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Best Large Grants for Nonprofit Organizations in South Carolina

Find the perfect Large Grants for Nonprofit Organizations in South Carolina on Instrumentl. 9,000+ Large Grants for Nonprofit Organizations in South Carolina in the United States.

9,000+

Available grants

$3.79B

Total funding

$5K

Median grant

9,000+ grants
$3.79B total
$5K median

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9,313 Results based on applied filters

Retail Food Safety Regulatory Association Collaboration

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
United States
US $4,000,000
The Retail Food Safety Regulatory Association Collaboration program supports state, local, tribal, and territorial (SLTT) food safety initiatives to mitigate food-borne illness risks. Funded by the FDA, this initiative aids SLTT agencies in research and intervention implementation, aiming to enhance public health and establish a cohesive national food safety framework. Eligible applicants include non-profit organizations connected to higher education institutions, focusing on retail food safety.
Food Safety

Equus Research Career Award

Equus Foundation Inc
Private
United States
US $6,500
The Equus Veterinary Research Fellowship, established by the Equus Foundation and The Foundation For The Horse, offers a $5,000 scholarship and a $500 travel stipend to support equine research. Open to graduates of AVMA-accredited veterinary schools nearing residency or doctoral completion, this fellowship encourages innovative research in horse health care. Applications are accepted from mid-July to August, promoting the advancement of equine veterinary practices and the training of future researchers.
Veterinary Science & Services Animal Welfare - Domestic Animals & Pets

Seymoure, Fred and Mildred (Young) Memorial Scholarship Fund

Noble County Community Foundation
Private
United States
US $751
The Seymoure, Fred and Mildred (Young) Memorial Scholarship Fund offers a $500 scholarship to a Central Noble High School senior or graduate, or a resident of the Albion area pursuing a BS or MS in education. Established by the Noble County Community Foundation, this fund aims to support future educators in making a positive impact in their communities. Since 1991, the foundation has been dedicated to enhancing the quality of life in Noble County.
Career / College Preparation

USS ST. LOUIS (LCS 19) Scholarship

The Scholarship Foundation of St. Louis
Association/Society
United States
Up to US $12,000
The USS ST. LOUIS (LCS 19) Scholarship, established by the Commissioning Committee in 2020, supports crew members and their dependents pursuing undergraduate degrees or technical training. Administered by The Scholarship Foundation of St. Louis, it awards up to $12,000 annually, renewable for up to ten semesters. This initiative honors the commitment of the USS ST. LOUIS crew while fostering educational advancement and community engagement.
Vocational & Trade Education Academic Scholarship Programs

SAGES Education & Research Foundation Grants

Sages Education And Research Foundation
Private
United States
US $1,000 - US $100,000
The SAGES Education & Research Foundation Grants promote advancements in minimally invasive surgical techniques aiming to reduce patient trauma and recovery time. They offer competitive funding ranging from $1,000 to $100,000, with a total allocation of $500,000 to $600,000 this year. Eligible applicants include 501(c)(3) or 501(c)(6) organizations aligned with the Foundation's mission. Grants are awarded annually, requiring reapplication for multi-year support.
Surgery Medical Education & Professional Training

ACS - Fanconi Cancer Foundation Discovery Boost Grant

American Cancer Society
Association/Society
United States
More than US $135,000
The ACS - Fanconi Cancer Foundation Discovery Boost Grant invites innovative proposals for translational cancer research addressing the challenges faced by individuals with Fanconi anemia (FA). This grant supports high-risk, high-reward projects aimed at improving detection, prevention, or treatment of FA-related cancers. With funding of up to $135,000 per year for two years, it encourages research in early detection technologies, prevention mechanisms, and therapeutic strategies tailored to the unique sensitivities of the FA population.
Cancer / Oncology

Rural Health Fellows Leadership Program

National Rural Health Association
Private
United States
Unspecified amount
The Rural Health Fellows Leadership Program, offered by the National Rural Health Association (NRHA), is an intensive yearlong initiative aimed at cultivating a diverse network of rural health leaders. Selected participants engage in leadership training, policy advocacy, and collaborative projects. The program includes monthly virtual sessions, in-person meetings at key conferences, and opportunities for financial support, thereby empowering fellows to make a significant impact on rural healthcare.
Health Disparities & Social Determinants of Health

Good Eats Scholarship Fund

Hawai'i Community Foundation
Private
United States
Unspecified amount
The Good Eats Scholarship Fund aims to support aspiring professionals in agriculture and culinary arts who will bring enhanced food quality to Hawaii. Eligible applicants must demonstrate financial need, maintain a minimum GPA of 2.7, and show commitment to food-related programs. Preference is given to previous recipients who continue to meet the criteria. This initiative fosters local talent and encourages a strong connection to food production in the islands.
Agriculture Academic Scholarship Programs Culinary Arts

Wofford College Fund

Coastal Community Foundation of South Carolina
Private
Berkeley County, South Carolina, Charleston County, South Carolina +1 more
Approximately US $900
The Wofford College Fund, established by the Samuel Freeman Charitable Trust, aims to support high school seniors from Berkeley, Charleston, and Dorchester counties pursuing a four-year degree at Wofford College. This initiative is part of the Coastal Community Foundation's broader mission to address community needs through strategic investments and grantmaking, fostering equity and opportunity for all residents in South Carolina's coastal region.
Education - Higher Education Academic Scholarship Programs

Warren O. Pinckney Scholarship Fund

Coastal Community Foundation of South Carolina
Private
Berkeley County, South Carolina, Charleston County, South Carolina +1 more
US $500 - US $2,000
The Warren O. Pinckney Scholarship Fund, established in 1973, provides essential financial support to students from Berkeley, Charleston, or Dorchester counties pursuing higher education. Managed by the Coastal Community Foundation, this fund addresses the financial needs of local students, ensuring they have the opportunity to achieve their educational goals. With a legacy of impactful scholarships, the fund continues to empower future leaders in the community.
Education - Higher Education Academic Scholarship Programs

UPLIFT Scholarship

Coastal Community Foundation of South Carolina
Private
Berkeley County, South Carolina, Charleston County, South Carolina +1 more
Approximately US $5,000
The UPLIFT Scholarship, established by East Cooper Medical Center in 2020, supports students from Berkeley, Charleston, or Dorchester Counties maintaining a GPA of 2.5 or higher. This initiative, part of the Coastal Community Foundation's mission, aims to enhance equity and opportunity in the community. Preference is given to applicants with a relative employed by ECMC or its parent company, Tenet Healthcare, ensuring that local families benefit from this educational support.
Education - Higher Education Academic Scholarship Programs

Shannon Sudderth Scholarship Endowment

Coastal Community Foundation of South Carolina
Private
Charleston County, South Carolina
Approximately US $2,500
The Shannon Sudderth Scholarship Endowment, established in 2020, aims to support high school seniors residing in Charleston County by providing two renewable scholarships. This initiative is part of the Coastal Community Foundation's mission to foster equity, opportunity, and well-being in the community. Through strategic grantmaking and resources, the foundation addresses local needs and empowers future leaders to pursue their educational goals.
Education - Higher Education Academic Scholarship Programs

Rufus C. Barkley, Jr. Leadership Scholarship Fund

Coastal Community Foundation of South Carolina
Private
Berkeley County, South Carolina, Charleston County, South Carolina +2 more
Approximately US $10,000
The Rufus C. Barkley, Jr. Leadership Scholarship Fund, established in 2000, supports students from Charleston, Berkeley, Dorchester, or Colleton counties. This scholarship prioritizes academic merit and character, considering financial need. Applicants should demonstrate well-rounded interests and a commitment to helping others. One renewable award will be granted for up to four years of college. The fund reflects the Coastal Community Foundation's mission to enhance equity and opportunity in local communities.
Education - Higher Education Academic Scholarship Programs

Donald C. and Johanna Miller Scholarship Endowment

Coastal Community Foundation of South Carolina
Private
Berkeley County, South Carolina, Charleston County, South Carolina +1 more
Approximately US $1,000
The Donald C. and Johanna Miller Scholarship Endowment, established in 2019 by Don and Jo Miller, supports high school seniors residing in Berkeley, Charleston, and Dorchester Counties. This scholarship is part of the Coastal Community Foundation's mission to create equitable opportunities for students. By leveraging community resources, the foundation aims to empower local youth to achieve their educational goals, ultimately fostering vibrant communities along South Carolina's coast.
Academic Scholarship Programs Education - Higher Education

Decker Scholarship

Coastal Community Foundation of South Carolina
Private
Berkeley County, South Carolina, Charleston County, South Carolina +1 more
Approximately US $700
The Decker Scholarship, established by the Coastal Community Foundation of South Carolina, aims to provide higher education funding for students in Berkeley, Charleston, and Dorchester counties. This initiative is part of a larger commitment to fostering equity and opportunity within the community. By leveraging endowment funds, the foundation addresses local needs while empowering students to pursue their academic goals. This scholarship reflects a dedication to supporting the educational aspirations of future leaders in the region.
Education - Higher Education Academic Scholarship Programs

Amanda’s Scholarship Fund

Coastal Community Foundation of South Carolina
Private
Berkeley County, South Carolina, Charleston County, South Carolina +1 more
Approximately US $5,000
Amanda’s Scholarship Fund, established in memory of Amanda Welling Dykes, supports students from Berkeley, Charleston, and Dorchester counties. Funded through the Coastal Community Foundation, it honors Amanda’s love for learning and character. The foundation invests in community needs, promoting equity and opportunity through scholarships and grants, while addressing critical challenges like education access. This initiative reflects a commitment to nurturing the potential of young learners in South Carolina.
Academic Scholarship Programs Education - Higher Education

Lexington Medical Center Grant

Lexington Medical Center Foundation Inc
Private
Lexington County, South Carolina
Unspecified amount
The Lexington Medical Center Grant supports 501(c)(3) nonprofit organizations that address community health care needs in the Midlands. The foundation prioritizes increasing access to healthcare for underserved populations, enhancing education on health issues, and fostering collaboration with existing healthcare initiatives. Their goal is to bridge health care gaps and improve the capacity of safety-net services, ensuring vulnerable populations receive necessary support and services.
Health Disparities & Social Determinants of Health

USTA Player Development Excellence Grant

United States Tennis Association
Private
United States
US $3,000 - US $12,000
The USTA Player Development Excellence Grant supports aspiring U.S. tennis players by providing financial assistance based on performance and potential. Grants of up to $12,000 are awarded to players who meet specific criteria, encouraging their development into top 100 professionals. By utilizing USTA facilities and coaching, players can maximize their growth. The program aims to nurture young talent and ensure they have the resources necessary to succeed in competitive tennis.
Tennis

New Music Creator Fund

New Music Usa Inc
Private
American Samoa, Guam +4 more
Unspecified amount
The New Music Creator Fund provides financial support to individual music creators across all genres, helping them advance their creative practice. This initiative covers costs associated with developing new work and collaborative projects. Applicants must be at least 21 years old and have three years of professional music experience. The fund aims to empower diverse music creators in the U.S. by facilitating the development of innovative musical ideas and fostering artistic collaboration.
Music

Special Excellence Scholarship

CIRI Foundation
Private
United States
Up to US $20,000
The Special Excellence Annual Scholarship, offered by the CIRI Foundation, supports full-time students in 4-year undergraduate or graduate programs who demonstrate exceptional academic achievements and community service. With awards up to $20,000 for one academic year, this merit-based scholarship emphasizes the importance of maintaining a minimum GPA of 3.7 and encourages contributions to the Alaska Native community. This initiative fosters educational success and economic self-sufficiency among Alaska Natives and their descendants.
Education - Higher Education Academic Scholarship Programs

Raven Fund Scholarships

CIRI Foundation
Private
United States
Up to US $3,500
The Raven Fund Scholarships, offered by the CIRI Foundation, support educational aspirations for CIRI voting shareholders who are not original shareholders or descendants. Award amounts include $200 per credit for full-time students, up to $3,000 per term, and similar support for part-time students. Funds cover tuition, fees, books, supplies, and housing. Applicants must have a high school diploma, be enrolled in an accredited program, and maintain a minimum GPA of 2.0 to qualify.
Academic Scholarship Programs Education - Higher Education

Genentech Career Development Award for Underrepresented Minority Emerging Vision Scientists

The Association for Research in Vision and Ophthalmology
Private
United States
US $100,000
The Genentech Career Development Award for Underrepresented Minority Emerging Vision Scientists, offered by ARVO, supports early-career underrepresented minority investigators in establishing independent vision research programs. This two-year grant provides $100,000 for research and personnel costs, aiming to foster innovative project ideas and promising preliminary results. Successful applicants will receive strong mentorship within the eye and vision research community, facilitating career advancement and the potential for impactful scientific publications.
Eye Diseases & Disorders

Raven Fund Jump Start Award

CIRI Foundation
Private
United States
Up to US $2,000
The Raven Fund Jump Start Award, established by the CIRI Foundation, provides scholarships of up to $2,000 per year for CIRI voting shareholders who are high school students. Eligible applicants must be enrolled in a recognized post-secondary education program, maintaining a minimum GPA of 2.0. The funding covers direct educational costs such as tuition, books, and housing. The award allows for multiple applications within the year, encouraging ongoing educational pursuits.
Education - Higher Education Academic Scholarship Programs

Raven Fund Career Technical Education Scholarships

CIRI Foundation
Private
United States
Up to US $9,000
The Raven Fund Career Technical Education Scholarships, offered by the CIRI Foundation, aim to support CIRI voting shareholders pursuing technical skill training. With awards up to $9,000 per year, eligible applicants must be enrolled in recognized programs and maintain a minimum GPA of 2.0. The scholarships cover essential educational expenses, including tuition and fees, and also allow for personal expenses under certain conditions. This initiative fosters economic self-sufficiency and educational advancement among Alaska Native beneficiaries.
Academic Scholarship Programs Vocational & Trade Education

WNDB: Walter Dean Myers Grant Program

We Need Diverse Books
Private
United States
US $2,000
The Walter Dean Myers Grant Program, established by We Need Diverse Books, offers $2,000 grants to promising unpublished diverse writers and illustrators. Aimed at enhancing their craft and supporting traditional publication pursuits, this initiative has awarded over 70 grants since 2015, resulting in nearly 60 published books and numerous literary accolades. Applicants must identify as diverse and be U.S. residents, working towards a career in children's literature.
Writing & Literature Diversity, Equity & Inclusion

EMF SAMFund Financial Assistance Grants

Expect Miracles Foundation
Private
United States
Up to US $19,000
The EMF SAMFund Financial Assistance Grants support young adult cancer survivors facing financial hardships due to their diagnosis. With 80,000 young adults diagnosed with cancer each year in the U.S., these grants provide critical assistance for essential living expenses like rent, car payments, and education. By prioritizing applicants who demonstrate financial need and articulate how the grant will aid their recovery, the program aims to alleviate financial toxicity and empower survivors to move forward with their lives.
Cancer / Oncology

Excellence Annual Scholarship

CIRI Foundation
Private
United States
Up to US $15,000
The Excellence Annual Scholarship, offered by the CIRI Foundation, supports full-time undergraduate and graduate students with a minimum GPA of 3.5. This merit-based scholarship recognizes academic excellence and community service, providing up to $10,000 for one academic year. Funding covers direct educational expenses and personal expenses, ensuring Alaska Native beneficiaries can pursue their educational and career aspirations while preserving their rich cultural heritage.
Education - Higher Education Academic Scholarship Programs

Large Grants for Nonprofit Organizations in South Carolina Highlights

Looking for large grants for nonprofit organizations in South Carolina?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in South Carolina recommended for your specific programs.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

54 Large Grants for Nonprofit Organizations in South Carolina over $25K in average grant size

41 Large Grants for Nonprofit Organizations in South Carolina over $50K in average grant size

32 Large Grants for Nonprofit Organizations in South Carolina supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in South Carolina supporting programs / projects

1,000+ Grants on Instrumentl focused on Health Care Access & Delivery

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in South Carolina?

Most grants are due in the first quarter.

Q1
28.9%
Q2
26.6%
Q3
24.1%
Q4
20.4%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in South Carolina?

Grants are most commonly $15,000.

$500 $500 Min.
$15,000 $15 K Median
$530,911 $530.9 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in South Carolina changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081