Best Large Grants for Nonprofit Organizations in South Carolina

Community Foundation of the Holland/Zeeland Area

Our Mission

The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.

Scholarships

CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.

All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.

The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.

Franz Family Scholarship for Families Impacted by Cancer

• Graduating senior who attends public, private, or home school in the primary service area of the Community Foundation
• Accepted into a 2 or 4-year degree program at an accredited post-secondary school (including vocational/technical school) within the United States
• Financial need, a consideration (encouraged to submit the page of the FAFSA Submission Summary showing the Student Aid Index amount)
• A cancer patient or survivor; or a sibling or child of a cancer patient, survivor, or victim

Who We Are

Founded in 1996, the Community Foundation of South Georgia is a 501(c)(3) nonprofit organization committed to making South Georgia a better place to live through effective philanthropy. We help individuals, families, nonprofit organizations and businesses establish and manage charitable funds that carry out their philanthropic interests. Serving a geographic area of 35 counties in South Georgia, we facilitate our donors’ charitable plans and goals by creating custom designed funds that meet their specific interests and ensure solid financial management and administration for each fund. 

Geraldine Grant Memorial Scholarship

The award is based on Academics, Leadership Qualities, Extracurricular School Activities, Community Service and Financial Need. Special consideration will be given to applicants from an underrepresented minority population as well as applicants who intend to major in Business, Accounting, Finance, Management or another business-related field of study. 

The Ernest L. Pellegri Scholarship, offered by the National Italian American Foundation, supports outstanding Italian American students pursuing undergraduate or graduate degrees in Latin or related fields. Applicants must demonstrate financial need and maintain a GPA of 3.5 or higher. This scholarship aims to encourage the preservation of Italian culture and heritage while promoting academic excellence within the community.

Community Foundation of the Holland/Zeeland Area

Our Mission

The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.

Scholarships

CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.

All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.

The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.

Franz Family International Adoption Scholarship

• Graduating senior who attends public, private, or home school in the primary service area of the Community Foundation
• Accepted into a 2 or 4-year degree program at an accredited post-secondary school (including vocational/technical school) within the United States
• Financial need, a consideration (encouraged to submit the page of the FAFSA Submission Summary showing the Student Aid Index amount)
• From a family with an internationally adopted child or children (applicants do not have to be adopted themselves but must have at least one sibling who is internationally adopted)

The Emanuele Gianturco Memorial Scholarship, offered by the National Italian American Foundation, supports outstanding Italian American students who are first-generation college attendees, demonstrating financial need and maintaining a GPA of 3.5 or higher. Applicants must hold an active NIAF membership and be enrolled in a U.S. accredited institution. This scholarship aims to encourage the preservation of Italian heritage and culture among students while facilitating their academic pursuits.

Community Foundation of the Holland/Zeeland Area

Our Mission

The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.

Scholarships

CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.

All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.

The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.

DeLong and Brower, P.C. Scholarship

• Graduating senior, graduating early college student, or college freshman or sophomore who attends/attended public, private, or home school in the primary service area of the Community Foundation
• Enrolling/enrolled in a 2 or 4-year degree program at an accredited post-secondary school (including vocational/technical school) within the United States
• Financial need (must submit the page of the FAFSA Submission Summary showing the Student Aid Index amount)
• GPA of 3.0 or greater
• Planning to study accounting, finance, or economics
• Potentially renewable for one additional year

The Andy Warhol Foundation for the Visual Arts Grant supports innovative visual arts projects through a diverse grantmaking program. It funds artists and organizations that challenge the status quo and promote inclusivity in the contemporary art landscape. Grants are available for curatorial research, exhibitions, and public programs, encouraging creativity and exploration. The foundation prioritizes projects that reflect the diverse population of the United States and reject bigotry, fostering an environment of free expression and artistic growth.

The Donald Mazzoni Scholarship, offered by the National Italian American Foundation, is designed for two exemplary Italian American undergraduate students majoring in business. To qualify, applicants must demonstrate at least 50% Italian heritage, maintain a GPA of 3.0 or higher, and possess an active NIAF membership. This scholarship aims to support students dedicated to preserving Italian culture and heritage while pursuing their academic goals in the United States.

The Caroline Guarini Memorial Scholarship, offered by the National Italian American Foundation, supports outstanding Italian American students majoring in music or related fields. Eligible applicants must be from New York, New Jersey, or Connecticut, maintain a GPA of 3.5 or higher, and hold an active NIAF membership. This scholarship aims to foster musical talent while honoring Italian heritage and culture.

The A. Lucchetti Martino Scholarship is awarded to outstanding Italian American undergraduate students majoring in International Relations, requiring a minimum GPA of 3.5. Applicants must hold an active NIAF Membership, which can be obtained through a parent or grandparent. This scholarship fosters commitment to Italian culture and heritage while supporting students enrolled full-time in U.S. accredited institutions. The National Italian American Foundation, a non-profit organization, promotes the rich traditions and contributions of Italian Americans.

The DAR Historic Preservation Grants, offered by the National Society Daughters of the American Revolution, provide $250,000 annually to support projects that preserve historic resources and sites. Eligible applicants must secure additional funding and adhere to preservation guidelines. Projects must recognize DAR's contribution publicly and can include restoration, digitization, and conservation efforts. Preference is given to projects reflecting Colonial to Federal periods, fostering a deep appreciation for American history.

The Petco Foundation offers disaster relief support for animal welfare organizations affected by disasters. Eligible applicants include authorized members of IRS-designated 501c3 nonprofits, government agency representatives with operational insight, and invited for-profit entities focused on animal welfare. However, the foundation does not fund individuals, organizations outside the U.S., or those whose primary mission does not relate to animal welfare. This initiative aims to provide critical assistance during times of crisis.

About

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Rett Syndrome (RS) Fund

Help with healthcare costs for Rett syndrome.

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses. Check your eligibility with our quick and easy tools below. If this fund is open, apply today for an instant approval decision and use your grant funding right away

About the disease

Rett syndrome (RS or RTT) is a rare, genetic neurological disorder that causes a loss of motor and spoken language skills, as well as other physical and neurologic impairments early in life.

Diagnosis codes

F84.2

The Agnes E. Vaghi Scholarship, offered by the National Italian American Foundation, supports outstanding female Italian American undergraduates majoring in Italian, English, literature, or journalism. Applicants must maintain a GPA of 3.5 or higher and hold an active NIAF membership, which can be obtained through a parent or grandparent. This scholarship aims to promote the rich cultural heritage of Italian Americans while encouraging academic excellence.

The College Well-Being Funding Opportunity aims to enhance the health of college students through innovative programs and research. Offered by the American College Health Foundation, it provides up to two awards of $3,500 to eligible institutions for improving campus infrastructure that promotes student well-being. This initiative encourages creativity and collaboration among campus health professionals to develop effective, measurable outcomes in student wellness. By fostering a culture of well-being, the foundation seeks to address the evolving needs of contemporary students.

The U.S. Department of Labor's Bureau of International Labor Affairs announces a $6 million cooperative agreement to enhance traceability and responsible sourcing in South Asian cotton supply chains. This initiative aims to promote U.S.-produced cotton as a sustainable alternative while reducing the risk of forced labor in supply chains. Over 36 months, the project will incentivize suppliers to adopt better labor practices and improve verification processes, ultimately benefiting American producers and ensuring ethical sourcing.

The Visionary Prize for Women’s Economic Empowerment, established in 2022 by Visionary Women and the Hostetler/Wrigley Foundation, honors a visionary woman leader of a nonprofit focused on advancing women's economic empowerment in the U.S. This prestigious award provides $100,000 in unrestricted funds to support the recipient's agency and its initiatives. Eligible candidates must have a minimum of four years of operation and an annual budget exceeding $500,000, actively working towards women's economic advancement.

Northern Chautauqua Community Foundation

Vision: We envision a vibrant, prosperous northern Chautauqua community, rich in opportunity today and tomorrow.

Our Mission

To realize our vision we focus on:

• strategic and responsive grant making
• encouraging local philanthropy and building permanent endowments for the future
• actively serving as a community leader and partner for the benefit and enrichment in our community.

Scholarships

Northern Chautauqua Community Foundation proudly manages over 200 individual scholarship funds,

Roger Testrake Memorial Scholarship

The Roger Testrake Memorial Scholarship benefits students residing in Ripley, NY who plan on continuing their education after high school and have a relative who has served in the military.

Roger Testrake was instrumental in building a monument in Ripley to honor all veterans. This scholarship was renamed to honor him for all his perseverance, dedication and hard work on behalf of the Ripley Veterans Roll of Honor Organization. 

Northern Chautauqua Community Foundation

Vision: We envision a vibrant, prosperous northern Chautauqua community, rich in opportunity today and tomorrow.

Our Mission

To realize our vision we focus on:

• strategic and responsive grant making
• encouraging local philanthropy and building permanent endowments for the future
• actively serving as a community leader and partner for the benefit and enrichment in our community.

Scholarships

Northern Chautauqua Community Foundation proudly manages over 200 individual scholarship funds,

Timothy Ryan Memorial Scholarship

The Timothy Ryan Memorial Scholarship Fund provides scholarships to students who exemplify characteristics exhibited by Timothy during his brief life: loving, caring, generous, family-oriented, genuine, sincere, and humorous.

The Tyndale House Foundation Grant supports faith-driven organizations that align with their mission to serve both Word and Deed. Focused on high-kingdom impact, this grant funds a variety of projects in areas like literature, training, education, compassion, and discipleship. Eligible applicants must be U.S. 501(c)(3) organizations or have a fiscal sponsor if based internationally. Grants are not available for individuals, scholarships, or political projects.

The ASTR Thomas Marshall Graduate Student Awards aim to support graduate students researching theatre or performance by assisting with the costs of attending the annual ASTR conference. This grant offers up to three honorariums of $800 each, along with complimentary conference registration. Eligibility is open to any graduate student in relevant fields, with selection based on the applicant’s interest and academic achievements.

The Friends of Carl Sandburg Donald E. Hubbs Scholarship Fund, managed by the Community Foundation of Henderson County, aims to support Henderson County residents pursuing college degrees in Conservation, Animal Science, or Parks and Recreation. This fund prioritizes students specializing in American Literature but is open to those not necessarily at the top academically or financially. Established in 1982, the foundation has a strong history of facilitating community philanthropy.

The Good Eats Scholarship Fund aims to support aspiring professionals in agriculture and culinary arts who will bring enhanced food quality to Hawaii. Eligible applicants must demonstrate financial need, maintain a minimum GPA of 2.7, and show commitment to food-related programs. Preference is given to previous recipients who continue to meet the criteria. This initiative fosters local talent and encourages a strong connection to food production in the islands.

The Salute to Citizens Scholarship, offered by the Community Foundation of Abilene, honors individuals who enhance their communities through active citizenship. Open to Taylor County graduates pursuing higher education or trade certifications, applicants must demonstrate past contributions to society and outline their future commitment to community service. Established by Hannah Durbin, a dedicated Air Force veteran and educator, this scholarship aims to empower students with awards ranging from $500 to over $5,000.

The Sidney Awards, presented by the Sidney Hillman Foundation, celebrate outstanding journalism that serves the common good. Established to honor Sidney Hillman’s legacy, these monthly awards recognize investigative work and commentary that promote social justice. Nominations for the awards can be submitted for any medium, with a winner announced each month, receiving a $500 honorarium and a certificate. This initiative has been a prestigious platform for impactful storytelling for over 65 years.

The Retail Food Safety Regulatory Association Collaboration program supports state, local, tribal, and territorial (SLTT) food safety initiatives to mitigate food-borne illness risks. Funded by the FDA, this initiative aids SLTT agencies in research and intervention implementation, aiming to enhance public health and establish a cohesive national food safety framework. Eligible applicants include non-profit organizations connected to higher education institutions, focusing on retail food safety.

The SCI Research on the Translational Spectrum (SCIRTS) portfolio aims to promote innovative research that enhances function and alleviates complications following spinal cord injuries. It encourages studies that involve individuals with SCI, emphasizing translational significance in research designs. SCIRTS grants support diverse research areas, including mechanistic, preclinical, and clinical studies, to develop effective interventions. Funding categories include Postdoctoral Fellowships, Pilot Research Grants, and Senior Research Grants, targeting early-career and senior investigators to advance spinal cord injury research.