families without one. Home is where life happens, where plans are made, and futures begin. It is the foundation for dignity, health, education, wealth, and community. Yet rents keep going up, paychecks don’t keep pace, and good homes in strong neighborhoods are increasingly out of reach.

The system doesn’t work. It must be changed, and it must be changed by us.

Enterprise has the breadth, scale, and expertise to do it. We support community development organizations on the ground. We aggregate and invest billions to improve housing and strengthen communities across the U.S. We advance housing policy at every level of government. We build and manage communities ourselves. Everything we do is informed by the residents we serve.

Together with our partners, we focus on the greatest need — the massive shortage of affordable rental homes — to achieve three goals:

• Increase the supply of affordable homes
• Advance racial equity after decades of systematic racism in housing
• Support residents and strengthen communities to be resilient to the unpredictable, and make upward mobility possible

Since 1982, we have invested $92.0 billion and created 1.1 million homes across all 50 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. We do all this to make home and community places of pride, power, and belonging.

National Housing Innovation Grant Competition

Home is foundational. It’s where we plant roots, raise and care for our families, and build community bonds. Yet in every corner of the country, millions of people of all ages and backgrounds need a home they can afford.

Wells Fargo is meeting this moment with a powerful grant opportunity. Together with Enterprise, Wells Fargo has launched the third iteration of the Housing Affordability Breakthrough Challenge. The 2026 cycle of the housing innovation competition will identify and propel proven, ready-to-scale solutions that transform current practices and increase housing choice and access.

Eligible applicants will compete for five individual grants of $2 million to advance their innovation and drive meaningful, systems-level change in the housing and adjacent industries. Winners will gain access to mentorship and coaching from industry leaders and experts and join a powerful network of Breakthrough Challenge innovators.

Focus Areas

This third cycle of the Housing Affordability Breakthrough Challenge aims to meet the nation’s affordable housing challenges across all types of communities: Native, rural, suburban, tribal, and urban.

Proposals must encompass one or more of three focus areas:

• Design and Construction
• Finance
• Service Delivery and Programs

Applicants will be asked to show how their proof of concept or pilot program has achieved clear outcomes and success, and provide a clear pathway to expanding the innovation’s reach and impact

Round 1: Criteria and Scoring

Your innovation must meet the criteria below to advance to the official scoring stage.

Type of Community

Innovations can serve all types of communities:

• Rural
• Urban
• Suburban
• Tribal

Location

Priority scoring will be given to applications from entities that are based in – or whose innovations are designed for – one or more of these 28 states, plus D.C.:

• Alaska, Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Iowa, Maryland, Massachusetts, Minnesota, Montana, Nevada, New Jersey, New Mexico, New York, North Carolina, North Dakota, Pennsylvania, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, Washington D.C.

Affordability

Innovations must serve residents at these income levels:

• Rental: 80% AMI or below
• Homeownership: 120% AMI or below
• Workforce housing: 120% AMI or below

The Rosendin Foundation Annual Grant provides financial support to community-focused 501(c)(3) non-profit organizations across various states, aiding initiatives in emotional, occupational, and nutritional health. Grants can reach up to $50,000 and are geared towards organizations that positively impact their communities. However, the foundation does not fund discriminatory practices, political efforts, or religiously affiliated projects, ensuring that support is directed towards inclusive and impactful community services.

The Universal Leaf Foundation Grants support 501(c)(3) nonprofit organizations primarily in areas where Universal Leaf Tobacco Company operates. Focus areas include education for at-risk individuals, higher education, civic/community arts, and environmental initiatives. The Foundation emphasizes good corporate citizenship and community engagement through financial support and employee volunteerism. Organizations must operate within designated geographic areas and cannot be involved in political advocacy or restrict services based on demographics. Grants aim to enhance community well-being and educational opportunities.

The Z. Smith Reynolds Foundation invites eligible organizations to apply for the State-Level Systemic Change Grant. This grant supports initiatives aimed at creating lasting, systemic improvements across North Carolina. Emphasizing equity and inclusion, the Foundation seeks to address barriers faced by historically marginalized communities, ensuring access to quality education, a healthy environment, and economic opportunities. This grant aligns with the Foundation's mission to foster a thriving, equitable society for all North Carolinians.

The John William Pope Foundation provides annual grants focusing on human services and the arts, primarily in North Carolina's Wake and Vance Counties. Established in 1986, the Foundation promotes self-reliance and community responsibility, funding initiatives that address critical social challenges. By prioritizing private resources over government funding, it fosters creative expression and supports nonprofits that empower individuals and families. The Foundation's mission is to ensure future generations have equal opportunities for success.

The Louise Oriole Burevitch Endowment Grant, offered by the North Carolina Community Foundation, supports nonprofit organizations focused on education, health, and human services in eastern North Carolina. This competitive grant aims to enhance community well-being by funding programs that address basic human needs, promote health outcomes, and support educational initiatives. Eligible applicants include 501(c)(3) organizations, with preferences for projects benefiting women, children, and the elderly in the southeastern region.

Truist Foundation

The Truist Foundation is committed to Truist Financial Corporation's (NYSE: TFC) purpose to inspire and build better lives and communities. Established in 2020, the foundation makes strategic investments in nonprofit organizations to help ensure the communities it serves have more opportunities for a better quality of life. The Truist Foundation's grants and activities focus on building career pathways to economic mobility and strengthening small businesses.

Inspire Awards

This year’s Inspire Awards seeks nonprofits supporting the career navigation and workforce development needs of workers across the United States. The challenge seeks applications that help individuals gain the skills, guidance, and support needed to access quality jobs, advance in their careers, and build long-term stability in an evolving world of work.

2026 Truist Foundation Inspire Awards Challenge Question

How are nonprofits providing innovative direct services, training programs, and career navigation supports for adult workers in the age of AI?

Challenge Dimensions

Nonprofit organizations have long been critical advocates and service providers for workers in the United States. Nonprofits provide workers necessary upskilling opportunities, AI literacy training, career navigation support, and wraparound services in conjunction with career pathways programming. All necessary for the modern workforce. Meeting the moment, Truist Foundation and MIT Solve want to hear the ways in which nonprofits headquartered in the Truist operating footprint are providing innovative career pathway programming in the age of AI. Although solutions don’t need to focus on generative AI specifically, teams should demonstrate how their career pathways programming align with the following dimensions:

• Training and Upskilling Programs – Providing holistic, accessible programming that equips workers with essential skills, industry-validated credentials, and technical literacy for the modern workplace.
• AI Readiness and Literacy – Offering high-quality training that helps workers understand generative AI and agentic technologies as augmented intelligence tools, helping to build practical skills like effective prompting, domain expertise application, and ethical use.
• Additional Wraparound Services and Basic Needs Support – Supporting unemployed and underemployed workers on their journey to economic mobility through comprehensive, integrated resources including childcare, transportation support, mentorship, mental health services, benefits navigation, and more.
• Career Navigation in the AI Economy – Enabling workers to navigate career choices with clarity and confidence by providing accessible information about how AI is reshaping job roles and industries, facilitating informed decisions about high-quality career trajectories that align with individual circumstances, and connecting workers to industry-validated credentials or trainings.

Here are the grants for this challenge

• First place: $250,000
• Second place: $150,000
• Runners-up: $25,000
• Audience favorite: $75,000