Best Large Grants for Nonprofit Organizations in South Carolina

The Principal Student Support Services Grant, offered by the School-Based Healthcare Solutions Network, aims to enhance mental health support for students in grades 6-12 at under-resourced public schools. With funding available for hiring mental health professionals and performance-based awards, this initiative addresses critical challenges like chronic absenteeism and behavioral issues. By providing targeted interventions, the grant seeks to improve academic performance and overall well-being among students facing mental health crises.

The HEAL initiative aims to translate addiction research into practice to combat the opioid crisis and overdose events. It focuses on identifying barriers to reducing substance use and developing scalable, evidence-based interventions. Emphasizing recovery, prevention, and the integration of mental health, the initiative encourages collaboration among experts in various fields. Although applications are not currently solicited, potential applicants are urged to prepare for future opportunities to apply innovative solutions to enhance addiction treatment and prevention efforts.

The State Pilot Program for Treatment for Pregnant and Postpartum Women aims to enhance the state's capacity to deliver integrated and evidence-based services for substance use disorders and maternal mental health. The initiative focuses on supporting pregnant and postpartum women and their families, ensuring they receive comprehensive care tailored to their unique needs. Funded by the Substance Abuse and Mental Health Services Administration, this program is a vital step toward improving health outcomes for vulnerable populations.

Alkermes

At Alkermes, we apply our deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders, including addiction, serious mental illness and sleep disorders. With our portfolio of marketed medicines and investigational pipeline candidates, we seek to make a meaningful difference in the way people manage these chronic diseases. Our patient-inspired science, integrated research strategy, sophisticated development capabilities and specialized commercial infrastructure enable us to pursue the development and commercialization of innovative new medicines, including those for people with conditions that have traditionally been overlooked or stigmatized.

Our greatest strengths at Alkermes are our people and our inherent empathy for patients, families and caregivers. Neurological and psychiatric disorders strike people at the core of who they are and impact many facets of their lives. We work with urgency to develop new treatment options for people living with these conditions.

Investigator Sponsored Studies Program

Alkermes seeks to support research designed and conducted by independent clinicians and scientists through our Investigator Sponsored Studies (ISS) program. Alkermes may occasionally announce a Request for Proposals (RFP) for research in clinical areas where gaps in data have been identified. 

The ISS research Alkermes supports must be based in the United States and is typically conducted by experienced researchers who have an established history of successfully completing research with independent funding. Alkermes can provide its marketed products to the ISS programs it supports. In addition, there may be financial support available, but please note that study budgets cannot exceed $300,000 (inclusive of overhead).

• ISS Areas of Interest
  • Sleep Disorders
  • Schizophrenia & Bipolar I Disorder
  • Schizophrenia

The COPIC Medical Foundation Grants aim to improve healthcare outcomes by funding programs that enhance patient safety and reduce medical errors. With over $10 million awarded since its inception in 1991, the foundation focuses on scalable solutions to address healthcare fragmentation. This final grant cycle emphasizes innovative approaches that can be replicated across the healthcare community. Organizations must be 501(c)(3) certified or have a fiduciary partner to qualify for funding.

The Avant Garde Award supports innovative research on HIV and substance use disorders, encouraging creative scientists to explore high-risk, high-reward approaches. While applications are not currently being accepted, this initiative by the National Institute on Drug Abuse (NIDA) aims to stimulate collaborations and impactful research. Early-stage investigators are particularly encouraged to consider this opportunity as they develop their proposals for future funding. The program uses the DP1 activity code, fostering transformative advancements in biomedical and behavioral science.

The Downing-Nix Trust Grant provides funding for organizations engaged in research on muscular dystrophy, maintaining treatment wards in Atlanta hospitals, offering veterinary medicine scholarships, and supporting shelters for small animals. Organizations must qualify as 501(c)(3) charities. Applications are accepted year-round, but submissions by April 15 are required for annual meeting reviews. Priority may be given to hospitals and veterinary schools within Atlanta, GA.

Pershing Square Lotus Award for Ovarian Cancer Research

The Pershing Square Foundation (PSF) has worked across sectors to catalyze innovative approaches to the most difficult problems. Talented individuals have always been at the center of our approach. We aim to support leaders who transform systems, embrace new paradigms, and have an innate drive to make an impact.

PSF has funded pioneering cancer researchers through the Pershing Square Sohn Cancer Research Alliance for over a decade and supported women’s health initiatives in New York City. Through this Request for Proposals (RFP), PSF aims to combine these two priority areas of women’s health and cancer to shine a light on one of the most understudied and underfunded cancers—ovarian cancer. Ovarian cancer is the deadliest gynecologic cancer, with 80% of women diagnosed at an advanced stage. Only 27% of women diagnosed during an advanced stage survive for five years. Ovarian cancer remains a disease with a poor prognosis due to limited early detection and treatment options.

PSF supports research efforts by 

• deploying capital quickly, 
• funding high-risk, high-reward ideas, 
• bringing new perspectives into a field, 
• encouraging collaboration, and 
• leveraging our vast network. We challenge our scientific partners to think creatively and across silos, to spur innovation to fight ovarian cancer.

Through the Pershing Square Lotus Award for Ovarian Cancer Research, PSF is looking for investigators who are either already working on a promising project in ovarian cancer or in another type of cancer that could have an impact on ovarian cancer. Grantees each receive $250,000 a year for three years, totaling $750,000.

Researchers who are not studying ovarian cancer are encouraged to apply and required to find a collaborator with experience in ovarian cancer research.

This award aims to 

• inspire investigators with unique expertise to apply their knowledge to ovarian cancer and 
• empower ovarian cancer researchers to pursue their boldest, most innovative ideas. Facing a disease where too few have survived to-date, PSF ultimately aims to create a culture around ovarian cancer that offers women hope, akin to the breast cancer community. PSF is passionate about changing outcomes for tens of thousands of women a year and is hopeful that future scientific discoveries will allow for more survivors who can share their stories for years to come.

The Agriculture Innovation Center Grant Program aims to support Agriculture Innovation Centers by providing grants that facilitate technical assistance to agricultural producers. This initiative focuses on enhancing the marketing of value-added agricultural products, ultimately fostering growth in the agricultural sector. Funded by the USDA's Rural Business-Cooperative Service, this program is designed to empower producers and promote innovation in agricultural practices.

The NASPGHAN Foundation Abbott Advanced Fellowship in Pediatric Nutrition offers up to $75,000 for one year of advanced training in pediatric nutrition for members of NASPGHAN. This fellowship aims to enhance pediatric nutrition expertise by supporting a well-defined clinical experience and focused research project. Eligible applicants must be MDs or DOs and members in good standing, with a preference for those seeking training at different institutions. This initiative addresses the increasing importance of pediatric nutrition in child health.

The Measurement and Evaluation Graduate Student Award, offered by SHAPE America, aims to support graduate students specializing in psychomotor measurement and evaluation. This scholarship assists with professional expenses, ensuring candidates can focus on their studies. Eligible applicants must be current SHAPE America members and pursuing relevant master's or doctoral degrees. The award prioritizes those who have completed their first year of study, promoting excellence in health and physical education across the U.S.

The Koerner Family Foundation Scholarship, offered by the Four County Community Foundation, supports high school seniors and recent graduates from Almont, Dryden, and Romeo High Schools. Eligible students must plan to major in business, engineering, IT, medical health fields, natural sciences, or vocational training, with a minimum GPA of 2.50. Award recipients will be honored at a Scholarship Celebration in May and at their respective high school awards events.

The Mentored Quantitative Research Development Award (K25) aims to attract researchers in quantitative science and engineering to focus on NIH-relevant health research. This award provides protected time for supervised study and research, allowing professionals from fields like mathematics, statistics, and engineering to integrate their expertise into health-related studies. The K25 is specifically for lead investigators of independent clinical trials or related studies, fostering innovation in clinical research and career development.

The NCMA Education and Research Foundation Grant aims to support the concrete masonry and hardscape industry through research and educational initiatives. With over $2 million invested, the Foundation invites proposals from qualified professionals, emphasizing national and regional benefits. Eligible projects should focus on workforce development, educational opportunities for students, and collaborative efforts with other organizations. Notably, certain entities, such as those involved in political campaigns or proprietary projects, are ineligible for funding.

Michael Dean Guilliams Memorial Scholarship Fund

Fund provides scholarship assistance to deserving students who are pursuing further educational studies in a career and technical field.

Amount

$1,500+

The Zendesk Tech for Good Impact Awards support nonprofits by providing them with essential software, grants, and pro bono assistance to enhance their impact on vulnerable populations. The program aims to foster community connections, promote resilience during crises, and create career pathways in technology. Eligible organizations must demonstrate a commitment to utilizing technology in their services, enhancing their ability to support beneficiaries effectively. This initiative empowers nonprofits to leverage technology for greater social good.

The Fred J. Brunner Foundation Grant supports organizations that aid vulnerable populations, particularly the young and elderly, through education, shelter, and hunger initiatives. Established in 1956 by Fred J., the foundation distributes grants annually in the fall, focusing primarily on recipients in the greater Chicago area, although exceptions are made. The foundation operates without regard to race, creed, or ethnicity, allowing all recipients to reapply each year.

The Yéigo Action Grant, provided by the First Peoples Fund, offers financial support ranging from $100 to $2,500 for Native artists and culture bearers facing hardships that affect their creative practices. This grant aims to assist artists with specific professional opportunities, such as workshops or emergencies. By honoring the spirit of encouragement embodied in the Diné word 'yéigo', the grant helps ensure that artists can continue their vital work within their communities.

The Sidney R. Baer, Jr. Foundation offers Reintegration Grants aimed at supporting individuals with schizophrenia and bipolar disorder. By focusing on abilities rather than symptoms, the foundation promotes recovery through various programs. Their funding helps organizations that maintain a commitment to mental health, ensuring that recipients receive necessary support, such as scholarships and facility management, to enhance their quality of life. The foundation believes in empowering individuals to actively participate in their recovery journey.

The Community Foundation of Shelby County

Our Mission

To inspire donor generosity and transform it into meaningful, lasting impact through charitable gifts.

Our Vision

To be the primary partner for donors who want to advance the community’s quality of life and capacity for excellence.

Harry Emley and Mary Joslin Bennett Scholarship

Selection based upon:

• Academic achievement, financial need, community and school service, and recommendations.

Awards

• One $500 scholarship

The Research Experiences for Undergraduates (REU) program, funded by the National Science Foundation (NSF), promotes active research participation among undergraduate students across various research areas. It supports two mechanisms: REU Sites, which engage multiple students in ongoing research, and REU Supplements, which enhance existing NSF-funded projects. Participants must be U.S. citizens, nationals, or permanent residents, and each REU opportunity has its unique application process.

About Us

Making a Difference, Together

The Community Foundation of Monroe County (CFMC) builds a thriving, inclusive community through the power of philanthropy. By connecting generous donors with local causes, we help ensure Monroe County remains a place where everyone can thrive. Since our founding, we’ve been a trusted steward of community resources, fostering impactful collaborations and sustainable solutions to address challenges in education, health, poverty, and community development.

Life Needs Support

Life Needs Support provides need-based financial assistance to students and young adults from the Greater Milan area who face barriers that may prevent them from completing a degree or skilled trades training program. 

Requests are reviewed on a case-by-case basis. We recognize that unexpected hardships can disrupt educational progress, including expenses related to books and supplies, medical care, transportation, childcare, trade tools.

Applications are evaluated two times each year for awarding in the six months after application and selection.

Our Mission

UNCF envisions a nation where all Americans have equal access to a college education that prepares them for rich intellectual lives, competitive and fulfilling careers, engaged citizenship and service to our nation.

UNCF’s mission is to build a robust and nationally-recognized pipeline of under-represented students who, because of UNCF support, become highly-qualified college graduates and to ensure that our network of member institutions is a respected model of best practice in moving students to and through college.

UNCF’s North Star is to increase the total annual number of African American college graduates by focusing on activities that ensure more students are college-ready, enroll in college and persist to graduation. This is done through a three-pillar strategy. Positioning member institutions as a viable college option for students and investing in institutional capacity to improve student outcomes; creating transformational support programs to ensure students are enrolling and persisting through college completion; building awareness of educational attainment and cultivating college-going behaviors within the African American community.

About the UNCF Lighted Pathways Program

Increasing the number of Black investment management professionals one opportunity at a time

According to The American College and the CFP Board, African Americans only make up 5% of financial advisors and 2% of certified financial planners (CFP), even though African Americans represent 13.4% of the U.S. population.

The UNCF Lighted Pathways programs meets the disparity and lack of Black talent in asset management through the UNCF Lighted Pathways initiative which provides scholarships and internships to African American undergraduate students interested in the investment management industry. Through this initiative, UNCF Lighted Pathways aims to create a career pathway to attract, develop, and retain Black talent for the asset management industry.

The UNCF Lighted Pathways Program excites, educates, and empowers young people by supporting personal and professional development, driving company performance, and providing the asset management industry the talent they need to meet today’s challenges and tomorrow’s opportunities. This program offers students a glimpse inside the dynamic, global asset management industries and the career opportunities, potential and rewards within them.

Students are afforded the opportunity to receive $5,000 in scholarships and/or participate in internships in the financial industry provided by the program’s partners.

T7 Social Impact GrantsThe T.D. Jakes Foundation (TDJF), in partnership with Wells Fargo, is proud to launch the Social Impact Grant Challenge, a transformative funding opportunity designed to identify, support, and amplify nonprofit organizations creating meaningful change in communities across the United States.

Designed around the T.D. Jakes Foundation's pillars of service (Educational Access & Workforce Readiness, financial inclusion, and community transformation and well-being), the Challenge seeks innovative nonprofit organizations that are addressing critical social issues through impactful, scalable, and sustainable solutions.

Finalists selected through this process will have the opportunity to showcase their organization through a live presentation at the inaugural Thriving Seven (T7) Summit, taking place November 12 –14 in Atlanta, Georgia. In addition to competing for grant funding, finalists will gain national visibility for their work and connect with nonprofit leaders, funders, and changemakers from across the country.Grant Funding: A total of $1,500,000 in grant funding is anticipated to be awarded: 

• One (1) - $500,000 grant
• One (1) - $250,000 grant
• Two (2) - $100,000 grant
• Eleven (11) - $50,000 grant

The Intervention Research to Improve Native American Health (IRINAH), led by the National Institute on Drug Abuse, focuses on enhancing health outcomes in Native populations. It supports research to identify causes of health issues, develop and test effective interventions, and implement strategies that promote sustainability. Emphasizing community strengths, the initiative aims to rigorously evaluate solutions to reduce health disparities, ensuring interventions can be adapted and shared across diverse communities.

The Zone VI Fellowship in Urban Forestry, funded by the Garden Club of America, aims to promote urban forestry education among U.S. graduate and advanced undergraduate students. Established in 2006, this fellowship awards $7,500 annually to support students studying urban forestry and related fields. Recipients can reapply for additional funding, fostering ongoing research and engagement with the urban forest ecosystem. This initiative highlights the importance of healthy urban forests and their impact on communities.

About Us

As the community foundation for Eastern Washington and North Idaho, we partner with people who want to improve their communities and make the world better. We work together to identify and respond to our region’s greatest opportunities, help those in need, and leave a lasting impact.

Scholarship

Each year, Innovia awards over $500,000 in scholarships to deserving students like you who are college-bound or pursuing vocational or technical training. Single scholarship awards range between $500 and $10,000.

Diversity in Advertising Scholarship

The scholarship is open to Black, Indigenous, and other People of Color of all ages in Innovia's 20 county service region. The scholarship is intended for students studying Marketing, Advertising or Design with a career focus of Digital Marketing, Advertising, Design and/or Computer Science at any accredited institution. Applicants must demonstrate academic achievement.

Special consideration will be given to those active in school activities, community service, and work experience. Previous recipients of this award are eligible to reapply.