Best Large Grants for Nonprofit Organizations in South Carolina

The First Horizon Foundation, established by First Horizon National Corp., supports communities in Florida, North Carolina, and South Carolina. Since 1993, it has donated over $90 million to enhance lives through grants focused on arts, education, environment, financial literacy, and health services. Eligible nonprofits in various cities can apply, while individuals and certain organizations, such as K-12 schools and political groups, are excluded from funding. This foundation is dedicated to making a positive impact in the regions it serves.

The Harbor Freight Tools for Schools Grant Program, initiated by Eric Smidt through The Smidt Foundation, supports high school students in skilled trades education. This initiative facilitates pathways to graduation and fosters opportunities for meaningful employment. Each year, it awards $1.5 million in cash prizes to 25 exceptional U.S. public high school skilled trades teachers, enhancing support and investment in trades education. This program is a vital resource for schools aiming to improve their vocational training.

PFund Foundation

PFund Foundation builds equity with LGBTQ+ communities across the Upper Midwest by providing grants and scholarships, developing leaders, and inspiring giving.

PFund Foundation Scholarship

PFund Scholarship Grants are for LGBTQ+ students of all ages who are either from or studying in the Upper Midwest. Grants range from $1,000-$12,000 and can be used for a wide variety of expenses and programs. Scholarships also include a lifetime membership to the PFund Scholar Alumni program which includes annual professional development and networking opportunities. There is one application window per year.

The Colonel David Marcus Memorial Scholarship Award supports students from Burlington, Camden, or Gloucester Counties pursuing post-high school education, particularly in military programs. Established by the Jewish Community Foundation, this scholarship prioritizes candidates who embody Col. Marcus's ideals. Eligible applicants must be high school seniors and may apply for multiple awards. The fund has a strong community leadership background, managing over $35 million in assets to support educational initiatives.

Dick & Judy Hoyt Inclusion Grant

The Doug Flutie, Jr. Foundation for Autism is excited to collaborate with the Hoyt Foundation for the Dick and Judy Hoyt Grant for Inclusion. Our joint effort is driven by a shared vision of fostering a society where individuals with autism and other disabilities are embraced and valued within their communities. In tribute to the pioneering spirit of Dick and Judy Hoyt, we will be distributing $50,000 through this community grant to support people with autism and other disabilities. Successful ways grant funds can be used: 

• Side-by-side participation with non-disabled peers in a swim program, the grant provides a private lifeguard to allow individualized support to ensure an inclusive experience.
• Grant provides the purchase of a racing chair to allow an individual with a disability to run in races with non-disabled peers.
• Competitive horseback riding supported by the grant to purchase specialized equipment to allow a rider to compete against non-disabled peers.
• Grant provides the purchase of an adaptive ski prosthetic to allow an individual to participate side by side with non-disabled peers on their high school ski teams.
• Participation in dance training and competitions to allow a student with a disability to compete in a dance competition with non-disabled peers, grant lessons, and staff to assist in dance training.
• Grant provides a mobile stand to allow a student with a disability to participate side by side with non-disabled peers in the college marching band. 

The NIH Blueprint for Neuroscience Research Network aims to enhance foundational research on human consciousness, addressing critical biomedical issues such as coma and dementia. By fostering a collaborative framework among 14 NIH institutes, the initiative seeks to improve diagnosis and treatment of neurological disorders through interdisciplinary approaches. Key objectives include detecting consciousness in minimally responsive patients, enhancing understanding of sleep disorders, and exploring new methodologies. This effort will ultimately strengthen U.S. leadership in neuroscience and improve patient outcomes.

The Lisa and Douglas Goldman Fund, established in 1992, supports charitable organizations that enhance society, focusing on democracy and civil liberties. The fund prioritizes projects that ensure equal citizen participation in the democratic process and protect civil liberties, especially those implemented nationally or across multiple states. It operates by invitation only and emphasizes flexible, informed grantmaking to qualified projects that align with its mission and values.

The NRF Foundation Rising Stars Scholarship aims to inspire high school students to explore diverse career paths in the retail industry. By encouraging early participation in the NRF Foundation Student Program, the scholarship allows nominated freshmen and sophomores to gain invaluable insights. Eligible students, nominated by university members, receive a $1,000 travel stipend for the program held in New York City from January 8-11, 2026, fostering their academic and professional growth.

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

Edith R. and Alvin J. Domroe Foundation Scholarships

The Foundation supports college scholarships and has funded two scholarships to encourage academic excellence.

About Us

Children’s Cancer Research Fund is a national nonprofit dedicated to ending childhood cancer. Our main focus is to support the research of bright scientists across the country whose ideas can make the greatest impact for children fighting cancer. We also fund resources and programs that help kids and families as they navigate the difficult experience of cancer treatment and survivorship.

Since 1981, we’ve contributed over $235 million to research, support programs for children and families, and awareness and education outreach. In 2024, over 81 percent of funds raised went directly to these program services areas.

Children’s Cancer Research Fund (CCRF) is a national nonprofit committed to finding safer, more effective therapies for kids battling cancer. Thanks to donors and partners around the country, we have contributed over $235 million to research, education and awareness, and quality-of-life programs for childhood cancer families. We believe kids deserve safer, less toxic treatments, and we’re committed to funding groundbreaking research and services that enhance healing and care.

In 2026, Children’s Cancer Research Fund will focus our research funding efforts on three main areas:

• Hard-to-Treat Cancers
• Survivorship
• Health Disparities

Accelerating Hope: Clinical Trials for Hard-to-Treat Cancers Award

This funding opportunity is limited to support for clinical trials focused on hard-to-treat cancers, prioritizing Phase 0 – Phase 2 studies. Learn more about eligibility criteria and other key details below.

The Funding the Future of Finance in Indian Country/Johnson Scholarship offers financial support to eligible American Indian and Alaska Native undergraduate students pursuing full-time degrees in business, accounting, or finance. The program aims to enhance diversity in these fields and provides awards of up to $10,000 per academic year based on need. Applicants must demonstrate Tribal affiliation through a Tribal Eligibility Certificate.

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

Jesse and Hertha Adams Charitable Trust Scholarship

The Jesse and Hertha Adams Trust Scholarship is made available for those individuals who wish to achieve their dreams. Success is acknowledged through hard work and the effort you put forth. And the Jesse and Hertha Adams Scholarship acknowledges both. In addition to funding this named scholarship, the trust generously contributes to our program travel expenditures for our winners and many of our National Federation of the Blind other scholarships.

The Mitchell Patrick Mielnik Scholarship, established by the Community Foundation of Middle Tennessee, honors the legacy of Mitchell Mielnik, a passionate hockey player who exemplified integrity. This scholarship supports scholastic hockey players demonstrating excellence in athletics and academics. By fostering Mitchell's spirit of generosity, the foundation aims to empower young athletes to excel in their personal and professional lives, ensuring a positive impact on the community for years to come.

The BIE Special Higher Education Program offers financial assistance to American Indian and Alaska Native graduate and professional students enrolled full-time in accredited institutions across various fields. Awards fluctuate annually based on applicant qualifications and available funding, ensuring support aligns with need-based criteria. To qualify, applicants must demonstrate Tribal affiliation through a Tribal Eligibility Certificate. This initiative aims to empower Indigenous scholars in their academic pursuits.

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

Kurzweil Foundation and Ray Kurzweil

The Kurzweil Foundation and Ray Kurzweil contribute to each recipient’s award, and provide each finalist with a commemorative plaque in both print and Braille. Ray Kurzweil is a long-time friend of the Federation and deserves our special recognition.

The ENF Community Investments Program offers Gratitude Grants between $3,000 and $5,000 to Elks Lodges that have met the GER’s per-member-giving goal. These grants empower Lodges to enhance community service and foster local engagement, supporting initiatives that promote health, education, and welfare. The program exemplifies the Elks' commitment to charity and community improvement, showcasing their dedication to building stronger neighborhoods and helping those in need.

About Us

We enable donors and nonprofit partners to tackle the most critical needs facing San Diegans.

Mission & Values

Our vision is for just, equitable and resilient communities.

Our mission is to inspire enduring philanthropy and enable community solutions to improve the quality of life in our region.

We value all people, all partners and our region.

Common Scholarship Application

Achieve your Higher Education Dreams

In just one application, our Common Scholarship Application provides students access to more than 150 scholarship opportunities with awards ranging from $1,000 to more than $5,000.

In 2025, San Diego Foundation awarded a record-breaking $5.5 million in scholarships to nearly 1,400 students.

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

National Federation of the Blind Scholarships

All other scholarships proudly carry the name National Federation of the Blind. Our members acknowledge academic excellence and leadership in making these awards.

The San Antonio Association of Hispanic Journalists Scholarship Fund, administered by the San Antonio Area Foundation, supports students pursuing degrees in Journalism or Communications. Eligible applicants include high school seniors and college students from specific Texas counties or those attending schools in San Antonio. The scholarship aims to foster educational opportunities and promote diversity in media, helping students achieve their career goals in the communications field.

The Six Flags Lamond Jasper Maintenance Scholarship supports dedicated maintenance associates of Six Flags Entertainment Corporation. Eligible applicants must have at least 12 months of employment, be a high school graduate or GED holder, and be enrolled in a vocational training or apprenticeship program focused on trade or maintenance roles in the U.S. This scholarship aims to empower individuals to enhance their skills and contribute positively to their communities.

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.

The Central Presbyterian Church - Raisner Family Scholarship Fund

The Central Presbyterian Church-Raisner Family Scholarship Fund assists deserving Stark County students who are active in the church or who are children or dependents of an active member of Central Presbyterian Church who are pursuing first-year post-secondary education. Applicants must have a minimum GPA of 2.5 and demonstrate financial need.

Amount:

• Varies. Minimum $500.

Renewable:

• No

The Pabst Steinmetz Foundation Grant supports innovative projects at the intersection of arts, education, and wellness. It aims to empower organizations that address critical community issues and foster sustainable models for change, particularly in Florida. The foundation encourages collaboration and seeks initiatives that create a ripple effect, enhancing community capacity and promoting impactful solutions. Eligible applicants are 501(c)(3) entities in the U.S. focusing on community betterment through creative approaches.

The Luck Companies Foundation Grants aim to foster long-term positive impact in communities through values-based leadership and environmental stewardship. Established to support community growth, the foundation matches donations from associates and provides grants to purpose-driven organizations. It collaborates with local leaders and institutions to turn visions into reality, ensuring that their contributions benefit communities for decades. By reviewing requests quarterly, they prioritize initiatives that align with their mission and emphasize sustainable community development.

The IUE-CWA Local 88502 Union Scholarship, established by union members, supports students pursuing vocational studies. This scholarship is available to graduating seniors with a parent or grandparent who are union members or retirees. Candidates must be enrolled in a post-secondary vocational degree or certification program and submit an essay explaining their career aspirations. The award amount is determined annually, reflecting the commitment to fostering vocational education within the community.

The Six Flags Associate Scholarship, offered by the Erie County Community Foundation, aims to support recent high school graduates or college students with financial need. Eligible applicants must have a minimum 2.5 GPA and be enrolled in an accredited institution in the U.S. Preference is given to those demonstrating community service and leadership. This scholarship can be renewed for up to three additional years, ensuring ongoing support for scholars committed to enhancing the quality of life in Erie County.

About Us

We enable donors and nonprofit partners to tackle the most critical needs facing San Diegans.

Mission & Values

Our vision is for just, equitable and resilient communities.

Our mission is to inspire enduring philanthropy and enable community solutions to improve the quality of life in our region.

We value all people, all partners and our region.

Common Scholarship Application

Achieve your Higher Education Dreams

In just one application, our Common Scholarship Application provides students access to more than 150 scholarship opportunities with awards ranging from $1,000 to more than $5,000.

In 2025, San Diego Foundation awarded a record-breaking $5.5 million in scholarships to nearly 1,400 students.

Dr. Barry T. Katzen Master Clinician Award

Honors an interventional radiologist who exemplifies dedication to clinical practice, patient care, diligence in their work and continuous improvement within the field and who has also made a demonstrable impact at their institution or practice as a result.

About

The Dr. Barry T. Katzen Master Clinician Award seeks to honor an interventional radiologist who exemplifies dedication to clinical practice, patient care, diligence in their work and continuous improvement within the field as well as who has made a demonstrable impact at their institution or practice as a result. This award recognizes individuals who have made significant contributions to enhancing patient outcomes and advancing the reputation and practice of interventional radiology through their hard work, commitment and, most importantly, clinical practice. The award is being given in the name of Barry T. Katzen, MD, FSIR, who pioneered clinical practice for IR in 1976 and became a vocal advocate, champion and example for colleagues of the importance of IR being a clinical discipline for advancement of the specialty.

The recipient will receive:

• Complimentary annual meeting registration
• Recognition during the SIR Annual Scientific Meeting