Best Large Grants for Nonprofit Organizations in South Carolina

The Connections to Care initiative aims to modernize and expand digital infrastructure across South Carolina’s rural healthcare ecosystem. This grant opportunity seeks proposals from eligible organizations to implement or enhance electronic health records (EHRs) and remote patient monitoring (RPM).

The Leveling Up initiative aims to expand and integrate proven chronic disease management programs statewide, ensuring rural communities have access to comprehensive, coordinated care for serious and chronic conditions such as diabetes, hypertension, and sickle cell disease. Historically, these programs have been implemented in limited regions due to resource constraints, leaving rural areas underserved and often last to benefit from advancements in chronic care. This grant opportunity seeks proposals from eligible organizations to expand chronic disease programs.

The Call for Kindness Grant, offered by Riley's Way Foundation, empowers young leaders aged 13-23 to launch impactful social projects focused on kindness and community connection. With grants up to $5,000, recipients receive essential mentorship, coaching, and community support. This initiative has already benefited over 3,500 youth nationwide, promoting values of empathy and social change. Applicants can pursue projects in diverse areas, including environmental justice, ensuring a broad impact in their communities.

About SCRA

The South Carolina Research Authority (SCRA) was chartered in 1983 by the State of South Carolina as a public, non-profit organization. The mission of SCRA is to fuel South Carolina’s Innovation Economy by accelerating technology-enabled growth in research, academia, entrepreneurship, and industry. SCRA supports its stakeholders in key technology sectors, which include but are not limited to, Advanced Materials/Manufacturing; Life Sciences; Clean Tech, Sustainability, and Resilience, and Information Technology. SCRA grant funding is made possible, in part, by Industry Partnership Fund (IPF) contributions. Contributors receive a dollar-for-dollar South Carolina income tax credit, making it a no-cost way to create a direct, positive economic effect and job creation

Mission

Fuel South Carolina’s innovation economy by accelerating technology-enabled growth of academia, entrepreneurship, and industry.

Vision

SCRA will be a leading catalyst in making South Carolina the top choice for technology-focused industry, entrepreneurs, investors, and academics.

Federal Matching Grant (formerly SBIR/STTR Phase I)

Managed by the Academic Innovations Team, the objective of the Federal Matching Grant is further federal funds received by small businesses in South Carolina to advance translational research in support of one or more critical milestones towards commercialization. Other Federal matches will be considered on a case-by-case basis. Key milestones include developing the technology past the minimum viable product (MVP) and demonstrating product-market fit, in the DEVELOP stage of startup development. In the ACCELERATE stage of startup development, key milestones include enabling product execution through testing and demonstrations.

The Park Foundation Grants for Animal Welfare focus on advancing the protection and conservation of wildlife, particularly through policy and advocacy efforts for threatened species. The foundation supports innovative, solution-oriented models that foster systemic change and compassion. Key areas include organizing for endangered wildlife, indigenous management practices, and supporting sanctuaries for great apes. Additionally, the foundation is committed to local efforts, including support for the Tompkins County SPCA, ensuring a compassionate society for all living beings.

Creative West

Established in 1974 as a nonprofit U.S. Regional Arts Organization (USRAO), Creative West was founded on the belief that place matters to the creative process. Fifty years later, communities of place, practice, experience, and identity remain fundamental to our work, framing our understanding of how culture is creatively produced and collectively experienced.

Creative West empowers artists and culture-makers with direct, practical resources, delivered regionally.

We offer practical, equity-centered learning experiences and funding opportunities that connect and inspire artists, culture-bearers and communities to build a more inclusive sector, strengthen the arts field, and catalyze change.

National Arts Futures Fellowship

The National Arts Futures Fellowship (NAFF) is a six-month virtual leadership development program rooted in democracy, wellness, and belonging. It calls on early and mid-career arts and culture professionals from all backgrounds to step into their power as civic leaders and cultural innovators—building the skills, networks, and vision needed to shape a future where creativity drives justice, care, and connection.

Fellows join a national network committed to strengthening public life, nurturing collective wellness, and fostering deep belonging across communities. Together, they learn, experiment, and act—advancing a shared vision of leadership that is sustainable, community-rooted, and future-focused.

Each fellow enters NAFF with a Personal Action Project (PAP)—a concrete idea they will develop and implement with support from peers, coaches, guest experts, and flexible seed funding of $250–$1,000. Projects may include launching a cultural initiative, organizing a community campaign, supporting artist-led advocacy, seeking a public leadership role, or piloting another form of civic or community action. Throughout the fellowship, each project evolves through coaching, peer feedback, strategy sessions, and real-world experimentation. Fellows conclude the program by sharing their project, leadership growth, and next steps at the National Fellows Summit.

What’s New in Cohort Two?

• Cohort Two expands NAFF from six to seven monthly sessions and adds two new elements that support fellows in moving their Personal Action Projects from development into implementation:
• Seed Funding: Fellows may request $250–$1,000 in flexible funding to test, pilot, or implement their projects during the fellowship.
• Artists Thrive Framework: Fellows will use the framework to assess their work, identify opportunities for growth, and strengthen artist-led advocacy, collaboration, and community impact.

Guiding Principles

• Democracy — Use the arts to strengthen civic participation, expand public trust, and make decision-making more accessible and inclusive.
• Wellness — Treat care, rest, and healing as strategic leadership tools for sustaining movements and communities.
• Belonging — Create spaces where leaders can thrive together across differences, build trust, and celebrate shared humanity.

What kinds of projects are supported?

Examples: Running for office, launching cultural programs, organizing campaigns, supporting policies. Projects can be local, regional, or national in scope.

The FY26 Defense Established Program to Stimulate Competitive Research (DEPSCoR) Capacity Building opportunity aims to enhance the capabilities of university researchers in eligible states. Managed by the DoD, this initiative focuses on increasing the number of researchers capable of conducting relevant science and engineering research. The program also seeks to strengthen institutions of higher education and improve their competitiveness for federal research funding, ultimately fostering long-term growth in financial assistance for scientific research.

The Encova Foundation of West Virginia is dedicated to improving communities by supporting local causes that align with the values of its associates and policyholders. They focus on health, education, and wellness, emphasizing the importance of children's success. Organizations applying for grants must be U.S.-based and verified as charitable. Preference is given to initiatives impacting health and education, especially those involving Encova associates as active participants.

The NRA Foundation offers grants in South Carolina aimed at promoting charitable purposes, including education about firearms and hunting safety. Eligible organizations must have a Federal Employer Identification Number and can be IRS 501(c)(3) entities, government entities, or recognized nonprofits. The foundation prioritizes activities that support the shooting sports and firearms safety, while excluding labor organizations, private businesses, and individuals from eligibility. The grant helps foster a safer and more educated community.

Navigant Credit Union 

Navigant Credit Union is the longest-operating, member-owned credit union in Rhode Island. Since its founding in 1915, Navigant Credit Union has been dedicated to providing its members with unparalleled financial products and services, while working every day to stay committed to the financial well-being of the families, businesses and communities we serve. 

Navigant Credit Union Charitable Foundation Grant

For over a century, Navigant Credit Union has been committed to making a meaningful difference in the community. In 2017, we established the Navigant Credit Union Charitable Foundation to further amplify our impact in five strategic areas:

• Education & Financial Literacy: Organizational and capital support for programs, supplies, building products, sports facilities and teams.
• Social Services: Financial support for programs and organizations for children, veterans, hunger and housing.
• Public Health, Safety & Well-Being: Support for programs addressing public safety, emergency care and eradication of disease.

The Frankenmuth Insurance Foundation Charitable Grant supports qualified charities focused on community betterment and basic human needs. Founded in 2016, it aims to enhance lives through initiatives such as affordable housing, health programs, and the arts. Organizations eligible for funding must be tax-exempt and serve areas where Frankenmuth Insurance operates. Notably, the foundation excludes support for individuals, political groups, and projects typically financed by governments, ensuring its resources benefit the wider community.

Project Lead The Way is offering a rolling grant opportunity for schools across the US to implement the PLTW Gateway program for the first time. With total funding of $9,100, the grant covers participation fees and training registration costs. Schools, including public, private, and charter, are encouraged to apply, particularly those serving low-income and minority majority populations. This initiative aims to enhance educational pathways in STEM for diverse student groups.

The Carolyn L. Kuckein Student Research Fellowship, awarded by Alpha Omega Alpha Honor Medical Society, supports first and second-year medical students conducting research over 2 to 12 months. With a total funding of $7,000, students can receive reimbursement for travel expenses up to $1,000 for presenting their findings at national conferences. Eligibility requires enrollment in schools with active AΩA chapters, while those taking a year off for research or holding a PhD are ineligible.

Wegmans Family Foundation Inc focuses on cultivating healthy communities through support for hunger relief, health initiatives, education, and youth programs. They prioritize collaborations with local nonprofits to enhance community well-being, offering assistance in key areas like economic mobility and youth engagement. Despite their wide-ranging support, they have specific ineligibility criteria, such as not accommodating personal requests or solicitation on their property, aiming to direct resources effectively where they are needed most.

Project Lead The Way (PLTW)

Our Mission: Empower Students to Thrive in an Evolving World

Our Philosophy for Education: We believe all students – beginning at a young age – need access to real-world, applied learning experiences that empower them to gain the skills they need to thrive in college, career, and beyond.

We believe teachers play an immeasurable role in empowering students, and our programs provide teachers with the support and resources they need to devote more time to inspiring students.

PLTW Engineering - New Program In Partnership With Ardagh Group

Ardagh Group has partnered with PLTW to support education in its local communities where Ardagh employees live and work. This partnership recognizes the critical role education, and access to education, plays in ensuring equal opportunities and in building successful, vibrant communities. It is expected that over the next 10 years, Ardagh sponsored education programs will benefit more than 500,000 PreK-12 students as well as delivering best-in-class teacher training to more than 5,000 teachers across 2,000 schools in Ardagh's U.S. communities.

Ardagh is a global supplier of sustainable packaging solutions with 16,000+ employees worldwide, and proud local employer.

Program Requirements

The purpose of this grant is to assist the grantee's implementation of the PLTW Engineering program. Grantee must offer the PLTW Engineering program for three academic years. Grantee must offer at least one PLTW Engineering course in the 2027-2028 academic year and must offer one additional course in the 2028-2029 academic year (two different courses in two years). Grantee may implement any PLTW Engineering courses of their choosing. Grantee must complete three years of grant reporting.

The Kalliopeia Foundation Grant focuses on supporting projects that foster cultural and ecological renewal through a deep reverence for the Earth. By prioritizing US-based organizations that demonstrate strong community relationships and intergenerational leadership, the foundation seeks to empower marginalized voices and traditional practices. With an emphasis on land care and Indigenous leadership, Kalliopeia aims to cultivate a resilient future where diverse ways of knowing and being thrive harmoniously with nature.

Relentless Challenge Grants

The Relentless Challenge is a statewide competitive grant program and is South Carolina’s call to action for innovative problem-solving and entrepreneurial impact. Aligned with the Launch to Legacy brand, S.C. Commerce’s vision to support businesses at every stage and position the state as the new home for American innovation, the 2026 Relentless Challenge supports two complementary tracks: traditional small business and innovation.

While distinct in focus, both tracks share a common thread: empowering South Carolina’s businesses to launch, grow and innovate for long-term success. Traditional small businesses form the backbone of local economies and play a vital role in sustained economic growth. Innovation-driven companies, whether new or well-established, contribute to future advancement through R&D and product innovation. Together, they create a balanced ecosystem where stability and disruption coexist, enabling businesses to thrive and fueling statewide prosperity.

Track One: Traditional Small Business

Every business has the potential to innovate. This track funds creative, actionable solutions to the challenges facing South Carolina’s traditional small businesses. The goal is to spark the development of new ventures, strengthen existing ones, and improve access to capital through targeted funding and financial education resources — ultimately helping traditional small businesses grow, flourish, and contribute to the state’s economic vitality.

Track Two: Innovation

Designed to advance South Carolina’s innovation economy, this track supports projects that foster a resilient ecosystem for innovation. Emphasis is specifically placed on catalyzing high-growth entrepreneurship, expanding access to risk capital, and deepening collaboration between higher education institutions and companies of all sizes — laying the foundation for next-generation industries and long-term economic impact.

The Lowcountry Scholarship for Nontraditional Students offers financial aid up to $5,000 for eligible nontraditional students attending accredited technical colleges in South Carolina. Aimed at those in Beaufort, Colleton, Jasper, and Hampton counties, it supports individuals ineligible for most federal and state aid. Applicants must maintain a 2.5 GPA and meet specific criteria, including being a returning learner or having obtained a GED. This scholarship is renewable for up to two years, fostering educational opportunities for underserved populations.

Secretary's Intent

The Department's Purpose

The South Carolina Department of Veterans' Affairs exists to serve this state's Veterans, service members, and their families and to promote the value Veterans bring to their communities and their fellow citizens.

Veterans' Homelessness and Transition Grant

The Veterans’ Homelessness and Transition Grant was established on October 16, 2023, to provide funding to organizations that serve homeless Veterans or Veterans at imminent risk of being homeless with resources to obtain permanent housing. The Veterans Homelessness and Transition Grant Program is funded through an appropriation by the South Carolina General Assembly and managed by the South Carolina Department of Veterans’ Affairs (SCDVA).

The grant aims to enhance nonprofit organizations and state agencies' housing assistance programs for Veterans. The South Carolina Department of Veterans' Affairs will award a grant to nonprofit groups and state governmental agencies that assist eligible South Carolina Veterans with housing assistance, utility assistance, rental assistance, or drug addiction treatment and transitional housing programs.

The minimum grant award is $50,000, and the maximum grant award amount is $250,000 per grant cycle. Veteran eligibility is defined by Title 38 of the Code of Federal Regulations, as “a person who served in the active military, naval, or air service and who was discharged or released under conditions other than dishonorable.”

The Dr. Carolyn Ghazal Dental Assistant Scholarships, offered by the Pacific Dental Services Foundation, provide financial aid of up to $5,000 for eligible dental assistant students. Applicants must be over 18, U.S. citizens or legal residents, and enrolled in a qualifying program. The scholarship emphasizes mentorship and training, supporting the next generation of dental assistants. Awards are based on financial need and application quality, with multiple cycles each year to support aspiring professionals.

For 30 years, the Carolinas Credit Union Foundation has served as a partner in philanthropy to credit unions, with a mission to empower and inspire credit unions in the Carolinas through collaborative opportunities to enrich our communities. A great example of this collaborative philanthropy is our scholarship program. 

More than 20 credit unions in North Carolina and South Carolina have active managed funds at the Foundation. The generosity of these credit unions helps hundreds of high school seniors as well as undergraduate and graduate students receive scholarship funds each year.

As a member of any of the following credit unions, you may apply for a scholarship. 

Revity Federal Credit Union Scholarship Fund

Revity FCU awards two $5,000 scholarships every year to two outstanding high school seniors to help them achieve their college education.

All applications and related information will be reviewed by the Scholarship Review Committee appointed by the Board. 

Additionally, applying for the Revity FCU Scholarship above will also apply you for the Carolinas Credit Union Foundation Scholarship. The CCUF Scholarship is open to anyone seeking higher education in North Carolina or South Carolina.

The E.B. Henderson Award, presented by SHAPE America, honors minority members who have demonstrated exceptional commitment to scholarship, mentorship, and advocacy for ethnic minorities within health and physical education. Established in 1885, SHAPE America serves over 200,000 professionals, promoting high-quality education standards. The award recognizes individuals who have significantly contributed to increasing the participation of underserved populations in the field. Limited to two awards annually, it highlights the importance of diversity and inclusion in health education.

The Bonnie Cardone Memorial Scholarship, offered by the Women Divers Hall of Fame, awards $1,500 to a woman diver enrolled in a U.S. or Canada degree program in journalism, graphic arts, photography, or videography. This scholarship aims to support those committed to using their education to benefit the ocean environment and community, promoting greater awareness and conservation efforts. Eligible applicants must demonstrate their dedication to these fields and their potential impact on marine ecosystems.

The MagMutual Foundation Grant supports 501(c)(3) organizations dedicated to enhancing healthcare access and diversity. It funds initiatives like pro-bono medical care for underserved populations, scholarships for minority medical students, and support for healthcare workers facing challenges. The foundation aims to maximize its positive influence in communities by advocating for policyholders and promoting meaningful changes in medical practices. Eligible applicants must have a policyholder's recommendation and be a registered non-profit.

The Douglas K. Fletcher Scholarship, established by the Community Foundation of the Lowcountry, aims to support students in their pursuit of higher education by providing funding for essential supplies, equipment, and textbooks. Eligible applicants must be first-generation college students residing in Beaufort, Hampton, Jasper, or Colleton counties, enrolled full-time at designated local institutions, and maintaining a minimum GPA of 3.0. This scholarship fosters educational opportunities and community growth.

The Stephen Nicholas Smith Memorial Scholarship, established by the Community Foundation of the Lowcountry, honors Stephen Nicholas Smith's legacy by providing financial assistance to high school seniors or recent graduates from Hampton, Barnwell, or Colleton counties in South Carolina. This scholarship targets students demonstrating significant financial need who are pursuing post-secondary education in technical colleges within the South Carolina Technical College system. It aims to empower local youth and foster educational opportunities.

Margaret and Jack Paylor Family Scholarship Fund

The Margaret and Jack Paylor Family Scholarship Fund was created to provide financial assistance for higher education attainment to economically disadvantaged students residing in Greenville County and planning to be attending a South Carolina public college/university. 

Funding

• $5,000 per academic year.
• The goal of this fund is to award four $5,000 scholarships annually for a total annual distribution of $20,000.
• The number of annual awards is limited to the fund’s distributable amount based on the terms outlined in the Fund Agreement.
• All award distributions will be made by the Community Foundation on the recommendation of the Scholarship Advisory Committee and will be paid in two installments ($2,500 per semester) to an approved educational institution in the name of the recipient.
• Scholarship recipients must maintain a 2.5 GPA. If scholarship eligibility is lost during the first semester of an academic year, the second installment of $2,500 will not be issued.
• Scholarship funds are awarded for one academic year.