Best Large Grants for Nonprofit Organizations in South Carolina

The Antonio and Antoinette Pieropan Scholarship Fund, established by the Berkshire Taconic Community Foundation, supports local students from Stockbridge and West Stockbridge pursuing higher education. This fund prioritizes those in financial need, particularly encouraging vocational training in trades. It reflects the values of its namesakes, promoting independence and community contribution. Scholarships can be renewed annually through age 23, providing essential support for students seeking careers in technical fields and trades.

Next Jazz Legacy is a mentorship program that supports emerging jazz artists through intergenerational mentorship, performance opportunities, and professional networking. Funded by the Mellon Foundation and led by renowned artist Terri Lyne Carrington, the initiative aims to provide a comprehensive support package to seven artists annually from 2025 to 2027. Awardees will receive financial investment, mentorship, and learning opportunities to help them thrive in their careers and contribute to a vibrant jazz future.

Greene County Foundation

Founded as a public charity in 1997, the Greene County Foundation is a vital and sustainable organization that serves the Greene County community. A volunteer Board of Directors, whose makeup reflects the diversity of the communities it serves, governs the Foundation. The Foundation annually awards over a quarter million dollars in grants through fund payouts, competitive grants, and student scholarships and has made an impact in every school, town, city, and informal community in Greene County.

Sarah D. Bailey Nursing Scholarship

The Sarah D. Bailey Nursing Scholarship is intended for any Greene County resident pursuing a degree in nursing. Dr. Roger and Pam Bailey established a nursing school scholarship in memory of his grandmother, Sarah D. Bailey. Roger indicated his grandmother was the singular reason he returned to Linton in 1991 after completing his residency. Sarah was an RN, and in addition to working as a nurse, raised her 4 children and later in life worked as a volunteer RN at Glenburn Nursing Home. As the oldest of the grandchildren, Roger noticed the wide recognition in honor of his grandfather’s medical practice, but he also recognized the sacrifices his grandmother made to keep the household running smoothly. Her contributions were largely unrecognized at the time, but significant. Through this scholarship, Roger and Pam are pleased to support upcoming nurses while also remembering the one dearest to his heart.

This is a scholarship for current college students & non-traditional students.

The PCORI Call for Proposals for HSII Implementation Projects invites innovative approaches to address barriers in healthcare settings. These projects should enhance practice change through active, multi-component strategies and include rigorous evaluations to measure implementation effectiveness. While developing tools to support these strategies is permitted, it should not be the main focus. Successful proposals will demonstrate their potential impact on healthcare outcomes and patient experiences.

The Truman Scholarship, established by the Truman Foundation, supports college juniors committed to public service. It offers up to $30,000 for graduate studies, alongside mentoring and career development opportunities. Ideal candidates demonstrate leadership, a strong commitment to public service, and the potential for success in graduate school. This prestigious award aims to cultivate future leaders dedicated to making a positive impact in their communities and beyond.

The Valley Hospital Auxiliary has been supporting future healthcare professionals since 1961 by providing scholarships to high school seniors and undergraduate students. In 2025, they awarded $30,000 to 21 exceptional students who have shown academic excellence and a commitment to healthcare. This initiative not only benefits the recipients but also contributes to the community by nurturing the next generation of medical leaders. Eligible high school students can reapply throughout their college years, ensuring continuous support for their educational journeys.

The Gladys and Thomas “T.B.” Stewart Scholarship, administered by the East Texas Communities Foundation, supports graduating seniors from Smith County and nearby districts pursuing education at any U.S. college. Established to empower students through financial assistance, this renewable scholarship requires FAFSA documentation to assess financial need. The foundation was created in 1989, promoting educational opportunities in East Texas, reflecting the commitment of its founders to uplift local youth through academic achievement.

Bold Foundation

Our Mission: Fighting Student Debt

The average student today will graduate more than $30,000 in debt and is far less likely to start small businesses, seek the highest impact careers, buy homes, or start families. At Bold.org®, we believe that’s a problem worth solving.

Fishers of Men-tal Health Scholarship

The Fishers of Men-tal Health Scholarship honors the life and legacy of Dima Kapelkin—a beloved brother, son, and friend who loved fishing, Jesus, and serving those in need.

Today, mental health and addiction are among the most pressing challenges facing individuals and families. Each struggle is difficult on its own, and yet they often coexist—nearly 50% of people with severe mental illness also experience substance abuse. To support those on the path to healing, we need compassionate, well-equipped professionals who are called to this work.

To apply, please share how your personal experiences with mental health have shaped your beliefs, relationships, and career aspirations.

"Follow me, and I will make you fishers of men." Matthew 4:19

The Robinson Crowell & Rotary Club of Sacramento Foundation Annual Scholarships support local high school seniors from C.K. McClatchy, Sacramento Charter, and West Campus High Schools. Each school awards two scholarships, with amounts of $2500 and $1750, respectively. These scholarships promote higher education and embody the Rotary spirit of service. Candidates must be academically strong and committed to full-time undergraduate studies, while ensuring no familial ties to Rotarians.

The Gerald & Sybil Cohen Family Foundation Scholarship aims to ease the financial burden of college costs for students pursuing education in STEM fields. Open to U.S. citizens aged 18 and older with a minimum GPA of 3.5, the scholarship is available for public colleges and universities. Preference is given to dependents of former employees of Information Builders, Inc. Awards are not guaranteed and may vary in amount.

Community Foundation of the Central Blue Ridge

The Community Foundation of the Central Blue Ridge is a charitable organization that has served the independent cities of Staunton and Waynesboro, and the counties of Augusta, Highland and Nelson since 1992. 

Kenny W. Rodeffer Scholarship

Established by the Rockingham Feeder Cattle Association, this scholarship honors the memory of Kenny Rodeffer, a Virginia Department of Agriculture Livestock Grader and farmer in Bridgewater, VA who was an avid supporter of improved livestock production and agriculture.

Description

The Kenny W. Rodeffer Scholarship supports graduating high school seniors from the counties of Augusta, Highland, Rockbridge, and Rockingham, who are pursuing a two- or four-year degree in an agricultural related field.

Selection Criteria Used by the Selection Committee

• Academic/scholastic achievement
• Involvement in agricultural youth programs such as 4-H clubs and FFA chapters
• Other extracurricular activities

The Tulsa Achievement Investment Scholarship of Kappa Alpha Psi, established by the Tulsa Community Foundation, supports collegiate members of Kappa Alpha Psi Fraternity Inc. This scholarship targets students who graduated from Tulsa County high schools and plan to attend accredited colleges in the U.S. Founded in 1998, TCF is dedicated to enhancing community welfare through philanthropic efforts, investing in educational opportunities to foster growth and development in Tulsa and beyond.

The Terry Hessong Memorial Scholarship, offered by the Tulsa Community Foundation, supports students graduating from high school in Nowata County, Oklahoma. Established in 1998, the Tulsa Community Foundation is dedicated to enhancing communities through charitable initiatives. This scholarship exemplifies their commitment to investing in local education and empowering the next generation. By providing financial assistance, the foundation aims to foster academic achievement and enrich the lives of students in the region.

The RAE Family Community Scholarship, established by the Tulsa Community Foundation, supports high school graduates from Mayes County, Oklahoma, seeking to enroll in undergraduate programs. Since its inception in 1998, the Tulsa Community Foundation has been dedicated to enhancing the community through charitable efforts and grants, ensuring that all individuals and families can thrive. This scholarship is a vital resource for students aiming to further their education and make a positive impact in their communities.

The Joyce Bright Scholarship Award, established by the Tulsa Community Foundation in 1998, aims to provide financial assistance for higher education to deserving students. Eligible applicants are high school graduates from Tulsa County, Oklahoma, who have demonstrated academic excellence by ranking in the top 3% of their class. This scholarship reflects the Foundation's commitment to empowering local communities and supporting educational aspirations.

The J.D. Fletcher Family Scholarship Award, established by the Tulsa Community Foundation in 1998, supports graduating seniors from Creek County, Oklahoma. Eligible applicants must plan to attend an accredited four-year college or university and pursue a bachelor's degree in science. This scholarship aims to foster education and empower local students to achieve their academic goals, contributing to a vibrant community and a brighter future.

The Child Protection Compact Annual Program Statement invites proposals aimed at combating child trafficking through collaborative efforts between the United States and other countries. This initiative focuses on enhancing the capacity to prosecute traffickers, providing care for victims, and implementing preventive measures. Organizations interested in applying must align with the objectives of the CPC to ensure comprehensive support and effective intervention against all forms of child trafficking.

The Denmark Lions Scholarship Fund, established by the Maine Community Foundation, offers financial assistance to deserving high school graduates from Denmark. This initiative supports local students pursuing post-secondary education and those with a history of community service. Since its inception 30 years ago, the fund has aimed to empower individuals and strengthen the community through education, ensuring that financial barriers do not hinder academic aspirations.

The HTR Foundation Grant supports the preservation of American Civil War sites and educational projects related to this heritage. Grants are available to tax-exempt organizations and government agencies, focusing on land acquisition and public engagement while excluding endowments, individual support, and local interest projects. This initiative promotes the historical, cultural, and environmental legacy of the United States, ensuring the continued education and awareness of the Civil War's significance.

The Carolyn Lewis Scholarship Fund, established by Barrett Lewis's estate, supports residents of Lubec in pursuing post-secondary education. Managed by the Maine Community Foundation, which has been serving Maine since 1983, this fund aims to empower local students through financial assistance for college or community college. With a focus on strategic giving and community leadership, the foundation ensures that resources are effectively utilized to foster educational opportunities in the region.

The Cad and Dorothy Kelley Scholarship Fund, established by the Maine Community Foundation in 1983, supports two graduating seniors residing in Lubec to pursue post-secondary education. This initiative reflects the foundation's commitment to strategic giving and community leadership, offering personalized service and deep local expertise. By facilitating educational opportunities, the fund aims to empower young individuals and contribute to the development of their community in Maine.

The Allen C. & Leurene F. Hodgkins Scholarship Fund, established by the Maine Community Foundation, offers renewable scholarships for high school seniors or recent graduates from Lamoine, Maine. This fund supports those pursuing post-secondary education, prioritizing academic achievement and financial need. Founded in 1983, the Maine Community Foundation connects resources to enhance community well-being, ensuring that students from Lamoine can access the education they need to succeed.

Dominique's Musician Corner Scholarship, established in 2016 in memory of Dominique Williams, supports students from Beaufort or Jasper Counties in South Carolina and Chatham County in Georgia pursuing post-secondary education in performing arts. This merit-based scholarship does not require financial information and focuses on specific eligibility criteria to ensure the most deserving candidates receive assistance in their artistic endeavors.

The NAEMT Foundation Scholarships provide financial support for individuals pursuing careers in Emergency Medical Services (EMS). Scholarships are available for those seeking certification as Emergency Medical Responders (EMR) or Emergency Medical Technicians (EMT). Recipients must begin their educational programs in the awarded term and maintain good academic standing. Funds are paid directly to educational institutions. The foundation aims to strengthen the EMS profession through education and research funding.

The CoreCivic Foundation Grant aims to support nonprofit organizations that help former offenders, victims of crime, and underserved youth. Eligible organizations must be 501(c)(3) tax-exempt charities with a commitment to measurable outcomes. Preference is given to those with a history of collaboration with CoreCivic and those operating in Tennessee. This grant provides essential resources to enhance the quality of services delivered to these vulnerable populations, fostering rehabilitation and community support.

The 9.11 Promise Run Scholarships provide financial support to children of first responders and military personnel who have been killed or injured. Established in 2019, these scholarships range from $5,000 to $15,000 and can be applied toward trade school or college tuition. Eligible applicants must be under 25 years old and maintain a minimum GPA of 2.0. Awards are issued directly to accredited institutions and can be renewed for up to six years, ensuring continued support for eligible students.

The SOT Science Policy Leadership Award honors elected officials who advocate for scientific research that protects health and the environment. By recognizing individuals who support public policy that advances safety for people and animals, this award promotes the importance of science in decision-making processes. The Society of Toxicology aims to highlight the contributions of leaders in science policy, encouraging further advancements in health and safety research while fostering a collaborative relationship between science and government.