Best Large Grants for Nonprofit Organizations in South Carolina

The ISF Impact Campaign Grant supports completed short or feature-length films that aim to create a positive societal impact through outreach and community engagement. This grant is available to all filmmakers, focusing on projects that depict American Muslim narratives. Recipients will receive funding along with mentorship to enhance their impact campaigns, which must include a comprehensive proposal detailing goals and success metrics.

The Holthouse Foundation for Kids supports organizations that empower at-risk youth through character education, life skills, and entrepreneurship. They provide grants to non-profit entities recognized under Section 501(c)(3) of the Internal Revenue Code, focusing on community enrichment in Houston and beyond. While inquiry letters are accepted year-round, they do not guarantee funding, and applicants must understand that proposals are not a promise of financial support.

About Us

Leadership. Collaboration. Impact.

The Community Foundation of the Mahoning Valley helps philanthropists support the causes closest to their heart while connecting local residents to the resources they need for a better quality of life.

Our Mission

To serve as a leader and advocate for strategic philanthropy, partnering with donors to anchor a permanent and growing endowment and making investments in the Mahoning Valley that improve the quality of life for all residents.

Scholarship Opportunities

Your Community, Your Support System

Our community members support hundreds of local students every year through various scholarships facilitated by the Community Foundation of the Mahoning Valley.

Established in memory of Melinda “Mindy” Henning.

The NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) aim to bridge the funding gap that often hinders the commercialization of medical biotechnology products. This initiative encourages partnerships between NINDS awardees and third-party investors to advance projects requiring federal regulatory approval. By supporting the next milestones necessary for product development, this opportunity fosters the transition of innovative research tools to market, ultimately enhancing public health outcomes.

The Louder Than Words Grant Program, supported by the Finish Line Youth Foundation, focuses on empowering diverse and underserved communities in Indianapolis and beyond. With grant cycles addressing areas like health, workforce development, and safe communities, organizations can request up to $10,000 to support impactful programming. Eligible applicants must be 501(c)(3) organizations dedicated to fostering positive change, particularly for communities of color, ensuring equitable access to resources and opportunities.

GardenScape Professional Association/Ted Burnett Memorial Scholarship

To award scholarships to residents of the Genesee-Finger Lakes region who are students of horticulture/landscaping.

Number and Size of Awards

One award of $1,000; paid in one lump sum in the Fall and divided equally between the Fall and Spring semesters.

Allowed Use of Award

Awards may be used for tuition, fees, books, and other expenses associated with higher education.

The National Institutes of Health (NIH) is set to publish a Notice of Funding Opportunity (NOFO) for research on isolated human islets as a diabetes treatment. This initiative aims to gather data from clinical trials, aiding the research community in future publications and trial designs. While applications are not currently being accepted, potential applicants are encouraged to start forming collaborations and consider applying when the opportunity opens.

The AAAE Diversity, Equity & Inclusion Scholarship, provided by the AAAE Foundation, supports ethnic diversity students pursuing aviation studies in the U.S. or Canada. With two awards of $5,000 each, recipients are chosen based on their academic achievements, financial need, and community involvement. Eligible applicants include college juniors, seniors, or graduate students with a minimum GPA of 3.0. This scholarship aims to foster future leaders in the aviation industry, enhancing diversity and inclusion.

Don and Bern Holcomb Memorial Scholarship

This scholarship was created in memory of Don and Bern Holcomb and is for high school students from any school in Cattaraugus or Allegany county who plans to attend an accredited post-secondary institution, with a preference for a student majoring in an agricultural or conservation-related field or a female pursuing an engineering degree.

About Us

Marshfield Area Community Foundation, Inc. is a public, 501-C-3 charity. There are 30 community foundations in Wisconsin and more than 750 in the nation. The purpose of all community foundations is to accumulate charitable dollars that impact a specific geographic region in areas such as education, the arts, economic development, recreation, environmental protection, health care, and social services. They may be relatively small, as we are (assets of $14 million), or very large, as is the Greater Milwaukee Foundation (assets over $400 million).

Most people are familiar with private foundations, established by individuals, families, or corporations. Typically, in order to establish a private foundation, one has to have considerable wealth. You could say Community Foundations are much more democratic. We are, in a sense, an umbrella foundation containing many small foundations. We call those small foundations “funds.”

Marshfield Area Community Foundation Scholarships

The mission of the Marshfield Area Community Foundation is “Connecting people who care with causes that matter to enrich the quality of life in the Marshfield area”. Education is a valuable tool and a cause that matters to all of us. Through assisting students with financial support to receive an education, not only do students and the families of those students benefit, but also our community benefits, which further allows us to achieve our mission of enriching the quality of life in the Marshfield area.

Sophia Smrz Memorial Scholarship (2025)

The Alfred P. Sloan Foundation Research Fellowship supports innovative and fundamental research by early-career scientists across various fields. This prestigious two-year fellowship offers $75,000 in a lump sum, allowing recipients to allocate funds towards research-related expenses. Eligible candidates must hold a Ph.D. and be tenure-track faculty at U.S. or Canadian institutions. The fellowship aims to nurture the next generation of leaders in research and academia.

The Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) award aims to assist federally recognized AI/AN Tribes, Tribal colleges and universities, and Tribal health organizations in creating or enhancing Institutional Review Boards (IRBs). This initiative is crucial for ensuring ethical research practices within Tribal communities, fostering cultural sensitivity in research, and protecting the rights of AI/AN participants. Applications must be submitted by 5:00 PM local time of the applicant organization.

The Armando "Frank" Quaglia Veteran's Scholarship, offered by the Grand Rapids Community Foundation, supports full-time graduate or upper-level undergraduate students from Kent or Ionia County pursuing healthcare or engineering degrees. With a minimum 3.0 GPA, preference is given to veterans and their families. This scholarship aims to eliminate barriers to education, fostering academic success and connecting students to opportunities in West Michigan's inclusive community.

Confederated Tribes of Siletz Indians

The Confederated Tribes of Siletz Indians is a sovereign nation and has three main branches of government – Judicial, Executive, and Legislative. One of our most important resources is our people.

Education

The Confederated Tribes of Siletz seeks to provide opportunities for Tribal members to reach potential, establish independence and improve quality of life through lifelong learning and education.

Cathern Tufts Memorial Scholarship

Cathern Tufts, affectionately known as “Cat” in the offices of the CTSI administrative offices and Tribal elder woodcuts, was the Tribal Attorney for fourteen and a half years until she passed in 2018 following a short illness. She was a Siletz Tribal member who graduated from Arizona State University School of Law. She served an internship in Washington D.C. prior to going to work as an attorney. Her parents and friends wished to honor her life and achievements through this memorial scholarship. This scholarship is for students in pre-law, law, or in a natural resource field.

Driving University Impact: Expanding the Public Exchange Network Grant

How the Public Exchange Network Works

No single university – even a large R1 – has enough faculty expertise available to meet the needs of every partner. The Public Exchange Network was designed to help universities work together seamlessly to build robust partnerships and generate more collective impact. Universities joining the network are independent but affiliated members, with full control over their own program and project portfolios. As a national network with local, on-the-ground capacity, Public Exchange Network members can also share approaches that work, scale solutions to common problems, and build cross-regional partnerships together. 

As an institutional partner in the Public Exchange Network, universities will build capacity to develop, test and implement solutions to the most urgent problems in their regions and beyond. Universities joining the Public Exchange Network get:

• The tools, templates and training they need to start right away;
• A shared brand they can plug into on day one;
• A network of faculty, past and potential partners and philanthropic relationships, benefitting everyone in the network. 

Public Exchange Network Expansion grants will cover 75-80% of the minimum estimated annual costs for two years to launch a new Public Exchange. To launch a Public Exchange, universities must have the following in place: (1) a staff executive director with experience launching and leading social impact partnerships, (2) a project seed fund, and (3) a modest operations budget. We also recommend some in-kind project management support from an existing university staff member. The grant includes a two-year Public Exchange Executive Director (ED) compensation subsidy of $300,000 to launch the Public Exchange on campus, and a 2-year license to use the Public Exchange brand. New Public Exchange Network members will also receive ongoing support and guidance from current Public Exchange leadership and staff at USC and WashU, including recruitment support and intensive training for hiring and onboarding an executive director, a sub-site on the Public Exchange website, incubation and project management support from current Public Exchange staff, and a suite of tools for developing and implementing Public Exchange projects.

The Big 33 Academic Scholarship Fund, managed by The Foundation for Enhancing Communities, offers financial assistance to Pennsylvania high school seniors planning to pursue higher education. Eligible students must maintain a minimum GPA of 2.0 and demonstrate academic achievement, community service, and leadership. Since its inception in 1985, the fund has awarded over $3.9 million in scholarships, helping countless students achieve their academic goals and overcome obstacles.

The Clark and Ruby Baker Foundation Grant aims to support charitable organizations that align with the philanthropic mission of the Baker family, focusing on Methodist-affiliated educational institutions, aid for disadvantaged children, and assistance for the sick in Georgia. The Foundation considers funding for construction projects of educational and medical facilities, ensuring that grants are awarded to meet specific community needs and promote long-term benefits.

The NRF Foundation Retail Management Scholarship, in partnership with CVS Health, is designed to inspire undergraduate students to pursue careers in retail leadership. Eligible candidates can receive a $10,000 scholarship and attend the NRF Foundation Student Program in NYC in January 2026. This program provides networking opportunities with top retail executives and recruiters, along with insights into career pathways in the retail industry, making it a valuable experience for aspiring leaders.

The Les Paul Foundation Grant supports innovative music education and medical research related to hearing loss. Eligible organizations must be U.S.-based public charities under 501(c)(3) and avoid religious, political, labor, or business affiliations. The foundation prioritizes projects that enhance music production, performance, and STEM/STEAM initiatives, particularly those benefiting individuals in challenging situations. Proposals must detail how they will share Les Paul's legacy in their work.

Nurses Educational Funds

Nurses Educational Funds, Inc. depends solely on donations to advance our only mission, to promote nursing leadership through annual scholarship support for professional nurses seeking masters and doctoral degrees in nursing education, practice, research, and administration.

NEF’s only purpose is to provide nursing scholarship assistance to make graduate level nursing education possible. NEF is one of the largest, national, private, professionally endorsed source of funds for advanced nursing study with over one hundred years of service to and for professional nursing. NEF is a non-profit organization with 501(c) status.

Martha Rodriguez Scholarship Fund

Martha Rodriguez Memorial Scholarship was initiated in 2025 by Lisa Ackerman, close friend and then Director of the Columbus Citizens Foundation. Raised in Gary, Indiana and a true New Yorker, Martha died as the result of traumatic head injuries from a tragic accident just outside her NYC apartment. Martha Rodriguez gave in life, working as a nurse helping patients navigate the trauma of breast cancer at Memorial Sloan Kettering Cancer Center. In her death, she was lauded by the President of LiveOnNY, an organization that coordinates and oversees organ donations, for her last selfless act of giving. Martha donated organs that gave life and hope and helped three people lead better lives. Her zest for life was contagious, and her dedication, compassion, and expertise left an indelible mark on the lives of countless MSKCC patients and caregivers. She was a friend and mentor to many. She loved being a nurse at MSKCC and worked for more than 28 years as a nurse practitioner and for the last 15 years of her life dealing with breast cancer patients. This scholarship is awarded to nurses studying in master's or doctoral programs who are dedicated to oncology care, or women’s health, or are Latinx nurses.

The AISES RISE Scholarship offers $2,000 annually to support Indigenous students pursuing careers in STEM, particularly in the casino gaming industry. This initiative, powered by Aristocrat Gaming, aims to empower Indigenous talent through exposure, resources, and programming. Eligible applicants must be full-time students and current AISES members, demonstrating a commitment to their education and community. The scholarship seeks to enhance diversity in STEM fields by providing critical financial support to deserving students.

The Mercer Vu Farms/Ron and Judy Hissong Scholarship for Agriculture Fund honors Ron Hissong, a dedicated dairy farmer. Established by his family, this scholarship supports students from the Tuscarora School District pursuing education in agriculture or related fields, ensuring they can continue Ron's legacy of community contribution. Applicants must demonstrate financial need and a commitment to agriculture, making this opportunity vital for aspiring agricultural professionals.

The Jennie K. Scaife Charitable Foundation Grant focuses on enhancing family support, women's and children's health, and animal welfare. It aims to fund programs that promote beneficial human-animal interactions and early intervention in addiction prevention. Eligible organizations must have a valid 501(c)(3) designation. Grants align with at least one of the foundation's focus areas, ensuring impactful contributions to community welfare and well-being.

The John D. Dixon and Louise A. Dixon Memorial Scholarship Fund honors the legacy of its namesakes by supporting graduating seniors from Cedar Cliff and Northern York High Schools. This scholarship aims to assist students with a minimum GPA of 2.5 who demonstrate financial need and a commitment to volunteerism or extracurricular activities. It is a one-time award intended to help students pursue higher education at colleges or technical schools.

Erin Marie Masling Memorial Scholarship

This scholarship encourages students who have the potential and desire to pursue a post-secondary education despite the effects of an ongoing medical condition or illness.

Number and Size of Awards

Number of recipients and award amounts vary; minimum award $500. Award paid in one lump sum in the Fall and divided equally between the Fall and Spring semesters.

Allowed Use of Award

Awards may be used for tuition, fees, books, and other expenses associated with higher education.

The LEGO Foundation Fellowship

Advancing the science and practice of supporting children to thrive

The LEGO Foundation Fellowship is a global initiative supporting researchers working to deepen our understanding of how children thrive. Spanning disciplines from education and psychology to public health, data science, and humanitarian studies, the fellowship brings together early- and mid-career scholars whose work has the potential to generate evidence that matters for children’s lives.

Fellows receive three years of flexible support to pursue rigorous, practically relevant research, and join a cohort of peers working across the fellowship’s themes. In addition to funding research, the program fosters a community of scholars engaged in meaningful exchange with one another and with research, policy, and practice audiences.

The LEGO Foundation Fellowship is developed in partnership with the LEGO Foundation, and administered by SSRC as part of its commitment to supporting scholars whose work bridges research and real-world impact.

Research themes

The LEGO Foundation Fellowship welcomes research proposals that advance understanding of children’s thriving through one of the following three themes: the youngest children in crisis and conflict settings; inclusion and wellbeing of neurodivergent children; and children’s learning and development in an AI-enabled world. Applicants may explore the role of play where it is relevant to the research question. The consideration of play is optional and not a condition of eligibility.

The ASSP Foundation Career Development Grant supports individuals in the environmental health and safety field by providing financial assistance for certification and professional development activities. Since its inception in 1990, the foundation has awarded over $6 million in grants and scholarships, aiming to enhance the skills and careers of safety professionals. Preference is given to applicants who have not previously received a grant, promoting a sustainable talent pipeline within the industry.