Best Large Grants for Nonprofit Organizations in South Carolina

The Climate Smart Communities Initiative (CSCI) Grant supports US-based projects aimed at enhancing community resilience against climate change. With a budget of $1.5-2 million, grants typically range from $75,000 to $115,000. CSCI prioritizes projects that focus on historically disinvested populations facing climate vulnerabilities, emphasizing equity, nature-based solutions, and community capacity building. The initiative encourages collaboration between climate adaptation practitioners and local government entities to address climate impacts effectively.

Fuel Up

We’re Fuel Up – an initiative created by America’s Dairy Farmers to help meet the needs of schools across the country when it comes to fueling healthy bodies and healthy minds.

Fuel Up is all about educators, students and partners working together to make a difference in their schools and their communities.

Fuel Up is an initiative focused on helping educators and students fuel wellness in the areas that matter most, like being mindful and staying healthy. Our educational resources, partnerships and grant/funding opportunities aim to broaden access to good nutrition and overall wellness.

School Nutrition Equipment Grants

Nutrition equipment grants are now available through GENYOUth's End Student Hunger initiative, with applications now open in the new School Wellness Portal.

K-12 schools can apply for an equipment grant to help increase students' access to, and participation in, nutritious school meals.

Overview of Fuel Up Equipment Grant

• One of two nutrition equipment kits—each valued at $2,000—is available to qualified K-12 schools to improve access to nutritious foods.

• Your application must demonstrate how the funding will increase your students’ access to and their consumption of dairy products (milk, yogurt, cheese). Your local Dairy Council can help you with ideas for how to increase dairy.

• Applications will be evaluated based on a variety of factors, including school enrollment, student reach, in-school support, school location, and the sustainability of the proposed program. Consideration will be given to schools in underserved communities whose students are most at risk for poor nutrition and childhood obesity.

• You are encouraged to contact your local Dairy Council with questions about the application process. They can be especially helpful in suggesting ways to increase dairy consumption at your school.

Schools can visit the GENYOUth School Wellness Portal to review eligibility requirements, explore equipment options, and begin an application.  

The American Occupational Therapy Foundation's AOTF Intervention Research Grant Program supports innovative research in occupational therapy, providing up to $100,000 for projects that address health inequities and social justice. This initiative aims to generate preliminary data essential for larger studies, aligning with the profession's Vision 2025. By focusing on underrepresented populations, the program encourages inclusivity and ethical research practices, ensuring a diverse study population. This funding opportunity is crucial for advancing evidence-based practices in occupational therapy.

The Pediatric Cancer Research Foundation (PCRF) is dedicated to funding innovative research aimed at curing childhood cancer. With a focus on collaborative efforts, PCRF has contributed over $51 million since 1982, significantly improving survival rates for childhood cancers. The Translational Research Grant supports cutting-edge clinical trials and therapeutic approaches, enhancing the journey from laboratory discoveries to patient care. This initiative underscores the urgent need for effective treatments, offering hope for children diagnosed with cancer and their families.

The Pediatric Cancer Research Foundation (PCRF) offers the Emerging Investigator Fellowship Grant to support post-doctoral fellowships and clinical investigator training for promising pediatric cancer researchers. This grant aims to accelerate advancements in childhood cancer treatment by funding innovative research ideas. Applicants must have completed a minimum of two years in their fellowship or be within two years of their junior faculty role. This initiative fosters the next generation of researchers dedicated to combating childhood cancer.

The Edna B. Collins Scholarship, offered by the Community Foundation of Central Wisconsin, supports graduating seniors from Wautoma pursuing a degree in business. With awards ranging from $500 to $40,000, this scholarship aims to help students achieve their educational goals. Selection is based on academic performance, financial need, and extracurricular involvement, encouraging a diverse range of applicants to apply for this valuable opportunity.

The Pediatric Cancer Research Foundation (PCRF) offers Donor Designated Grant Programs aimed at funding innovative projects addressing childhood cancer. These grants support researchers dedicated to finding cures, enhancing treatment, and improving care. With an annual commitment to extraordinary researchers, PCRF ensures funds are directed towards promising advances in prevention and treatment. Since 1982, PCRF has raised over $51 million, significantly impacting survival rates and striving to eliminate childhood cancer through collaborative efforts and cutting-edge research.

The OAR Community Grant aims to enhance the quality of life for autistic individuals by funding community-led projects that address physical health and support services. Grants ranging from $1,000 to $15,000 are available for initiatives designed to produce practical tools and resources. Eligible applicants include family members, autistic individuals, and community organizations committed to improving the lives of those affected by autism. Projects should be innovative, publicly accessible, and focus on priority topics such as health systems and community services.

LSC’s Basic Field Grants aim to enhance access to civil legal services for low-income individuals across the U.S. and territories. These grants support eligible organizations for up to three years through a competitive application process. The funding is allocated to specific service areas, which change annually, and focuses on providing comprehensive legal assistance. The program includes three types of service areas, ensuring diverse populations, including agricultural and Native American communities, receive necessary legal support.

The Stanley Fahn Junior Faculty Award, offered by the Parkinson's Foundation, supports early-career scientists in Parkinson's research. With $300,000 in funding over three years, it aims to bridge the gap for junior faculty transitioning to independent research. Eligible applicants must hold a PhD or MD and be U.S. or Canadian faculty members. This award promotes innovative research proposals that advance understanding and treatment of Parkinson's disease, fostering the next generation of scientists in this critical field.

The Anderson Foundation for Autism Grant supports organizations aiming to enhance the quality of life for individuals with autism. Grants of up to $50,000 are available for qualified 501(c)(3) organizations, enabling them to implement impactful programs. The foundation not only funds its own initiatives but also extends support to other entities dedicated to similar goals. This initiative emphasizes a collaborative approach to improving autism care and support.

The ACS Award for Encouraging Women Into Careers in the Chemical Sciences recognizes individuals who promote women's interests in chemistry, fostering their professional development. The award includes a $5,000 cash prize, a certificate, and a $10,000 grant to an academic institution designated by the recipient. Additionally, up to $1,500 for travel expenses to the award presentation will be reimbursed. This initiative highlights the importance of diversity in the chemical sciences and supports women's career advancement.

The Our Village Grants by the Jack and Jill of America Foundation aim to support 501(c)(3) non-profit organizations dedicated to uplifting African American families. These grants focus on programs that address educational and economic disparities, particularly those exacerbated by the pandemic. Initiatives may include digital learning resources, tutoring, and support for health and food security. The foundation prioritizes organizations that align with their mission to create lasting positive impacts in under-resourced communities.

The Joseph James Scholarship, managed by 10,000 Degrees, offers support to students from Bayside Martin Luther King Jr. Academy who graduated between 2013 and 2019. Eligible candidates can receive funding for up to two years, depending on their attendance duration. This scholarship aims to combat educational segregation and provides recipients with access to vital internship opportunities, enhancing their career readiness and skill development in various fields.

The Beattie Family Foundation offers educational scholarships aimed primarily at medical and nursing students facing financial challenges. These scholarships, ranging from $2,000 to $5,000, support individuals currently enrolled in accredited institutions who demonstrate strong academic capabilities. Additionally, limited funds are available for vocational or trade school tuition for those aspiring to enter skilled labor professions. The foundation prioritizes applicants based on financial need and academic performance.

The Samuel Robinson Award is a scholarship for college juniors and seniors attending Presbyterian-related institutions. To qualify, students must memorize the Westminster Shorter Catechism's 107 questions and answers within 18 months. Eligible applicants for 2024 are those graduating in 2024 or 2025. This award encourages academic achievement and religious education among students committed to their faith and educational pursuits.

The Classics for Kids Matching Grant Program, established by the Classics for Kids Foundation, aims to enhance music education for at-risk and rural youth by providing matching grants for fine stringed instruments. Since 1998, over $2 million has been allocated to support more than 300 programs across all 50 states. Schools and non-profits demonstrating need and commitment are encouraged to apply, fostering lifelong benefits of music participation and education.

The CART Fund Grant supports innovative Alzheimer’s Disease research projects in the U.S. with funding up to $500,000 for a two-year period. It invites full-time faculty from public and private institutions to submit Letters of Intent, emphasizing novel concepts that advance biomedical knowledge. Selected finalists will be invited to apply for standard grants. The initiative aims to foster groundbreaking research initiatives lacking extensive preliminary data, ensuring a focus on projects with transformative potential.

The Laboratory Flexible Funding Model (LFFM) aims to enhance state food testing laboratories' capabilities, supporting an integrated food safety system. By prioritizing sample testing and food defense preparedness in microbiology, chemistry, and radiochemistry, this cooperative agreement facilitates method development and expands testing capacity, ensuring safer food for consumers.

The Walking College Fellowship, offered by America Walks, is an innovative online program aimed at empowering community champions to enhance walkability. Participants engage in six modules, committing 5-10 hours weekly, to develop actionable plans addressing local challenges. Over 200 alumni have successfully implemented initiatives such as sidewalk installations and complete streets policies. The program encourages diverse candidates, fostering collaboration and effective advocacy for safer, more accessible communities.

The Arthur F. Burns Fellowship offers journalists from the U.S., Canada, and Germany a unique opportunity to enhance their skills through a two-month exchange program. Participants engage in a structured orientation in Washington, D.C., followed by hands-on training at German media outlets. This fellowship not only enriches careers but also fosters international understanding, with many alumni advancing in prominent media roles globally. With financial support for living and travel expenses, this program significantly enhances the quality of transatlantic news coverage.

The AED Grant Program, run by the Hopey’s Heart Foundation, aims to enhance sports safety by providing life-saving AEDs to eligible schools and recreational centers. Although the program is currently closed, it will reopen for applications in April 2026. The Foundation focuses on preventing Sudden Cardiac Arrest among student athletes through education and medical equipment. Eligible organizations include 501(c)(3) entities and government bodies, ensuring broader access to vital resources for sports safety.

The William L. and Diane C. Wilson Scholarship for Karst Science, established in 2002, honors the legacy of William L. Wilson and aims to support innovative karst scientists. Funded by Diane C. Wilson, it provides a one-time award of $2,500 and recognition at the KWI spring banquet. Eligible candidates must be enrolled in a master's program focused on karst science and its subfields, while PhD students are excluded. This scholarship fosters the growth of new talent in karst research.

The MASOT Conney W. Berger Jr. Memorial Graduate Student Award, established in honor of a dedicated toxicologist, supports doctoral students in toxicology/pharmacology. Eligible candidates must present at the MASOT meeting and meet specific criteria, including GPA requirements and MASOT membership. This award, valued at $500, encourages academic excellence and is made possible through the generous support of SafeBridge Consultants, Inc.

The Clinical Scientist in Nephrology Fellowship, funded by the American Kidney Fund, supports nephrologists pursuing academic careers. This prestigious program enhances training and promotes clinical research aimed at improving patient care and outcomes for those with chronic kidney disease. With a funding maximum of $90,000 per year for two years, it covers salary and training-related expenses, fostering the next generation of leaders in nephrology.

The Russell Sage Foundation's Race, Ethnicity, and Immigration Grant Program funds innovative research on the intersections of race, ethnicity, and immigration. It aims to explore how these factors influence social, economic, and political outcomes for various populations, including immigrants and U.S.-born minorities. Projects should focus on original data collection, rigorous research designs, and address critical questions regarding diversity, policy impacts, and intergroup relations. Funding caps are set at $200,000, promoting multifaceted approaches in social science research.

The Abortion Bridge Collaborative Funds, initiated by the Women Donors Network, aim to enhance abortion access across the U.S. in response to the 2022 Dobbs decision. The fund prioritizes support for 501c3 organizations committed to reproductive justice, focusing on immediate community needs and sustainable solutions. Emphasizing grassroots leadership and innovative approaches, the fund seeks to build a robust infrastructure for reproductive care, ensuring equitable access for all individuals in need.