Best Large Grants for Nonprofit Organizations in South Carolina

The AMVETS Spouse Scholarship offers financial support to the spouses of honorably discharged veterans and active military personnel, including National Guard and Reserves. This scholarship aims to bridge financial gaps after other federal and state resources have been exhausted. Eligible applicants must be U.S. citizens enrolled in accredited undergraduate programs, demonstrate financial need, and not be in default on federal student loans. AMVETS stands committed to empowering military families through education.

The Klingenstein-Simons Fellowship Awards in Neuroscience support early-career investigators conducting basic or clinical research focused on neurological and psychiatric disorders. Awardees receive $150,000 annually for three years, aimed at fostering innovative research that contributes to understanding and treating these disorders. The fellowship encourages applications from underrepresented groups and prioritizes candidates with promising scientific careers who may not have received substantial prior funding, promoting collaboration and mentorship in the neuroscience community.

The AMVETS Children/Grandchildren Scholarship supports the educational aspirations of children and grandchildren of honorably discharged U.S. veterans and active military. This scholarship aims to bridge financial gaps after all federal and state assistance has been utilized. Eligible applicants must be U.S. citizens, high school seniors, and demonstrate financial need while enrolled in accredited four-year universities. Incomplete applications will be disqualified, ensuring that the award goes to deserving candidates committed to their education.

The Research Enhancement Award Program (REAP) aims to boost basic and clinical research at health professional and graduate schools that have historically received limited NIH funding. By supporting small-scale research projects led by faculty, REAP fosters student engagement in significant research endeavors, enhancing their educational experience. Eligible institutions must grant advanced degrees in health professions and have received under $6 million in NIH support in four of the last seven years, promoting broader participation in the nation's biomedical research efforts.

Junior Ranger Angler Grant

The Junior Ranger Angler program, where anyone young at heart can earn their Junior Ranger Angler badge, inspires young people to catch their first fish and encourages families and communities to enjoy the vast outdoor experiences and opportunities of the national park system. Today, neighbouring communities of nearly 200 national parks—both urban and rural— can participate in fishing in some capacity. Whether it be through engaging communities through recreational fishing or ensuring the continuation of traditional subsistence fishing practices among Indigenous Tribes in ancestral waters, through education, skill building, and community connections, fishing presents a valuable opportunity to both educate and engage the next generation of park stewards through meaningful experiences.

This grant opportunity specifically supports connecting children and families in their local communities with fishing activities in their national parks through inclusive and authentic engagement, community co-creation, and shared leadership and vision of programmatic activities. Funds can be used to support programs that encourage and engage a wide variety of audiences such as fishing clinics, gear libraries, intergenerational programming, community engagement programs, fishing focused Junior Ranger Day activities, and more.

Funding

Applicants may request up to $25,000. Please round your request amount to the nearest dollar.

The U.S. Hillman Prize for Magazine Journalism, awarded by the Sidney Hillman Foundation, recognizes outstanding journalism that serves the common good. Open to global journalists, it requires works to be published in English and accessible to a U.S. audience within the past year. Winners receive a $5,000 honorarium and a certificate at the annual ceremony in New York City. The foundation prioritizes stories with U.S. impact across diverse topics.

The James Paul Sutton Medical Research Fund Grant supports non-profit organizations engaged in cancer and medical research, established through a trust by the Sutton family. Eligible organizations must be 501(c)(3) exempt. Preference is given to cancer research initiatives, while grants are not available for individuals, political groups, or for-profit entities. This fund aims to sustain medical research efforts for the long term, continuing the legacy of the Sutton family.

The U.S. Hillman Prize for Newspaper Journalism, awarded by the Sidney Hillman Foundation, recognizes outstanding journalism that serves the common good. Open to global journalists, entries must be published in English and accessible to U.S. audiences within the last year. Winners receive a $5,000 honorarium and a certificate at a New York City ceremony. The foundation also honors work related to racial and economic justice through additional awards. Entries should focus on impactful stories.

The Bolick Foundation Grant, established in 1967, supports nonprofit 501(c)(3) organizations that promote the Christian faith. Located in Conover, NC, the foundation emphasizes grant-making to strengthen religious, charitable, and educational initiatives. Applicants must be registered in the USA and possess a tax identification number. Importantly, the foundation does not provide grants to individuals, ensuring that funds are directed towards collective community impact. For further details, please refer to the FAQs on their official website.

The Player Foundation Grant, offered by the NFL Foundation, supports the charitable initiatives of current and former NFL players through their nonprofit organizations. Eligible applicants must be vested under the Bert Bell/Pete Rozelle NFL Retirement Plan and operate a tax-exempt organization. This grant does not guarantee funding and should not be relied upon in annual budgeting. Organizations must have been established for at least three years and be capable of functioning without NFL Foundation support.

The AOFAS Resident Scholarship Program provides orthopaedic residents from the US and Canada the opportunity to attend the AOFAS Annual Meeting 2025 in Savannah, Georgia. Covering registration fees, lodging, and transportation, this program supports residents interested in foot and ankle surgery. Eligible applicants are PGY1, PGY2, or PGY3 residents who can attend the full program on September 10-11. This unique experience allows networking with leading surgeons and gaining insights into foot and ankle procedures.

The Shakespeare in American Communities: Apprenticeships program by Arts Midwest offers grants of up to $30,000 to support paid apprenticeships for emerging theater professionals across the U.S. This initiative aims to enhance community-based theater activities, providing essential on-the-job training for early-career administrators and technicians, while fostering engagement with Shakespeare's works. Organizations of all sizes are encouraged to apply, ensuring diverse representation and opportunities in the arts.

The Kathryn Cramer Early Career Research Development Award provides essential start-up funding for orthopedic trauma surgeons in the U.S. and Canada, who have completed their fellowship within the last five years. This award aims to support innovative research projects that can be accomplished within two years, fostering professional development and collaboration among surgeons. Applicants must be members of AO Trauma and demonstrate early success in their research endeavors.

The Gainbridge Assists Powered by Parity Grant, in partnership with Parity and the Women’s Sports Foundation, supports girls and women in sports and education. In 2024, $222,000 will be awarded through 32 grants, including a $50,000 grant honoring Billie Jean King. This initiative aims to empower over 5,000 participants, fostering community transformation through sports and educational opportunities.

The Vaccinated & Loved Campaign Grant, offered by Petco Love, supports organizations that provide free vaccine services to communities in need. Eligible applicants include 501c3 nonprofits, government agencies, and invited for-profit companies with a nonprofit purpose related to animal welfare. However, individuals and organizations outside the U.S. or not focused on animal welfare are ineligible for funding. This initiative aims to enhance public health and animal welfare through vaccination efforts.

The Aarón Sánchez Impact Fund, a program of the Emeril Lagasse Foundation, aims to uplift Latino youth through food. This grant offers up to $20,000 to non-profit organizations focused on nutrition education and food access for youth aged 0-18. Eligible applicants must have 501c3 status and serve a community where at least 60% of the population is Latino. This fund is by invitation only, encouraging innovative projects that align with its mission.

The Hanger Foundation's Veteran Grant aims to empower veterans facing physical challenges by providing support for rehabilitation services and athletic programs. This grant seeks to positively impact veterans' lives, particularly those with limb differences, through community engagement and employee involvement in charitable efforts. With a focus on 501(c)(3) organizations, the foundation invests in projects that address trauma and promote social activities, ensuring that veterans receive the assistance they need.

The Veterans United Foundation Scholarship supports the educational aspirations of military families by providing financial assistance to eligible applicants. This scholarship is open to veterans with service-related disabilities, surviving spouses, and children of deceased servicemembers. Since its inception in 2012, over $1 million has been awarded, making a significant impact on the education of those who serve our country. The application process requires proof of eligibility and documentation to ensure support for education-related expenses.

The Resident Clinical Research Award, supported by the ACG Institute and the American College of Gastroenterology, fosters original clinical research by medical residents in gastroenterology and hepatology. This award encourages promising trainees to undertake a mentored research project, with funding for diverse studies and reimbursement for travel to the ACG Annual Scientific meeting. Since 1994, over $31.9 million has been awarded to more than 745 recipients, promoting careers in clinical research.

The ACG/ASGE Epidemiologic Research Award in Gastrointestinal Endoscopy supports research projects that study the use and outcomes of gastrointestinal endoscopy through the GI Quality Improvement Consortium (GIQuIC). Co-sponsored by the American College of Gastroenterology and the American Society for Gastrointestinal Endoscopy, this award is aimed at enhancing the quality and outcomes of GI endoscopic procedures, benefiting both practitioners and patients.

The Amy Erickson Memorial Award, provided by the Sioux Falls Area Community Foundation, supports full-time medical students entering their third or fourth year. Applicants must demonstrate financial need and be enrolled in clinical courses focusing on complementary and alternative therapies. This scholarship not only assists students in their educational pursuits but also aligns with the foundation's mission to enhance community well-being through philanthropy.

The Leonidas Berry Health Equity Research Award, presented by the ACG Institute, honors Dr. Leonidas H. Berry and supports innovative research aimed at reducing health disparities among underrepresented groups in gastrointestinal health. With a funding opportunity of $75,000 over two years, this award encourages eligible U.S. or Canadian physicians to develop impactful research careers that enhance our understanding of health equity in gastrointestinal practice. Applications are open until June 30, 2028.

The Established Investigator Bridge Funding Award, supported by the ACG Institute for Clinical Research and Education and the American College of Gastroenterology, offers $300,000 in funding over two years for established researchers facing funding gaps. Designed for clinical gastroenterology and hepatology, this grant aims to sustain impactful research programs during federal funding lapses. Eligible applicants must be ACG members and have at least eight years of experience post-training, along with a proven track record of federal funding in relevant fields.

The Spirit of Sioux Falls Scholarship supports college students pursuing business degrees while emphasizing community engagement and academic excellence. Eligible applicants must reside in Lincoln or Minnehaha County, South Dakota, and maintain full-time enrollment in appropriate programs. The scholarship aims to inspire philanthropy and improve local quality of life through educational advancement. Notably, previous recipients are ineligible for reapplication, ensuring fresh opportunities for new candidates. Multiple awards are available, promoting further education in the business field.

The Junior Faculty Development Award, funded by the American College of Gastroenterology, offers $450,000 over three years to support junior researchers in gastroenterology or hepatology. Aimed at ACG members, this award allows recipients to dedicate 50% of their time to clinical research, enhancing their skills and advancing their careers. Eligible candidates include those within seven years post-fellowship who can guarantee protected research time. The initiative fosters novel research that directly impacts gastrointestinal health.

The Worden Christian Youth Ministry Scholarship supports full-time students entering their third or fourth year at an accredited four-year college or university, who plan to pursue a career in youth ministry. Candidates must demonstrate financial need and engage in school and community activities. Preference is given to those intending to serve as youth ministers in the Sioux Falls area, ensuring that the scholarship aligns with the mission of enriching local lives through philanthropy.

The Good Neighbor Firefighter Safety Program Grant, initiated by State Farm and the National Volunteer Fire Council, aims to support volunteer fire departments in acquiring critical safety equipment. In 2025, the program will award $1.5 million in grants, providing $10,000 each to 150 eligible departments. This initiative not only enhances firefighter safety and operational efficiency but also fosters community service, ensuring that these departments are well-equipped to respond effectively to emergencies.