Best Large Grants for Nonprofit Organizations in South Carolina

The OVW Fiscal Year 2026 Tribal Sexual Assault Services Program provides crucial support to Indian Tribes and organizations in addressing sexual assault through intervention and advocacy. This program aims to assist victims of all ages, including youth and children, as well as their families and those affected by the trauma, except for perpetrators. Applications must be submitted by September 3, 2026, at 4:59 PM ET in JustGrants.

The Life Comes From It Grant, funded by the Tides Foundation, supports grassroots initiatives focused on restorative, transformative, and indigenous justice. It prioritizes projects led by communities of color, emphasizing alternatives to incarceration and community-led solutions. Applicants must be 501c3 organizations based in the United States. This grant fosters a collaborative approach to healing and justice, aiming to shift power dynamics and promote inclusive practices across generations.

The Harry Kramer Memorial Fund Grant supports U.S. charitable organizations that assist individuals and institutions in Israel, focusing on welfare, healthcare for the sick and aged, and education in South Florida. Founded by Harry A. Kramer, a successful entrepreneur and veteran, the fund reflects his deep commitment to charitable causes. Organizations must qualify under Section 501(c)(3) and meet specific eligibility criteria to apply for funding, ensuring that aid reaches those in need.

The RSLAAIS Leadership Award, presented by the American Academy of Allergy, Asthma & Immunology (AAAAI), honors exemplary leaders within state, regional, or local allergy societies. This prestigious award recognizes individuals for their significant contributions to community involvement, clinical education, and the advancement of the AAAAI's mission. Candidates are nominated by the RSLAAIS Board of Governors and must demonstrate a commitment to enhancing their local allergy societies and the broader medical community.

The Syringe Service Program Grant, offered by The Comer Family Foundation, aims to enhance harm reduction initiatives by funding syringe access programs across the U.S. These programs provide sterile syringes, education, and support services to mitigate the risks associated with drug use, including HIV and hepatitis transmission. Priority is given to organizations in underserved areas and those led by marginalized communities. Grants are available for operational costs, program development, and staff training, with a focus on sustainability and local partnerships.

The Sociedad Amigos de Colombia de Indiana (SADCO) Scholarship, managed by the Central Indiana Community Foundation, supports Latinx and Hispanic students pursuing post-secondary education. Applicants must be Indiana residents with a GPA of 3.0 or higher, demonstrating financial need and community service. Preference is given to first, second, or third generation Latinx and/or Hispanic students. Scholarship funds assist with tuition, fees, and other educational expenses, reinforcing the foundation's mission to build inclusive opportunities.

The 1954 Project - Luminary Award seeks visionary nonprofit leaders dedicated to advancing educational equity for Black students. Awardees receive $1 million in funding, leadership development, and networking opportunities. The selection prioritizes leaders demonstrating strategic vision, community commitment, adaptability, and collaborative spirit. Applicants must align with one of three impact areas: Innovation in Teaching and Learning, Diversity in Education, or Pathways to Economic Mobility, ensuring their initiatives foster systemic change and uplift marginalized communities.

The FY26 Pancreatic Cancer Research Program (PCARP) Idea Development Award promotes innovative, high-risk research aimed at significant advancements for pancreatic cancer outcomes. This award supports projects with preliminary data, focusing on impactful discoveries. It features a Partnering Principal Investigator option, enhancing funding for collaborations between experienced mentors and early-career researchers. All applications must align with the FY26 PCARP Focus Areas, ensuring relevance and potential for transformative results in pancreatic cancer research.

The Holloway Family Foundation, established in North Central Texas, aims to enhance community quality of life regardless of race, gender, or religion. Their mission focuses on financial security, creative expression for under-resourced youth, and mentorship for personal development. The foundation supports organizations that provide workforce training, artistic opportunities for children, and guidance for youth in need. By fostering individual growth and economic stability, they empower families and strengthen communities, staying true to the founders' core values and personal experiences.

The AAAAI Special Recognition Award honors individuals who significantly contribute to the allergy and immunology community. Offered by the American Academy of Allergy, Asthma & Immunology, this prestigious award recognizes outstanding efforts in advancing care and research in the field, promoting optimal patient outcomes. The AAAAI, with over 7,000 members worldwide, is a leading authority in allergy and immunology, dedicated to enhancing the knowledge and practice of these critical health areas.

The AAAAI Distinguished Scientist Award recognizes exceptional contributions in allergy and immunology research, honoring those who have significantly advanced the field and demonstrated leadership. This prestigious award is presented by the American Academy of Allergy, Asthma & Immunology, a leading organization for over 7,000 professionals dedicated to improving patient care and promoting research in allergic diseases. The award highlights the commitment to excellence and innovation within the specialty.

The AIDS Drug Assistance Program (ADAP) Emergency Relief Funds aim to provide essential funding to states and territories. This initiative focuses on preventing, reducing, or eliminating waiting lists for ADAP services, ensuring timely access to necessary medications and support for individuals living with HIV/AIDS. This program addresses critical funding shortfalls, enhancing the healthcare infrastructure and improving health outcomes in affected communities.

The Bezos Scholars Program, supported by the Bezos Family Foundation, is a transformative, no-cost leadership development initiative designed for high school juniors. Each year, selected scholars from the U.S. and Africa engage in a year-long program, developing leadership skills through civic engagement and community projects. Participants receive personalized college advising, funding for their projects, and an all-expenses-paid trip to the Aspen Ideas Festival, fostering a diverse community of changemakers committed to making a difference.

The National Institutes of Health is launching a funding opportunity to explore the mechanisms of skin injuries caused by toxic chemicals. This initiative aims to understand the common pathways of injury from various harmful substances, facilitating the discovery of therapeutic targets. Researchers are encouraged to collaborate and apply their expertise in cutaneous wound healing. The goal is to develop broad-spectrum medical countermeasures for mass casualty events involving toxic exposures, enhancing public health safety.

The Labcorp Charitable Foundation, a private 501(c)(3) entity, aims to enhance healthcare access and education for all. With grant opportunities focusing on food programs, healthcare services for underserved populations, and STEM initiatives, it seeks to support community health and well-being. Organizations eligible for funding must be U.S.-based and hold tax-exempt status. Requests are reviewed biannually, in March and September, to foster impactful community projects.

Seattle Foundation is an agent of change, igniting powerful, rewarding philanthropy to make Greater Seattle a stronger, more vibrant community for all.

At Seattle Foundation, we believe that community is more than a place. It’s the shared understanding that our joy and well-being are tied to one another. Every day we work with nonprofits, philanthropists, and partners like you to strengthen community by igniting powerful philanthropy and advancing long-term solutions. Because it takes all of us to create a joyful region where every person can thrive.

Microsoft Disability Scholarship

This scholarship supports high school seniors living with a disability defined by WHO (World Health Organization — an impairment in a person’s body structure or function, or mental functioning (visual, hearing, mobility, cognitive, speech, or other disability). Eligible applicants must plan to study Engineering, Computer Sciences, Computer Information Systems, Law, Business (including Paralegal, Pre-Law, Finance, Business Administration, or Marketing) at an accredited two- or four-year college, university, or vocational-technical school. This scholarship is a $5,000 award with up to eight (8) scholarships granted.

The Menasha Corporation Foundation, established in 1953, supports nonprofit organizations across North America, focusing on community betterment, education, environmental sustainability, and health initiatives. Grants are awarded to projects that enhance the lives of individuals and strengthen communities, particularly in areas where Menasha Corporation operates. Eligible organizations must be tax-exempt and prioritize non-public funding. The foundation also encourages involvement from Menasha Corporation employees in supported projects.

The Strategic Projects: Capital Grants by the M J Murdock Charitable Trust offer vital funding opportunities for nonprofit organizations in the Pacific Northwest. These grants support transformative projects that enhance community well-being through construction, renovation, and infrastructure investments. Eligible entities include 501(c)(3) nonprofits and government entities. The Trust emphasizes projects that demonstrate strong community impact and funding diversification, ensuring sustainable growth and lasting benefits for the communities served.

The M J Murdock Charitable Trust offers Strategic Projects: Equipment & Technology Grants to nonprofits in the Pacific Northwest. These grants focus on capacity-building projects and essential equipment, requiring recipients to cover at least 50% of costs. Eligible organizations include 501(c)(3) nonprofits and tribal entities. Priority is given to projects enhancing community services, education, and environmental stewardship, supporting initiatives that foster human flourishing and demonstrate diversified funding.

The Slomo and Cindy Silvian Foundation Grant supports a range of subjects including education, children's welfare, medical care, medical research, and Jewish philanthropic endeavors. Established in honor of Cindy Silvian, the foundation has awarded over $30 million since 2008. Applications are by invitation only, and organizations must meet specific eligibility criteria to be considered for funding. This year, the foundation allocated over $2.4 million to more than 110 organizations, highlighting its commitment to impactful philanthropy.

The M J Murdock Charitable Trust offers the Strategic Projects: Program & Staff Grants to support nonprofits in the Pacific Northwest. These grants focus on capacity-building for mission-driven projects and infrastructure investments. Eligible organizations must demonstrate a commitment to community flourishing, with funding available for new programs or expansion of existing ones. The Trust prioritizes initiatives that align with its strategic goals, fostering sustainable nonprofit growth and impact in the region.

The Pat and John MacTavish Fund, established in 2007 by John Mac Tavish in memory of his wife Pat, provides scholarships aimed at encouraging young women to pursue higher education in the hard sciences. Awarded by the Grand Haven Area Community Foundation, scholarships are competitive and based on criteria such as financial need and academic achievement. Applicants from Northern Ottawa County or specific school districts are eligible. The fund emphasizes the importance of education in fields such as math, chemistry, and computer science.

The Alfred P. Sloan Foundation's Creating Equitable Pathways to STEM Graduate Education initiative aims to foster partnerships between Minority Serving Institutions (MSIs) and graduate programs to enhance equitable learning environments. Grants of up to $500,000 will support projects addressing systemic barriers, promoting effective practices, and ensuring seamless transitions from MSIs to advanced degrees in various STEM fields. The initiative seeks to create lasting impacts on student access and success in graduate education.

The Alfred P. Sloan Foundation's initiative, "Creating Equitable Pathways to STEM Graduate Education: Seed," aims to enhance graduate education access for students from Minority Serving Institutions (MSIs). The program provides grants of up to $500,000 to foster partnerships between MSIs and various higher education institutions. Projects should focus on overcoming barriers to success in graduate studies, including recruitment and admission processes, thereby promoting equitable learning environments in STEM fields.

Mission Statement

Beckley Area Foundation exists to inspire and facilitate generous charitable giving that advances our community.

The Beckley Area Foundation is committed to enriching lives and strengthening communities across Southern West Virginia.

Scholarship

Supporting Student Success

The Beckley Area Foundation proudly manages scholarship funds established by individuals, businesses, and organizations dedicated to helping students pursue higher education. Many of these scholarships are tailored for specific schools, fields of study, or graduates from local high schools, while others offer broader opportunities. No matter the path, our scholarships aim to support students from our region as they work toward achieving their educational goals.

Margaret Thorne-Dilley Scholarship for Science Teachers Scholarship

Eligibility

Equally weighted as a need and merit based award for a Raleigh County high school graduate with a 3.5 cumulative GPA; Pursuing baccalaureate degree in education at an accredited institution; Preference will go to students pursuing a science field including the biological, physical and natural sciences. If none apply with the preferences listed, mathematics will also be considered.

The Alfred P. Sloan Foundation's Creating Equitable Pathways to STEM Graduate Education initiative aims to foster partnerships between Minority Serving Institutions (MSIs) and graduate programs. By addressing barriers in graduate education, the initiative seeks to promote equitable learning environments. Planning grants will support collaborations that assess needs and develop systemic changes to enhance pathways for students in STEM fields, ensuring that all students can thrive in their academic pursuits.

The Cecelia Springmeyer Memorial Scholarship, managed by the Decatur County Community Foundation, aims to support North and South Decatur students pursuing post-secondary education in law enforcement, criminal justice, animal husbandry, agronomy, or teaching. Applicants must reside within the Decatur County Community Schools district and may receive a minimum scholarship of $1000 to ease their educational costs. For more details, visit ndsdscholarships.com.