Best Large Grants for Nonprofit Organizations in South Carolina

The B-Fund Grant by the Brem Foundation aims to enhance early detection of breast cancer by funding crucial screening and diagnostic tests for women in need. This initiative supports entities in the DC metro area, providing financial assistance for services like mammograms and ultrasounds, while ensuring equitable access regardless of socio-economic status. However, it excludes costs related to post-diagnosis care, employee salaries, and administrative expenses, promoting targeted and effective use of funds in the fight against breast cancer.

The Lipsky-Whittaker LGBTQ Scholarship, established by the SouthCoast Community Foundation, provides financial support to graduates from New Bedford area high schools who identify as LGBTQ+. Applicants must be under 24 years old and enrolled in or accepted to an accredited college. This scholarship aims to empower students committed to addressing LGBTQ+ issues in their communities, contributing to a more inclusive society.

Kids' Chance of Massachusetts offers scholarships to children of workers who have been severely injured or killed in workplace accidents. This 501(c)(3) non-profit organization awards funds based on financial need, with applications accepted annually. Eligible students must be dependents aged 17-22, enrolled full-time in post-secondary education, and demonstrate financial need. Renewal applications are available for previous recipients who maintain satisfactory academic progress.

The Arthritis Foundation's Clinical Fellowship RFP aims to address the rheumatology workforce shortage by inviting applications from institutions with clinical training programs. It encourages innovative training approaches to prepare future rheumatologists for the evolving needs of the arthritis community. Funding includes $150,000 for a two-year adult fellowship, $225,000 for a three-year pediatric fellowship, and $300,000 for a four-year Med-Peds fellowship, all designed to enhance access to specialized care.

The Craft Artists Emergency Relief Grant provides $3,000 to U.S.-based individual craft artists aged 18 and older who are facing recent, unforeseen emergencies. Established by the Craft Emergency Relief Fund (CERF+) in 1985, this grant aims to empower artists during critical times, allowing them to use the funds as needed for recovery. Applications are accepted on a rolling basis, ensuring timely support for artists in distress.

The CERF: Artist Get Ready Grant offers up to $1,000 to craft artists for safeguarding their studios and preparing for emergencies. Priority is given to underrepresented artists, including BIPOC and folk/traditional artists. Eligible activities encompass studio safety upgrades and disaster readiness. Applicants must be 18 years or older, residing in the U.S. for two years, and not have received this grant in the previous year. Funds must be used within six months, with outcomes documented for CERF+.

The AABCF Research Grants, offered by the American Association of Birth Centers Foundation, provide funding up to $5,000 for research projects focused on the birth center model of care. Open to individuals and organizations, these grants aim to enhance knowledge and practices in maternity and women's health care. Projects must demonstrate a clear plan and ability to complete the research on schedule, ensuring impactful contributions to the field.

Devinci's Community Grant Program aims to support North American cycling organizations with financial assistance for development projects. Eligible applicants include cycling clubs, non-profits, and individuals leading community initiatives. Projects must occur in Canada or the U.S. within the year, with a maximum grant of $5,000 CAD. The program collaborates with key industry partners to foster growth in the cycling community, making a lasting impact through local initiatives.

The OREF/Goldberg Arthritis Research Grant aims to support innovative research proposals focused on arthritis treatment, particularly arthroplasty. It seeks to foster new investigators by providing seed funding for projects that demonstrate clinical relevance and potential for practical application. Proposals must highlight their orthopaedic significance and aim to advance research that could lead to larger scale funding opportunities, enhancing the field of orthopaedics.

The ChemClub Student Scholarship, offered by the American Chemical Society and the American Association of Chemistry Teachers, supports high school seniors who are active members of a Chartered ChemClub. Eligible students must demonstrate academic excellence and express their commitment to STEM fields. This scholarship provides financial assistance directly to the recipient's chosen college, fostering future leaders in chemistry and related disciplines.

The Parkinson Association of the Rockies Eric Wright Memorial Fund honors Eric Wright's legacy by providing scholarships to high school seniors and college students affected by Parkinson Disease. Recipients, eligible for up to $20,000 over four years, are selected based on merit and financial need. This fund aims to inspire the next generation while supporting students who have experienced loss or hardship due to this condition, promoting education and resilience within the community.

The Shubert Foundation provides unrestricted grants to not-for-profit professional theatre and dance companies in the U.S. Its focus is on organizations with a proven track record in artistic and administrative excellence. Eligible applicants must have a minimum annual budget of $150,000 and demonstrate financial stability, strong community engagement, and the ability to generate income. The foundation does not fund individuals, project-specific requests, or organizations without 501(c)(3) status.

The AISES Sports and Technology Scholarship aims to empower Indigenous students pursuing degrees in STEM fields. Sponsored by the American Indian Science and Engineering Society, this scholarship supports American Indian, Alaska Native, Native Hawaiian, Pacific Islander, and First Nations students, ensuring they have the financial resources needed to excel. Eligible applicants must be full-time students in accredited programs and demonstrate tribal affiliation, contributing to a diverse future in technology and science.

The Trans Justice Funding Project (TJFP) provides grants to grassroots trans-led organizations in the U.S. and territories, focusing on those with budgets under $250,000. TJFP supports initiatives that address varying needs within trans communities, including health, legal aid, and mutual aid projects. The organization prioritizes groups led by trans people of color and emphasizes the importance of centering marginalized voices in the fight for trans justice.

The ADDF-Harrington Scholar Program aims to transform academic discoveries into effective treatments for Alzheimer’s disease and related dementias. With funding of up to $600,000 annually, this program prioritizes innovative drug targets and supports research from hit-to-lead optimization to IND-enabling studies. Eligible applicants include academic investigators with a strong potential to advance meaningful therapeutics. The program emphasizes collaboration with industry experts, making it a significant opportunity for advancing dementia research.

The Bonita Kraft Occupational Therapy Doctoral Student Scholarship, valued at $5,000, supports doctoral candidates in occupational therapy focusing on mental health research. This scholarship honors Bonita Kraft, a dedicated advocate for integrating occupational therapy into mental health services. Eligible applicants must be enrolled in a doctoral program, have IRB approval, and conduct research addressing chronic mental health conditions in adults. The scholarship aims to enhance the visibility of occupational therapy within mental health treatment.

The AOTF Implementation Research Grant supports innovative research aimed at integrating evidence-based practices into occupational therapy. This grant encourages projects that directly involve stakeholders, particularly from underrepresented populations, to address health inequities. With funding options of up to $100,000 for two years or $50,000 for one year, the AOTF seeks to enhance the effectiveness of care through practical implementation strategies in diverse clinical settings.

A Little HOPE, Inc. is a charitable foundation that provides grants to organizations offering bereavement support services and grief counseling for children and young adults who have lost a loved one. The grant amounts vary based on project scope and budget. Applications are by invitation only, sent out each October, and interested organizations should submit an email with necessary details for consideration.

Tyson Foods Community Giving Grants support initiatives that enhance the quality of life for communities and their members. With a focus on scaling existing effective programs, these grants are aimed at organizations that operate in underserved areas. Eligible nonprofits must have a 501(c)(3) status and local Tyson plant support. Applications are accepted annually, with priority given to projects addressing systemic community issues. Notable past support includes a $25,000 grant to the Arkansas Foodbank Mobile Pantry Initiative.

The Lynches River Conservation Grant supports land acquisition and conservation projects aimed at enhancing water quality and ecological integrity in the Lynches River watershed of South Carolina. Funded by the Central Carolina Community Foundation, this grant prioritizes projects in specific service areas, with funding covering full costs for priority projects and up to 50% for expanded areas. Eligible applicants include 501(c)3 organizations and government entities, with a preference for accredited land trusts.

The NCAA Jim McKay Graduate Scholarship honors the legacy of journalist Jim McKay by awarding a one-time $10,000 scholarship to one male and one female student-athlete annually. Eligible candidates must have a minimum GPA of 3.5, demonstrate integrity, and show interest in sports communication. There is no limit to the number of nominations from institutions, highlighting the NCAA's commitment to supporting student-athletes in their academic and professional pursuits.

The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33) invites research proposals for early phase clinical trials of natural products, including botanicals and dietary supplements, emphasizing scientific validity for further testing. Applicants may receive up to three years of funding for pharmacokinetics and bioavailability studies, with potential for an additional three years to evaluate clinical outcomes. This initiative aims to optimize natural product delivery through innovative study designs.

The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.

The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) grant invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements. It aims to advance scientific knowledge by determining optimal dosing and patient responses. Applicants must provide preliminary data demonstrating bioavailability and measurable impacts on target engagement. This initiative will not support efficacy trials for cancer treatments and encourages early contact with NCCIH scientific contacts.

The NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22) aims to support postdoctoral fellows from underrepresented backgrounds in transitioning to tenure-track positions. This award provides essential funding for salary and research support for three years, enabling candidates to establish independent biomedical careers. Key deadlines for applications range from February 2025 to October 2027, ensuring ample opportunity for eligible researchers to secure funding for their career development.

The NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) aims to support innovative research in behavioral and social interventions for dental, oral, and craniofacial conditions. This funding opportunity includes a milestone-driven planning phase of up to 2 years, with potential transition to implementation for an additional 5 years, facilitating comprehensive trial development and assessment.

The Anna Lalor Burdick Program supports initiatives that enhance women's access to reproductive health care, contraception, and pregnancy termination. It prioritizes funding programs that provide comprehensive sexual and reproductive health education, particularly for disadvantaged women. The program seeks innovative approaches, clear goals, and sustainable models, while emphasizing advocacy efforts. Organizations dedicated to reproductive rights in restrictive environments are encouraged to apply, as the foundation aims to empower women through informed choices.