Best Large Grants for Nonprofit Organizations in South Carolina

The Aman Armaan Ahmed Family SURF for Success Program offers summer undergraduate research fellowships for students from underrepresented groups in biomedical research. Awardees engage in 10 weeks of research related to digestive diseases under expert mentorship, receiving a stipend of $6,200. This initiative aims to inspire students to pursue careers in science and medicine, enhancing diversity in the field of gastroenterology and hepatology.

The FDA is funding a Center for Research on Complex Generics to enhance collaboration with the generic drug industry. This initiative aims to identify scientific challenges in generic product development, facilitate expert engagement, and coordinate research projects. By hosting workshops and providing public access to research outcomes, the center will support the FDA's mission to improve patient access to high-quality, safe, and effective generic drugs, thus strengthening regulatory science efforts.

The National Science-Health-Environment-Reporting Fellowships are intended to support early-career journalists who are pursuing—or have a strong interest in pursuing —careers reporting on science, health, or environmental issues (or all three).

The program is primarily aimed at journalists in their first decade of professional work, who are interested in boosting their ability and confidence to tackle some of the most important stories of the 21st century.

The fellowship is designed to enable fellows to maintain their regular employment while attending concentrated training opportunities across the country, many of which will lead to stories for their employer or clients. Fellowship leaders and mentors will provide support and guidance through seminars, calls and e-mail consultations.

Curriculum will include basic science, interpreting medical studies, analyzing data, explaining evidence-based decisions, understanding climate science and more.

The program hopes to provide essential on-the-job training that might otherwise take years to accumulate.

Over the course of a year, selected fellows will: 

• Participate in workshops and other events held at the annual Environmental Journalism , Health Journalism  and Science Writers conferences. 
• Learn from custom webinars scheduled throughout the year for additional opportunities to gain skills, connections and resources to inform their reporting. 
• Be matched with a professional mentor.
• Receive prepaid memberships in the National Association of Science Writers, SEJ and AHCJ.
• Participate in peer-to-peer networking platforms. 
• Receive project support stipends if they are an independent journalist.

The Faye Lynn Deckard Memorial Scholarship Fund, managed by the Brown County Community Foundation, aims to provide scholarships for students accepted into accredited two- or four-year institutions. This fund supports residents of Brown County pursuing degrees in early childhood education, ensuring that financial barriers do not hinder their educational aspirations. Since its inception, the foundation has been dedicated to enhancing educational opportunities for local students, reinforcing its commitment to community development and academic achievement.

The U.S. Air Force Academy Association & Foundation presents the Young Alumni Excellence Award to honor recent graduates who exemplify leadership, service, and excellence. This award recognizes individuals who have made significant professional or philanthropic contributions within 0 to 15 years of graduation. Nominees must maintain high standards of integrity and character, reflecting the prestigious values of the Air Force Academy while positively impacting their communities.

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Mucopolysaccharidosis Type VII (MPS VII) Health Equity Fund

Help with healthcare costs for mucopolysaccharidosis type VII (health equity)

This TotalAssist Health Equity Fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code.

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

The Central States Manufacturing Scholarship Program, managed by the Tulsa Community Foundation, offers education scholarships to dependents of full-time Central States employees. This initiative encourages high school seniors and college students to pursue their educational goals by providing financial assistance for undergraduate studies. Established in 1998, the Tulsa Community Foundation supports charitable giving to enhance opportunities for the community and ensure future generations can meet their philanthropic needs.

The Covenant Foundation's Signature & Ignition Grants celebrate excellence in Jewish education by funding innovative projects that enhance educational practices. The Foundation supports diverse institutions across North America, inviting applications for creative programs that can adapt and disseminate effective practices. While Signature Grants may reach up to $150,000 over three years, Ignition Grants focus on untested ideas with funding up to $20,000 for one year. One application per cycle is permitted.

The J.D. Fletcher Family Scholarship Award, established by the Tulsa Community Foundation in 1998, supports graduating seniors from Creek County, Oklahoma. Eligible applicants must plan to attend an accredited four-year college or university and pursue a bachelor's degree in science. This scholarship aims to foster education and empower local students to achieve their academic goals, contributing to a vibrant community and a brighter future.

Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Mucopolysaccharidosis Type VII (MPS VII) Fund

Help with healthcare costs for mucopolysaccharidosis type VII

This TotalAssist Health Equity Fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Approved medications

Patient Advocate Foundation covers all the prescription medications for each diagnosis, including generic or bioequivalent drugs, that meet any of the following criteria: FDA-approved, listed in official compendia, and/or listed in published evidence-based or clinical guidelines. See approved medication list for this condition.

Patient Advocate Foundation verifies your diagnosis and treatment plan with your provider directly. We also automatically verify the income eligibility for every applicant. 

The Kiwanis Club of Rancho Murieta offers scholarships to graduating high school seniors who are residents of Rancho Murieta, Sloughhouse, or Wilton. With three scholarships available at $2,000 each, eligibility includes a minimum GPA of 2.0 and full-time enrollment in a post-secondary institution. Applicants must participate in school and community activities, and provide two letters of recommendation. This initiative supports local youth in their educational pursuits.

The Charter Fund: Seed Funding program supports nonprofit organizations operating high-performing public charter schools that aim to expand their reach by serving 250 to 1,000 additional students within two years. Eligible applicants must demonstrate proven leadership, strong academic performance, and a commitment to underserved communities. The fund offers general operating grants ranging from $250,000 to $600,000 to assist leaders in opening new schools, providing vital resources and cohort-based learning opportunities to foster growth and innovation.

The Lawrence Cheung, MD Scholarship for Public Health and Advocacy, offered by the AMA Foundation, supports medical students dedicated to leadership in public health. Each year, recipients receive $10,000 to assist with tuition, focusing on those from California. This initiative is part of the Physicians of Tomorrow program, which fosters the next generation of physician leaders committed to health equity. Students must demonstrate their advocacy interest in their personal statements.

The SAA Native American Graduate Archaeology Scholarship, funded by the Society for American Archaeology, supports Native American graduate students pursuing studies in archaeology. Each year, one scholarship is awarded, providing up to $10,000 to cover tuition, travel, housing, and other educational expenses. This initiative aims to foster collaboration between archaeologists and Native American communities while promoting ethical practices and preservation of cultural heritage.

The SAA Native American Undergraduate Archaeology Scholarship, funded by the Society for American Archaeology, supports Native American students pursuing undergraduate studies in archaeology. With an award of up to $6,000 available annually, this scholarship aims to empower students and promote the preservation of cultural heritage through education and collaboration. It encourages participation from all Native peoples across the Americas, ensuring accessibility and support for educational advancement in the field of archaeology.

This competitive program seeks to encourage organizations to submit grant applications for educational activities focused on healthcare professionals involved in the management and care of people with migraine.

Individual projects requesting up to $200,000 will be considered. Maximum project length is 2 years.

The AK Chen Memorial Scholarship Fund, administered by the Hawai‘i Community Foundation, provides financial assistance to students pursuing higher education in Hawaii. Eligible applicants must be residents of Hawaii, demonstrate financial need, and maintain a minimum GPA of 2.0. Preference is given to students from specific high schools and those majoring in STEM or education fields. Scholarships cover various educational expenses, ensuring support for students' academic journeys.

The Wexner Field Fellowship is a three-year program aimed at enhancing the leadership skills of Jewish professionals in North America. Participants engage in leadership institutes, receive personalized coaching, and gain access to professional development funds. This fellowship fosters a robust network of leaders committed to serving the Jewish community, encouraging a deeper understanding of its diversity and strengthening essential leadership competencies. Eligible candidates must be full-time employees at Jewish organizations with at least five years of relevant experience.

The Alton & Barbara McDonald Scholarship, provided by the Community Foundation of Central Wisconsin, offers financial support to students from Portage and Waushara counties. With awards ranging from $500 to $40,000, it is available to high school seniors and college students pursuing veterinary science at UW. Applicants must demonstrate a strong community service record, a minimum 3.0 GPA, and financial need, ensuring opportunities for deserving students in the region.

The Avis M. Wysocki Memorial Scholarship supports Central Wisconsin college students pursuing degrees in Nursing or as Physician’s Assistants. Sponsored by the Community Foundation of Central Wisconsin, this scholarship is available to those who have completed 25% of their coursework with a minimum GPA of 3.0. Special consideration is given to immediate family members of Wysocki Family of Companies employees, ensuring opportunities for deserving students. Award amounts range from $500 to $40,000 annually.

The Linda R. Benavides Memorial Scholarship-Community Fellowship Award, managed by the Coastal Bend Community Foundation, offers financial support to graduating high school seniors and GED recipients in the Coastal Bend area. Awards range from $100 to $16,000, with an average of $1,000. Applicants must demonstrate financial need and a commitment to community service, reflecting Linda Benavides' legacy of advocacy and leadership. This scholarship aims to uplift local students and foster educational opportunities.

The Coastal Bend Community Foundation Scholarship supports high school seniors from a seven-county area in Texas, providing grants ranging from $100 to $16,000, with an average award of $1,000. This initiative aims to enhance educational opportunities for local students attending accredited colleges or universities across the United States. The foundation, known for its integrity and community stewardship, has a longstanding commitment to philanthropy in the Coastal Bend region.

The Wexner Davidson Fellowship (WDF) is a transformative leadership development program designed for Jewish communal professionals in North America aged 26-36. Over three years, Fellows engage in cohort-based learning at biannual institutes, receive coaching, and deepen their Jewish knowledge while building a strong professional network. This initiative fosters personal and professional growth, equipping the next generation of leaders to serve their communities effectively and connect with a global alumni network.

The Joann and C.W. Carpenter Endowed Scholarship, established in 2016 by C.W. Carpenter in memory of his wife JoAnn, supports high school seniors from CCISD. With awards ranging from $100 to $16,000, this scholarship aims to assist those in financial need pursuing higher education, including vocational schools. This initiative reflects the Carpenter's commitment to community service and educational support, ensuring that deserving students receive the help they need to succeed.

The Combined Pilot Research Grants by the AAPPS and PSF aim to promote innovative research in pediatric plastic surgery and hand surgery. With funding up to $15,000 for one-year pilot projects, these grants support the development of surgeon scientists and encourage applications that will enhance the scientific understanding and improve care for children with deformities requiring reconstructive surgery. This initiative fosters collaboration among various subspecialty organizations dedicated to advancing surgical research.

The Thomas L. McKenzie Research Award, offered by SHAPE America, supports emerging researchers in physical education and public health. With a funding pool exceeding $600,000 since 1997, it provides annual awards of up to $2,000 to graduate students and early career professionals (within 4 years of graduation) who are members of SHAPE America. The focus is on behavioral research related to physical activity, particularly in natural environments, contributing to disease prevention and promoting overall health.

The Charter Fund: Scale Funding supports nonprofit organizations that operate high-performing public charter schools. It seeks leaders dedicated to expanding their impact, aiming to serve an additional 1,000+ students over the next 3-5 years. The fund offers grants and low-interest loans starting from $750,000, alongside strategic partnerships and community-building initiatives to help schools navigate growth challenges, enhance educational quality, and foster collaboration among charter leaders.