Best Large Grants for Nonprofit Organizations in South Carolina

The McInnes Charitable Trust, founded by Sally and John McInnes, aims to support organizations in Colorado focused on animal welfare, children's health, education, and empowerment. The Trust prioritizes funding for exempt organizations under Section 501(c)(3) with a proven track record. It typically does not fund capital improvements or multi-year commitments. By fostering a spirit of generosity, the Trust honors the McInnes family's legacy and commitment to various charitable causes.

The AERA Minority Dissertation Fellowship in Education Research aims to enhance diversity in education research by supporting doctoral dissertation projects from advanced graduate students belonging to historically underrepresented racial and ethnic groups. By providing a $25,000 stipend and opportunities for mentorship, the program encourages high-quality research across various educational topics, including STEM education and achievement gaps. This fellowship not only aids in academic development but also fosters the competitiveness of minority scholars in higher education.

The Change Happens Foundation Grant focuses on supporting charitable initiatives aligned with environmental science, education, and human services. With a commitment to diversity, equity, and inclusion, the foundation prioritizes funding for organizations holding 501(c)(3) status, while advocating for innovative solutions to pressing global challenges. Grants aim to foster systemic change, empower underrepresented communities, and bridge gaps in access to nutrition and healthcare. The foundation operates nationally and internationally, seeking to create significant impact through strategic investments.

The NRF Foundation x Licensing International Scholarship offers a $5,000 tuition scholarship and a trip to New York City for undergraduate students pursuing careers in brand licensing. Eligible candidates must be enrolled full-time at an accredited U.S. college, have a minimum GPA of 3.0, and be available to attend the NRF Foundation Student Program in January 2026. Bilingual students are especially encouraged to apply, enhancing diversity in the retail industry.

The National Science Foundation (NSF) seeks proposals for Arctic research to enhance understanding of the rapidly changing Arctic environment and its social systems. This initiative encourages innovative research that connects the Arctic region with lower latitudes, aiming to improve projections of future changes. Collaborations with federal and international partners are encouraged for co-reviewing proposals. Proposals that extend beyond the Arctic must clearly articulate their relevance to Arctic knowledge advancement.

The Bargain Box of Hilton Head Grant, established in 1965, supports Beaufort County non-profits with cash grants derived from store sales. Operating as a 501(c)(3), it has contributed over $15.3 million to local charities, aiding in community activities related to education, health, and safety. Organizations must meet eligibility criteria, including having an active Board of Directors and a community focus. The grant fosters local engagement and supports a diverse array of charitable efforts.

Just One More Grant aims to transform lives by providing financial support to individuals and nonprofit organizations in the U.S. who are overcoming challenges like mental health issues, drug misuse, and educational barriers. The foundation encourages applications from those committed to personal growth and community support. Though current grants are paused for nonprofits, interested individuals with actionable plans are invited to apply. More information and past winners can be found on their website.

Native Forward awards are allocated based on the financial aid information provided by the institution’s Financial Aid Office. Awards can vary, ranging from $100 to $30,000 per academic year.

Native Forward Scholars Fund members of federally and state-recognized Tribes as well as first and second-generation descendants. However, Native Forward Scholars Fund scholarship opportunities have different Tribal eligibility requirements and can be determined by submitting a Tribal Eligibility Certificate.

Hillman Barnett Adkins Endowed Fund Scholarship

The Hillman Barnett Adkins Endowed Fund is provided in honor of members of the Hillman, Barnett, and Adkins families. The purpose of the Hillman Barnett Adkins Endowed Fund is to provide financial assistance to eligible American Indian and Alaska Native vocational, undergraduate, and graduate students enrolled at an accredited not-for-profit college/university, vocational school, or Tribally controlled college or university (TCU) and pursuing degrees with a focus in Fine Arts (studio arts), Performing Arts (music, drama, musical theater, dance), Creative Writing, Art History, Visual Communication, Photography, Culinary Arts, Film (Cinematography, Screenwriting), or Fashion Design & Jewelry Design.

This opportunity is a merit-based award.

The NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) support small businesses in conducting clinical trials for NIH-funded projects. This initiative encourages partnerships with investors to assist in the commercialization of innovations in neurological disorders. Applicants must submit a comprehensive Commercialization Plan detailing anticipated funding. The program aims to promote effective transitions from research to market, enhancing the development of drugs, devices, and therapies for neurological conditions.

The HEAL Initiative aims to combat the opioid crisis through action-oriented research that enhances the translation of addiction epidemiology, prevention, treatment, and recovery services into practice. It prioritizes scalable, evidence-based approaches targeting various levels, including individual and community. The initiative supports a range of methods for research deployment, emphasizing collaboration between researchers and decision-makers to improve outcomes for those affected by addiction and related chronic pain.

The Quality of Life Grants Program, established by the Dana Reeve Foundation, aims to enhance the lives of individuals with disabilities and their families by funding nonprofit organizations. Priority Impact Grants - Tier 2 provide support for critical issues affecting those with paralysis, with grants ranging from $25,000 to $30,000. These grants focus on improving access, independence, and community engagement through innovative programs, including assistive technology, disaster preparedness, and respite services.

The Basil O'Connor Starter Scholar Research Awards, offered by March of Dimes, support emerging researchers in maternal and child health. With a $150,000 grant over two years, the program prioritizes projects addressing preterm birth and health equity. Eligible applicants must be within four to nine years of completing their clinical training or terminal degree, holding a tenure-track position. This initiative aims to foster impactful research that enhances clinical treatments for serious maternal and newborn health conditions.

The IAF Research Fellowship Program, administered by the Social Science Research Council, aims to support rigorous research on community-led development in Latin America and the Caribbean. The fellowship provides a $20,000 stipend for twelve months, fostering innovative solutions to pressing issues such as economic opportunity, migration, and social inclusion. Researchers are encouraged to explore how community-led models can create lasting impacts and respond to global trends, enhancing local resilience and development.

The National Institutes of Health (NIH) is inviting applications for the Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV and HBV (MRA-HBV) program. This initiative aims to enhance understanding of hepatitis B persistence and pathogenesis, identify biomarkers, validate drug targets, and create non-invasive diagnostics. It supports observational cohorts paired with multidisciplinary teams utilizing existing clinical data, contributing to innovative research in hepatitis B cure strategies.

The McMillen Foundation Grants Program supports research in cardiology, lipids, and organ transplant, along with educational initiatives and social services in Washington and Alaska. With a single grant cycle annually, nonprofits certified under 501(c)(3) can apply for funding, preferably those benefiting children and promoting equity. The foundation emphasizes programs that leverage the arts to foster social change, impacting youth and disadvantaged communities. Applications must be submitted by July 31 to be considered for the current cycle.

The Sensata Foundation, established in 2017, is a 501(c)(3) nonprofit supporting community development and STEM education across the U.S. With a focus on improving access to STEM resources and empowering youth, the Foundation partners with nonprofits to address food insecurity, homelessness, and environmental sustainability. By fostering community partnerships and providing financial support, Sensata Foundation aims to inspire future leaders and enhance the quality of life for all, particularly in underserved areas.

The Kars4Kids Small Grant Program aims to support educational initiatives globally, impacting the lives of children. This program welcomes applications from IRS-recognized nonprofit organizations focused on youth development, mentorship, and education. Grants typically range from $500 to $2,000, depending on mission alignment and available funds. Kars4Kids, a national Jewish nonprofit, is dedicated to nurturing productive community members through educational and mentoring opportunities.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Young Investigator

$100,000 over 3 years

• PI must hold an academic appointment at the instructor level or higher
• PI must be within 5 years of completing a training fellowship in Pediatric Hematology/Oncology or a closely related discipline that has direct clinical contact with pediatric cancer patients
• Research must be within 2-3 years to translation to a clinical trial or already associated with a clinical trial

• Evidence of Mentor's commitment to the PI's career development plan
• Translational potential

The William T. Grant Scholars Program provides crucial support for early-career researchers aiming to expand their expertise through innovative research and mentoring. This five-year program focuses on reducing inequality and improving the use of research evidence to benefit young people in the U.S. By emphasizing the development of new disciplines and methods, the program encourages applicants to take bold risks in their research trajectories, ultimately fostering a supportive academic community.

The Michael R. Priddy Music Scholarship, offered by the Central Kentucky Community Foundation, aims to support graduating high school seniors from Hardin County Schools, specifically Elizabethtown and LaRue County High Schools. This scholarship is intended for students who have demonstrated involvement in classical orchestra or music performance, or who plan to pursue music studies, thereby fostering musical education in the community.

The Comis Foundation Grant aims to provide equitable opportunities for children to thrive through education and community engagement. It supports innovative programs that enhance educational outcomes, focusing on areas such as capacity building and pilot projects. With funding ranging from $5,000 to $75,000, the foundation prioritizes nonprofit organizations that foster inclusive environments. By emphasizing trust and collaboration, Comis Foundation strives to create lasting impacts in the communities it serves.

The Elizabeth M. Pfriem Foundation, established in 2015 in Rye Brook, New York, is committed to enhancing the human condition through grants to 501(c)(3) public charities. Focusing primarily on the greater Bridgeport, Connecticut area, it supports initiatives in education, healthcare, food security, and housing. The foundation prioritizes organizations demonstrating fiscal responsibility and innovative programs with significant impact potential, ensuring sustainable support for vulnerable populations, especially children and families in need.

The Robert B. and Ruth K. Lee Foundation Grant aims to enhance the quality of life in Greenville County, South Carolina. Established in 2000, the foundation supports diverse areas including arts, education, health, and human services. With no geographic limitations, it primarily funds programs benefiting the local community. Grants typically range from $2,000 to $5,000, emphasizing initiatives for the elderly, children’s programs in the arts, and literary projects. Organizations must be 501(c)(3) exempt to be eligible.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required) invites applications for high-risk clinical trials that involve multiple centers and aim to change clinical practice or public health. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline, with various deadlines set from February 2025 to October 2026. Planning activities must be completed before submission, and consultation with NIDDK staff is advised.

What We Do

At the North Carolina Community Foundation, we bring together generous people and connect them to causes and organizations they care about.

Our mission is to inspire North Carolinians to make lasting and meaningful contributions to their communities.

Our Philanthropic Network

We believe in the power of permanent philanthropy to strengthen our communities and people. By stewarding and growing donors’ gifts, our philanthropic network makes a powerful impact through robust grants and scholarships programs.

Geraldine Mayo Beveridge Scholarship Endowment

About Geraldine Mayo Beveridge

Geraldine “Gerry” Mayo Beveridge taught school in Carteret County for 40 years. She was a Home Economics teacher and thought of her students as her children; she and husband “Captain David” had none of their own. Gerry would discreetly provide classroom supplies and clothing items for students in need. She quietly contributed money toward college for capable students who couldn’t afford it.

Gerry’s concern for students continued after retirement. As a member of the Carteret County Retired School Personnel (CCRSP), Gerry convinced members of the importance of awarding a scholarship to a graduating senior in each high school – East Carteret, West Carteret, and later, Croatan. To raise money, she organized bake sales and brought plants and canned foods to sell to members. The scholarships, though small, were a great effort for members and were greatly appreciated by recipients.

Gerry left a considerable sum of money to CCRSP with the expectation that it be managed well and used for scholarships. Today, the Geraldine Mayo Beveridge Scholarship is awarded to qualifying graduating seniors who want to teach Vocational Education, now called Career and Technical Education.

Gerry’s passion for her students and her love of education continues through this scholarship. She was an amazing educator whose philanthropy will last in perpetuity.

The NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01) aims to support clinical trials that evaluate interventions for communication disorders. This funding opportunity encourages collaboration between NIDCD Project Scientists and investigators, focusing on trials that require FDA oversight, establish efficacy, or pose risks of harm. By fostering well-designed studies, the NIDCD seeks to advance treatment and prevention strategies in the field of communication disorders.

About Us

Making a Difference, Together

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Skilled Trades Scholarship

The Greater Milan Area Community Fund is proud to support students pursuing skilled trades and hands-on career pathways that build practical skills, open doors to stable employment, and strengthen our local community.

Scholarship awards are typically paid directly to the accredited trade program or educational institution and are generally non-taxable.

Applications are evaluated two times each year for awarding in the six months after application and selection.