Best Large Grants for Nonprofit Organizations in South Carolina

Central Kentucky Community Foundation

Established in 1960 as North Central Education Foundation, Central Kentucky Community Foundation is one of more than 780 community foundations in the United States today. We serve the Lincoln Trail Region, offering our donors and partners a variety of ways to touch our community through philanthropic giving.

James and Betty Holeman Scholarship

The applicant must be a graduating senior from a high school in the Lincoln Trail Region of Kentucky (Breckinridge, Grayson, Hardin, LaRue, Marion, Meade, Nelson, and Washington counties)

The UNICO Foundation Inc. offers the Cancer Research & Prevention Grant to support vital research projects addressing various types of cancer, including colon, breast, and prostate cancer. Established in 1962, this non-profit organization aims to enhance lives through charitable contributions and educational initiatives. Grants are exclusively for direct research and preventive measures, ensuring that all funds are utilized effectively. This initiative reflects UNICO's commitment to combating cancer and its impact on individuals and families across the United States.

Community Foundation for Mason County, MI

The mission of the Community Foundation is to engage donors and connect them with opportunities to make a lasting impact, build community endowment, provide leadership on key issues, and make grants that reflect the communities we serve.

Scholarships

If you’re a high school or homeschooled senior, current college student, early college senior, or a student pursuing a master’s or doctoral degree, the Community Foundation for Mason County may have a scholarship for you.

Jack & Jean Ereon Scholarship

This scholarship has been made possible by the generosity of the family of Doug Ereon, who established the Jack & Jean Ereon Scholarship Fund of the Community Foundation for Mason County.

Doug Ereon credits scholarships with making his college education possible and leading to a successful career in oil and gas. Inspired by his own experiences and the support of his parents, Jack and Jean Ereon, Doug established this scholarship fund. Jack and Jean were devoted community members; Jack played a key role in developing Ludington's marina, and Jean always encouraged her children to pursue higher education despite financial constraints.

This Fund will support scholarships for graduates of any Mason County High School pursuing a degree or certification at any accredited college, university, or vocational/technical school. The Jack and Jean Ereon Scholarship Fund provides unlimited renewals until education is complete, with the hope that deserving local students can pursue higher education without the burden of mounting debt. 

Jerald W. Peterson Memorial Scholarship

To provide financial support to graduates of Groton, Webster, and Langford high schools.

The Hillman Innovations in Care Grant seeks innovative, nursing-driven proposals to address the impact of racism on health equity for marginalized communities. This includes addressing health disparities faced by BIPOC, LGBTQ+, and economically disadvantaged populations. The program encourages bold, evidence-based interventions that enhance healthcare delivery and outcomes. Grants of up to $600,000 will support projects that demonstrate potential for broad replicability and sustainability over a 36-month period.

The Craig H. Neilsen Foundation's Psychosocial Research Postdoctoral Fellowship supports early-career researchers in spinal cord injury (SCI) psychosocial studies. It aims to enhance professional interest and training in this vital field, focusing on areas such as caregiving, employment, and technology access. The fellowship offers mentored training, covering salary and up to $35,000 for non-personnel costs over two years, ensuring comprehensive support for fellows to advance their careers.

Cox Enterprises Scholarship Program

A need-based scholarship for students attending UNCF member institutions with preference given to students majoring in STEM.

Individual Award

• Up to $5,000

Sioux Falls Area Community Foundation

Founded in 1984, we are a 501(c)(3) public charity. Today, we manage more than 1,000 charitable funds, serving as the trusted stewards for more than $390 million in assets.

Our Community Investment team works with local nonprofits, schools and community leaders to identify gaps, assess critical needs and explore opportunities and possibilities. Our Philanthropy team works with individuals, families, advisors, businesses, and nonprofits, offering deep and broad experience and expertise in philanthropic strategy, charitable and organizational endowments, and legacy planning.

Scholarship Opportunities

The Sioux Falls Area Community Foundation manages one of the state's largest scholarship programs, awarding more than $500,000 in scholarships to local students each year. If you’re interested in pursuing higher education, it's likely we have a scholarship that can help you achieve your dream.

Verne and Ardith Forbes Scholarship

Awarded to a graduating senior of any high school program in Dell Rapids, SD, or a graduating senior from a public high school program in Huron, SD. This award is renewable for one additional year if requirements are met and if funds are available.

Community Foundation of Northern Nevada

Established in 1998 as a Nevada nonprofit 501(c) 3 Corporation, the Community Foundation of Northern Nevada has distributed more than $200 million in grants and scholarships from over 300 charitable funds to strengthen our Nevada home. 

Scholarship Program

The Community Foundation of Northern Nevada’s Scholarship Program is intended to help students cover the ever-increasing cost of tuition. Some of our scholarships are based on financial need, but others represent an award for achievement. These scholarships typically go to students who have excelled in an academic area or have shown they can balance academics, volunteer work, and extracurricular activities. There are also scholarships designated for students who have overcome adversity, students pursuing degrees in high-need areas, and adult learners outside the traditional college age group. Community Foundation scholarships can help cover tuition, books, and on-campus housing.

Mary J. Yamamoto Memorial Scholarship

The Mary J. Yamamoto Memorial Scholarship helps young women graduating high school seniors from Nevada and Michigan who will be attending accredited colleges, universities, trade schools to obtain a 2 or 4-year degree or certificate. This scholarship is established in memory of Mary J. Yamamoto to support equal access to education. 

KBF Ski Racing Safety

The KBF helps alpine ski clubs around the country purchase safety equipment like netting and padding, and also contributes to venue improvement initiatives. Funding requests are reviewed through an annual grant cycle with an application process. Over the past decade, the Kelly Brush Foundation has purchased thousands of rolls of b-netting, supported trail widening projects, and helped with the purchase of other safety equipment. 

KBF Ski Racing Safety Equipment Grants are all matching grants–meaning that any grant awarded by the Kelly Brush Foundation will need to be matched by the ski club. We expect that clubs will join us in making safety a priority by fundraising or finding room in their budget for safety.

The Cancer Center Support Grants (CCSGs) aim to bolster NCI-Designated Cancer Centers by funding comprehensive, clinical, and basic cancer research. These grants facilitate the integration of diverse research capabilities, promoting innovative approaches to cancer prevention, diagnosis, and therapy. CCSGs encourage collaboration among researchers and the development of Shared Resources, ultimately enhancing the understanding of cancer and its treatment. This initiative supports the continuous discovery and dissemination of crucial research findings for community benefit.

The Centers of Excellence Program, funded by the US HHS: HRSA, aims to improve health professions education for under-represented minority individuals. It provides grants to health schools and organizations to enhance academic performance, expand clinical education, and strengthen faculty recruitment. This initiative promotes strategic partnerships to develop a competitive applicant pool and supports research on health issues affecting minority groups, ensuring better health outcomes and career opportunities in the health professions.

ExtremeTerrain's Clean Trail Grant Program offers $250 for trail improvement projects, encouraging responsible off-roading. Eligible participants include Wrangler and 4x4 clubs, environmental organizations, and trail managers. The program aims to enhance trails through clean-ups, restorations, and expansions. Grants can be used for tools, food for volunteers, and promotional materials. Applicants must meet specific criteria, such as having a website and providing project photos. This initiative promotes stewardship of the natural landscapes we cherish.

LRPenn.com is home to the novels, plays, and screenplays of LR Penn. His books specializes in Thrillers, Dramatic Comedies, and Film Noir. Thanks to the generous support of our sponsors, grants may be available to nonprofit theater companies in the United States with 501(c)(3) status that are staging productions of plays written by LR Penn.  

Northern Piedmont Community Foundation

The Northern Piedmont Community Foundation (NPCF) began in December 2000 when nine concerned citizens from Virginia’s Piedmont region were searching for solutions to the charitable needs in Culpeper, Fauquier, Madison, and Rappahannock counties. With modest beginnings, our funds have grown to over $39 million in support of local charities, scholarships and community need in our northern Piedmont region.

Scholarships

Northern Piedmont Community Foundation manages the scholarship application process for dozens of scholarships for students in Culpeper, Fauquier, Madison, and Rappahannock counties (as well as a handful serving students from surrounding counties too). 

Fauquier NAACP – Dr. Ellsworth Weaver Education Scholarship

The Dr. Ellsworth Weaver Education Scholarship celebrates the legacy of Dr. Ellsworth Weaver, a former president of the Fauquier County NAACP Branch 7059 and a dedicated advocate for education and equality. Each year, a $1,000 scholarship is awarded to one graduating senior from each of Fauquier County’s three public high schools. Eligible applicants must have a minimum 2.5 GPA and plan to attend an accredited trade, technical, or vocational school, community college, or four-year university. Selection is based on academic achievement, leadership, service, citizenship, and extracurricular involvement.

Minority students, those facing financial or personal hardships, and individuals committed to improving their communities are strongly encouraged to apply. As part of the required essay, applicants should describe a significant challenge or barrier they encountered during their educational journey and explain how they overcame that difficulty.

The National Mesothelioma Virtual Bank (NMVB) aims to enhance biomedical research on malignant mesothelioma by expanding its collection of biospecimens, including tumor tissues and blood samples, alongside demographic and clinical data. Established in 2006, the NMVB serves as a crucial resource for researchers, providing access to a diverse library of samples and data, which can help identify disease markers and develop improved treatment options. This initiative is essential for advancing the understanding and treatment of mesothelioma.

Northern Piedmont Community Foundation

The Northern Piedmont Community Foundation (NPCF) began in December 2000 when nine concerned citizens from Virginia’s Piedmont region were searching for solutions to the charitable needs in Culpeper, Fauquier, Madison, and Rappahannock counties. With modest beginnings, our funds have grown to over $39 million in support of local charities, scholarships and community need in our northern Piedmont region.

Scholarships

Northern Piedmont Community Foundation manages the scholarship application process for dozens of scholarships for students in Culpeper, Fauquier, Madison, and Rappahannock counties (as well as a handful serving students from surrounding counties too). 

Dr. Eric J. Maybach Memorial Scholarship

This scholarship was established in memory of a local family practitioner, Dr. Eric J. Maybach. Dr. Maybach treated countless residents of Fauquier County, and in his honor, a scholarship was created. Qualifying applicants must be a resident of Fauquier County and pursuing a degree in medicine – medical school, nurse practitioner, physician’s assistant. Award amount varies.

Jack and Jill - Jacqueline Moore Bowles Scholarship

The Jack and Jill of America Foundation is committed to the positive development of youth and future leaders. Through providing programs focused on financial literacy, education, mentoring, health and wellness, and early childhood development, the Foundation promotes the preparation of succeeding generations of leaders.

In partnership with UNCF, the Jack and Jill of America Foundation - Jacqueline Moore Bowles Scholarship was developed to provide a one-time need-based scholarship of up to $2,500 to service-oriented undergraduate students majoring in Communications. 

Applicants must have completed a minimum of 60 hours of volunteer and community service within 12 months preceding the application deadline. Awards will be issued in the 2025-2026 spring term.

Trinity Grants: Capacity - Mission Real Estate Development empowers Episcopal Church parishes and Anglican Communion organizations to enhance community impact through innovative church property development. With a focus on sustainability, the initiative addresses pressing community needs by generating revenue streams, providing affordable housing, and improving education in underserved neighborhoods. Grants support real estate feasibility studies, pre-development expenses, and construction of income-generating projects, fostering strategic advisory and training for faith leaders.

This funding opportunity aims to foster innovative mechanistic research on precision probiotic therapies, utilizing a phased R61/R33 award mechanism. The goal is to identify and understand individual variations influencing probiotic responses, thereby enhancing clinical outcomes. The R61 phase focuses on uncovering unique biological patterns over two years, while the R33 phase applies findings to improve probiotic responsiveness through rigorous studies. Ultimately, this initiative seeks to overcome barriers in personalized probiotic interventions.

The Family Medicine Cares USA Free Health Clinics Grants support new and existing clinics in the U.S. that provide care to the uninsured. With applications accepted annually from March 15 to July 15, these grants assist clinics in purchasing essential medical equipment. The initiative aims to address the needs of over 50 million uninsured individuals, ensuring access to primary care and promoting volunteerism among AAFP members and medical students. Grants of up to $10,000 are available to eligible clinics.

The McKnight Endowment Fund for Neuroscience offers Scholar Awards to early-career neuroscientists focusing on learning and memory disorders. The awards provide up to $225,000 over three years, emphasizing research that could lead to significant clinical advancements. Eligible candidates must work as independent investigators at U.S. non-profit institutions, hold an Assistant Professor position for less than four years, and demonstrate their research program's potential. The program aims to foster innovative solutions in neuroscience.

The Collegiate Community Hub Grant, offered by the United States Tennis Association (USTA) in collaboration with the ITA, provides up to $10,000 to collegiate organizations operating a tennis facility as a new 'Collegiate Community Hub.' This initiative aims to enhance community engagement by offering accessible tennis instruction and playing opportunities for all ages. Eligible facilities must meet specific operational criteria and demonstrate their commitment to serving the local community.

UNCF STEM Scholars Program

The UNCF STEM Scholars Program is an initiative designed to identify and provide scholarship and academic support for students who aspire to earn STEM degrees and to pursue careers in STEM fields, awarding 75 scholarships. The program enables highly capable young people to pursue undergraduate STEM majors and prepares them for successful careers in a variety of STEM professions.

Individual Award

• Maximum total up to $25,000, please see Program Benefits below.

Through the generosity of fundholders and donors, NCCF has awarded more than half a million dollars in scholarships to assist students in Northwest Connecticut with the cost of higher education.

NCCF awards more than $530,000 in scholarships a year. 

Donald E. Heisinger Scholarship

Academic Focus:

• Accounting, Finance, or Business

Award:

• $750

Established by the Dillon Family, this scholarship is awarded to a student whose primary residence is in Torrington and who pursues, or intends to pursue, a degree in accounting, finance, or business at an accredited university or college. This scholarship is not financially need-based. (No FAFSA required)

The Actors' Equity Foundation, established in 1962, is dedicated to supporting the professional theatre community through grants. Annually, it funds over 150 nonprofit theatres and arts organizations, promoting initiatives that enhance the performing arts landscape. The Theatre Grants are specifically aimed at organizations with 501(c)(3) status, ensuring a commitment to artistic excellence and fiscal responsibility. By investing in diverse programs, the Foundation plays a pivotal role in nurturing both emerging and established talent within the theatre industry.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Alex Masters Memorial Scholarship

Following the unexpected passing of their son, Alex Masters, a memorial scholarship fund was created at the River Valley Education Foundation by Randy and Kathy Masters and Morgan Masters Quickel, Alex’s sister. In 2013, the fund was migrated to Marion Community Foundation and became the Alex Masters Memorial Scholarship Fund.

Alex never knew a stranger and loved to discuss and debate any subject with others. He loved baseball and football, was an avid reader, and was pursuing a career in medicine. But, perhaps his biggest love—outside of his family—was his love for music. It is his family’s hope that his song will live on through this scholarship.

The fund honors Alex’s memory and supports the educational goals of graduating seniors from River Valley High School. According to Kathy, the family created the scholarship with the intention of supporting those who have encountered adversity and to overcome and cope with life’s challenges through education.