Best Large Grants for Nonprofit Organizations in South Carolina

The PTA Healthy Minds program, supported by the New York Life Foundation, provides $1,250 to 75 local PTAs to enhance mental health resources for students and families. This initiative aims to empower PTAs to connect their communities with essential mental health support and programming, fostering resilience and emotional well-being among children. By engaging families and school leadership, the program promotes informed decision-making regarding mental health and ensures accessibility to resources for all students.

The Craig Newmark Philanthropies Grants, established in partnership with the Bob Woodruff Foundation, aim to support military and veteran communities through funding initiatives that enhance health and well-being. Since 2020, this program has positively impacted over 1.6 million veterans, service members, and their families. The grants focus on improving health determinants, increasing access to healthcare, and facilitating veterans' successful transitions to civilian life.

The Hematology Inclusion Pathway Resident Award supports underrepresented medical residents in hematology in the U.S., Canada, and Mexico. Participants receive $5,000 for research, mentorship from ASH members, and funding for the ASH annual meeting. Eligible candidates are in internal medicine or pediatric residencies, self-identify as underserved, and must conduct research with an ASH mentor. This program aims to enhance diversity and support crucial blood science research.

The Ken and Eileen Gross Memorial Scholarship, established by friends of the couple, supports Saginaw County high school seniors pursuing a teaching degree. With a focus on fostering education, this scholarship honors Ken, a dedicated educator, and Eileen, a successful property manager. Eligible students must demonstrate a minimum 3.0 GPA and financial need, ensuring that those committed to teaching can pursue their aspirations. Awards typically range from $500 to $4,000, empowering the next generation of educators.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Cushing’s disease or syndrome

Help with healthcare costs for Cushing's disease or syndrome

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Cushing’s Disease or Syndrome, also known as Cushing’s Syndrome, hypercortisolism and hyperadrenalism, is a condition where the pituitary gland releases high levels of the hormone cortisol. It is a rare disease that affects the endocrine system.

The Hearst Journalism Awards Program, established in 1960, supports journalism education through scholarships and competitions. With up to $700,000 in awards across various categories, it encourages undergraduate journalism majors and minors from accredited institutions to showcase their work. The program includes multiple writing, photojournalism, audio, television, and multimedia competitions, providing a platform for emerging journalists to gain recognition and experience in their field.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Amyloidosis

Help with healthcare costs for amyloidosis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Amyloidosis is characterized by a build-up in amyloid protein in specific organs or throughout the body. It is a rare disease that affects multiple systems. Subtypes include hereditary amyloidosis, light chain amyloidosis (AL amyloidosis), and amyloid A (AA) amyloidosis (secondary amyloidosis).

Dale and Tillie Jessup Scholarship

The Dale and Tillie Jessup Scholarship is intended for graduating high school seniors who have attended a Greene County high school for all four years and have been a resident of Greene County or Clay County for those four years. Applicant must be planning to major, on a full-time basis, in agriculture or an agriculture-related field. Dale and Tillie Jessup established a unique scholarship fund for Greene County high school graduating seniors. The Jessup’s donated 100 acres of farm land to the Foundation. The land is leased for farming and the proceeds are used to provide scholarships to students in financial need. Students awarded the Jessup scholarship as a graduating high school senior may re-apply in subsequent years for additional awards.

The NIH grant focuses on elucidating the role of transporters in key perinatal barriers such as the placenta and blood-brain barrier. By establishing a multi-barrier transport network, the initiative aims to enhance understanding of maternal and infant health regarding nutrient and medication transport. This research will create essential resources and standards, fostering future studies on perinatal exposure and intervention strategies. Ultimately, it aims to advance knowledge in pediatric pharmacology and neurodevelopment.

The Fall Programs Grants: STEM + Families Propelling Our World initiative by the National PTA aims to engage families in hands-on STEM activities. Sponsored by Huntington Ingalls Industries, this program empowers local PTAs to conduct engineering challenges that foster collaboration between students and parents. With grants of $1,250 awarded to 20 selected PTAs, the program seeks to inspire interest in STEM careers and provide essential resources for family engagement in educational activities.

Albert Smith Conservation Scholarship

Albert A. Smith was born in Omer, Mich., in 1913. He began his education in a one room schoolhouse near Omer and successfully completed his first three grades in the first year of school. Upon graduation from Flint Northern High School at age 15, he went on to receive an undergraduate degree from the University of Michigan and thereafter a law degree in 1939. In the mid-1950s, he opened a law office in Saginaw that later became the law firm of Smith Bovill, P.C.

Mr. Smith’s love of the law was matched by his interest in the outdoors, and in particular his beloved Ruffed Grouse. He used his rolling farm and woods to entertain his friends, clients and courtroom adversaries. He was a consummate host to anyone who shared his love for the hunt.

Al was generous with his time and resources. He supported and served on the boards of his favorite charities and civic groups, including the Salvation Army, the Ruffed Grouse Society where he served as national president, the Samaritan Center and First Congregational Church. In 1976, he was recognized for his outstanding conservation work when he received the Wildlife Conservationist of the Year Award from the Michigan United Conservation Clubs.

Louis R. & Helen E. Schwartz FFA Agricultural Scholarship

The Louis R. and Helen E. Schwartz FFA Agricultural Scholarship was established to help prepare Saginaw County students for a future in agriculture or an agriculture-related field. Both Lou and Helen Schwartz were raised on farms in Iowa, so they knew from first-hand experience that farming can be a difficult business. They moved to Frankenmuth when Lou opened area S&H Stores in 1962. The stores were sold to Quality Farm and Fleet in 1982.

Scholarships are awarded to students from Saginaw County, Michigan; Lyon County, Minnesota and Muscatine County, Iowa.

The Grief Reach Cycle 3 grant offers $15,000 to U.S.-based 501(c)(3) nonprofits dedicated to supporting grieving children and youth. This funding aims to enhance organizational capacity through strategic planning, volunteer engagement, and collaborative partnerships. Organizations must demonstrate a commitment to providing direct services and align their projects with the grant's focus areas. This competitive opportunity seeks to empower underserved communities by expanding access to vital grief support services.

The Mary Lou and Dwight Pitman Scholarship supports area public high school students in Sangamon County, excluding Springfield and Chatham districts, who have siblings planning to attend college. Established through the Sangamon County Foundation in 1924, this scholarship honors the legacy of community leaders and aims to empower the next generation by aiding students' educational pursuits. Eligible applicants include graduating high school seniors and current college students who are direct descendants of U.S. Service Members.

The FY26 Reconstructive Transplant Research Program Concept Award encourages innovative research addressing critical issues in reconstructive transplantation. It supports groundbreaking concepts and untested theories, emphasizing creativity and relevance to specific focus areas. Notably, preliminary data presentation is prohibited, yet applications must demonstrate potential for interpretable results. Early-career investigators are particularly encouraged to apply, fostering new talent in this vital research field.

The NIDCD Research Fellowship for Audiologists provides clinical audiologists enrolled in Ph.D. programs with essential research training. This initiative encourages the integration of clinical and translational research, fostering strong research foundations vital for advancing audiology and hearing healthcare. Although applications are not currently being solicited, the program aims to prepare potential candidates for meaningful collaborations and impactful research projects in the biomedical, behavioral, or clinical sciences.

The National Scleroderma Foundation supports pediatric scleroderma research with up to $500,000 in funding for new and established investigators. Their mission focuses on advancing medical research and promoting awareness of scleroderma, with the vision of improving the lives of those affected. This initiative aims to encourage innovative research that could lead to better treatments and a potential cure for pediatric scleroderma, enhancing support for affected families.

The JSF Indigenous Peoples Grant Program is dedicated to fostering economic development in Indigenous communities through entrepreneurship and business education. With over 30 years of experience, the program supports Indigenous students with scholarships and capacity-building grants. It has produced more than 80 graduates from its MBA in American Indian Entrepreneurship, addressing barriers to education and employment, and enhancing opportunities for entrepreneurs. JSF's commitment to these initiatives is evident in its annual investment of approximately $500,000.

The Council of Independent Colleges

Founded in 1956, the Council of Independent Colleges (CIC) is an association of nonprofit independent colleges and universities, state-based councils, and higher education affiliates that works to support college and university leadership, advance institutional excellence, and enhance public understanding of independent higher education’s contributions to society.

CIC is the major national organization that focuses on providing services to leaders of independent colleges and universities and state-based councils. CIC offers conferences, seminars, publications, and other programs and services that help institutions improve educational quality, administrative and financial performance, student outcomes, and institutional visibility.

NetVUE Program Development Grants

Colleges and universities that are members of NetVUE are already committed to campus activities that encourage vocational exploration by students. These institutions are making significant investments of their own resources to develop and sustain vocational exploration initiatives. In order to support NetVUE member campuses in their work, Lilly Endowment Inc. has provided funding to CIC to be used for NetVUE Program Development Grants. Many NetVUE campus leaders have observed that grants for program development at even modest levels would enable their institutions to strengthen and expand existing programs significantly.

NetVUE Program Development Grants may be requested in amounts up to $100,000 for use over two years to deepen, expand, or otherwise strengthen programs that are already underway (including those planned or initiated through recently completed NetVUE Professional Development Awards) and supported by the institution itself. A wide range of proposals that augment existing programs in vocational reflection and discernment will be considered; examples include

• mini-grants to support released time for designing or revising courses to include greater engagement with vocational reflection;
• programming that brings faculty members and administrative staff (from, for example, career services, student life, or campus ministry) into partnership for advising, mentoring, and/or experiential learning opportunities; and
• projects that integrate reflection on calling and vocational discernment into an institution’s general education requirements or into their major or minor field requirements.

The JSF People with Disabilities Grant supports organizations that empower students with disabilities through education and employment opportunities. With a focus on scholarships and mentorship, the Foundation addresses barriers that hinder access to higher education. It has established partnerships with universities and schools, including Gallaudet University, to create impactful programs. Additionally, it funds initiatives that help transition individuals into the workforce, ensuring inclusivity in educational and professional settings.

This funding opportunity invites applications for investigator-initiated clinical trials that deliver complementary and integrative health interventions remotely or via mobile health technologies. Emphasizing no in-person contact, the trials should demonstrate feasibility, safety, and potential clinical benefits. A Plan for Enhancing Diverse Perspectives is required for submission, and applicants are encouraged to consult with NCCIH contacts before applying. Deadlines for submissions range from February 2025 to October 2026.

The Council of Independent Colleges

Founded in 1956, the Council of Independent Colleges (CIC) is an association of nonprofit independent colleges and universities, state-based councils, and higher education affiliates that works to support college and university leadership, advance institutional excellence, and enhance public understanding of independent higher education’s contributions to society.

CIC is the major national organization that focuses on providing services to leaders of independent colleges and universities and state-based councils. CIC offers conferences, seminars, publications, and other programs and services that help institutions improve educational quality, administrative and financial performance, student outcomes, and institutional visibility.

NetVUE Grants to Individuals for Vocational Exploration

CIC is pleased to announce the first NetVUE grant program for individual projects by staff and faculty members. While NetVUE offers a number of grant programs for institutions, this new program—Grants to Individuals for Vocational Exploration—is its first program designed explicitly for individual projects by faculty members and staff at NetVUE member institutions.

Many employees at NetVUE member institutions engage and contribute to the exploration of vocation in undergraduate education through their scholarship, teaching, and practice. The NetVUE program seeks to support this work by offering them more resources to support new research and pedagogical innovation. Through the NetVUE Grants to Individuals for Vocational Exploration, CIC will offer funding and guidance to support projects that will generate artifacts or products (such as scholarly articles, course syllabi and learning activities, program designs, or other resources) that will develop and expand the existing field of scholarship, conversation, and pedagogy on vocation in undergraduate education.

This grant is intended to support innovative projects in the scholarship, pedagogy, leadership, and/or practice of vocation in undergraduate education. Proposals are welcome from both new and established scholars and practitioners. Particularly welcome are projects that seek to make vocational exploration and discernment available to all students, as well as projects that invite the NetVUE community toward fresh considerations and new frameworks in vocation as a lens for undergraduate education.

The Great Lakes Bay Community Resource Association Scholarship, founded in May 2023, aims to enhance health outcomes and educational opportunities for underserved individuals. With a focus on human medical-related fields, this scholarship supports students pursuing careers in nursing, psychology, and more. Beneficiaries will engage with professional mentors and gain hands-on experience in community health initiatives. The scholarship reflects a commitment to addressing healthcare disparities and empowering future professionals in the medical field.

The Great Lakes Safety Training Center Scholarship, established by local contractors and businesses, aims to support residents of Gratiot or Saginaw County pursuing careers in trades or construction with a focus on safety. This scholarship is available to individuals enrolled in degree or certification programs at accredited institutions in Michigan, emphasizing the importance of safety in skilled trades. With awards typically ranging from $500 to $4,000, this initiative addresses the growing demand for skilled workers in the community.

The Guadalupe “Lupe” Gomez Memorial Scholarship, established by Lupe's family after her passing in 2009, honors her legacy of dedication and service in education and the community. This scholarship supports students from Saginaw County who demonstrate hard work and self-motivation, particularly those pursuing Career and Technical Education (CTE) or other degrees. With awards ranging from $500 to $4,000, it aims to empower the next generation of skilled workers in various trades.

The Hebert Memorial Scholarship, established by Jacquelyn and Donald Hebert, aims to support Saginaw County residents pursuing higher education. With a minimum GPA requirement of 3.0, this scholarship is available to graduating high school seniors and current college students enrolled full-time. The Heberts, who valued education and community service, created this fund to help students achieve their academic goals, reflecting their commitment to enhancing the lives of local youth.

Chicken & Egg Pictures Inc

Chicken & Egg Films was founded in 2005 by documentary film industry veterans Julie Parker Benello, Wendy Ettinger, and Judith Helfand. As filmmakers, teachers, funders, and impact producers, they were inspired to utilize their collective expertise to uplift the power of fellow women storytellers. Chicken & Egg was thus created to help address financial and creative challenges uniquely faced by women in the field–a model that married funding with mentorship to create not just an organization, but a growing community. 

Chicken & Egg Films shapes a more equitable and just world with the catalytic power of documentary films by providing funding, mentorship and industry access to a global community of women and gender-expansive filmmakers. 

Chicken & Egg Award

The Chicken & Egg Award recognizes women and gender-expansive filmmakers at advanced stages in their careers who are poised to reach new heights in their creative and impact trajectories across the world.

Despite progress by talented women and gender-expansive documentary filmmakers across the globe, there are often still numerous roadblocks that stand in the way of a true industry breakthrough. These barriers are often tied to gender, race, class, disability, and geography. Only a few women and gender-expansive nonfiction directors in the United States and abroad are able to work full time as independent storytellers, and few are folks of color, from working-class backgrounds, or from under-represented countries. 

There are, however, a growing number who are getting close. Each has made several films, and each is an influential leader for the issues they explore on screen. With this Award, Chicken & Egg Films is making a bold investment in these creatives and a statement about gender equity. A greater diversity of voices participating in storytelling drives change. We believe this effort is inextricably connected to elevating critical social justice, environmental, and human rights issues. 

The Chicken & Egg Award consists of a $75,000 USD cash award and a year-long mentorship program. Of the total, $50,000 is unrestricted, allowing filmmakers to decide how to use the funding to support their creative and business practices. The additional $25,000 is a grant for the project(s) the filmmaker will work on during their program year. Our in-depth mentorship program is focused on strengthening Awardees’ professional infrastructure, increasing their visibility, and fulfilling their personal and creative goals.