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Best Grants for 501(c)(3) in South Carolina

Find the perfect Grants for 501(c)(3) in South Carolina on Instrumentl. 9,000+ Grants for 501(c)(3) in South Carolina in the United States.

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$3.79B

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$5K

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9,000+ grants
$3.79B total
$5K median

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9,313 Results based on applied filters

OTA Resident Research Grant

Orthopaedic Trauma Foundation Inc
Private
North America
Up to US $20,000
The OTA Resident Research Grant supports resident-led clinical, translational, or basic research projects aimed at improving orthopaedic trauma care. With a maximum funding of $20,000 for a 12-month period, it encourages innovation and research within North America. Eligible applicants must be orthopaedic residents, ensuring that the projects are driven by their unique perspectives and needs. This initiative promotes diversity and aims to enhance the quality of patient care through education and research.
Musculoskeletal Diseases

OTA Member Full Research Grant

Orthopaedic Trauma Foundation Inc
Private
North America
US $25,000 - US $40,000
The OTA Member Full Research Grant, offered by the Orthopaedic Trauma Association, aims to fund clinical, translational, or basic research projects related to musculoskeletal trauma. Grants of up to $40,000 per year for two years are available for clinical research, and $25,000 per year for two years for basic research. Eligible applicants include OTA members in good standing, and research must be conducted in North America. The initiative seeks to enhance the quality of care for injured patients.
Musculoskeletal Diseases

Education Focused Giving

Genentech Foundation
Corporate
United States
Unspecified amount

Education Focused Giving

At Genentech, we invest in bold ideas and innovative solutions that address systemic inequities in science and medicine to advance a more just healthcare system. We focus on efforts that diversify the scientific and medical workforce, advance health equity, and help our communities thrive. We also further advance excellence in medicine and healthcare through our grants for independent medical education. IIncluding efforts to promote diversity in STEM across the education pathway, and efforts to support continuing medical education of healthcare providers. Select the option below that best fits your grant focus:

There are multiple ways to apply for funding. Before you submit an application, we encourage you to explore the following materials to learn more about our opportunities for funding, eligibility requirements and considerations, and the process for submitting a proposal within our Funding Request System (gFRS).

Diversity, Equity & Inclusion Medical Education & Professional Training

John Kepner Seva Award

International Association of Yoga Therapists
Private
United States
More than US $1,008

International Association of Yoga Therapists

IAYT’s mission is to advance yoga therapy as a recognized health profession.

The International Association of Yoga Therapists has championed yoga as a healing art and science since 1989. Membership is open to all who are aligned with our mission—yoga practitioners, yoga teachers, yoga therapists, healthcare practitioners who use yoga in their practices, and yoga researchers.

More than 5,000 individual members from 50+ countries, together with more than 150 Member Schools, help IAYT to support research and education in yoga.

Nearly 70 IAYT-accredited yoga therapy training programs educate the next generation of IAYT-certified yoga therapists, or C-IAYTs, who come from a range of lineages and backgrounds.

John Kepner Seva Award 

The annual Seva Award recognizes yoga therapists who bring yoga to those who have not had full access to these practices. This award was named in honor of Executive Director Emeritus John Kepner and his tireless efforts to advance the field and give back to the yoga therapy community.

Intended to help support and significantly advance the work of C-IAYTs or yoga therapists in training, the John Kepner Seva Award offers seed funding and publicity for well-defined and well-planned service projects.

IAYT and co-sponsor, the Give Back Yoga Foundation, commit annual support to these awards. 

What projects will be considered?

We’re seeking to support active and ongoing projects that benefit a population that may not otherwise be able to access yoga therapy. We're looking for innovative work that fosters accessibility, inclusivity, diversity, and social justice in yoga therapy, including initiatives focused on overcoming systemic barriers to accessing or training in yoga therapy. Positive consideration is given to yoga therapists from historically underresourced, underserved, marginalized, minoritized, and underrepresented backgrounds. Your application should include specifics about how your project will be communicated to and integrated into the community.

One winner will receive:

  • $1,008 (US) prize for project facilitation
  • Registration for one person to attend IAYT's Symposium on Yoga Therapy and Research (SYTAR),
  • Three nights at the conference hotel
  • $400 toward travel to the conference
  • Up to 20 yoga mats from Give Back Yoga Foundation to facilitate project classes (if applicable)
  • Opportunity to tell the project's story in IAYT’s magazine Yoga Therapy Today
  • Recognition at SYTAR 2026
  • Social-media coverage from IAYT and Give Back Yoga Foundation
  • Two-year beYogi membership (valued at $327)
  • Lifetime Sequence Wiz membership (valued at $199/year)

Four runners-up will receive:

  • $500 (US) prize for project facilitation (increased from previous years to support travel to SYTAR)
  • Up to 20 yoga mats from Give Back Yoga Foundation to facilitate project classes (if applicable)
  • Opportunity to tell the project's story in an upcoming IAYT publication
  • Recognition at SYTAR 2026
  • Social-media coverage from IAYT and Give Back Yoga Foundation

Mindfulness, Meditation & Yoga

Grants Program for Penn Investigators - Faculty Awards

Trustees Of The University Of Pennsylvania
Private
United States
Up to US $400,000

Grants Program for Penn Investigators - Faculty Awards

Research grant applications in basic science, prevention, disease interception, and early detection that are relevant to the study of BRCA1/2 will be considered. The Basser Cancer Interception Institute focuses on funding new endeavors in emerging, orthogonal fields beyond DNA damage (e.g. mechanisms of haploinsufficiency, cancer evolution and tissue tropism). 

Grants focused on the following are of particular interest:

  • Cancer interception and the pre-cancer disease state
  • Issues relevant to men (including but not limited to prostate cancer, pancreatic cancer, male breast cancer)
  • Potential for translation into clinical practice
  • Early detection

Grants that demonstrate a potential for translation into clinical practice will be prioritized for funding.

Faculty Awards

Faculty awards are for two years with a funding level up to $200,000 per year.

Cancer / Oncology

Grants Program for Penn Investigators - Early career awards for Fellows, Postdocs and Instructors

Trustees Of The University Of Pennsylvania
Private
United States
Up to US $100,000

Grants Program for Penn Investigators - Early career awards for Fellows, Postdocs and Instructors

Research grant applications in basic science, prevention, disease interception, and early detection that are relevant to the study of BRCA1/2 will be considered. The Basser Cancer Interception Institute focuses on funding new endeavors in emerging, orthogonal fields beyond DNA damage (e.g. mechanisms of haploinsufficiency, cancer evolution and tissue tropism). 

Grants focused on the following are of particular interest:

  • Cancer interception and the pre-cancer disease state
  • Issues relevant to men (including but not limited to prostate cancer, pancreatic cancer, male breast cancer)
  • Potential for translation into clinical practice
  • Early detection

Grants that demonstrate a potential for translation into clinical practice will be prioritized for funding.

Early career awards for Fellows, Postdocs and Instructors

Early career awards for Fellows, Postdocs and Instructors up to $100,000 for one year. Grants are eligible for competitive renewal upon reapplication and are contingent on progress the first year.

Cancer / Oncology

AHNS Endocrine Surgery Section ThyCa: Thyroid Cancer Survivors’ Association Award for Thyroid Cancer Research Grant

American Head & Neck Society (AHNS)
Association/Society
Canada, United States
Up to US $10,000
The AHNS Endocrine Surgery Section ThyCa Research Grant offers $10,000 for one year to support innovative research projects focused on thyroid cancer. Eligible candidates include U.S. or Canadian AHNS members, including medical students and faculty. Proposals should advance understanding of thyroid cancer's diagnosis, prevention, and treatment. Preference is given to early-stage investigators or those pursuing new inquiries. Applications require letters of support and a detailed budget, with funding limitations on indirect costs.
Cancer / Oncology Thyroid Cancer Otorhinolaryngology

OREF Prevention of Musculoskeletal Youth Sports Injuries Research Grant

Orthopaedic Research and Education Foundation
Private
Canada, United States
US $25,000
The Prevention of Musculoskeletal Youth Sports Injuries Grant provides essential funding for new investigators focused on clinical and social research aimed at reducing youth sports injuries. This initiative emphasizes the importance of clinical relevance in project proposals, ensuring that outcomes are practical and applicable. Only one grant will be awarded per institution each year, supporting innovative approaches to enhance youth sports safety and health.
Orthopedics Children’s Health & Pediatrics

Townsend, R.E. Educational Scholarship

Community Foundation Of Northwest Missouri
Private
United States
US $1,000 - US $2,000

Community Foundation of Northwest Missouri

The Community Foundation of Northwest Missouri Inc. was established in 2009 as a 501(c)3 public charity to help donors support their favorite charities while receiving maximum tax advantage.

We serve as a vehicle for charitable giving, helping donors give to the causes they care about. Donor gifts will strengthen nonprofits increasing programs and services. Individuals and organizations are encouraged to establish a fund with us. 

Townsend, R.E. Educational Scholarship

This fund was established by the trustees of the R.E. Townsend Educational Fund to provide academic scholarships to students intending to further their education.

Guidelines:

Scholarships will be awarded on an annual basis and disbursed in August.

Amount:

Minimum of $1,000 and maximum of $2,000 per recipient depending on the fund balance. 

Vocational & Trade Education Teacher Development & Training

PLTW Launch - New Program- Initiative: PLTW Grant- ( within 50 states of US)

Project Lead The Way Inc
Private
United States
US $4,900 - US $13,900
PLTW Launch offers a rolling grant for schools across the U.S. to implement the PLTW Launch program for the upcoming academic year. All schools, especially those serving low-income and minority populations, are encouraged to apply. The grant covers participation and training fees, with requirements to implement multiple PLTW modules over time. This initiative aims to enhance STEM education, ensuring diverse access to innovative learning opportunities.
STEM / STEAM Education Teacher Development & Training

Combined Pilot Research Grants: PSRC/PSF

Plastic Surgery Foundation
Private
Canada, United States
Up to US $15,000
The Combined Pilot Research Grants program, supported by the Plastic Surgery Foundation and various surgical organizations, aims to promote innovative research in hand and plastic surgery. With funding of up to $10,000 for one-year pilot projects, this initiative encourages the development of surgeon scientists and seeks to enhance research funding in the field. Eligible applicants must be medical professionals holding relevant positions in U.S. or Canadian institutions.
Reconstructive Surgery

Henry Hanff Fellowship Award

Ao North America Inc
Private
Europe, North America
Up to US $5,900
The Henry Hanff Fellowship Award offers a unique opportunity for practicing North American trauma surgeons to enhance their skills through a short-term fellowship at a trauma clinic in North America or Europe. Sponsored by AO North America, the fellowship lasts four to eight weeks and covers airfare and a stipend for living expenses, with a total award not exceeding $5,900. Participants must submit a report on their experience for publication, enhancing professional development and collaboration.
Orthopedics Medical Education & Professional Training

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required) (357282)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,125,000
The Academic Research Enhancement Award (AREA) supports small-scale research at institutions that receive limited NIH funding, emphasizing biomedical research for undergraduate students. This program aims to enhance the research environment and provide valuable experiences for students. Eligible institutions must award baccalaureate science degrees and have received no more than $6 million in NIH support over four of the last seven years. This funding opportunity encourages investigator-initiated minimal risk clinical trials to advance NIH missions.
Biology Health & Medicine Medical Education & Professional Training

Local Filmmaker Fund

People’s Media Fund
Private
United States
US $10,000 - US $30,000
The Local Filmmaker Fund by the People's Media Fund supports filmmakers in Greater Philadelphia, enhancing their skills and film projects through a 12-month cohort program. This initiative prioritizes under-resourced filmmakers committed to social justice, offering funding up to $400,000. Eligible applicants must be at least 18 years old, live in designated areas, and either direct their film or secure fiscal sponsorship. The program fosters community storytelling and aims to amplify diverse voices in media.
Film

NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $249,000
The NCI Pathway to Independence Award (K99/R00) supports talented postdoctoral researchers in transitioning to independent faculty positions. This program provides essential NCI research funding to facilitate the development of competitive, independent research careers. Applications are due by 5:00 PM local time of the applicant's organization, emphasizing the importance of timely submissions for prospective awardees.
Biology Health & Medicine Medical Education & Professional Training

Hans-Olaf Pfannkuch & E. Calvin Alexander, Jr. Hydrogeology Field Camp Award

Minnesota Ground Water Association (MGWA) Foundation
Association/Society
Canada, United States
US $1,500
The Hans-Olaf Pfannkuch & E. Calvin Alexander, Jr. Hydrogeology Field Camp Award, provided by the Minnesota Ground Water Association Foundation, offers two $1,500 scholarships for the summer of 2025. This award aims to support students enrolled in hydrogeology or related fields by alleviating educational costs associated with field camps. It seeks to foster a diverse learning environment and build a stronger community of hydrogeology professionals through shared life experiences.
Hydrology Academic Scholarship Programs

The Land and Water Conservation Fund: Outdoor Recreation and Legacy Partnership Program

Connecticut Department of Energy and Environmental Protection
State/Local Government
American Samoa, District of Columbia +5 more
US $300,000 - US $15,000,000
The Land and Water Conservation Fund's Outdoor Recreation Legacy Partnership Program aims to enhance recreational opportunities in underserved communities through significant funding. Offering matching grants up to 50%, with awards ranging from $300,000 to $15,000,000, this program encourages applicants to connect with the Connecticut Department of Energy and Environmental Protection early in the application process for guidance. This initiative supports large-scale projects that improve access to recreational facilities.
Outdoor Recreation Parks & Public Spaces

Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $5,000,000
The Environmental Health Sciences Core Centers Program (P30) invites grant applications to support innovative research in environmental health. These centers serve as critical hubs for advancing the goals of the 2025-2029 NIEHS Strategic Plan, providing essential infrastructure and resources for collaborative research. By fostering community engagement and translational research, the program aims to enhance understanding of the connections between environmental factors, human biology, and disease, ultimately improving public health outcomes.
Environmental Health

NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Not Allowed) (357072)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIDCR Dentist Scientist Career Transition Award (K22) supports dentists transitioning from NIH postdoctoral roles to tenure-track faculty positions. It provides two years of mentored research training in the NIH Intramural Research Program, followed by three years of independent research funding at an extramural institution. Key deadlines for grant applications include February 12, 2025, and subsequent dates in June and October 2025, with additional deadlines for renewal and AIDS-related applications.
Dental Health Medical Education & Professional Training

USF: Adult Learn-to-Swim Grants

Usa Swimming Foundation
Private
United States
US $1,000 - US $5,000
The Adult Learn-to-Swim Grants, offered by the USA Swimming Foundation in collaboration with U.S. Masters Swimming, aim to enhance swimming safety for adults aged 18 and over. This initiative provides funding to programs that promote swim education, targeting underserved communities. Grants can be used for expenses like pool rentals and scholarships, with a maximum award of $5,000. The goal is to reduce drowning risks and encourage ongoing participation in swimming activities.
Swimming

Auer, Arthur and Hazel Scholarship Fund

Noble County Community Foundation
Private
United States
Up to US $2,000
The Arthur and Hazel Auer Scholarship Fund, established by Hazel Auer's will, provides financial support to two East Noble seniors each year as they prepare for 4-year bachelor's programs at accredited colleges. Each recipient receives about $500 per semester for the first two years, totaling $2,000. This fund is managed by the Community Foundation of Noble County, which aims to enhance the quality of life in the region through philanthropic efforts.
Education - Higher Education Academic Scholarship Programs

USF: Community Impact Grant

Usa Swimming Foundation
Private
United States
Up to US $5,000
The USF Community Impact Grant, established by USA Swimming and the USA Swimming Foundation, aims to enhance competitive opportunities in swimming clubs. Grants of up to $5,000 are available for registered USA Swimming clubs committed to fostering community engagement and collaboration. Eligible clubs can renew their grant for up to three years, promoting diverse access to swimming programs. This initiative particularly supports clubs that partner with educational or public entities and those led by women or minorities.
Swimming

Seeding Critical Advances For Leading Energy Technologies With Untapped Potential (Scaleup) Ready

United States Department of Energy (DOE)
Federal Government
American Samoa, Guam +4 more
US $5,000,000 - US $20,000,000
The Seeding Critical Advances for Leading Energy Technologies (Scaleup) Ready initiative by ARPA-E invites applications for funding to advance transformative energy technologies. This program supports innovative projects that demonstrate potential for significant market disruption and emphasizes rigorous project management and technology risk mitigation. Eligible organizations must have inventions conceived during an ARPA-E award, reported in the iEdison system, and hold relevant U.S. patent applications. For further details, visit ARPA-E's website.
Emerging Technology Development Energy Renewable/Sustainable Energy +2 more

BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The BRAIN Initiative's funding opportunity aims to support the establishment of facilities at minority-serving and IDeA-eligible institutions for the production and distribution of brain cell type-specific reagents. These reagents will enhance neuroscience research by enabling precise manipulation and access to brain cell types, facilitating advancements in understanding circuit functions in various species. The initiative encourages collaboration among awardees to optimize the use of these essential resources across the neuroscience community.
Neuroscience

NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $8,750,000
The NICHD Resource Program Grants in Bioinformatics aim to support the operation and enhancement of vital bioinformatics databases for research on animal models of embryonic development. These grants promote user training, data curation, and interoperability with NIH resources, ensuring wide dissemination of critical tools and resources to the research community. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the proposal deadline.
Biomedical informatics Developmental Biology / Embryology

Emergency Educational Grants

Elks National Foundation Inc
Private
United States
Unspecified amount
The Emergency Educational Grants offer vital financial support of up to $5,000 for undergraduate students who are children of deceased or totally disabled Elks. This grant is renewable for one year and is intended solely for educational purposes, helping cover costs such as tuition and books. Eligible applicants must demonstrate financial need and maintain full-time enrollment in an accredited U.S. college or university, while being unmarried and under 24 years old during the application year.
Education - Higher Education Academic Success & Enrichment

JKC Foundation: College Scholarship Program

Jack Kent Cooke Foundation
Private
United States
Unspecified amount
The Jack Kent Cooke Foundation's College Scholarship Program offers financial support to high-achieving high school seniors with financial need. Scholarships cover significant educational expenses, including tuition and living costs, potentially providing up to $55,000 annually. Eligible applicants must maintain a GPA of 3.75 or higher and plan to enroll in an accredited four-year institution. This competitive program not only alleviates financial burdens but also connects students to a network of over 3,400 Cooke Scholars.
Education - Higher Education Academic Scholarship Programs

Grants for 501(c)(3) in South Carolina Highlights

Looking for grants for 501(c)(3) in South Carolina?


Read more about each grant below or start your 14-day free trial to see all grants for 501(c)(3) in South Carolina recommended for your specific programs.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Grants for 501(c)(3) in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Grants for 501(c)(3) in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

54 Grants for 501(c)(3) in South Carolina over $25K in average grant size

41 Grants for 501(c)(3) in South Carolina over $50K in average grant size

32 Grants for 501(c)(3) in South Carolina supporting general operating expenses

100+ Grants for 501(c)(3) in South Carolina supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for grants for 501(c)(3) in South Carolina?

Most grants are due in the first quarter.

Q1
28.9%
Q2
26.6%
Q3
24.1%
Q4
20.4%

Typical Funding Amounts

What's the typical grant amount funded for Grants for 501(c)(3) in South Carolina?

Grants are most commonly $15,000.

$500 $500 Min.
$15,000 $15 K Median
$530,911 $530.9 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Grants for 501(c)(3) in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Grants for 501(c)(3) in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Grants for 501(c)(3) in South Carolina changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081