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Best Large Grants for Nonprofit Organizations in South Carolina

Find the perfect Large Grants for Nonprofit Organizations in South Carolina on Instrumentl. 9,000+ Large Grants for Nonprofit Organizations in South Carolina in the United States.

9,000+

Available grants

$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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B.W. Bastian Foundation Grant

B.W. Bastian Foundation
Private
United States
US $100 - US $15,000
The B.W. Bastian Foundation Grant supports organizations committed to equality for all Americans, including the LGBTQ+ community. Grants typically range from $100 to $15,000, and applicants must have 501(C)3 tax status. Funding is primarily for projects in the Intermountain West and may include general operating support or specific programs. Organizations should first inquire before applying, especially if requesting more than previous grants. The foundation does not fund individuals or lobbying efforts.
Racial / Ethnic Justice & Rights Social Justice / Human Rights Disability Rights & Justice +5 more

ACA Education Foundation Fellowship

American Cement Association
Private
Canada, United States
US $35,000

About

The Portland Cement Association (PCA), founded in 1916, is the premier policy, research, education, and market intelligence organization serving America’s cement manufacturers. PCA supports sustainability, innovation, and safety while fostering continuous improvement in cement manufacturing, distribution, infrastructure, and economic growth.

ACA Education Foundation Fellowship

The American Cement Association Education Foundation funds a wide variety of educational activities that will increase public knowledge regarding appropriate uses of cement and concrete. Within that global goal is a specific purpose to:

Advance general scientific understanding of cement and concrete by providing scholarships, fellowships, grants, and other support for the study of engineering and the physical sciences relating to the production and use of cement and concrete.

The support provided by the Education Foundation is used to identify and attract outstanding candidates in the field of engineering and the physical sciences and provide them with the necessary support to complete their studies. Additionally, this support is intended to provide candidates an opportunity for productive work in the cement and concrete industries.

Sustainability and Resilience

  • Estimating the impact of optimized use of recycled materials, including alternative fuels and raw materials in clinker manufacture, in hydraulic cements, and in concretes, to improve the CO2 footprint, improve life-cycle performance, reduce the burden on landfills, and improve the circular economy.
  • Improving recognition of concrete system performance through better use of life cycle assessments (LCAs) and environmental product declarations (EPDs) to account for both service impacts and embodied impacts of construction.
  • Other research investigating the optimization of cement and concrete for sustainable and resilient concrete construction, including use of novel approaches to optimize the clinker-to-cement ratio of cement blends, or to optimize design of structural concrete.

Cement Manufacturing

  • Improving raw mix burnability using mineralizers, alternative raw materials, or other means.
  • Advanced grinding technology for raw materials or cements.
  • Optimizing performance by separate grinding and blending of cement ingredients.
  • Advancement of carbon capture, utilization, and storage (CCUS) technology, including novel approaches to capture CO2 from cement kiln emissions, beneficially utilize the captured carbon, or transport and store it.

Testing and Tools

  • Quantitative method to characterize the reduction in CO2 footprint of cement manufacture using alternative fuels.
  • Method or method(s) for quantitative determination of CO2 uptake in fresh and/or hardened concrete, mortar, or paste, in either laboratory or field exposures or both.
  • Updated software tools with consideration of blended cements for mass concrete, crack prediction, and service life prediction of transportation structures.
  • Novel non-destructive test (NDT) techniques to assess finishing timing of flatwork, especially when using concrete mixtures containing newer cementitious materials or other ingredients that may affect concrete performance.
  • New or novel test methods for assessing the finishability, pumpability, bleed rate, set time, and sensitivity to early age curing that may be different for blended cements compared to traditional portland cements.

Architecture Engineering Science +2 more

AFI Grant - Multi-year Grants

Adient Foundation Inc
Private
United States
Unspecified amount
The AFI Grant, administered by the Adient Foundation, Inc., aims to support philanthropic organizations in the U.S. that are tax-exempt. While primarily offering one-time grants, the Foundation evaluates proposals based on organizational structure, community impact, and management capacity. The Foundation complements public institutions and does not guarantee future funding based on past contributions. Grantees must operate with equal opportunity objectives, and past recipients must submit new applications each year.
Art & Culture Education Community Services +11 more

AFI Grant - One-time Grants and Renewals

Adient Foundation Inc
Private
United States
Unspecified amount
The AFI Grant, administered by the Adient Foundation, Inc., supports charitable organizations across the U.S. with a focus on philanthropic efforts. These one-time grants do not guarantee future funding, emphasizing a need for organizations to demonstrate sound management and community impact. Each year, past recipients must reapply under the standard application process, ensuring that support aligns with equal opportunity objectives and the Foundation's mission to complement public funding.
Community Services Performing Arts Civic Engagement & Education +11 more

Scientific & Regulatory Consultants, Inc. Scholarship

Community Foundation of Whitley County
Association/Society
United States
Unspecified amount

Scientific & Regulatory Consultants, Inc. Scholarship

Science plays a vital role in our daily lives and includes a wide range of fields such as physician or veterinary services, nursing, microbiology, biology, chemistry, engineering, mathematics, psychology, music, etc. This scholarship views “scientific” very broadly and invites you to be creative.

Your application will be reviewed based upon the quality, not quantity, of the response to each question.

Applicants may apply every year.

Education - Higher Education Science Career / College Preparation +9 more

Richard L. Blinder Award

James Marston Fitch Charitable Foundation
Private
United States
Up to US $15,000
The Richard L. Blinder Award, presented biennially by the James Marston Fitch Charitable Foundation, recognizes architects and professionals in historic preservation for innovative proposals that advance architectural preservation in the U.S. The award encourages originality, whether through real projects or polemical exercises. With a funding limit of $15,000, recipients must demonstrate a need for their study and a realistic dissemination plan within 24 months, contributing to the preservation community.
Urban Planning Architecture Landscape Architecture +6 more

Wallerstein Foundation Grant

Wallerstein Foundation for Geriatric Life Improvement Inc.
Private
United States
Unspecified amount
The Wallerstein Foundation for Geriatric Life Improvement is dedicated to enhancing the lives of elderly individuals through targeted support for non-profit organizations. Grants focus on critical areas such as dementia care, wellness programs, and community engagement initiatives. The foundation prioritizes projects that meet the unique needs of seniors, promoting health and active lifestyles. By funding specific projects rather than general support, the foundation aims to make a meaningful impact on the quality of life for senior citizens.
Senior Services Aging / Gerontology Dementia & Alzheimer’s Disease +3 more

United Health Foundation Grants

United Health Foundation
Private
United States
Unspecified amount

United Health Foundation

The United Health Foundation was established by UnitedHealth Group in 1999 as a nonprofit, private foundation dedicated to improving health and healthcare. To date, the United Health Foundation has committed $880 million to programs and communities around the world, including a $100 million commitment to help support the healthcare workforce.

Grants

Our Philanthropic Partnerships

The United Health Foundation partners with local and national organizations to help build healthier communities. We focus on expanding access to care and improving health quality and outcomes by:

  • Advancing and supporting the healthcare workforce
  • Addressing mental and behavioral health
  • Improving maternal and infant health outcomes
  • Helping individuals manage chronic conditions
Workforce Preparation & Job Readiness Mental Health & Psychiatric Diseases Maternal And Perinatal Health +2 more

John C. Bock Foundation Grants

John C Bock Foundation
Private
United States
Unspecified amount
The John C. Bock Foundation supports the preservation and enhancement of natural land areas, particularly those near Lake Mendota, Wisconsin. It aims to educate builders and developers on the importance of conserving mature woodlands and old-growth forests. The Foundation funds educational activities and research while supporting qualified conservation organizations committed to protecting these valuable landscapes. Its mission is centered on public education and the custodianship of natural resources.
Forestry Environmental Conservation Habitat & Ecosystem Restoration

Community Forest and Open Space Conservation Program (363348)

USDA: Forest Service (USFS)
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
The Community Forest and Open Space Conservation Program, offered by the USDA Forest Service, aims to support Indian Tribes, local governments, and qualified non-profits in acquiring private forest lands to establish community forests. This competitive grant program focuses on protecting forestland from non-forest uses while enhancing public access and community benefits such as recreation and education. Applications are due by October 13, 2026, requiring coordination with State Foresters or Tribal officials.
Forestry Greening & Beautification Parks & Public Spaces +1 more

NFWF: Five Star Grant Program

National Fish and Wildlife Foundation (NFWF)
Private
Puerto Rico, United States +1 more
US $30,000 - US $150,000
The NFWF's Five Star and Urban Waters Restoration Grant Program aims to enhance community capacity for sustaining local natural resources through financial assistance for diverse partnerships. With approximately $2.5 million available, projects focus on improving water quality, restoring habitats, and engaging underserved communities. By promoting ecological improvements and community outreach, this program seeks to increase access to nature's benefits while addressing environmental hazards. A blend of urban and rural initiatives is expected for effective implementation.
Environmental Conservation Habitat & Ecosystem Restoration Water Resource Management +1 more

Innovative Water Infrastructure Workforce Development Grant

United States Environmental Protection Agency (EPA)
Federal Government
American Samoa, Guam +4 more
US $250,000 - US $7,800,000
The Innovative Water Infrastructure Workforce Development Grant, offered by the U.S. Environmental Protection Agency (EPA), aims to enhance career pipelines in the water utilities sector. This funding opportunity supports institutions and organizations in expanding access to water utility jobs through apprenticeship, education, and training programs. By fostering collaborations and increasing public awareness, the initiative seeks to address the workforce needs of water systems, contributing to community health and environmental protection.
Sanitation & Clean Drinking Water Water Resource Management Workforce Preparation & Job Readiness

Tickets for Kids Grant Program

Tickets For Kids Foundation
Private
United States
Unspecified amount in in-kind support
The Tickets for Kids Grant Program, offered by the Tickets For Kids Foundation, aims to support low-income, at-risk children and youth by providing access to ticketed experiences at no cost. Organizations eligible for partnership include nonprofit agencies, schools serving primarily low-income students, and government agencies. The application process typically takes 2-4 weeks, with responses expected within five business days after review. This initiative enriches existing programming through valuable experiences.
Theater Arts / Culture Access & Participation Academic Success & Enrichment +4 more

Assisting Specialty Crop Exports: Low Oxygen Storage and Packaging Systems for U.S. Tree Nuts with Phytosanitary Traceability

Foreign Agricultural Service
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The Assisting Specialty Crop Exports initiative aims to enhance U.S. specialty crop market access by developing low-oxygen storage and packaging systems for tree nuts. By addressing phytosanitary requirements and pest control, the initiative supports producers in maintaining product quality while complying with international standards. This funding opportunity from the Foreign Agricultural Service encourages innovative solutions that can improve export processes and reduce reliance on costly fumigation methods, ultimately benefiting U.S. agribusiness and ensuring competitiveness in global markets.
Agricultural Crops Insect Pest Control Agricultural Pest Management +1 more

Lawson Charitable Foundation - Amplify Grants

Lawson Charitable Foundation
Private
United States
US $1,000 - US $2,000
The Lawson Charitable Foundation offers Amplify Grants to support nonprofits in New England and beyond, focusing on large-scale initiatives and fundraising efforts. With grants ranging from $1,000 to $2,000, these funds are intended to inspire additional donations and enhance organizational capacity. Eligible applicants must be registered 501(c)(3) nonprofits, aligning with the foundation's mission and demonstrating sustainability beyond the grant period. Priority is given to projects serving New England.
Disability Care & Services Military & Veterans Services Crisis Intervention +2 more

Brinker International Charitable Giving Program

Brinker International
Corporate
Acadia Parish, Louisiana, Ada County, Idaho +620 more
Unspecified amount
The Brinker International Charitable Giving Program focuses on giving back to communities through support for kids, hunger, and education. Organizations eligible for funding must be 501c(3) non-profits and submit requests at least six weeks prior to events. The program does not support individuals, political or religious organizations, or explicit discrimination policies. Funding is provided through monetary donations or in-kind contributions like dining certificates.
Food Access & Hunger Youth Services Children’s Health & Pediatrics +5 more

Cooperative Agreement to Support Activities Related to Analgesics, Anesthetics, and Addiction (U01) Clinical Trials Allowed

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
United States
US $2,000,000
The Cooperative Agreement to Support Activities Related to Analgesics, Anesthetics, and Addiction (U01) aims to enhance research in Anesthesia, Addiction Medicine, and Pain Medicine. It focuses on critical areas such as clinical trial endpoints for chronic pain, outcome measures in stimulant use disorders, and neurodevelopmental assessments in pediatric patients. The initiative encourages applicants to propose comprehensive, evidence-based plans to improve the prescribing of analgesic and anesthetic drug products, with multiple awards available.
Pharmacology Chronic / Acute Pain Anesthesia and Pain Medicine +3 more

CAPTRUST National Partnership Grant

CAPTRUST Community Foundation Inc
Private
United States
Unspecified amount
The CAPTRUST National Partnership Grant aims to support local and national charities that serve children's needs. Each year, a Charity of Choice is selected, typically receiving a grant of over $100,000, while additional national grants are awarded to organizations aligned with the CCF mission. This initiative represents 40% of the CAPTRUST Community Foundation's annual giving budget, underscoring its commitment to impactful charitable partnerships.
Children’s Health & Pediatrics Youth Services Children’s Mental Health +5 more

Food as Medicine Initiative Grant

National Association of Free and Charitable Clinics Inc
Private
United States
US $20,000

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Food as Medicine Initiative

The Food as Medicine Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to address food insecurity as a critical driver of health outcomes for uninsured and medically underserved patients. Research continues to demonstrate the strong connection between food insecurity and poor health, including increased risk of chronic conditions such as diabetes, hypertension, obesity, and certain cancers. Through this initiative, NAFC will provide $20,000 grants to member free and charitable clinics to implement or expand food insecurity screening and patient-centered interventions that improve access to healthy food and nutrition education as measured by the US Household Food Security Module or Hunger Vital Signs and patient education focused on food as medicine for eligible patients in order to increase the percentage of patients with improved food security scores within one year of project implementation.

Patient Care & Services Health Care Access & Delivery Community Health Education +4 more

Fort Orange Garden Club Centennial Endowed Scholarship

The Community Foundation for the Greater Capital Region
Private
United States
Unspecified amount
The Fort Orange Garden Club Centennial Endowed Scholarship is designed for third- and fourth-year undergraduate or current graduate students majoring in plant sciences, conservation, environmental sciences, or landscape architecture. Scholarship recipients must demonstrate financial need and reside in specific counties in New York, including Albany and Schenectady, fostering academic growth while contributing to environmental stewardship.
Academic Scholarship Programs Landscape Architecture Education - Higher Education +5 more

Cigarette Litter Prevention Program (CLPP) Grants

Keep America Beautiful (KAB)
Private
United States
US $5,000 - US $20,000
The Cigarette Litter Prevention Program (CLPP) Grants, offered by Keep America Beautiful, aim to significantly reduce cigarette waste in public spaces across the U.S. since 2003. The program has successfully implemented strategies in over 1,800 communities, achieving an average 50% reduction in litter. Eligible applicants include KAB affiliates and local organizations focused on recycling and public education. Priority is given to partnerships and projects that expand the program's reach, especially those targeting clean water initiatives.
Recycling Waste Management Environmental Contamination & Pollution

Disaster Distress Helpline

US HHS: Substance Abuse and Mental Health Services Administration (SAMHSA)
Federal Government
American Samoa, Guam +4 more
Up to US $1,200,000
The Disaster Distress Helpline (DDH) offers 24/7 crisis counseling to individuals in the U.S. and its territories facing emotional distress from disasters. Managed by SAMHSA, the helpline aims to enhance and strengthen access to crucial support services year-round, ensuring that those affected by natural or human-caused disasters receive the help they need to mitigate behavioral health impacts.
Mental Health & Psychiatric Diseases Crisis Intervention Suicide Prevention

Scaife Family Foundation Grant

Scaife Family Foundation
Private
United States
Unspecified amount
The Scaife Family Foundation Grant has been supporting vulnerable community members for nearly 40 years, providing over $180 million in donations to non-profits. The Foundation aims to match organizations with aligned goals, focusing on women and children, addiction prevention, and animal welfare. It offers grants for general operating and program support, prioritizing impactful programs that address societal issues. Notably, the Foundation considers proposals that foster healthy relationships and promote treatment for addiction, enhancing the welfare of both humans and animals.
Children’s Health & Pediatrics Children’s Mental Health Child Welfare Services +6 more

The Frances M. Peacock Scholarship for Native Bird Habitat

Garden Club of America
Association/Society
United States
US $4,500
The Frances M. Peacock Scholarship, established in 1994 by the Garden Club of America, supports college seniors and graduate students studying seasonal habitats for endangered native birds in the U.S. With an annual award of $4500, this scholarship aims to promote effective land-management practices. Eligible candidates must be U.S. citizens or permanent residents enrolled in a U.S. institution. Note that international applicants are not eligible for funding due to IRS restrictions.
Habitat & Ecosystem Restoration Ornithology Ornithological Conservation

Lawson Charitable Foundation - Impact Grants

Lawson Charitable Foundation
Private
United States
Unspecified amount

About The Lawson Charitable Foundation

The Lawson Charitable Foundation, created in 2021 by Cathy and Tom Lawson, helps those that are working hard to help themselves and others.

For Grant Seekers

The Lawson Charitable Foundation is committed to supporting organizations that drive meaningful change in our communities. While our primary geographic focus is New England, we welcome applications from organizations, doing extraordinary work beyond the region as well.

We are happy to offer two types of grants to support nonprofit organizations making a difference: Impact Grants and Amplify Grants.

Impact Grant

Impact Grants provide funding for programs and initiatives that closely align with our mission of helping those who are working hard to help themselves and others. These grants are designed to support opportunities that create positive change within our focus areas, ensuring resources are directed toward impactful and mission-driven efforts.

Disability Care & Services Military & Veterans Services Crisis Intervention +2 more

James Marston Fitch Mid-Career Fellowship

James Marston Fitch Charitable Foundation
Private
United States
Up to US $15,000
The James Marston Fitch Mid-Career Fellowship offers research grants up to $15,000 for mid-career professionals in fields like historic preservation, architecture, and urban design. Applicants must demonstrate a commitment to innovative research and a clear dissemination plan. The fellowship encourages impactful projects that contribute significantly to the field, ensuring that only qualified individuals can apply, as it does not fund organizational projects or dissertation research.
Historic Preservation Architecture Landscape Architecture +5 more

Sidney R. Baer, Jr. Foundation: Criminal Justice Grants

Sidney R Baer Jr Foundation
Private
United States
Unspecified amount
The Sidney R. Baer, Jr. Foundation offers Criminal Justice Grants aimed at improving the lives of individuals with serious mental illnesses, particularly schizophrenia and bipolar disorder. With an emphasis on effective programs and support services, the foundation seeks to address the challenges faced by mentally ill individuals in the criminal justice system. The foundation prioritizes organizations that demonstrate a commitment to making a meaningful impact and improving the quality of life for those affected by these conditions.
Mental Health & Psychiatric Diseases Schizophrenia Criminal Justice System Reform +4 more

Large Grants for Nonprofit Organizations in South Carolina Highlights

Looking for large grants for nonprofit organizations in South Carolina?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in South Carolina recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

53 Large Grants for Nonprofit Organizations in South Carolina over $25K in average grant size

40 Large Grants for Nonprofit Organizations in South Carolina over $50K in average grant size

32 Large Grants for Nonprofit Organizations in South Carolina supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in South Carolina supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in South Carolina?

Most grants are due in the first quarter.

Q1
28.9%
Q2
25.2%
Q3
24.8%
Q4
21.1%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in South Carolina?

Grants are most commonly $15,000.

$500 $500 Min.
$15,000 $15 K Median
$535,356 $535.4 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in South Carolina changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081