Best Large Grants for Nonprofit Organizations in South Carolina

The Edward P. Suchecki Family Scholarship, established by the Grand Haven Area Community Foundation, supports local high school senior athletes pursuing a business career. Named after Ed Suchecki, a dedicated coach and businessman who valued education, this scholarship prioritizes financial need and favors football and golf players. Applicants must submit their transcripts and other required documents. This initiative aims to empower young athletes to achieve their educational goals.

Transportation Research and Policy

Arnold Ventures (AV) is a philanthropy dedicated to improving the lives of all Americans through evidence-based solutions that maximize opportunity and minimize injustice.

The Infrastructure team has been investing in efforts to build better, faster, and lower-cost infrastructure with a focus on housing, energy, and transportation. For transportation, we are investing in policymaking and research that tackles the inefficiencies that make U.S. transportation infrastructure so difficult and expensive to build. 

Purpose

Transportation policy represents an avenue for improving the systems moving people, goods, and services. The Infrastructure team is seeking proposals evaluating the effectiveness and/or benefits of existing transportation or transportation-adjacent policies on outcomes for communities in the United States.

Eligible Projects and Topic Areas of Interest

This Request for Proposals (RFP) aims to bolster the knowledge base of potentially effective policies, programs, and interventions by funding efforts that align with key AV Infrastructure policy areas.

AV is primarily focused on traditional surface transportation — road and public transit — but is open to proposals in aviation, maritime, passenger and freight rail, trucking, and more.

We seek proposals for: 1) research, expanded data sets, or analysis; 2) administrative or legislative policy reforms at the federal, state, or local level; or 3) models of effective implementation including proposals for implementing agencies to partner with researchers or program evaluators to conduct baseline and post-intervention research on implementation effectiveness that will advance the knowledge base and provide illustrative examples within, but not limited to, the following topic areas:

• Transportation Capital Investment Reform. Evaluating how capital funding is prioritized and selected at the federal, state, or regional level, including discretionary grant programs and formula-based funding. What reforms could ensure projects deliver higher public returns?

• Cost Estimation, Oversight, and Accountability. Why do major transportation projects frequently exceed budgets and timelines, and how can we identify strategies to improve transparency, cost realism, and performance oversight?

• Access in Mobility Outcomes. Measuring how current transportation investments affect access to jobs, services, and economic opportunities for workers and families, and what policy changes could improve access.

• Performance-Based Project Selection. How can public agencies shift from current, politically driven allocations to datadriven, performance-based decision-making on capital project selections?

• Institutional Barriers to Reform. What organizational, legal, or procedural hurdles prevent DOTs and MPOs from adopting better practices (e.g., outcome-based planning, integrated land use/transportation policy)?

• Permitting and Permit Reform. How do current local, state, and federal permitting practices affect project cost, quality, timeline, and other concerns?

• Intergovernmental Dynamics. How do federal, state, and local funding structures and requirements enable or constrain effective transportation investment? What governance structures would improve outcomes when it comes to transportation planning and project delivery?

• Data Sets and Root Causes of High Delivery Costs. Expanded data sets on unit costs and/or research illuminating the root causes of why transportation and transit projects cost so much and take so long to deliver. What policy and practice changes could manage project delivery risks and improve the likelihood that projects will be delivered on s chedule and on budget?

• Domestic Content. How do Buy America and domestic content requirements affect the cost, speed, innovation, and effectiveness of transportation infrastructure projects?

• Procurement Process. How do current procurement practices affect project cost, quality, innovation, and accountability — and what policy and regulatory reforms could improve outcomes?

• Other. AV also welcomes innovative proposals on other transportation issues that align with our mission.

These research, policy development, and implementation proposals can be relevant to federal surface transportation reauthorization legislation or federal administrative changes; state reforms to Departments of Transportation; and/or local-level reforms relevant either to regional transportation agencies, transit agencies, or municipal governments.

Who We Are

The Community Foundation of Central Illinois will make a sustainable philanthropic impact in our community through visible leadership in connecting people who care with causes that matter.

Epilepsy Scholarship Fund

The Epilepsy Scholarship Fund was established in memory of David S. Izard, who lived in Canton, Illinois, and was active in football, track, and basketball. He graduated from Western Illinois University and worked as an Assistant Manager at Wal-Mart in Georgia. Diagnosed with epilepsy at age 3½, David lived a full and active life. He passed away on December 5, 1992, just fifteen days before his 27th birthday. Additional contributions have also been made in memory of other individuals. 

The fund provides scholarships to students pursuing an education at a junior college or four-year college or university.

BAE Systems offers community investment grants aimed at enhancing the well-being of military families and supporting future workforce development in STEM fields. As a U.S. subsidiary of a global defense and aerospace leader, they require applicants to be recognized 501(c) organizations. The initiative underscores a commitment to charitable partnerships that uplift local communities and contribute positively to society.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5413 - Comparison of PFAS Contributions to Agricultural Systems

Grant Information

• Report per- and polyfluoroalkyl substance (PFAS) concentrations from a variety of agricultural inputs, including animal manures, fertilizers, pesticides, composts, soil amendments, seed coatings, and biosolids-based products.
• Compare the impact of the various agricultural inputs on PFAS concentration in the soil profile over varying timeframes.
• Evaluate the fate and transport of different inputs to PFAS contributions in agricultural systems at field-scale.
• Determine the relative contributions from biosolids-based products and other inputs to help develop and prioritize risk management strategies.

The William F. Mann Scholarship, established in 2018, supports Albuquerque High School students pursuing full-time college education. It aims to assist students in achieving their educational goals while encouraging community service and good citizenship. Scholarships of up to $2,000 are awarded annually, with recipients expected to maintain a minimum GPA of 3.0 for renewal eligibility. Preference is given to those with a strong community service background, fostering mentorship among peers for future success.

The Davis-Kozoll Scholarship, established in 2019 by the Sandia Foundation, supports students from northwest New Mexico pursuing higher education in science or human service disciplines. Scholarships range from $1,000 to $5,000 and can be renewed annually based on academic progress. Applicants must have a minimum GPA of 2.0, demonstrate community ties, and may pursue various degrees or vocational certificates. Priority is given to students from specific local communities, enhancing educational opportunities in the region.

The Joyce Price Johnson’s Samaritan Fund provides scholarships for young people in North Carolina who are exiting foster care or facing poverty. Eligible candidates include undergraduates, graduates, and adult re-entry students attending various accredited institutions. Applications for NCCF scholarships open on December 16, 2025, and close on March 3, 2026. Preference is given to applicants from Wayne County and adjacent areas, ensuring support for those with exceptional financial need.

The NRF Foundation Retail Management Scholarship, in partnership with CVS Health, is designed to inspire undergraduate students to pursue careers in retail leadership. Eligible candidates can receive a $10,000 scholarship and attend the NRF Foundation Student Program in NYC in January 2026. This program provides networking opportunities with top retail executives and recruiters, along with insights into career pathways in the retail industry, making it a valuable experience for aspiring leaders.

The James Knott Memorial Scholarship, established by the New Mexico Manufactured Housing Association, supports graduating high school seniors residing in manufactured homes. Awards of up to $1,000 are given annually to students with a minimum GPA of 3.0 who attend a nonprofit or public educational institution full-time. Applicants must provide proof of residency, a written statement of financial need, and a reference from a teacher or counselor. This scholarship aims to empower students to achieve their educational goals.

The Carson Bailey Memorial Scholarship, established by the Children's Brain Tumor Foundation, honors the memory of Carson Bailey, a dedicated student and beloved family member. This scholarship is aimed at brain tumor survivors who have been diagnosed before the age of 21 and seek to pursue higher education. It provides $1000 to eligible applicants, supporting their educational aspirations while promoting inclusiveness and respect for all backgrounds within the brain tumor community.

The DGF Bridge Grants provide essential financial support of $500 to professional dramatists facing hardships. This one-time award helps cover non-emergency daily expenses such as housing, utilities, and healthcare. Eligible applicants must be U.S.-based dramatists with limited financial resources and have not previously received a DGF Bridge Grant. By nurturing today's creators, DGF ensures the continuation of impactful storytelling in the theater community.

The HEAL Initiative aims to address the significant overlap between chronic pain (CP) and opioid use disorder (OUD), with 40-75% of individuals affected by both. The IMPOWR project focuses on testing innovative interventions and implementation strategies to integrate care for CP and OUD across various health systems. The BEACON Center will enhance network coordination, build capacity, and develop resources to address barriers in service delivery, ultimately improving sustainability and scalability of evidence-based practices.

Scholarships

We partner with donors to administer scholarships for students across the state. Most NCCF scholarships open for applications on Dec. 16, 2025, and close on March 3, 2026.

Undergraduates, graduates, medical and professional school students and adult re-entry students who are attending community colleges, four-year universities, career/technical schools, teaching credential programs and graduate, medical or professional schools in the United States are eligible for scholarships offered at NCCF.

Each scholarship has specific eligibility requirements defined by the donor when the scholarship was established. Be sure to read the requirements of each scholarship carefully as directed through the universal application and address those elements as needed in your application.

Grayce Wills MacDonald and Ivan A. MacDonald Endowment

Shall support students who attended high school in Cherokee, Graham, Clay, Swain, Macon, Jackson, Haywood, Buncombe, and Henderson counties, and who are pursuing a college or post-graduate level degree in the field of nutrition with emphasis on the study of natural foods and the vegetarian lifestyle. Scholarships may be based on both need and merit.

The Charles B. Decker Memorial Scholarship, established in 1991, supports college and graduate students from the Tri-Lakes area pursuing journalism careers. This scholarship emphasizes the importance of education in the Adirondack region by providing essential financial assistance to students dedicated to journalism. Candidates are evaluated based on financial need, demonstrated commitment to journalism, and academic achievements, ensuring that the scholarship aligns with the foundation's mission to invest in educational opportunities.

Yawkey Foundation

The story of Tom and Jean Yawkey and their impact on the lives of children and families goes back over eight decades to the commitments they made to the people of Massachusetts, New England, and Georgetown County, South Carolina. The Yawkeys’ love for these communities, and their quiet sense of responsibility for those in need, is captured in the careful steps they took to ensure that their legacy would live on through the work of the Yawkey Foundation. The Yawkeys were perhaps best known for their longtime ownership of the Boston Red Sox. More quietly, but with just as much passion and commitment, Tom and Jean Yawkey were also engaged in an unwavering dedication to those most in need.

Today, the Yawkey Foundation remains as committed as ever to continuing to honor Tom and Jean Yawkey and their commitment to those in need. Having awarded more than $620 million to-date in charitable grants to organizations focused on Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife, the Yawkey Foundation is committed to preserving and sustaining the charitable values of the Yawkeys by investing in impactful nonprofits providing resources, opportunity, and dignity to the vulnerable and underserved. The Yawkey Foundation is committed to providing support for program and small capital needs connected to a nonprofit’s established mission and proven program/service delivery connected to the mission.

Program and Small Capital Grants

Program and Small Capital Grants support high-impact, strategic, and responsive nonprofit organizations in delivering their core missions through discrete and timebound projects. Program & Small Capital Grants help address an immediate need that is critical to the organization’s work.

Program and Small Capital Grants may fund a discrete timebound program need, one small project, or a piece of equipment aligned with a nonprofit’s purpose. These grants are extremely competitive, and the Yawkey Foundation will receive many more compelling Initial Proposals than it will be able to fund. Initial Proposals should demonstrate an awareness of and alignment with the Yawkey Foundation’s mission and Areas of Giving. Additionally, the most competitive Initial Proposals will reflect a nonprofit’s strong leadership and proven impact in providing direct services and programs for unmet needs in underserved regions aligned with the Yawkey Foundation’s geographic priority areas, including Gateway Cities in Eastern Massachusetts.

Nonprofits may submit only one Initial Proposal to the Yawkey Foundation during a calendar year, irrespective of the Type of Grant. Organizations that have not been previously funded by the Foundation in recent years are encouraged to submit Initial Proposals for Program & Small Capital Grants to familiarize the Foundation with its work before submitting an Initial Proposal for Strategic Investment or Transformational Capital.

Areas of Giving: Human Services; Youth & Amateur Athletics; Education; Conservation & Wildlife; Arts & Culture; and Health Care.

Health Care Support

Access to high quality health care, particularly for those disadvantaged members of the community, was an issue of great importance to Tom and Jean Yawkey. Tom Yawkey was instrumental in the founding of Georgetown Memorial Hospital, which brought much-needed health care to the rural area of Georgetown, South Carolina. In addition, the Yawkeys first lent their extraordinary support to Dr. Sidney Farber by initiating the Red Sox relationship with Dr. Farber, and laid the groundwork for establishment of The Jimmy Fund in 1953. That relationship lasted throughout both of their lifetimes and continues to this day.

The Yawkey Foundation continues to support medical institutions, including transformational construction and renovation projects to help leading medical institutions expand their footprints and ability to provide expert medical care. Understanding the real link between medical needs and behavioral health needs, particularly in children, the Foundation has also played a leading role in supporting organizations providing access to behavioral and mental health treatment programs. 

The Retail Merchants Association of Tyler Scholarship, administered by the East Texas Communities Foundation, supports graduating seniors planning to major in Business. Eligible students must be from specific Smith County high schools and demonstrate financial need through FASFA. This scholarship, amounting to $1,000, can be used for tuition, fees, and educational supplies. The unique application process matches students with scholarships, ensuring they apply only once and receive consideration for multiple opportunities.

Every Battle Creek area resident shall have the resources to access post-secondary education and training.

Your dreams matter — and we want to help you achieve them. Whether you’re a graduating high school senior, an adult returning to school, or a graduate student pursuing advanced education, we’re here to support you by opening doors to opportunity.

Beyond tuition, many funds support total cost of attendance — books, fees, equipment, and in some cases childcare or transportation.

Checks are made payable to the educational institution indicated on the follow-up and mailed directly to the educational institution. Checks are typically mailed in early August.

Multiple Sclerosis Scholarship

Dr. Rose Marie Lovio designed this scholarship with her favorite quote in mind: "Life is 10% what happens to us and 90% how we react to it". This scholarship is designed for a student who has been directly diagnosed with the disease or who has a close family member who lives with multiple sclerosis. This chronic illness offers a multitude of challenges and this scholarship seeks a recipient who exudes positivity despite those challenges.

The NIDCD Research Career Enhancement Award (K18) supports established investigators in enhancing or redirecting their research efforts. This program is crucial for acquiring new skills relevant to hearing, balance, smell, taste, voice, speech, and language sciences. Key deadlines for applications span from June 2024 to February 2027, including specific dates for AIDS-related grants, ensuring timely funding opportunities for innovative research.

The EMF EMRA Resident Research Grant, funded by the Society for Academic Emergency Medicine Foundation, aims to enhance research in emergency medicine by providing up to $10,000 for residents in accredited programs. This grant promotes the development of future researchers, improves patient care, and supports effective health policy through rigorous scientific inquiry. Eligible applicants must be ACGME-approved residents and secure a faculty preceptor's support, ensuring a robust educational experience in research methodologies.

The David R. Woodling Memorial Scholarship, established by The Stocker Foundation in 2007, supports students pursuing certificates or degrees in metals technology, focusing on machine tool technology and welding. Open to legal residents of New Mexico, eligible applicants include high school seniors and nontraditional students. The scholarship aims to provide financial assistance for tuition, fees, books, and required materials, ensuring that recipients can achieve their educational and career goals in this vital field.

The Edith M. Pritchard Scholarship, offered by Nurses Educational Funds Inc., supports nurses pursuing master's or doctoral degrees in nursing education and public health. Applicants must hold a current RN license, maintain a GPA of 3.6, and have at least two semesters of study remaining post-award notification. This scholarship promotes nursing leadership and is funded through donations, reflecting over a century of commitment to nursing education.

Ben & Rose Schwabenbauer Educational Scholarship

Established by Ben and Rose Schwabenbauer, former long-time teachers in the Olean City School District, this fund awards scholarships for graduating seniors from Olean High School, Otto-Eldred High School, Portville Central School or Bradford Area High School who will be attending a 4-year college with a preference for students majoring in education, particularly elementary education; criminal justice or a law enforcement-related field; or healthcare-related fields of study. 

The National Cancer Institute (NCI) invites applications for studies on mechanisms by which bariatric surgery influences cancer risk. This funding opportunity encourages exploration beyond short-term outcomes like weight loss and diabetes. The goal is to support innovative proof of concept studies, emphasizing feasibility without prior development in the literature. Unpublished data is not allowed, but references from preprints with a DOI are acceptable. Deadlines for applications span from February 2025 to November 2027.

The Amazing Grace Scholarship, established by the Children's Brain Tumor Foundation, honors Grace Fulcher, a brain tumor survivor. This scholarship supports students diagnosed with brain or spinal cord tumors before age 21, who reside in the U.S. and are pursuing higher education. With a $1000 award, the scholarship aims to empower survivors to achieve their educational goals, inspired by Grace's resilience and academic success despite her challenges.

The National Cancer Institute (NCI) is seeking applications for studies that explore how bariatric surgery influences cancer risk, emphasizing the need for innovative research in this area. This funding opportunity encourages the participation of researchers who focus on the long-term impacts of bariatric surgery beyond weight loss and diabetes, addressing critical gaps in understanding the disease mechanisms involved. Key deadlines for application submissions span from February 2025 to October 2027.

Cures Within Reach

Cures Within Reach is the philanthropic leader in drug, device and nutraceutical repurposing research, which has the potential to transform the lives of patients with unsolved diseases by delivering treatments that can be used in the near-term. Our focus: we find and fund proof-of-concept clinical trials that, once successful, de-risk and catalyze follow-on funding, building the clinical evidence required for regulatory approval or to support off-label use by patients everywhere.

Clinical Repurposing Research to Impact US Veterans/Military

This Request for Proposals (RFP) from Cures Within Reach (CWR) is seeking clinical repurposing trials from US-based research institutions using already approved treatments to address unmet and high-priority medical needs of US veterans and/or active US military, such as mental health, post-traumatic stress disorder (PTSD) and brain injuries. Our strongest preference is for proof of concept, pivotal, Phase I or Phase IIA clinical repurposing trials. Eligible trials may be conducted at accredited US-based academic, nonprofit and governmental research institutions and/or health systems involved with medical research, including Veterans Administration (VA) health systems and hospitals. 

Repurposed therapies must be approved and/or generally recognized as safe for human use by some regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and may include drugs, devices, nutraceuticals or diagnostics, as well as combination therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care to improve patient outcomes and/or quality of life.