Best Large Grants for Nonprofit Organizations in South Carolina

NetJets Scholarship

NetJets is the leader in private aviation. We believe that service is everyone’s job and our company mission is “To enhance the life of each owner, one exceptional travel experience at a time.” The NetJets Scholarship was designed to reinforce a love of business aviation and hospitality, reward academic merit and exemplary character, as well as inspire students to consider an exciting and rewarding career with NetJets.

Award Amount:

• Three Scholarships for $25,000 each

The Extramural Discovery Science Accelerator Award supports the commercialization of ongoing cancer research projects, focusing on experiments that facilitate technology validation and de-risking. Applications are accepted on a rolling basis, with a budget of up to $75,000 for one year. This award encourages independent investigators at any career stage to advance their technologies, with a strong emphasis on commercial viability and collaboration within a learning community.

Louis P. and Betty A. Iacona Nursing Scholarship

To provide financial assistance to students in Monroe County pursuing a career in nursing.

Number and Size of Awards

One award of $12,000; divided into equal annual installments paid over four consecutive years of undergraduate study. Award may be split between two recipients and is paid in the Fall and divided equally between the Fall and Spring semesters. Minimum award $4,000; paid as $1,000 per year for up to four years.

Allowed Use of Award

Awards may be used for tuition, fees, books, and other expenses associated with higher education.

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

James P. Humphrey, Black Achievers Scholarship

Shelby County residents who are of African-American descent and a graduating senior at a Shelby County High School maintaining a high school GPA of no less than 2.0.

Selection based upon (in order of priority):

Financial need, academic ability, demonstrated community and school service, and recommendations, and an interview.

Awards Vary.

KajjecK Scholarship

To provide financial assistance to Rochester City School District students pursuing a college degree. 

Number and Size of Awards

One award of $4,000; paid as $1,000 per year for up to four consecutive years of undergraduate study. Award paid in the Fall and divided equally between the Fall and Spring semesters. ***Offered in even years. ***

Allowed Use of Award

Awards may be used for tuition, fees, books, and other expenses associated with higher education.

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

Jim and Pat Dietz Skills Scholarship

Must be planning to attend an accredited adult education program or trade school or pursuing up to an Associate’s Degree, where the completion of coursework satisfies requirements leading to a skilled profession.

Selection based upon:

• Demonstrated interest and passion for a specific career path, demonstrated work experience, demonstrated community or school service, and recommendations.

Awards

• Two $1,000 scholarships

American Physical Society

The American Physical Society is a nonprofit membership organization working to advance physics by fostering a vibrant, inclusive, and global community dedicated to science and society. APS represents more than 50,000 members, including physicists in academia, national laboratories, and industry in the United States and around the world.

APS Honors recognizes and celebrates the accomplishments of the global physics community. Guided by our core values, APS Honors encourages nominations that reflect the full range of talent, distinction, and experience in our field, and supports broad canvassing for professional achievement across diverse backgrounds, perspectives, and expertise.

Neil Ashcroft Early Career Award for Studies of Matter at Extreme High Pressure Conditions

The award recognizes outstanding theoretical or experimental contributions by an early-career scientist to studies of matter at extreme high pressure conditions. This includes static and/or dynamic compressions within the disciplines of Physics, Chemistry, Materials Science, Earth and Planetary Science, Soft Matter and Biology. The honor is conferred annually and includes of a $5,000 stipend, a certificate citing the contributions of the recipient, and an allowance for travel to an APS meeting to receive the award to deliver an invited lecture at either the biennial SCCM Conference or the APS March Meeting.

Nominations are active for three years provided the the nominator re-certifies the nomination before the next deadline and all eligibility criteria are still met.

Lorraine Halsch Memorial Scholarship

To provide financial assistance to college-bound students who have overcome adversity (i.e., family tragedy, illness, etc.).

Number and Size of Awards

One award of $6,000; divided into equal annual installments paid over four consecutive years of undergraduate study. Award may be split between two or three recipients and is paid in the Fall and divided equally between the Fall and Spring semesters. Minimum award $4,000; paid as $1,000 per year for up to four years.

Allowed Use of Award

Awards may be used for tuition, fees, books, and other expenses associated with higher education.

St. Julian and Adrienne Simpkins Book Award

To provide book awards to students pursuing higher education.

Number and Size of Awards

Up to five awards of $500 each; paid in one lump sum in the Fall semester.

Allowed Use of Award

Awards may be used for college textbook expenses.

This grant opportunity from the NIH aims to enhance mechanistic research on precision probiotic therapies through a biphasic R61/R33 award mechanism. It encourages innovative studies to identify specific biological factors influencing probiotic responses, thereby improving clinical outcomes. The program supports up to five years of research, with the initial phase focused on discovering unique host characteristics and the second phase assessing improvements in probiotic efficacy through rigorous studies.

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

Vera DoLean Ginn Kiwanis Scholarship

Shelby County resident pursuing a career in elementary education. 

Selection based upon:

• Intent to pursue the field of elementary education, financial need, academic ability, community and school service, recommendations.

Awards

• Two $1,000 scholarships

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

Tom and Sandy Shoemaker Skills Scholarship

Adults or graduating seniors who reside in Shelby County, Ohio or in the School Districts of Shelby County, Ohio, who are enrolling in an accredited adult educational program or trade school or pursuing an Associate’s Degree shall be eligible to apply.

Selection based upon:

• Demonstrated interest and passion for a specific career path, demonstrated work experience, demonstrated community or school service and recommendations.

Awards

• One $1,000 scholarship

Greenville County Fire Chiefs’ Association Scholarship

In 1995, the Greenville County Fire Chiefs’ Association established a scholarship fund to promote higher education for firefighters and their spouses or children.

Funding

• A minimum of $5,000 will be awarded annually and the number and amount of each award will be determined annually.
• Scholarship funds are paid to an approved educational institution in the name of the student.
• Scholarship funds are awarded for one academic year and are not subject to automatic renewal. 

Tampa Jazz Club

The Tampa Jazz Club was incorporated as a non- profit organization in 1995, with the objective of “generating interest in preserving, understanding and performing jazz.”

Tampa Jazz Club Scholarship

The Tampa Jazz Club is committed to encouraging talented young jazz students and to presenting great live jazz in Tampa.

Since 2003, we have awarded Tampa Jazz Club scholarships to graduating area high school seniors who went on to study jazz performance or education. To date, we have awarded $24,750 to 22 graduates.

Fishburn Family Scholarship Fund

The fund was formed with funds donated to the Karen Fishburn Memorial Fund after her passing in September 2013. Karen’s dedication to numerous Morrow County organizations and countless hours of volunteer work for organizations such as the Red Cross, Key Ministries, Morrow County Association of Business Women, Morrow Country Board of Elections, and Marengo United Methodist Church, resulted in an unprecedented community outpouring at her calling hours. Annual scholarships are the Fishburn family’s way of honoring Karen for many years to come.

Award Amount:

• Minimum $2,000

The Thoracic Surgery Foundation

The Thoracic Surgery Foundation is the premier philanthropic organization in cardiothoracic surgery, with nearly four decades of dedicated investment in the work of cardiothoracic surgeons and professionals. TSF is committed to improving patient care through support for research, education, innovation, and humanitarian outreach, aiming to advance heart and lung health for all.

As the charitable heart of The Society of Thoracic Surgeons, TSF collaborates globally to drive progress in cardiothoracic surgery. Through the efforts of TSF and its worldwide partners, patients with heart and lung disease experience improved longevity and a high quality of life.

STS Perioperative & Critical Care Conference Resident Scholarship

Purpose

This Resident Scholarship allows CT surgery residents to attend the STS Perioperative & Critical Care Conference. The scholarship covers course registration fees, two nights' lodging at the host hotel, and and expense reimbursement of eligible travel expenses.

Course Description

Attendees of the 2026 STS Perioperative & Critical Care Conference will explore the latest techniques and management strategies in cardiovascular and thoracic (CVT) critical care and enhanced recovery after surgery (ERAS). This two-day event features dynamic and interactive presentations, hands-on demonstrations, scientific abstracts, and expert panel discussions designed for all members of the CVT perioperative and critical care team. Learn more here.

Genevieve Griffith Scholarship

The scholarship was established by Mildred Griffith in memory of her sister Genevieve Griffith, the girls' principal at Central High School in Ohio for many years. To be eligible, students must reside in the area served by Central High School when it closed in 1982, with Briggs, East, and South high schools each awarding one scholarship.

Award Amount:

• One $1,200 scholarship for each of the three named high schools.

Parkview Health Foundation

The Parkview Health Foundation plays a vital role in supporting Parkview Health and its ability to provide expert, specialized healthcare to our entire region. As the area’s largest health system, Parkview Health serves a population of more than 1.3 million in northeast Indiana and northwest Ohio.

Since 1878, charitable giving has been an important part of Parkview’s ability to deliver excellent care for every person, every day. The Parkview Health Foundation helps ensure philanthropic donations are used to support Parkview patients and the community at large by enhancing the patient experience through comfort and healing.

Scholarships

Helping train and educate the next generation of Parkview caregivers is an important part of our purpose. Through the generosity of donors, we are able to offer scholarships to Parkview co-workers and area students who are pursuing their nursing degrees or EMT certifications — helping ensure the excellence in care continues.

Karen Denney Nursing Scholarship

Karen Denney was a caring and compassionate nurse, who dedicated her 35-year career to patients at McCray Hospital and Parkview Noble Hospital. During her career, Karen was the manager of the OB department for over 25 years, an infection control and employee health nurse, and worked in a number of other departments. She was an inspiration to many who worked with her, demonstrating an uncommon love for nursing and the patients she treated.

The Charter Fund: Scale Funding supports nonprofit organizations that operate high-performing public charter schools. It seeks leaders dedicated to expanding their impact, aiming to serve an additional 1,000+ students over the next 3-5 years. The fund offers grants and low-interest loans starting from $750,000, alongside strategic partnerships and community-building initiatives to help schools navigate growth challenges, enhance educational quality, and foster collaboration among charter leaders.

The Charter Fund: Seed Funding program supports nonprofit organizations operating high-performing public charter schools that aim to expand their reach by serving 250 to 1,000 additional students within two years. Eligible applicants must demonstrate proven leadership, strong academic performance, and a commitment to underserved communities. The fund offers general operating grants ranging from $250,000 to $600,000 to assist leaders in opening new schools, providing vital resources and cohort-based learning opportunities to foster growth and innovation.

About ASTS

The American Society of Transplant Surgeons (ASTS) was founded in 1974 by 127 surgeons to unite the professionals who were advancing the fledgling field of organ transplantation.

From this small group of dedicated individuals, we have grown to represent over 2,000 transplant professionals who are dedicated to saving and improving lives through the transformative power of organ donation and transplant surgery. 

Mission Statement

ASTS advances the art and science of transplant surgery through patient care, research, education, and advocacy.

ASTS-TransMedics Perfusion Faculty Grant

ASTS continues its commitment to provide qualified ASTS Members with research funding in the field of organ transplantation.

This research grant is intended to further explore the use of portable normothermic machine perfusion and its ability to 1) predict organ allograft function, outcomes and impact of reduced ischemia/reperfusion injury 2) increase of DBD and DCD donor organ utilization for transplantation, 3) rehabilitate organs that would otherwise be discarded, 4) increase access to organ transplantation, 5) revisiting historical functional warm ischemic limits in the new era of portable normothermic perfusion, and 6) be a platform for targeted therapeutic interventions during perfusion. Competitive applications for this grant could include, but are not limited to, investigations into biomarkers predicting post-transplant function, minimization of ischemia/reperfusion injury, elucidating the mechanisms of organ recovery during perfusion, optimizing and customizing perfusion protocols, understanding and overcoming barriers to utilization, and developing new applications of portable normothermic machine perfusion to solid organ transplantation.

 Funding includes in-kind support as needed.

Other Requirements

• The Awardee must attend the ASTS Grant Ceremony at the American Transplant Congress (ATC) to formally accept the grant.
• An abstract must be submitted for presentation at an ATC or ASTS Winter Symposium during the grant period or within 6 months of completion.
• A mid-report to the ASTS National Office must be submitted in the spring of the first year.
• A final report to the ASTS National Office must be submitted in the spring of the last year of funding.
• Awardee will be expected to present a brief review of the research progress supported by the grant at a future ASTS Winter Symposium

Robert & Grace Karst R.N. Scholarship

This scholarship was created by Grace Karst RN, who dedicated 44 years to the nursing profession and as a nursing home administrator. Her husband Robert served in the Army, was a White House guard, and eventually retired after 36 years working for the railroad.

This award is presented to a Whitley County student intent upon becoming a Registered Nurse.

About The NRA Foundation

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

Awards

The NRA is proud to recognize the contributions of those who have demonstrated dedication to the promotion of the Second Amendment, significantly impacted the preservation of the shooting sports, advanced the purposes and goals of the NRA and exemplified leadership through public service. Each year, women, youth, clubs, law enforcement officers and NRA Foundation volunteers are awarded for their efforts in pursuit of these principles.

NRA Outstanding Achievement Youth Award

The NRA Outstanding Achievement Youth Award encourages and recognizes those junior shooting sports participants who take an active part in their community and shooting sports through individual contributions, educational pursuits, and accomplishments.

The award is designed to promote a greater appreciation of the programs the NRA has to offer and to increase awareness of the shooting sports activities in which youth can participate. 

Once a participant meets the requirements, he or she will be eligible for our National prizes. Our National award winners will receive:

• 1st place - $5,000 
• 2nd place - $3,000
• 3rd place - $2,000

About The NRA Foundation

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

The Annual NRA Club Awards Program

Each year the National Rifle Association recognizes outstanding clubs, state associations, youth clubs and an individual or organization for public service. The Annual Awards program recognizes significant accomplishments achieved in areas of organization, operation and public service rendered.

Outstanding State Association Awards

The Outstanding Youth Club Award is presented in honor of a State Association's effectiveness in carrying out the purpose and objectives of the National Rifle Association in the State or Territory for which the State Association is organized.

All Club Award recipients receive:

• A free range evaluation from an NRA Range Team Advisor
• A free year of club membership
• $1,000 award

About The NRA Foundation

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

The Annual NRA Club Awards Program

Each year the National Rifle Association recognizes outstanding clubs, state associations, youth clubs and an individual or organization for public service. The Annual Awards program recognizes significant accomplishments achieved in areas of organization, operation and public service rendered. 

Outstanding Club Awards

The Outstanding Club Award is presented to the club that has demonstrated noteworthy achievement in all aspects of club operation. 

All Club Award recipients receive:

• A free range evaluation from an NRA Range Team Advisor
• A free year of club membership
• $1,000 award

About The NRA Foundation

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

The Annual NRA Club Awards Program

Each year the National Rifle Association recognizes outstanding clubs, state associations, youth clubs and an individual or organization for public service. The Annual Awards program recognizes significant accomplishments achieved in areas of organization, operation and public service rendered.

Outstanding Youth Club Awards

The Outstanding Youth Club Award is presented to the club that has demonstrated noteworthy achievement in all aspects of club operation.

All Club Award recipients receive:

• A free range evaluation from an NRA Range Team Advisor
• A free year of club membership
• $1,000 award

The WGPF: National Register Signage Grant Program, administered by the William G Pomeroy Foundation, aims to support public properties and historic districts in the U.S. that are listed on the National Register of Historic Places. By providing grants for signage, the program helps these sites commemorate their historic significance and share their achievements with the community, fostering awareness and appreciation for the nation's heritage.