Upcoming Webinar
Instrumentl Fall Launch: Your Grant Operating System Has Leveled Up.
Wed, Nov 4 @ 2PM ET

Skip to main content
Main content

Best Large Grants for Nonprofit Organizations in South Carolina

Find the perfect Large Grants for Nonprofit Organizations in South Carolina on Instrumentl. 9,000+ Large Grants for Nonprofit Organizations in South Carolina in the United States.

9,000+

Available grants

$3.79B

Total funding

$5K

Median grant

9,000+ grants
$3.79B total
$5K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

9,313 Results based on applied filters

Partnership Grants

Music Movement
Association/Society
United States
US $2,500 - US $5,000
The Partnership Grants, offered by Music Movement, provide funding between $2,500 and $5,000 for eligible entities such as academies, public schools, hospitals, and non-profit organizations within the United States. Applications are reviewed semi-annually, and existing non-profits must submit their 501(c)(3) TIN. Grants can be resubmitted for reconsideration annually, but international applications are not accepted.
Music

The Sagol Network GerOmic Award for Junior Faculty

American Federation for Aging Research
Private
United States
Up to US $150,000
The Sagol Network GerOmic Award for Junior Faculty supports early career investigators in aging research, focusing on -omics studies related to biological aging and age-related diseases. Research areas include genomics, proteomics, and interventions targeting aging. Eligible applicants are independent researchers at U.S. not-for-profit institutions, with 10 years or fewer since their postdoctoral training. The award may cover overhead costs, promoting innovative research in the vital field of gerontology.
Aging / Gerontology Genetics & Genomics

College Prep Grants

Jack And Jill Of America Foundation Inc
Private
United States
Up to US $5,000
The Jack and Jill of America Foundation offers College Prep Grants aimed at enhancing college readiness for African American children. These grants are available to 501(c)(3) organizations dedicated to building a pipeline of talent. Eligible applicants include public agencies and organizations aligned with the Foundation's mission. The funding excludes scholarships, operational costs, and individual applicants, focusing solely on direct program implementation costs.
Career / College Preparation

URAF Conference Funding

Harvard University
Private
Countries
US $500 - US $750
The URAF Conference Funding program at Harvard University provides support for undergraduate students presenting original research at academic conferences. With awards up to $500 for domestic conferences and $750 for international presentations, students must be enrolled and in good standing. The program encourages applications year-round, allowing for different iterations of the same presentation. However, funding cannot be applied retroactively, and group applications are not permitted.
Academic Success & Enrichment Education - Higher Education

Native American Church Property Grants

Presbyterian Mission Agency
Private
United States
Unspecified amount
The Native American Church Property Grants, administered by the Presbyterian Foundation, support essential repairs and improvements to Native American church properties. This initiative is crucial for maintaining the infrastructure of churches and chapels, ensuring their safety and functionality for congregations and visitors. The program reflects the Presbyterian Church's commitment to serving Native American communities, fostering faith and ministry. Through these grants, urgent needs are addressed, strengthening the presence and mission of Native American congregations within the PC(USA).
Native American Services

Mobile Learning Fund

ProLiteracy
Private
American Samoa, Guam +4 more
Unspecified amount
The Mobile Learning Fund provides grants to adult literacy programs in the U.S. and Canada, enabling access to digital learning solutions. These grants support various online learning tools, such as New Readers Press, Learning Upgrade, and EnGen, aimed at enhancing literacy, math, and digital skills. Eligible programs must implement the solutions within 30 days and ensure active learner engagement. This initiative empowers educators to expand their reach and improve student outcomes through innovative digital resources.
Literacy Adult Education

Reading is Fundamental Matching Grant - Read for Success

Reading Is Fundamental Inc
Private
United States
Unspecified amount
The Reading is Fundamental Matching Grant for Read for Success empowers local organizations to enhance literacy by providing matching funds for books and resources. Since 1966, RIF has partnered with communities to foster a culture of reading among children in need, offering diverse books that reflect their lives. This grant matches local investments dollar-for-dollar, maximizing the impact of funding for educational programs. Eligible applicants include schools and youth-serving organizations across the U.S., supporting children from birth through grade 12.
Youth Services Literacy

Reading is Fundamental Matching Grant - Books for Ownership

Reading Is Fundamental Inc
Private
United States
Unspecified amount
The Reading is Fundamental Matching Grant - Books for Ownership program supports local literacy initiatives by providing funding for diverse books and literacy resources. Established in 1966, RIF aims to foster a culture of literacy among children in under-resourced communities. Eligible organizations can apply for funding to double their impact through matched funds, ensuring children have access to high-quality books that reflect their experiences and broaden their perspectives.
Literacy Youth Services

Cottrell SEED: New Research Directions

Research Corporation
Private
Canada, United States
Up to US $60,000
The Cottrell SEED: New Research Directions grant supports early career researchers in chemistry, physics, and astronomy to launch innovative projects. With a maximum award of $60,000, this initiative encourages interdisciplinary and exploratory research without requiring preliminary data. Eligible applicants include Cottrell Scholars and Holland Award recipients, with a focus on fostering a diverse scientific community. The grant aims to enhance impactful research and academic leadership, aligning with the mission of the Research Corporation for Science Advancement.
Chemistry Physics Astronomy & Astrophysics

U.S. Western Digital STEM Scholarships

Scholarship America Inc
Private
United States
US $5,000
The U.S. Western Digital STEM Scholarships aim to support underrepresented and underserved youth in pursuing STEM degrees. Offered by Western Digital and administered by Scholarship America, this program provides a $5,000 award to students transferring from community colleges to four-year universities. Eligibility includes a minimum GPA of 2.7 and demonstrated financial need. Preference is given to first-generation college students and those from historically underrepresented backgrounds, fostering diversity in STEM fields.
Education - Higher Education STEM / STEAM Education

Cottrell SEED: Exceptional Opportunities

Research Corporation
Private
Canada, United States
Up to US $60,000
The Cottrell SEED: Exceptional Opportunities grant supports high-impact research activities for Cottrell Scholars and Holland Award recipients. It encourages innovative projects at primarily undergraduate institutions, with a maximum award of $60,000. The initiative aims to advance existing research to new levels of innovation and impact. Eligible applicants include those six years post-Cottrell Scholar Award, with a focus on interdisciplinary collaboration. Preference is given to proposals in Physics and Astronomy in odd years, while Chemistry is prioritized in even years.
Chemistry Physics Astronomy & Astrophysics

Helen M. McLoraine Foster Care and Emancipated Youth Scholarship

The Denver Foundation
Private
United States
US $1,000 - US $10,000
The Helen M. McLoraine Foster Care and Emancipated Youth Scholarship provides financial support for youth from the foster care system in Colorado. With a minimum award of $1,000, the scholarship is aimed at those pursuing post-secondary education, including trade schools and universities. Recipients are selected based on academic performance, resilience, and financial need, ensuring that deserving individuals receive the assistance they need to succeed in their educational goals.
Child Foster Care & Adoption Services

First Responders Children's Foundation Scholarship Fund

First Responders Childrens Foundation
Private
United States
Unspecified amount
The First Responders Children's Foundation Scholarship Fund offers college scholarships to children of first responders, emphasizing financial need and academic merit. Applicants must maintain a minimum GPA of 2.7, provide a current transcript, and demonstrate community involvement. Scholarships are renewable for up to four years based on eligibility criteria. Preference is given to students whose parents have experienced line-of-duty disabilities or deaths. This program supports the educational aspirations of those who have sacrificed for their communities.
Education - Higher Education First Responders

Kids' Chance of New Jersey Scholarship

Kids Chance of New Jersey
Private
United States
Unspecified amount
The Kids' Chance of New Jersey Scholarship provides financial support for college and vocational education to children of New Jersey workers who have suffered serious injuries or fatalities in work-related accidents. This initiative helps alleviate the financial burdens faced by families during difficult times, ensuring that deserving young individuals can pursue their educational aspirations. Eligible applicants must be dependents aged 18-26 of injured workers with an accepted workers' compensation claim.
Education - Higher Education Vocational & Trade Education

Kids' Chance of Tennessee Scholarship

Kids’ Chance of Tennessee
Private
United States
Unspecified amount
The Kids' Chance of Tennessee Scholarship provides vital financial support to young individuals who have lost a parent in a work-related accident or who have experienced severe injuries. This scholarship aims to assist students aged 16-25 who are legal residents of Tennessee, demonstrating financial need and maintaining a GPA of 2.5 or higher. By offering this opportunity, Kids' Chance of Tennessee empowers students to pursue higher education and achieve their academic goals.
Education - Higher Education Vocational & Trade Education

Tartt Venture Group Scholarship Fund

Tartt Venture Group
Corporate
United States
US $5,500
The Tartt Venture Group Scholarship Fund, established by Tartt Venture Group, aims to support students in good academic standing who demonstrate financial need. This scholarship is open to both undergraduate and graduate students across all majors, provided they are U.S. residents and enroll full-time at accredited institutions. Awards are based on academic excellence, community involvement, and the potential to be positive role models, thereby fostering a commitment to academic and community success.
Education - Higher Education Vocational & Trade Education

Strengthening Evidence - Support for RCTs to Evaluate Social Programs and Policies RFP

Arnold Ventures
Private
United States
Unspecified amount
Arnold Ventures invites proposals for randomized controlled trials (RCTs) to evaluate social programs and policies. Focused on evidence-based solutions, this RFP aims to fund rigorous research that identifies effective interventions for pressing social issues. By supporting RCTs, Arnold Ventures seeks to enhance the understanding of what works in policy implementation, thereby informing decision-makers and improving resource allocation. Proposals exceeding $500,000 may require additional approval time.
Governance & Democracy Public Policy

Dr. Ralph and Marian Falk Medical Research Trust – Falk Transformational Awards

Health Resources in Action
Private
United States
Up to US $1,000,000
The Dr. Ralph and Marian Falk Medical Research Trust offers the Falk Transformational Awards to provide critical bridge funding for successful Catalyst Award recipients. These awards, which can be up to $1M for a period of 2-3 years, aim to advance healthcare innovations, overcome scientific challenges, and promote new treatment avenues. Managed by Health Resources in Action, the program emphasizes improving medical treatments and finding cures for diseases that currently lack definitive solutions.
Diseases & Conditions Biomedical informatics

Disaster Relief and Resilience Scholarship

North Carolina Community Foundation Inc
Private
United States
More than US $1,000
The Disaster Relief and Resilience Scholarship supports residents of western North Carolina whose education funding has been affected by Hurricane Helene. Offered by the North Carolina Community Foundation, this scholarship is available for undergraduate and graduate students attending two- or four-year colleges. The minimum award is $1,000, aimed at helping students overcome financial hardships caused by the disaster and continue their educational pursuits.
Education - Higher Education Disaster Relief / Humanitarian Aid

Joe and Janet Barr Early Career Cornea and Contact Lens Research Award

American Academy of Optometry Foundation Inc.
Corporate
United States
US $2,000
The Joe and Janet Barr Early Career Cornea and Contact Lens Research Award supports first- or second-year MS or PhD students in vision science or physiological optics. Established in 2012 in honor of Joseph T. Barr, this $2,000 seed funding facilitates research in cornea/ocular surface or contact lenses. Recipients are required to attend the annual American Academy of Optometry meeting and submit progress reports detailing their research outcomes. Preference is given to North American applicants.
Eye Diseases & Disorders

ABMS Research and Education Foundation Grants

American Board of Medical Specialties
Association/Society
United States
Up to US $75,000
The ABMS Research and Education Foundation grants support innovative research aimed at enhancing healthcare quality through board certification. By encouraging collaborations among ABMS Member Boards, the program seeks original studies that inform improvements in certification processes. Proposals are reviewed based on relevance to the ABMS mission, research novelty, methods, team composition, and potential impact. Applications from diverse health organizations are welcomed, provided the principal investigator is unaffiliated with ABMS.
Epidemiology & Public Health Health Care Access & Delivery

Dr. Patricia L. Austin Family Physicians of Tomorrow Scholarship

American Medical Association Foundation
Private
United States
US $10,000
The Dr. Patricia L. Austin Family Physicians of Tomorrow Scholarship offers $10,000 in tuition assistance to medical students entering their final year. Sponsored by the AMA Foundation, this program supports a diverse group of students, including those of Eastern European descent and first-generation students. All applicants must be enrolled in accredited U.S. medical schools, ensuring equitable opportunities in pursuing their medical careers, while fostering representation in the field.
Medical Education & Professional Training Academic Scholarship Programs

Forecast for Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
The Forecast for Clinical Trial Readiness for Rare Diseases (R21) aims to enhance the development and testing of diagnostics and therapeutics for rare diseases. This funding opportunity invites researchers to facilitate clinical trial readiness by developing rigorous biomarkers and clinical outcome measures. Through collaborative efforts with various stakeholders, NCATS seeks to improve the efficiency of moving candidate therapeutics towards clinical trials, ultimately increasing the likelihood of successful treatments for rare diseases.
Rare Diseases

Implementing Shared Decision Making in Hemophilia Patient Care

Pfizer, Inc.
Corporate
United States
Up to US $30,000
The Shared Decision Making in Hemophilia Patient Care grant program, funded by Pfizer, aims to enhance patient outcomes through Quality Improvement projects that integrate shared decision-making tools into hemophilia care. This initiative encourages multidisciplinary collaboration to address healthcare disparities and empower patients in their disease management. Eligible organizations include healthcare institutions and professional schools, fostering innovative approaches to improve care for individuals living with hemophilia.
Hematological Systems

Center for the History of Family Medicine Oral History Grant

American Academy of Family Physicians Foundation
Corporate
United States
Up to US $3,000
The AAFP Foundation's Center for the History of Family Medicine Oral History Grant offers up to $3,000 annually for oral history interviews in family medicine. Aimed at researchers, physicians, and students, it encourages the documentation of family medicine's history in the U.S. The grant supports travel and research expenses to enhance the oral history collection, ensuring a diverse representation of experiences and perspectives in the field.
Historical Records & Archives History Of Science

The Ono Initiative Grant

Ono Pharma Foundation
Private
Canada, United States
Up to US $1,035,000
The Ono Initiative Grant by the Ono Pharma Foundation supports innovative research in Chemical Biology, aiming to transform human health. It welcomes proposals from Principal Investigators (PIs) at nominated institutions, focusing on groundbreaking solutions and promoting the development of young scientists. Grants of up to $1,035,000 over three years are available, fostering collaboration and transformative research aligned with the foundation's mission.
Biochemistry Chemistry Biology

AMVETS Veteran, Active Duty & Guard/Reserve Scholarship

Amvets National Service Foundation
Private
United States
Up to US $12,000
The AMVETS Veteran, Active Duty & Guard/Reserve Scholarship provides financial assistance up to $12,000 for qualified U.S. Veterans and active military members pursuing undergraduate degrees. This scholarship is designed to bridge the financial gap after all other federal and state aid has been utilized. Eligibility includes being an honorably discharged veteran or active service member, enrolled in an accredited institution, and demonstrating financial need. AMVETS is dedicated to serving those who have served our country.
Military & Veterans Services Academic Scholarship Programs

Large Grants for Nonprofit Organizations in South Carolina Highlights

Looking for large grants for nonprofit organizations in South Carolina?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in South Carolina recommended for your specific programs.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

54 Large Grants for Nonprofit Organizations in South Carolina over $25K in average grant size

41 Large Grants for Nonprofit Organizations in South Carolina over $50K in average grant size

32 Large Grants for Nonprofit Organizations in South Carolina supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in South Carolina supporting programs / projects

1,000+ Grants on Instrumentl focused on Health Care Access & Delivery

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in South Carolina?

Most grants are due in the first quarter.

Q1
28.9%
Q2
26.6%
Q3
24.1%
Q4
20.4%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in South Carolina?

Grants are most commonly $15,000.

$500 $500 Min.
$15,000 $15 K Median
$530,911 $530.9 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in South Carolina changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081