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Best Large Grants for Nonprofit Organizations in South Carolina

Find the perfect Large Grants for Nonprofit Organizations in South Carolina on Instrumentl. 9,000+ Large Grants for Nonprofit Organizations in South Carolina in the United States.

9,000+

Available grants

$3.79B

Total funding

$5K

Median grant

9,000+ grants
$3.79B total
$5K median

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Filters

9,313 Results based on applied filters

Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional) (357744)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
This funding opportunity supports exceptionally promising Early Stage Investigators in genomics, encouraging innovative research across various fields such as genomic sciences and medicine. Applicants must submit their proposals by 5:00 PM local time of their organization. The initiative, led by the US Dept. of Health & Human Services through the NIH, aims to foster long-term career development in genomic research while addressing its ethical, legal, and social implications.
Genetics & Genomics Medical Ethics

Travel & Training Fund

Women’s Sports Foundation
Private
United States
US $2,500 - US $10,000
The Travel & Training Fund, established by the Women’s Sports Foundation, has supported over 1,500 female athletes since 1984, including Olympians and national team members. Grants ranging from $2,500 to $10,000 aim to alleviate financial burdens for women athletes pursuing elite competition. Prioritizing those with a plan to contribute back to women's sports, the fund emphasizes eligibility for U.S. citizens or legal residents, ensuring a significant impact on the recipients' athletic journeys.
Women & Girl Services Sports & Athletics

AFS Travel Grant

Austin Film Society
Private
Africa, Americas +4 more
US $500 - US $1,000
The AFS Travel Grant, offered by the Austin Film Society, supports Texas-based filmmakers by covering travel costs to competitive film festivals worldwide. Since its inception, the grant has provided crucial financial assistance, enabling filmmakers to gain exposure and foster industry connections. Eligible applicants can receive up to $1,500 for travel, helping them navigate the financial challenges of festival participation. This initiative strengthens the local creative community and promotes diverse storytelling in the film industry.
Film

Outdoor Recreation Legacy Partnership Program (ORLP) Recurring Notice 5 Year

US Department of the Interior: National Park Service (NPS)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $15,000,000
The Outdoor Recreation Legacy Partnership Program (ORLP) is a competitive grant initiative by the National Park Service, aimed at enhancing parks and recreational opportunities in urban, underserved communities. This program supports the acquisition, development, and renovation of outdoor recreation areas through federal funding, addressing the needs of community organizations, local governments, and recognized tribes. Applications are accepted twice a year, before June 1 and November 1.
Parks & Public Spaces Outdoor Recreation Outdoor Equity

Kansas Osteopathic Medical Service Scholarship

Kansas Board of Regents
State/Local Government
United States
Up to US $41,000
The Kansas Osteopathic Medical Service Scholarship aims to attract primary care physicians to rural Kansas. It provides $41,000 annually for up to four years of study at accredited osteopathic schools. Recipients must commit to practice in designated underserved areas of Kansas for one year for each year of funding received. Eligibility requires residency in Kansas and completion of financial aid applications by specified deadlines.
Education - Higher Education Medical Education & Professional Training

Patricia L. Hartman and Lois C. Hartman Scholarship Fund

San Antonio Area Foundation
Private
United States
Unspecified amount
The Patricia L. Hartman and Lois C. Hartman Scholarship Fund, managed by the San Antonio Area Foundation, supports current high school seniors and college students pursuing Associate or Bachelor's degrees in the USA. It aims to enhance educational opportunities, with a preference for applicants from Alamo Heights ISD. This fund reflects a commitment to improving community life through education, making a lasting impact on students' futures.
Education - Higher Education Academic Scholarship Programs

Firstmark | Cunningham Scholarship Fund

San Antonio Area Foundation
Private
United States
Unspecified amount
The Firstmark | Cunningham Scholarship Fund, administered by the San Antonio Area Foundation, offers financial support for graduating high school seniors who are members or children of members at Firstmark Credit Union. Applicants must be in the top 15% of their class and pursue an accredited post-secondary education. This scholarship emphasizes academic achievement and community service, aiming to empower young individuals in their educational endeavors and contribute positively to society.
Education - Higher Education Academic Scholarship Programs

Feeding Student Success Scholarship Fund

San Antonio Area Foundation
Private
United States
US $5,000
The Feeding Student Success Scholarship Fund, managed by the San Antonio Area Foundation, empowers students by providing financial support for tuition, fees, books, and supplies. Open to all areas of study, this scholarship is available to full-time and part-time students who demonstrate financial need and have a minimum GPA of 2.5. With 120 awards available, the fund aims to enhance educational opportunities for those living near a Whataburger, promoting community growth and academic success.
Education - Higher Education Academic Scholarship Programs

Sammy Cahn Award

Ascap Foundation
Private
District of Columbia, Puerto Rico +1 more
US $5,000
The Sammy Cahn Award, presented by The ASCAP Foundation, honors exceptional lyric-writing talent among songwriters of original songs. Established in 1995 to commemorate Sammy Cahn's legacy, the award offers a $5,000 prize to recipients. Eligible entrants include ASCAP writer members in good standing or independent songwriters. Submissions are judged anonymously based on lyric quality and overall craft, ensuring the recognition of artistic excellence within the songwriting community.
Music

Peggy Lee Songwriter Award

Ascap Foundation
Private
District of Columbia, Puerto Rico +1 more
US $2,500
The Peggy Lee Songwriter Award, presented by the ASCAP Foundation, honors lyricists of original songs who exhibit a sophisticated command of language and demonstrate significant talent. This prestigious award recognizes contributions to jazz and popular music, with a prize of $2,500 shared among co-writers. Eligible entrants must be U.S. citizens or residents, at least 18 years old, and ASCAP members in good standing. This award celebrates the legacy of Peggy Lee, a pioneering figure in music.
Music

Jay Gorney Award

Ascap Foundation
Private
District of Columbia, Puerto Rico +1 more
US $2,500
The ASCAP Foundation's Jay Gorney Award honors songwriters who create original music with socially conscious themes. Established in 2009, this award commemorates composer Jay Gorney's legacy, particularly his iconic song 'Brother, Can You Spare a Dime?' Entrants are judged on their ability to convey powerful messages through artistry and lyrical excellence. The award includes a $1,000 monetary prize, fostering creativity and social awareness in the music community.
Music

Duncan Scholars Program Scholarship Fund

San Antonio Area Foundation
Private
United States
Unspecified amount
The Duncan Scholars Program Scholarship Fund, managed by the San Antonio Area Foundation, offers financial assistance for full-time students enrolled in various accredited institutions across the USA. This renewable scholarship is available to children of current Enterprise Products Company employees, ensuring that those with at least three years of service can support their child's educational pursuits. The program aims to enhance community well-being by investing in youth education and future leaders.
Education - Higher Education Academic Scholarship Programs

Deems Taylor/Virgil Thomson Awards

Ascap Foundation
Private
District of Columbia, Puerto Rico +1 more
Up to US $4,000
The Deems Taylor/Virgil Thomson Awards, established in 1967 by the ASCAP Foundation, honor exceptional books, articles, and liner notes about music. With total prizes of $4000, awards are given to top submissions in Pop and Concert Music genres. Eligible works must be published in the previous year and meet specific criteria. The foundation aims to celebrate the legacy of Deems Taylor and Virgil Thomson, prominent figures in American music history.
Music

Danette Honesto Scholarship Program

San Antonio Area Foundation
Private
United States
Unspecified amount
The Danette Honesto Scholarship Program, administered by the San Antonio Area Foundation, offers financial assistance to current high school seniors and college students pursuing various degrees in the USA. Applicants must be dependents of Sonterra Medical Management Group employees and meet specific eligibility criteria. This scholarship aims to enhance educational opportunities and is a testament to the Foundation's commitment to community development, having distributed millions in grants and scholarships since 1964.
Education - Higher Education Academic Scholarship Programs

CITGO Distinguished Scholars Program

San Antonio Area Foundation
Private
United States
US $5,000
The CITGO Distinguished Scholars Program, offered by the San Antonio Area Foundation, is designed for junior high school students in the Alief, Houston, and Spring Branch ISDs. This program supports students planning to enroll in a 2- or 4-year college with funding for tuition, fees, and books. A cumulative GPA of 2.5 is required, and awards are granted to 40 students, empowering them to pursue higher education.
Education - Higher Education Academic Scholarship Programs

Carvajal Educational Fund

San Antonio Area Foundation
Private
United States
US $2,000
The Carvajal Educational Fund, managed by the San Antonio Area Foundation, aims to support current high school seniors from specified Texas counties in their pursuit of higher education. With a focus on Judeo-Christian institutions, this scholarship provides financial assistance for tuition, fees, and books, promoting academic achievement with a minimum GPA requirement of 2.5. Established to foster educational opportunities, the fund emphasizes the importance of community impact and leadership.
Education - Higher Education Academic Scholarship Programs

Brian Morris College Gateway Scholarship Fund

San Antonio Area Foundation
Private
United States
Unspecified amount
The Brian Morris College Gateway Scholarship Fund, managed by the San Antonio Area Foundation, supports full-time students pursuing a Bachelor's degree at accredited U.S. colleges. This renewable scholarship, available since 1964, is targeted at high school seniors from San Antonio, particularly those with financial need and a GPA of 3.33 or higher. The fund aims to empower students to achieve their educational goals, making a lasting impact on the community.
Education - Higher Education Academic Scholarship Programs

PVA Research Grants & Fellowships

Paralyzed Veterans of America
Private
Canada, United States
Up to US $200,000
The Paralyzed Veterans of America Research Foundation offers grants and fellowships aimed at enhancing the quality of life for individuals with spinal cord injuries and diseases. With a history of funding over $54 million since 1976, the foundation supports innovative research across categories like Basic Science, Clinical Applications, Design & Development, and Fellowships. Grants can reach up to $200,000, fostering advancements in medical technologies and training for future experts in spinal cord research.
Spinal Cord Injuries

Judith Graham Pool Postdoctoral Research Fellowship

National Bleeding Disorders Foundation
Private
United States
Up to US $104,000
The Judith Graham Pool (JGP) Postdoctoral Research Fellowship, established by the National Bleeding Disorders Foundation (NBDF) in 1972, supports groundbreaking research in bleeding disorders. It offers up to $52,000 annually for two years to candidates engaged in pre-clinical or basic science studies related to hemophilia and other inherited bleeding disorders. The fellowship aims to advance understanding and treatment options, including gene therapy, while fostering new scientific talent in the field.
Hematological Systems

ASH HONORS Award

American Society of Hematology Inc
Private
Canada, Mexico +1 more
US $6,000
The ASH HONORS Award supports emerging hematologists, offering $5,000 for research projects and a $1,000 annual travel allowance for two years. Targeted at first- and second-year medical students and residents, the award encourages ongoing research careers in hematology. Recipients attend an orientation at the ASH annual meeting, gaining insights from experienced professionals. Eligibility includes current ASH membership and a research mentor, while restrictions apply to prior HONORS awardees and those with concurrent funding.
Hematological Systems

Founders Concept Development Grants

Children's Theatre Foundation of America (CTFA)
Private
United States
US $3,000 - US $6,000
The Founders Concept Development Grants, offered by the Children's Theatre Foundation of America (CTFA), support US non-profit theatres in developing innovative concepts and strategies for engaging young audiences. This initiative emphasizes diversity, equity, and inclusion, aiming to enhance the quality of theatre for youth. CTFA encourages artists to explore new ideas while ensuring that all children have access to impactful theatrical experiences. This grant embodies a commitment to fostering creativity and excellence in youth theatre.
Theater

William Webermeier Scholarship

Center for Scholarship Administration (CSA)
Private
United States
Unspecified amount
The William Webermeier Scholarship, administered by the Center for Scholarship Administration, offers financial support to full-time students from Milford High School in Nebraska. Eligible applicants must demonstrate academic achievement and good behavior, maintain a minimum GPA of 3.5, and show financial need. Additionally, recipients are required to honor the memory of the scholarship's namesake by placing flowers on his grave annually. This scholarship aims to assist students in achieving their educational goals.
Education - Higher Education Academic Scholarship Programs

ASNT Foundation: Faculty Grant

American Society For Nondestructive Testing Inc
Private
United States
US $10,000
The ASNT Foundation's Faculty Grant aims to enhance nondestructive testing (NDT) education at US universities and colleges. By providing $10,000 in funding, this grant supports faculty in revising or developing NDT curricula. Recipients who are not ASNT members receive a complimentary one-year membership. The initiative focuses on improving educational quality in the NDT field, ensuring students receive top-notch instruction, thus paving the way for successful careers in nondestructive testing.
Materials Science and Engineering Engineering Science +1 more

Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028, and 2029 (P50 Clinical Trial Required)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Cancer Institute (NCI) is inviting applications for the Specialized Programs of Research Excellence (SPOREs) in Human Cancers for 2027-2029. This funding opportunity supports innovative translational research aimed at improving prevention, detection, and treatment of organ-specific cancers. Eligible projects may address related cancer types from the same organ system or focus on common biological mechanisms. The program emphasizes research that translates findings into clinical applications, with the goal of achieving a human endpoint during the grant period.
Cancer / Oncology

BioLEAP Classroom Grants

National Anti Vivisection Society
Private
American Samoa, Guam +4 more
Up to US $1,000
The BioLEAP Classroom Grants, funded by the National Anti Vivisection Society, support U.S. educators in purchasing humane alternatives to animal dissection. Grants of up to $1,000 are available for innovative learning tools like 3D models and synthetic specimens. This initiative promotes ethical education in anatomy labs, ensuring teachers have access to effective resources while fostering a compassionate approach to learning.
Anatomy STEM / STEAM Education

International Visiting Professorship Award

American Heart Association
Association/Society
United States
Up to US $10,000
The American Heart Association's International Visiting Professorship Award aims to enhance global research experiences by bringing international scientists to the U.S. for one week. This initiative promotes scientific exchange and collaboration, aligning with the AHA's mission. With a budget of up to $10,000, the program supports various travel-related expenses, fostering valuable connections and advancing research in critical medical fields.
Cardiovascular Diseases & Systems

Nemo Herrera Scholarship Fund

San Antonio Area Foundation
Private
United States
Unspecified amount
The Nemo Herrera Scholarship Fund, managed by the San Antonio Area Foundation, supports graduating high school seniors pursuing further education in any field. This scholarship aims to assist those who demonstrate academic merit and involvement in extracurricular activities, particularly students from Lanier High School. As a non-renewable scholarship, it covers tuition, fees, and books, ensuring that financial barriers do not prevent deserving students from achieving their academic goals.
Education - Higher Education Academic Scholarship Programs

Large Grants for Nonprofit Organizations in South Carolina Highlights

Looking for large grants for nonprofit organizations in South Carolina?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in South Carolina recommended for your specific programs.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

54 Large Grants for Nonprofit Organizations in South Carolina over $25K in average grant size

41 Large Grants for Nonprofit Organizations in South Carolina over $50K in average grant size

32 Large Grants for Nonprofit Organizations in South Carolina supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in South Carolina supporting programs / projects

1,000+ Grants on Instrumentl focused on Health Care Access & Delivery

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in South Carolina?

Most grants are due in the first quarter.

Q1
28.9%
Q2
26.6%
Q3
24.1%
Q4
20.4%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in South Carolina?

Grants are most commonly $15,000.

$500 $500 Min.
$15,000 $15 K Median
$530,911 $530.9 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in South Carolina changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081