Best Large Grants for Nonprofit Organizations in South Carolina

The Rural Maternity and Obstetrics Management Strategies Program (Rural MOMS) aims to enhance access to maternity and obstetrics care in rural areas through collaborative networks. Funded by the US HHS: Health Resources & Services Administration (HRSA), this initiative focuses on innovative strategies to improve healthcare delivery for mothers and infants in underserved regions, ensuring that quality care is accessible where it is needed most.

The Wild Felid Legacy Scholarship, established by the Wild Felid Research and Management Association in 2009, supports graduate students researching wild felids in the Western Hemisphere. It awards one to three scholarships ranging from $1200 to $1500, based on financial need and research impact. To date, 38 scholarships totaling over $44,000 have been awarded in memory of dedicated biologists who contributed to wildlife conservation. Recipients are recognized in the WFA's newsletter, the Wild Felid Monitor.

The NIHCM Foundation's Television and Audio Journalism Award honors outstanding television and audio reporting that contributes to enhancing the affordability, accessibility, and quality of healthcare in the U.S. With a prize of $20,000, the award seeks entries that showcase creativity and originality while providing new insights relevant to health plans, policymakers, and consumers. Eligible entries include stories broadcasted in 2025, focusing on critical healthcare issues.

The Indigenous Scholarships: Arts Fund facilitates artistic development for Aboriginal Australian, Torres Strait Islander, Native American, Alaskan Native, and Native Hawaiian artists. Offering up to $5,000, it supports projects in each other's countries, with applications due in March and September. Since 2002, over $1 million has been awarded to more than 500 artists, fostering cultural exchange and growth in the arts between Australia and the USA.

The NIHCM Foundation Investigative and General Reporting Award honors outstanding reporting that enhances understanding of U.S. health care affordability and quality. A $20,000 prize is awarded to the winner, with entries evaluated for quality, originality, and impact. Eligible submissions include stories published in 2025 from national outlets, focusing on insightful reporting that informs health care policymakers and consumers about rising costs and access solutions.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Eosinophilic esophagitis

Help with healthcare costs for eosinophilic esophagitis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Eosinophilic Esophagitis (EoE) is a disorder of the esophagus and is increasingly recognized as a major cause of swallowing difficulties in children and adults. It is a chronic disease of the immune system and can be triggered by a food allergy, acid reflux, or an airborne allergy. An allergic trigger causes the immune system to overact which causes many white blood cells, or eosinophils, to collect in the esophagus. This causes the esophagus to become inflamed and not contract properly. The esophagus can also narrow and develop rings or abscesses. This condition can become worse over time.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS)

Help with healthcare costs for Multiple sclerosis (MS)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS) health equity

Help with healthcare costs for multiple sclerosis (health equity)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code. 

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

Michael Dean Guilliams Memorial Scholarship Fund

Fund provides scholarship assistance to deserving students who are pursuing further educational studies in a career and technical field.

Amount

$1,500+

The Zendesk Tech for Good Impact Awards support nonprofits by providing them with essential software, grants, and pro bono assistance to enhance their impact on vulnerable populations. The program aims to foster community connections, promote resilience during crises, and create career pathways in technology. Eligible organizations must demonstrate a commitment to utilizing technology in their services, enhancing their ability to support beneficiaries effectively. This initiative empowers nonprofits to leverage technology for greater social good.

The Mentored Quantitative Research Development Award (K25) aims to attract researchers in quantitative science and engineering to focus on NIH-relevant health research. This award provides protected time for supervised study and research, allowing professionals from fields like mathematics, statistics, and engineering to integrate their expertise into health-related studies. The K25 is specifically for lead investigators of independent clinical trials or related studies, fostering innovation in clinical research and career development.

The NCMA Education and Research Foundation Grant aims to support the concrete masonry and hardscape industry through research and educational initiatives. With over $2 million invested, the Foundation invites proposals from qualified professionals, emphasizing national and regional benefits. Eligible projects should focus on workforce development, educational opportunities for students, and collaborative efforts with other organizations. Notably, certain entities, such as those involved in political campaigns or proprietary projects, are ineligible for funding.

The Koerner Family Foundation Scholarship, offered by the Four County Community Foundation, supports high school seniors and recent graduates from Almont, Dryden, and Romeo High Schools. Eligible students must plan to major in business, engineering, IT, medical health fields, natural sciences, or vocational training, with a minimum GPA of 2.50. Award recipients will be honored at a Scholarship Celebration in May and at their respective high school awards events.

The Sidney R. Baer, Jr. Foundation offers Reintegration Grants aimed at supporting individuals with schizophrenia and bipolar disorder. By focusing on abilities rather than symptoms, the foundation promotes recovery through various programs. Their funding helps organizations that maintain a commitment to mental health, ensuring that recipients receive necessary support, such as scholarships and facility management, to enhance their quality of life. The foundation believes in empowering individuals to actively participate in their recovery journey.

Stark Community Foundation is one of the area’s major sources of college scholarship support— thanks to the generosity of caring individuals, families and businesses that have created scholarship funds.

The Foundation currently manages more than 100 scholarship funds that support hundreds of deserving students each year from Stark and Carroll counties. In 2025, more than $1,000,000 was awarded to local students to help them achieve their educational dreams.

The Velma Shotwell Griffin Memorial Scholarship Fund

The Velma Shotwell Griffin Memorial Scholarship Fund was established to assist graduates of Conotton Valley or Carrollton High Schools planning to enroll, or currently enrolled, at an accredited college or university to pursue further education in the following fields: History, Writing (not limited to, English, Journalism, Language Arts, Communications and programs in Mass Media), Graphic Arts, Music (which shall include but not limited to, vocal music, instrumental music, music history, music education, and music performance) and any other program or field of study approved by the Selection Committee. 

Amount:

• Varies. Minimum $500.

Renewable:

• Yes

The Weatherization Assistance Program (WAP) by the U.S. Department of Energy provides essential services to improve energy efficiency in homes, particularly for low-income households. Eligible participants include those below 200% of the poverty level, renters, and homeowners. The application process involves determining eligibility, identifying local providers, and submitting necessary documentation. By helping families save on energy costs and enhancing comfort, WAP plays a crucial role in supporting vulnerable communities.

The Research Experiences for Undergraduates (REU) program, funded by the National Science Foundation (NSF), promotes active research participation among undergraduate students across various research areas. It supports two mechanisms: REU Sites, which engage multiple students in ongoing research, and REU Supplements, which enhance existing NSF-funded projects. Participants must be U.S. citizens, nationals, or permanent residents, and each REU opportunity has its unique application process.

The Intervention Research to Improve Native American Health (IRINAH), led by the National Institute on Drug Abuse, focuses on enhancing health outcomes in Native populations. It supports research to identify causes of health issues, develop and test effective interventions, and implement strategies that promote sustainability. Emphasizing community strengths, the initiative aims to rigorously evaluate solutions to reduce health disparities, ensuring interventions can be adapted and shared across diverse communities.

About All Points North Foundation

All Points North Foundation is dedicated to navigating communities upward.

All Points North Foundation was founded in 2011 by a family who believes passionately that everyone has a “true North” – a place of achievement – and that everyone should have equal opportunity and access to realize their goals.

Our Vision

We envision a nation where the middle school years are seen as an important, vital time in the lives of youth, and where the public middle school education experience in underserved communities measurably improves

We also envision a nation where the integration of solar benefits families, local economies and the environment.

Our Priorities

All Points North Foundation funds grantees in two areas – public middle school education (grades 6-8) and solar – that have the power to help communities nationwide navigate upward.

Grant Making

All Points North Foundation seeks collaborative partnerships with grantees in our two priority areas.

Solar Energy

All Points North Foundation is focused on finding ways to significantly advance the penetration of solar through education, job training and use of solar electric technologies in the United States.

All Points North Foundation has three priority areas:

Providing solar and workforce development training for Tribal communities to expand and diversify the solar job pipeline.

Working with small- to medium-sized science centers to engage students, families and local communities on the benefits and science behind solar.

Providing solar installations to nonprofit organizations that build high-quality, safe and affordable residential housing, offsetting energy costs and enabling cost savings for households.

The cost of solar has dropped dramatically over the last decade, however the upfront cost of going solar remains a hurdle for most families, communities and nonprofits.

All Points North Foundation does consider funding solar projects outside of these focal areas, but the programs must demonstrate how solar will have a broader impact on local communities (e.g., economic, social or environmental), as well as showcase the potential for replication across the nation.

The Ferguson Cares Grant is an essential aspect of Ferguson's Sustainability strategy, focusing on social challenges and community wellbeing. This grant supports nonprofit organizations in the U.S. dedicated to affordable housing, skilled trades workforce development, clean water access, and enhancing local economic quality of life. Ferguson aims to create lasting partnerships that drive positive impact within their operational regions, reflecting their commitment to social responsibility and community support.

Each year, Innovia awards over $400,000 in scholarships to deserving students like you who are college-bound or pursuing vocational or technical training. Single scholarship awards range between $500 and $4,000.

Diversity in Advertising Scholarship

The scholarship is intended for students studying Marketing, Advertising or Design with a career focus of Digital Marketing, Advertising, Design and/or Computer Science at any accredited institution. Applicants must demonstrate academic achievement.

Special consideration will be given to those active in school activities, community service, and work experience. Previous recipients of this award are eligible to reapply. 

The AAO-HNSF Bobby R. Alford Endowed Research Grant offers $30,000 for one year to support innovative research in otolaryngology. This grant aims to facilitate the career development of young investigators and promote research that may lead to significant advancements in understanding diseases of the head and neck. Eligible projects should have direct clinical significance for patients and can include basic, translational, and clinical research.

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

Harry Emley and Mary Joslin Bennett Scholarship

Selection based upon:

• Academic achievement, financial need, community and school service, and recommendations.

Awards

• One $500 scholarship

The West Michigan Nursery and Landscape Association Scholarship, established in 2001, supports students from Ottawa, Oceana, Newaygo, Muskegon, or Allegan County pursuing careers in horticulture or the green industry. Administered by the Grand Haven Area Community Foundation, awards consider financial need and academic achievement. Applicants, including high school seniors and college students, must submit transcripts and additional required documents. This scholarship aims to foster education and partnerships within West Michigan's green industry.

The AISES ARDC Scholarship provides $5,000 annually to undergraduate and graduate students pursuing degrees in Electrical Engineering, Physics, Computer Science, or related fields. Funded by the American Indian Science and Engineering Society (AISES), this scholarship aims to support Indigenous students who are current AISES members and enrolled full-time. Eligible applicants must also be citizens or descendants of recognized Indigenous tribes, ensuring a commitment to enhancing representation in STEM education and careers.

The WDA Small Grants program supports projects that advance the mission of the Wildlife Disease Association (WDA), which focuses on promoting healthy wildlife, biodiversity conservation, and sustainable solutions to One Health challenges. Eligible projects include educational materials, public outreach, and other initiatives that align with WDA's goals. Funding will not cover overhead or accommodation expenses, and proposals must include measurable objectives that can be achieved within one year.

The Fred J. Brunner Foundation Grant supports organizations that aid vulnerable populations, particularly the young and elderly, through education, shelter, and hunger initiatives. Established in 1956 by Fred J., the foundation distributes grants annually in the fall, focusing primarily on recipients in the greater Chicago area, although exceptions are made. The foundation operates without regard to race, creed, or ethnicity, allowing all recipients to reapply each year.